Click here to switch to the map view.

The map label for this gene is phr [H]

Identifier: 87199776

GI number: 87199776

Start: 1854600

End: 1855964

Strand: Direct

Name: phr [H]

Synonym: Saro_1759

Alternate gene names: 87199776

Gene position: 1854600-1855964 (Clockwise)

Preceding gene: 87199775

Following gene: 87199777

Centisome position: 52.07

GC content: 65.49

Gene sequence:

>1365_bases
ATGAGCGACCCCGTAATCGTCTGGTTCCGACGCGACCTCCGCCTTGCAGATCAAGCCGCCCTCCTGGCTGCCGCAGCCGA
GGGGCCGGTCATTCCCGTCTACATCCTCGACGACGATACCCCGCGCCACTGCCGCATGGGTGGAGCGTCGCGCTGGTGGC
TCCACCACAGCTTGGCCGAGCTTGATGCCTCGCTGCGCAAGCTTGGATCGCGCCTGATCCTGCGTCGGGGCAAGTGCCAC
GAGGAGCTTGCCGCCGTTCGCCGCGAGGCCGGGGCGAGGGTCGTTCACGCATTGCAGCACTACGAGCCTTGGTGGCGCAA
TGCCGAAAAGGCGGTGGCCAAGACAATCCGCCTGGTCCTTCACGAAGGCAACTATCTGGCCCCCGCCGGTTCCGTCCGCA
CCGGGATGGGCCGGCCCTACAAGATCTACACGCCCTTCTGGCATGCCCTGCTCGAGCGCATGCCCCCTGCGCCGCCCTTG
CCGGCACCCGAACGGCTCGAAGCGCCCGCCGTCTGGCCCACGAGCGATGCGCTGGACGACTGGAAGCTGCTTCCGACGGC
ACCCGACTGGGCAGGTGGGTTCCGCGAGACATGGACTCCGGGCGAGAACGGTGCGGAAGAGCGGCTTCAGGACTTTGCCG
ACCGTGTGGCCCGCTACGGAGAAACGCGGAACCTGCCTTCGATCGAAGGCACCTCGCGCCTTTCGCCCCACCTTCATTTC
GGCGAGATCTCTCCAGCCACGATCTGGCATCGGGTGGTGAATGCGGGCGGTTCGGTCGACGTGTTTCTGGGTGAACTGGG
TTGGCGCGACTATGCCCAGAACGTAATCGTGCAATTCCCGGACTACGGTTCGAGGAATGCGCGCGAGGCGTACGACCGGC
TCGAATGGCGCGACGATCCCGAGGCATTGCGCGCCTGGCAACAGGGCCGGACCGGCTATCCCATCGTCGATGCCGGCATG
CGCGAGCTCTGGCACACCGGGTGGATGCACAACCGGGTGCGGATGATCGCCGCCAGCTTCCTTGTGAAACACCTTCTGAT
CGACTGGCGCGAGGGCGAGCGGTGGTTCTGGGACACGCTGGTCGATGCCGACTATGCATCCAACGCGGTCAACTGGCAGT
GGACAGCCGGTACGGGCGTCGATTCCAACATGTTCGTCAGGATCATGGCGCCGCTGACCCAGTCACCGAAGTTCGACGCG
GCAGGCTATATCCGGCAATGGGTGCCCGAACTGGCTCATCTTTCCGACCGCGATATTCACGATCCCGCCGTTCCGCCGCG
CGGCTATCCGGCAAAGATCGTCAGCCATTCCGAGGCGCGGGCACGTGCCCTTGCCGCGCATGACAGGATGAAGCAGCCGG
CGTGA

Upstream 100 bases:

>100_bases
AATTGAAGGGCGGTCCATCGCGGGCCGCCCTTTCAACATGCCCGAAGGGGCAGGTCTGGAGGGGTGGTAACTGCGCGGAG
CAGTCGCCAGAACAATCGGG

Downstream 100 bases:

>100_bases
CTTGCGCCGAGCGCCTGGCAGACACATAACAGCCGGATGAATGCTCAGACGCCACTGAGGGGAGGGCATCTGGTCACCGG
CGGACGAAAACTGTCGGCGT

Product: deoxyribodipyrimidine photo-lyase type I

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSDPVIVWFRRDLRLADQAALLAAAAEGPVIPVYILDDDTPRHCRMGGASRWWLHHSLAELDASLRKLGSRLILRRGKCH
EELAAVRREAGARVVHALQHYEPWWRNAEKAVAKTIRLVLHEGNYLAPAGSVRTGMGRPYKIYTPFWHALLERMPPAPPL
PAPERLEAPAVWPTSDALDDWKLLPTAPDWAGGFRETWTPGENGAEERLQDFADRVARYGETRNLPSIEGTSRLSPHLHF
GEISPATIWHRVVNAGGSVDVFLGELGWRDYAQNVIVQFPDYGSRNAREAYDRLEWRDDPEALRAWQQGRTGYPIVDAGM
RELWHTGWMHNRVRMIAASFLVKHLLIDWREGERWFWDTLVDADYASNAVNWQWTAGTGVDSNMFVRIMAPLTQSPKFDA
AGYIRQWVPELAHLSDRDIHDPAVPPRGYPAKIVSHSEARARALAAHDRMKQPA

Sequences:

>Translated_454_residues
MSDPVIVWFRRDLRLADQAALLAAAAEGPVIPVYILDDDTPRHCRMGGASRWWLHHSLAELDASLRKLGSRLILRRGKCH
EELAAVRREAGARVVHALQHYEPWWRNAEKAVAKTIRLVLHEGNYLAPAGSVRTGMGRPYKIYTPFWHALLERMPPAPPL
PAPERLEAPAVWPTSDALDDWKLLPTAPDWAGGFRETWTPGENGAEERLQDFADRVARYGETRNLPSIEGTSRLSPHLHF
GEISPATIWHRVVNAGGSVDVFLGELGWRDYAQNVIVQFPDYGSRNAREAYDRLEWRDDPEALRAWQQGRTGYPIVDAGM
RELWHTGWMHNRVRMIAASFLVKHLLIDWREGERWFWDTLVDADYASNAVNWQWTAGTGVDSNMFVRIMAPLTQSPKFDA
AGYIRQWVPELAHLSDRDIHDPAVPPRGYPAKIVSHSEARARALAAHDRMKQPA
>Mature_453_residues
SDPVIVWFRRDLRLADQAALLAAAAEGPVIPVYILDDDTPRHCRMGGASRWWLHHSLAELDASLRKLGSRLILRRGKCHE
ELAAVRREAGARVVHALQHYEPWWRNAEKAVAKTIRLVLHEGNYLAPAGSVRTGMGRPYKIYTPFWHALLERMPPAPPLP
APERLEAPAVWPTSDALDDWKLLPTAPDWAGGFRETWTPGENGAEERLQDFADRVARYGETRNLPSIEGTSRLSPHLHFG
EISPATIWHRVVNAGGSVDVFLGELGWRDYAQNVIVQFPDYGSRNAREAYDRLEWRDDPEALRAWQQGRTGYPIVDAGMR
ELWHTGWMHNRVRMIAASFLVKHLLIDWREGERWFWDTLVDADYASNAVNWQWTAGTGVDSNMFVRIMAPLTQSPKFDAA
GYIRQWVPELAHLSDRDIHDPAVPPRGYPAKIVSHSEARARALAAHDRMKQPA

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=492, Percent_Identity=28.2520325203252, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI188536100, Length=485, Percent_Identity=28.4536082474227, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI188536103, Length=445, Percent_Identity=27.1910112359551, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI1786926, Length=471, Percent_Identity=38.0042462845011, Blast_Score=259, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6324962, Length=504, Percent_Identity=28.3730158730159, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17137248, Length=481, Percent_Identity=30.5613305613306, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24585455, Length=481, Percent_Identity=30.5613305613306, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24648152, Length=513, Percent_Identity=26.3157894736842, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR019947
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 51580; Mature: 51449

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1 ; PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPVIVWFRRDLRLADQAALLAAAAEGPVIPVYILDDDTPRHCRMGGASRWWLHHSLAE
CCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHCCCCCHHHHHHHHHH
LDASLRKLGSRLILRRGKCHEELAAVRREAGARVVHALQHYEPWWRNAEKAVAKTIRLVL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHH
HEGNYLAPAGSVRTGMGRPYKIYTPFWHALLERMPPAPPLPAPERLEAPAVWPTSDALDD
CCCCEECCCCCCCCCCCCCEEEECHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
WKLLPTAPDWAGGFRETWTPGENGAEERLQDFADRVARYGETRNLPSIEGTSRLSPHLHF
CEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GEISPATIWHRVVNAGGSVDVFLGELGWRDYAQNVIVQFPDYGSRNAREAYDRLEWRDDP
CCCCHHHHHHHHHHCCCCEEEEEHHHCCHHHHCCCEEECCCCCCCCHHHHHHHCCCCCCH
EALRAWQQGRTGYPIVDAGMRELWHTGWMHNRVRMIAASFLVKHLLIDWREGERWFWDTL
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHH
VDADYASNAVNWQWTAGTGVDSNMFVRIMAPLTQSPKFDAAGYIRQWVPELAHLSDRDIH
HCCHHCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
DPAVPPRGYPAKIVSHSEARARALAAHDRMKQPA
CCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDPVIVWFRRDLRLADQAALLAAAAEGPVIPVYILDDDTPRHCRMGGASRWWLHHSLAE
CCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHCCCCCHHHHHHHHHH
LDASLRKLGSRLILRRGKCHEELAAVRREAGARVVHALQHYEPWWRNAEKAVAKTIRLVL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHH
HEGNYLAPAGSVRTGMGRPYKIYTPFWHALLERMPPAPPLPAPERLEAPAVWPTSDALDD
CCCCEECCCCCCCCCCCCCEEEECHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
WKLLPTAPDWAGGFRETWTPGENGAEERLQDFADRVARYGETRNLPSIEGTSRLSPHLHF
CEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GEISPATIWHRVVNAGGSVDVFLGELGWRDYAQNVIVQFPDYGSRNAREAYDRLEWRDDP
CCCCHHHHHHHHHHCCCCEEEEEHHHCCHHHHCCCEEECCCCCCCCHHHHHHHCCCCCCH
EALRAWQQGRTGYPIVDAGMRELWHTGWMHNRVRMIAASFLVKHLLIDWREGERWFWDTL
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHH
VDADYASNAVNWQWTAGTGVDSNMFVRIMAPLTQSPKFDAAGYIRQWVPELAHLSDRDIH
HCCHHCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
DPAVPPRGYPAKIVSHSEARARALAAHDRMKQPA
CCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2837735; 2110564; 9360600 [H]