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The map label for this gene is sdhA

Identifier: 87199763

GI number: 87199763

Start: 1839579

End: 1841393

Strand: Direct

Name: sdhA

Synonym: Saro_1746

Alternate gene names: 87199763

Gene position: 1839579-1841393 (Clockwise)

Preceding gene: 87199762

Following gene: 87199764

Centisome position: 51.65

GC content: 65.29

Gene sequence:

>1815_bases
ATGACTTCGACTCAGCCTGCCTACAAGATCATCGACCACACCTACGACACCGTCGTCGTGGGCGCGGGCGGTTCGGGCCT
GCGCGCGACCATGGGTTCGGCCCAGGCCGGCCTGCGCACCGCCTGCATCACCAAGGTCTTCCCGACCCGTTCGCACACCG
TGGCGGCACAGGGTGGCATCGCCGCCAGCCTCGGCAACAATTCGCCGGACCACTGGACCTGGCACATGTACGACACCGTC
AAGGGGTCTGACTGGCTGGGCGACCAGGATGCCATCGAATACATGGTGCGCGAGGCTCCGGCCGCGGTCTACGAACTGGA
ACACGCGGGTGTCCCGTTCAGCCGCAACCCCGAAGGCACGATCTACCAGCGTCCGTTCGGCGGTCACATGCAGAACATGG
GTGAAGGCCCGCCGGTTCAGCGCACCTGCGCCGCCGCCGACCGTACCGGCCACGCCATGCTTCACGCGCTGTACCAGCAG
AGCCTGAAGTACGACGCCGACTTCTTCATCGAATACTTCGCGATCGACCTGATCATGGAGAACGGTGAATGCCGCGGCGT
GATCGCGCTGTGCATGGACGACGGCTCGATCCACCGCTTCCGCAGCCATGCGGTCGTGCTGGCGACCGGCGGCTATGGCC
GTTCGTACTTCACCGCGACGTCGGCCCATACCTGCACCGGCGACGGCGGCGGCATGGTGCTGCGCGCGGGCCTGCCGCTG
CAGGACATGGAATTCGTGCAGTTCCACCCGACCGGCATCTACGGCGCGGGCGTGCTCATCACCGAAGGCGCGCGTGGTGA
GGGCGGCTACCTGACGAACTCCGAGGGCGAGCGTTTCATGGAGCGCTATGCCCCGTCGGCCAAGGACCTTGCGTCGCGCG
ACGTCGTGTCGCGTTCGATGGCGATGGAAATCCGCGAGGGTCGCGGCGTCGGTCCGCACAAGGACCACATCTACCTGCAC
CTCGACCACATCGACCAGAAGGTGCTGGCAGAGCGTCTGCCCGGCATCACCGAAAGCGGCAAGATCTTCGCGGGTGTCGA
TCTTACCCGCCAGCCGCTGCCGGTCGTGCCGACCGTGCACTACAACATGGGCGGCATCCCGACGAACTATCACGGCGAAG
TCGTCACCATCGGCGCCGACGGCAACCCCGAGACGATCGTCCCGGGTCTGTTCGCGGTAGGCGAAGCGGCCTGCGTTTCG
GTCCACGGCGCGAACCGCCTTGGCTCGAACTCGCTGATCGACCTTGTCGTGTTCGGCCGTGCCACGGGCCTGCGCCTCAA
GGAACTGATCAAGCCGGGCACCGCGCACAACTCGCTGCCCAAGGACAGCGCCGACCTCGCGCTGACCCGCCTCGATCACT
TCCGCCATGCCAAGGGCGGTTCGCCCACCGCCGAAGTGCGCATCGAAATGCAGCGCACGATGTCGGCCCACGCGGCGGTG
TTCCGCACCGACGAACTGATGGCGGAAGGCAAGGTCAAGCTGGCCGATACCTACAAGCGCATGGAAGACATCCACGTGTC
CGACCGTTCGCTGATCTGGAACTCGGACCTTGTCGAAACGCTCGAACTGGACAACCTGATCAGCCAGGCGACCGTGACGA
TGCATTCCGCGCATAACCGCAAGGAAAGCCGCGGTGCCCACGCGCACGAGGATTTCCCCGATCGCAACGACGCCGAGTGG
ATGAAGCACACCGCCACCTGGTTCAACGGATGGGGCGGCAAGGGTGGCGAAGTCCGCATCGACTATCGCCCGGTCCACGA
ATACACGCTGACCGACGACGTCGAGTACATCAAGCCGAAGAAGCGCGTGTACTGA

Upstream 100 bases:

>100_bases
CAAGATCGCGGCCTGGCTGCTGGTCAACATCGTGCCCTTCGTGGCAGCCGCCTTCGGCATCCTTTCGGTTCTGCGCATTG
CGCTCGGGGGCGCATAAGAC

Downstream 100 bases:

>100_bases
TCCGGCCTGAACGCCGATCCATCGCGGTCGGTCGTTTGTCGAACACCGAATGAGCTTGCGCCGGGGTAGGAATACCCCGG
CGCAATGCATTTGGGCCGCT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MTSTQPAYKIIDHTYDTVVVGAGGSGLRATMGSAQAGLRTACITKVFPTRSHTVAAQGGIAASLGNNSPDHWTWHMYDTV
KGSDWLGDQDAIEYMVREAPAAVYELEHAGVPFSRNPEGTIYQRPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHALYQQ
SLKYDADFFIEYFAIDLIMENGECRGVIALCMDDGSIHRFRSHAVVLATGGYGRSYFTATSAHTCTGDGGGMVLRAGLPL
QDMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRSMAMEIREGRGVGPHKDHIYLH
LDHIDQKVLAERLPGITESGKIFAGVDLTRQPLPVVPTVHYNMGGIPTNYHGEVVTIGADGNPETIVPGLFAVGEAACVS
VHGANRLGSNSLIDLVVFGRATGLRLKELIKPGTAHNSLPKDSADLALTRLDHFRHAKGGSPTAEVRIEMQRTMSAHAAV
FRTDELMAEGKVKLADTYKRMEDIHVSDRSLIWNSDLVETLELDNLISQATVTMHSAHNRKESRGAHAHEDFPDRNDAEW
MKHTATWFNGWGGKGGEVRIDYRPVHEYTLTDDVEYIKPKKRVY

Sequences:

>Translated_604_residues
MTSTQPAYKIIDHTYDTVVVGAGGSGLRATMGSAQAGLRTACITKVFPTRSHTVAAQGGIAASLGNNSPDHWTWHMYDTV
KGSDWLGDQDAIEYMVREAPAAVYELEHAGVPFSRNPEGTIYQRPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHALYQQ
SLKYDADFFIEYFAIDLIMENGECRGVIALCMDDGSIHRFRSHAVVLATGGYGRSYFTATSAHTCTGDGGGMVLRAGLPL
QDMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRSMAMEIREGRGVGPHKDHIYLH
LDHIDQKVLAERLPGITESGKIFAGVDLTRQPLPVVPTVHYNMGGIPTNYHGEVVTIGADGNPETIVPGLFAVGEAACVS
VHGANRLGSNSLIDLVVFGRATGLRLKELIKPGTAHNSLPKDSADLALTRLDHFRHAKGGSPTAEVRIEMQRTMSAHAAV
FRTDELMAEGKVKLADTYKRMEDIHVSDRSLIWNSDLVETLELDNLISQATVTMHSAHNRKESRGAHAHEDFPDRNDAEW
MKHTATWFNGWGGKGGEVRIDYRPVHEYTLTDDVEYIKPKKRVY
>Mature_603_residues
TSTQPAYKIIDHTYDTVVVGAGGSGLRATMGSAQAGLRTACITKVFPTRSHTVAAQGGIAASLGNNSPDHWTWHMYDTVK
GSDWLGDQDAIEYMVREAPAAVYELEHAGVPFSRNPEGTIYQRPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHALYQQS
LKYDADFFIEYFAIDLIMENGECRGVIALCMDDGSIHRFRSHAVVLATGGYGRSYFTATSAHTCTGDGGGMVLRAGLPLQ
DMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRSMAMEIREGRGVGPHKDHIYLHL
DHIDQKVLAERLPGITESGKIFAGVDLTRQPLPVVPTVHYNMGGIPTNYHGEVVTIGADGNPETIVPGLFAVGEAACVSV
HGANRLGSNSLIDLVVFGRATGLRLKELIKPGTAHNSLPKDSADLALTRLDHFRHAKGGSPTAEVRIEMQRTMSAHAAVF
RTDELMAEGKVKLADTYKRMEDIHVSDRSLIWNSDLVETLELDNLISQATVTMHSAHNRKESRGAHAHEDFPDRNDAEWM
KHTATWFNGWGGKGGEVRIDYRPVHEYTLTDDVEYIKPKKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=620, Percent_Identity=58.3870967741935, Blast_Score=716, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=558, Percent_Identity=54.4802867383513, Blast_Score=561, Evalue=1e-161,
Organism=Escherichia coli, GI1790597, Length=582, Percent_Identity=41.5807560137457, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1788928, Length=563, Percent_Identity=28.9520426287744, Blast_Score=193, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17550100, Length=615, Percent_Identity=59.1869918699187, Blast_Score=721, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=621, Percent_Identity=56.3607085346216, Blast_Score=693, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=598, Percent_Identity=61.2040133779264, Blast_Score=758, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=604, Percent_Identity=61.5894039735099, Blast_Score=749, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=614, Percent_Identity=61.0749185667753, Blast_Score=757, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=614, Percent_Identity=61.0749185667753, Blast_Score=757, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=614, Percent_Identity=61.0749185667753, Blast_Score=757, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=621, Percent_Identity=53.6231884057971, Blast_Score=665, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66089; Mature: 65958

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTQPAYKIIDHTYDTVVVGAGGSGLRATMGSAQAGLRTACITKVFPTRSHTVAAQGGI
CCCCCCHHHHHCCCCCEEEEECCCCCCEEECCCHHCCHHHHHHHHHCCCCCCEEEECCCE
AASLGNNSPDHWTWHMYDTVKGSDWLGDQDAIEYMVREAPAAVYELEHAGVPFSRNPEGT
EEECCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHEEEHHHCCCCCCCCCCCC
IYQRPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHALYQQSLKYDADFFIEYFAIDLIME
EEECCCCCHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHEEEEEEEE
NGECRGVIALCMDDGSIHRFRSHAVVLATGGYGRSYFTATSAHTCTGDGGGMVLRAGLPL
CCCCCEEEEEEECCCCEEEECCCEEEEEECCCCCEEEEECCCCEEECCCCCEEEECCCCC
QDMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRSM
CCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHH
AMEIREGRGVGPHKDHIYLHLDHIDQKVLAERLPGITESGKIFAGVDLTRQPLPVVPTVH
HHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCEEE
YNMGGIPTNYHGEVVTIGADGNPETIVPGLFAVGEAACVSVHGANRLGSNSLIDLVVFGR
ECCCCCCCCCCCCEEEECCCCCCCEECCHHHHCCCEEEEEEECCCCCCCCCEEEEEEECC
ATGLRLKELIKPGTAHNSLPKDSADLALTRLDHFRHAKGGSPTAEVRIEMQRTMSAHAAV
CCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHE
FRTDELMAEGKVKLADTYKRMEDIHVSDRSLIWNSDLVETLELDNLISQATVTMHSAHNR
EECHHHHHCCCEEEHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHEEHHHCCC
KESRGAHAHEDFPDRNDAEWMKHTATWFNGWGGKGGEVRIDYRPVHEYTLTDDVEYIKPK
HHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCCEEECCCHHHCCCH
KRVY
HCCC
>Mature Secondary Structure 
TSTQPAYKIIDHTYDTVVVGAGGSGLRATMGSAQAGLRTACITKVFPTRSHTVAAQGGI
CCCCCHHHHHCCCCCEEEEECCCCCCEEECCCHHCCHHHHHHHHHCCCCCCEEEECCCE
AASLGNNSPDHWTWHMYDTVKGSDWLGDQDAIEYMVREAPAAVYELEHAGVPFSRNPEGT
EEECCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHEEEHHHCCCCCCCCCCCC
IYQRPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHALYQQSLKYDADFFIEYFAIDLIME
EEECCCCCHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHEEEEEEEE
NGECRGVIALCMDDGSIHRFRSHAVVLATGGYGRSYFTATSAHTCTGDGGGMVLRAGLPL
CCCCCEEEEEEECCCCEEEECCCEEEEEECCCCCEEEEECCCCEEECCCCCEEEECCCCC
QDMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRSM
CCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHH
AMEIREGRGVGPHKDHIYLHLDHIDQKVLAERLPGITESGKIFAGVDLTRQPLPVVPTVH
HHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCEEE
YNMGGIPTNYHGEVVTIGADGNPETIVPGLFAVGEAACVSVHGANRLGSNSLIDLVVFGR
ECCCCCCCCCCCCEEEECCCCCCCEECCHHHHCCCEEEEEEECCCCCCCCCEEEEEEECC
ATGLRLKELIKPGTAHNSLPKDSADLALTRLDHFRHAKGGSPTAEVRIEMQRTMSAHAAV
CCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHE
FRTDELMAEGKVKLADTYKRMEDIHVSDRSLIWNSDLVETLELDNLISQATVTMHSAHNR
EECHHHHHCCCEEEHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHEEHHHCCC
KESRGAHAHEDFPDRNDAEWMKHTATWFNGWGGKGGEVRIDYRPVHEYTLTDDVEYIKPK
HHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCCEEECCCHHHCCCH
KRVY
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA