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The map label for this gene is clcA [H]

Identifier: 87199518

GI number: 87199518

Start: 1543701

End: 1545002

Strand: Direct

Name: clcA [H]

Synonym: Saro_1500

Alternate gene names: 87199518

Gene position: 1543701-1545002 (Clockwise)

Preceding gene: 87199516

Following gene: 87199520

Centisome position: 43.34

GC content: 62.52

Gene sequence:

>1302_bases
ATGAGTATTCTGGGAAGATTCCGGCTAGCGACCAACCAGCTCGATCGCAGGCTTTGGCTGATGCGCGTGGCTGCGGTTGC
AGGAGCGGTCCTGCTTGGGCTGGTCGCGATTCTTTTTGCGCAGGCCGGTGATCTGGCTCAGCACGTCTTTGCCCGCATGT
TCGCCGCCCATCCCGTGTTGGCATCTGCATCAACCCCGTTCGTATTCGTGGCAGTGGTGGGCCTGACCCGGCGCTGGTTT
CCGGAAGCGCGTGGATCGGGAATTCCGCAGGTCATGGCGGCAAGTCACAACCCCGCAGCAAGCGCAAACGGCCCGTTGAT
CTCGCTGCGTACAGCGGCGGCCAAGTTTGCCGGTACGCTGCTCTTGCTGCTTGGCGGGGGCGCGGTCGGCCGCGAAGGCC
CGACAGTGCAGATCAGTGCCGCGCTTATGATAGCTGTGCATCGCTGGTTGCGCATACCAGTCAATGCAGGCGTCATTATC
GCCGGGGGTGCGGCGGGTGTCTCTGCGGCCTTCAACACGCCTCTGGCCGGCGTCGCTTTCGCGATAGAGGAACTGGCGGC
AGCGTTCGAGCAGAAGGTTGCACTTCTGGTCATGGCAGCCGTCATGATCTCAGGGCTGGTCAGCCTGGGCATCGCTGGCG
ATTACGTTTATTTCGGTGCGATGACCCGGCACATGGCAATCCGTGACATTGCGGTCCTTGCTCCACTCATGGGCGTGCTT
GGAGGAATCGCCGGCGGAGCATTTTCACGCACGCTCGTTGCCCTGTCCGGTTCCAGGCACCCGTGGTTCGTCAGCGCAAG
GGCCAATCCGCTAAAGCTGGCCTTTGCCTGTGGCTGCGTGGTTGCAGGGCTAGGCCTTGCCACCGGCGGCGTCAGCTGGG
GCACGGGCTACGAGACTACACGGACCCTGCTTAGCGGCGGGGAGGCGACTCTTTCGTTCGGACCCGCAAAGTTCGTGGCC
ACCCTTGCAACCGCGTTGAGTGGTGCCCCTGGTGGCATTTTCGCACCATCTCTTTCGGTGGGGGCGGGCCTGGGACAACT
GGTAGCGGACATCACGGCAGGCGTGCCGTCCGGCGCGCTCGTCCTGCTTGGGGTCGCAGCCTACTTTACCGGCGTGGTCC
GCGCTCCCCTTACCGCAGTCATCATCGTGACCGAAATGACCGCCGATCGCGCGATGATCATTCCGTTGTTTATCGCTGCG
CTGATTGCCGATTGGGTCAGCAACAAGATTTGCCACGTGAAGCTCTACCATGCGCTTTCCCAAGGCTTCCGGCCAAGCCC
TGCAAAAGAGAGTGCTGCCTGA

Upstream 100 bases:

>100_bases
AAAGGCGTCTGCTTCCGTTCCCGGTGCGCGTTCCGACCCGCTCGTTGCACTACATGCCATTCTGGTTGAACCTCGATCTT
CTGATCCCTAGGCGGAAGCA

Downstream 100 bases:

>100_bases
TCTGCTCAATTCCTATCGGGAAATGTGCCCGGACGTTCATCGTCCAGCAAGAGCAGCGCCTCACGCTGGATTGCTAGCGC
GATCTCGTGGAAACTCTCGG

Product: Cl- channel, voltage gated

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MSILGRFRLATNQLDRRLWLMRVAAVAGAVLLGLVAILFAQAGDLAQHVFARMFAAHPVLASASTPFVFVAVVGLTRRWF
PEARGSGIPQVMAASHNPAASANGPLISLRTAAAKFAGTLLLLLGGGAVGREGPTVQISAALMIAVHRWLRIPVNAGVII
AGGAAGVSAAFNTPLAGVAFAIEELAAAFEQKVALLVMAAVMISGLVSLGIAGDYVYFGAMTRHMAIRDIAVLAPLMGVL
GGIAGGAFSRTLVALSGSRHPWFVSARANPLKLAFACGCVVAGLGLATGGVSWGTGYETTRTLLSGGEATLSFGPAKFVA
TLATALSGAPGGIFAPSLSVGAGLGQLVADITAGVPSGALVLLGVAAYFTGVVRAPLTAVIIVTEMTADRAMIIPLFIAA
LIADWVSNKICHVKLYHALSQGFRPSPAKESAA

Sequences:

>Translated_433_residues
MSILGRFRLATNQLDRRLWLMRVAAVAGAVLLGLVAILFAQAGDLAQHVFARMFAAHPVLASASTPFVFVAVVGLTRRWF
PEARGSGIPQVMAASHNPAASANGPLISLRTAAAKFAGTLLLLLGGGAVGREGPTVQISAALMIAVHRWLRIPVNAGVII
AGGAAGVSAAFNTPLAGVAFAIEELAAAFEQKVALLVMAAVMISGLVSLGIAGDYVYFGAMTRHMAIRDIAVLAPLMGVL
GGIAGGAFSRTLVALSGSRHPWFVSARANPLKLAFACGCVVAGLGLATGGVSWGTGYETTRTLLSGGEATLSFGPAKFVA
TLATALSGAPGGIFAPSLSVGAGLGQLVADITAGVPSGALVLLGVAAYFTGVVRAPLTAVIIVTEMTADRAMIIPLFIAA
LIADWVSNKICHVKLYHALSQGFRPSPAKESAA
>Mature_432_residues
SILGRFRLATNQLDRRLWLMRVAAVAGAVLLGLVAILFAQAGDLAQHVFARMFAAHPVLASASTPFVFVAVVGLTRRWFP
EARGSGIPQVMAASHNPAASANGPLISLRTAAAKFAGTLLLLLGGGAVGREGPTVQISAALMIAVHRWLRIPVNAGVIIA
GGAAGVSAAFNTPLAGVAFAIEELAAAFEQKVALLVMAAVMISGLVSLGIAGDYVYFGAMTRHMAIRDIAVLAPLMGVLG
GIAGGAFSRTLVALSGSRHPWFVSARANPLKLAFACGCVVAGLGLATGGVSWGTGYETTRTLLSGGEATLSFGPAKFVAT
LATALSGAPGGIFAPSLSVGAGLGQLVADITAGVPSGALVLLGVAAYFTGVVRAPLTAVIIVTEMTADRAMIIPLFIAAL
IADWVSNKICHVKLYHALSQGFRPSPAKESAA

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=368, Percent_Identity=30.4347826086957, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI87081943, Length=319, Percent_Identity=29.7805642633229, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 44023; Mature: 43892

Theoretical pI: Translated: 10.94; Mature: 10.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILGRFRLATNQLDRRLWLMRVAAVAGAVLLGLVAILFAQAGDLAQHVFARMFAAHPVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHH
ASASTPFVFVAVVGLTRRWFPEARGSGIPQVMAASHNPAASANGPLISLRTAAAKFAGTL
CCCCCCHHHHHHHHHHHHHCCHHCCCCCCHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHH
LLLLGGGAVGREGPTVQISAALMIAVHRWLRIPVNAGVIIAGGAAGVSAAFNTPLAGVAF
HHEECCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHCCCHHHHHH
AIEELAAAFEQKVALLVMAAVMISGLVSLGIAGDYVYFGAMTRHMAIRDIAVLAPLMGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GGIAGGAFSRTLVALSGSRHPWFVSARANPLKLAFACGCVVAGLGLATGGVSWGTGYETT
HHHCCHHHHHHHEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
RTLLSGGEATLSFGPAKFVATLATALSGAPGGIFAPSLSVGAGLGQLVADITAGVPSGAL
HHHHCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHCCCCCCHH
VLLGVAAYFTGVVRAPLTAVIIVTEMTADRAMIIPLFIAALIADWVSNKICHVKLYHALS
HHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHH
QGFRPSPAKESAA
CCCCCCCCCCCCC
>Mature Secondary Structure 
SILGRFRLATNQLDRRLWLMRVAAVAGAVLLGLVAILFAQAGDLAQHVFARMFAAHPVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHH
ASASTPFVFVAVVGLTRRWFPEARGSGIPQVMAASHNPAASANGPLISLRTAAAKFAGTL
CCCCCCHHHHHHHHHHHHHCCHHCCCCCCHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHH
LLLLGGGAVGREGPTVQISAALMIAVHRWLRIPVNAGVIIAGGAAGVSAAFNTPLAGVAF
HHEECCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHCCCHHHHHH
AIEELAAAFEQKVALLVMAAVMISGLVSLGIAGDYVYFGAMTRHMAIRDIAVLAPLMGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GGIAGGAFSRTLVALSGSRHPWFVSARANPLKLAFACGCVVAGLGLATGGVSWGTGYETT
HHHCCHHHHHHHEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
RTLLSGGEATLSFGPAKFVATLATALSGAPGGIFAPSLSVGAGLGQLVADITAGVPSGAL
HHHHCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHCCCCCCHH
VLLGVAAYFTGVVRAPLTAVIIVTEMTADRAMIIPLFIAALIADWVSNKICHVKLYHALS
HHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHH
QGFRPSPAKESAA
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA