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The map label for this gene is nat [H]

Identifier: 87199572

GI number: 87199572

Start: 1611187

End: 1612068

Strand: Direct

Name: nat [H]

Synonym: Saro_1555

Alternate gene names: 87199572

Gene position: 1611187-1612068 (Clockwise)

Preceding gene: 87199569

Following gene: 87199573

Centisome position: 45.24

GC content: 61.9

Gene sequence:

>882_bases
ATGGGGCACGCCGGTCATCCGGAGAACGGAAACAACGCCATGGCAAATCCCCTCATCGAGGACGACGAAATGACGCTGAA
CGAGACGCAACTTGCCGCATACCTCGCCAAGATCGGCATTGAAGGCGAAGTCTCGCTCGATCTTCATGGTCTGGCGAGGC
TTCACCGCGCCCACCTGTTGGGGATCACGTGGGAGGCTATCGATGCGTTCATGGACTGGCCGTCATCCGTCGCGCCGTCC
GCTGCTTTCGCCAAGATCATCGAACAAGGTCGCGGCGGCTGGTGTTACGAGATGAACGGCCTCTTCGGAGCGGCGCTTTC
GGCGCTCGGCTTCCGCGTGACGCGGCTTTGCGGCTGTGTCGACCGGCCGGTTCTGGGCGATGCCGCCATAGGCAACCACC
TGACGTTGCGGGTCGACCTGGATCGTCCCTACCTGGCTGAAGTCGGCGTGGCGGATGCTTTGTTCGAGCCGGTGCCGATC
GGCGTCGGGCCGATCCGTCAACGTGGCTTCGACTTCTCCATCAAGGCTGCGGACGACGGTTGGCTCCGCCTTCATAACCA
TGCCCATGGCACCGCCCGTACTGTCGATTTCAAGCCTGATCACAGCGACGAGGCCGCGCTGTCCGCGATGCAGGCGTGGC
TCATGCGTGAACCGGCCTCGCCCTTCACCAATGCCCTGGCGGTGTATCGTCACACTGTGGATGGCTATGTCGCGTTGCAA
AATGATCGACTGCGCCGTGTAACCGCCCTGGGTGTCCAGCAAGAGAACATCGATGGCGCGGATCACCTTGCGCAGGTGCT
GGAGGATGTGTTCAGTCTTTCGGTTCCGCACCCTGAGCGCATCTGGGAAAAGGTTGCCGCCATTCGTCTGGTCACAGCCT
GA

Upstream 100 bases:

>100_bases
AATCGCCCATGCTTTTCGCAATCATTTAGGAACGCGGCCGTTTCGTACCGTCTATTGAGCGTGTCGATGTGACGCGACCG
ACGAGCCGCTGCATTCCGCA

Downstream 100 bases:

>100_bases
CGGCCTGAAAACGGGGACAAGGCATTGAAACGACTTCTTACGATGTTCTGCGCGCTTGCCGCGCTGACTGGCAGCCCGCT
CTTCGCGCAGGACAACGGCG

Product: N-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MGHAGHPENGNNAMANPLIEDDEMTLNETQLAAYLAKIGIEGEVSLDLHGLARLHRAHLLGITWEAIDAFMDWPSSVAPS
AAFAKIIEQGRGGWCYEMNGLFGAALSALGFRVTRLCGCVDRPVLGDAAIGNHLTLRVDLDRPYLAEVGVADALFEPVPI
GVGPIRQRGFDFSIKAADDGWLRLHNHAHGTARTVDFKPDHSDEAALSAMQAWLMREPASPFTNALAVYRHTVDGYVALQ
NDRLRRVTALGVQQENIDGADHLAQVLEDVFSLSVPHPERIWEKVAAIRLVTA

Sequences:

>Translated_293_residues
MGHAGHPENGNNAMANPLIEDDEMTLNETQLAAYLAKIGIEGEVSLDLHGLARLHRAHLLGITWEAIDAFMDWPSSVAPS
AAFAKIIEQGRGGWCYEMNGLFGAALSALGFRVTRLCGCVDRPVLGDAAIGNHLTLRVDLDRPYLAEVGVADALFEPVPI
GVGPIRQRGFDFSIKAADDGWLRLHNHAHGTARTVDFKPDHSDEAALSAMQAWLMREPASPFTNALAVYRHTVDGYVALQ
NDRLRRVTALGVQQENIDGADHLAQVLEDVFSLSVPHPERIWEKVAAIRLVTA
>Mature_292_residues
GHAGHPENGNNAMANPLIEDDEMTLNETQLAAYLAKIGIEGEVSLDLHGLARLHRAHLLGITWEAIDAFMDWPSSVAPSA
AFAKIIEQGRGGWCYEMNGLFGAALSALGFRVTRLCGCVDRPVLGDAAIGNHLTLRVDLDRPYLAEVGVADALFEPVPIG
VGPIRQRGFDFSIKAADDGWLRLHNHAHGTARTVDFKPDHSDEAALSAMQAWLMREPASPFTNALAVYRHTVDGYVALQN
DRLRRVTALGVQQENIDGADHLAQVLEDVFSLSVPHPERIWEKVAAIRLVTA

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1787736, Length=253, Percent_Identity=24.5059288537549, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 31921; Mature: 31789

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHAGHPENGNNAMANPLIEDDEMTLNETQLAAYLAKIGIEGEVSLDLHGLARLHRAHLL
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHH
GITWEAIDAFMDWPSSVAPSAAFAKIIEQGRGGWCYEMNGLFGAALSALGFRVTRLCGCV
CCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHC
DRPVLGDAAIGNHLTLRVDLDRPYLAEVGVADALFEPVPIGVGPIRQRGFDFSIKAADDG
CCCCCCCCCCCCEEEEEEECCCCHHHHCCHHHHHHCCCCCCCCHHHHCCCCEEEEECCCC
WLRLHNHAHGTARTVDFKPDHSDEAALSAMQAWLMREPASPFTNALAVYRHTVDGYVALQ
EEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEC
NDRLRRVTALGVQQENIDGADHLAQVLEDVFSLSVPHPERIWEKVAAIRLVTA
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECC
>Mature Secondary Structure 
GHAGHPENGNNAMANPLIEDDEMTLNETQLAAYLAKIGIEGEVSLDLHGLARLHRAHLL
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHH
GITWEAIDAFMDWPSSVAPSAAFAKIIEQGRGGWCYEMNGLFGAALSALGFRVTRLCGCV
CCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHC
DRPVLGDAAIGNHLTLRVDLDRPYLAEVGVADALFEPVPIGVGPIRQRGFDFSIKAADDG
CCCCCCCCCCCCEEEEEEECCCCHHHHCCHHHHHHCCCCCCCCHHHHCCCCEEEEECCCC
WLRLHNHAHGTARTVDFKPDHSDEAALSAMQAWLMREPASPFTNALAVYRHTVDGYVALQ
EEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEC
NDRLRRVTALGVQQENIDGADHLAQVLEDVFSLSVPHPERIWEKVAAIRLVTA
CCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]