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The map label for this gene is ilvD

Identifier: 87199801

GI number: 87199801

Start: 1881817

End: 1883664

Strand: Direct

Name: ilvD

Synonym: Saro_1784

Alternate gene names: 87199801

Gene position: 1881817-1883664 (Clockwise)

Preceding gene: 87199800

Following gene: 87199802

Centisome position: 52.84

GC content: 65.31

Gene sequence:

>1848_bases
ATGCCCGCCTATCGTTCGCGCACGACCACCCACGGCCGCAACATGGCAGGTGCACGCGGCCTCTGGCGCGCTACCGGCAT
GAAGGACAGCGATTTCGGCAAGCCGATCATCGCCGTCGTGAACTCGTTTACCCAGTTCGTCCCCGGCCACGTCCACCTCA
AGGACCTGGGCCAGATGGTCGCCCGCGAAATCGAAGCAGCGGGCGGCGTCGCGAAGGAATTCAACACCATCGCGGTCGAC
GATGGCATCGCCATGGGCCATGACGGCATGCTCTATTCGCTGCCCAGCCGCGATCTGATCGCCGACAGCGTCGAATACAT
GGTCAACGCCCATTGCGCCGACGCGATGGTCTGCATCTCCAACTGCGACAAGATCACCCCCGGCATGCTCATGGCGGCAA
TGCGGATCAACATCCCGGTGGTCTTCGTGTCCGGCGGCCCGATGGAGGCCGGCAAGGTCATCCTCAAGGGCAAGGAACAC
GCGCTCGACCTCGTCGATGCGATGGTCGCCGCCGCAGACGAAAGCTTCACCGACGAGGAAGTGACCGCCATCGAGCGTTC
GGCCTGCCCGACCTGCGGTTCGTGCTCGGGCATGTTCACCGCCAATTCGATGAACTGCCTGACCGAGGCGCTTGGACTTT
CGCTGCCCGGCAACGGATCGACCCTTGCCACCCACGCCGATCGCCAGCGCCTGTTCCTCGAAGCAGGCCGCCTCGTGGTC
GACCTGTGCAAGCGCTACTACGAGCAGGACGACGAAAGCGTCCTGCCGCGTTCGATCGCCACGTTCGAGGCTTTCGAGAA
CGCGATGAGCCTCGACATCGCGATGGGCGGTTCGACCAACACCGTGCTGCATCTGCTGGCCGCCGCGCACGAGGCGGGCG
TCAACTTCACCATGTCCGACATCGACCATCTCAGCCGCAAGGTGCCGTGCCTGTCAAAGGTCGCTCCGGCAAAGTCCGAT
GTGCACATGGAAGACGTCCACCGCGCAGGTGGCATTTATGCCATCCTCGGCGAACTGGACCGCGCGGGCCTGCTTCATAC
CCATCTGCCGACCGTCCACAGCCGCACGCTTGGCGATGCGCTGAACCAGTGGGACGTGAAGCGCACCAACTCGCCCACGG
TGCAGGAATTCTTCCGCGCCGCGCCGGGCGGCGTGCCGACGCAGGTTGCCTTCTCGCAGGATCGCCGCTGGAAGGAACTC
GATCTGGACCGCGAAACGGGCGTGATCCGTTCGGCCGAGCATGCGTTCTCGAAGGACGGCGGCCTTGCCGTGCTGTTCGG
TAACATCGCCCGCGAGGGTTGCATCGTGAAGACCGCGGGCGTGGACGACAGCATCCTGAAGTTCACCGGTCCGGCAAAGG
TCTATGAAAGCCAGGATGCCGCCGTCACCGCGATCCTCACCGGGCAGGTGACCTCGGGCGACGTGGTCGTGATCCGGTAC
GAAGGGCCCAAGGGCGGCCCCGGCATGCAGGAAATGCTCTATCCGACGAGCTACCTGAAGTCGAAGGGCCTGGGTGCGGC
CTGCGCGCTGCTGACCGATGGCCGTTTCTCGGGCGGCACGTCGGGCCTGTCCATCGGCCACGTCTCGCCGGAGGCTGCCG
AGGGCGGGGAGATCGGTCTGGTCGAGAACGGCGACGTGATCGAGATCGACATTCCGAACCGCACCATCCACCTTGCCGTG
GCGGACGATGTCCTTGCCCAGCGCCGGGCGGAGCAGGAGGCGAAGGGCTGGAAGCCGGTCAAGGAACGCCCGCGCAAGGT
GTCGACCGCGCTCAGGGCCTATGCCGCGATGACCACCAGCGCGGCGCGCGGTGCGGTGCGCGATCTTTCGCAACTCAAGA
TCGACTGA

Upstream 100 bases:

>100_bases
CTGACAGCGAGGTAATTTAACCTTCGACATGGCCCCTTGCCCTGGGTTAGGGGCAAGCCCAAGTCGCACGTAAACTGATT
CCCTGTCCGGAGTTCCTGCA

Downstream 100 bases:

>100_bases
CGTGCGCCGGCTTGCGCCTCTCCTGCTGTGCGCGGCACTCGCCGCCTGCTCGGGGGGCGAAGCTGCGCCGAAGGGCCGGG
TCATTGACTGCATTGTGGCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQMVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRINIPVVFVSGGPMEAGKVILKGKEH
ALDLVDAMVAAADESFTDEEVTAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRQRLFLEAGRLVV
DLCKRYYEQDDESVLPRSIATFEAFENAMSLDIAMGGSTNTVLHLLAAAHEAGVNFTMSDIDHLSRKVPCLSKVAPAKSD
VHMEDVHRAGGIYAILGELDRAGLLHTHLPTVHSRTLGDALNQWDVKRTNSPTVQEFFRAAPGGVPTQVAFSQDRRWKEL
DLDRETGVIRSAEHAFSKDGGLAVLFGNIAREGCIVKTAGVDDSILKFTGPAKVYESQDAAVTAILTGQVTSGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSKGLGAACALLTDGRFSGGTSGLSIGHVSPEAAEGGEIGLVENGDVIEIDIPNRTIHLAV
ADDVLAQRRAEQEAKGWKPVKERPRKVSTALRAYAAMTTSAARGAVRDLSQLKID

Sequences:

>Translated_615_residues
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQMVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRINIPVVFVSGGPMEAGKVILKGKEH
ALDLVDAMVAAADESFTDEEVTAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRQRLFLEAGRLVV
DLCKRYYEQDDESVLPRSIATFEAFENAMSLDIAMGGSTNTVLHLLAAAHEAGVNFTMSDIDHLSRKVPCLSKVAPAKSD
VHMEDVHRAGGIYAILGELDRAGLLHTHLPTVHSRTLGDALNQWDVKRTNSPTVQEFFRAAPGGVPTQVAFSQDRRWKEL
DLDRETGVIRSAEHAFSKDGGLAVLFGNIAREGCIVKTAGVDDSILKFTGPAKVYESQDAAVTAILTGQVTSGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSKGLGAACALLTDGRFSGGTSGLSIGHVSPEAAEGGEIGLVENGDVIEIDIPNRTIHLAV
ADDVLAQRRAEQEAKGWKPVKERPRKVSTALRAYAAMTTSAARGAVRDLSQLKID
>Mature_614_residues
PAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQMVAREIEAAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRINIPVVFVSGGPMEAGKVILKGKEHA
LDLVDAMVAAADESFTDEEVTAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRQRLFLEAGRLVVD
LCKRYYEQDDESVLPRSIATFEAFENAMSLDIAMGGSTNTVLHLLAAAHEAGVNFTMSDIDHLSRKVPCLSKVAPAKSDV
HMEDVHRAGGIYAILGELDRAGLLHTHLPTVHSRTLGDALNQWDVKRTNSPTVQEFFRAAPGGVPTQVAFSQDRRWKELD
LDRETGVIRSAEHAFSKDGGLAVLFGNIAREGCIVKTAGVDDSILKFTGPAKVYESQDAAVTAILTGQVTSGDVVVIRYE
GPKGGPGMQEMLYPTSYLKSKGLGAACALLTDGRFSGGTSGLSIGHVSPEAAEGGEIGLVENGDVIEIDIPNRTIHLAVA
DDVLAQRRAEQEAKGWKPVKERPRKVSTALRAYAAMTTSAARGAVRDLSQLKID

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=615, Percent_Identity=74.9593495934959, Blast_Score=940, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=568, Percent_Identity=30.6338028169014, Blast_Score=196, Evalue=5e-51,
Organism=Escherichia coli, GI1786464, Length=554, Percent_Identity=31.7689530685921, Blast_Score=192, Evalue=6e-50,
Organism=Escherichia coli, GI1788157, Length=544, Percent_Identity=29.2279411764706, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=610, Percent_Identity=37.5409836065574, Blast_Score=355, Evalue=1e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_NOVAD (Q2G7E9)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_497058.1
- STRING:   Q2G7E9
- GeneID:   3918343
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1784
- NMPDR:   fig|48935.1.peg.2057
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   Q2G7E9
- ProtClustDB:   PRK12448
- BioCyc:   NARO279238:SARO_1784-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65600; Mature: 65469

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQMV
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRINIPVVFVSGGPMEAGKVILKGKEHALDLVDAMVAAADESFTDEE
CCCCCCHHHHHHHHEECCEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCHH
VTAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRQRLFLEAGRLVV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHH
DLCKRYYEQDDESVLPRSIATFEAFENAMSLDIAMGGSTNTVLHLLAAAHEAGVNFTMSD
HHHHHHHCCCCCHHCHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHCCCCEEHHH
IDHLSRKVPCLSKVAPAKSDVHMEDVHRAGGIYAILGELDRAGLLHTHLPTVHSRTLGDA
HHHHHHCCCHHHHCCCCCCCCCHHHHHHCCCEEEEEECCCCCCEEHHCCCCHHHHHHHHH
LNQWDVKRTNSPTVQEFFRAAPGGVPTQVAFSQDRRWKELDLDRETGVIRSAEHAFSKDG
HHHCCCCCCCCCHHHHHHHHCCCCCCCEEEECCCCCCHHCCCCCCCCCHHHHHHHHCCCC
GLAVLFGNIAREGCIVKTAGVDDSILKFTGPAKVYESQDAAVTAILTGQVTSGDVVVIRY
CEEEEEECCCCCCCEEEECCCCCCHHEECCCHHHCCCCCCEEEEEEECCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSYLKSKGLGAACALLTDGRFSGGTSGLSIGHVSPEAAEGGEIGL
CCCCCCCCHHHHHCCHHHHHCCCCCEEEEEEECCCCCCCCCCEEECCCCCCCCCCCCEEE
VENGDVIEIDIPNRTIHLAVADDVLAQRRAEQEAKGWKPVKERPRKVSTALRAYAAMTTS
EECCCEEEEECCCCEEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
AARGAVRDLSQLKID
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
PAYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQMV
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRINIPVVFVSGGPMEAGKVILKGKEHALDLVDAMVAAADESFTDEE
CCCCCCHHHHHHHHEECCEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCHH
VTAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRQRLFLEAGRLVV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHH
DLCKRYYEQDDESVLPRSIATFEAFENAMSLDIAMGGSTNTVLHLLAAAHEAGVNFTMSD
HHHHHHHCCCCCHHCHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHCCCCEEHHH
IDHLSRKVPCLSKVAPAKSDVHMEDVHRAGGIYAILGELDRAGLLHTHLPTVHSRTLGDA
HHHHHHCCCHHHHCCCCCCCCCHHHHHHCCCEEEEEECCCCCCEEHHCCCCHHHHHHHHH
LNQWDVKRTNSPTVQEFFRAAPGGVPTQVAFSQDRRWKELDLDRETGVIRSAEHAFSKDG
HHHCCCCCCCCCHHHHHHHHCCCCCCCEEEECCCCCCHHCCCCCCCCCHHHHHHHHCCCC
GLAVLFGNIAREGCIVKTAGVDDSILKFTGPAKVYESQDAAVTAILTGQVTSGDVVVIRY
CEEEEEECCCCCCCEEEECCCCCCHHEECCCHHHCCCCCCEEEEEEECCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSYLKSKGLGAACALLTDGRFSGGTSGLSIGHVSPEAAEGGEIGL
CCCCCCCCHHHHHCCHHHHHCCCCCEEEEEEECCCCCCCCCCEEECCCCCCCCCCCCEEE
VENGDVIEIDIPNRTIHLAVADDVLAQRRAEQEAKGWKPVKERPRKVSTALRAYAAMTTS
EECCCEEEEECCCCEEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
AARGAVRDLSQLKID
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA