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The map label for this gene is ffh [H]

Identifier: 87199425

GI number: 87199425

Start: 1447540

End: 1449015

Strand: Direct

Name: ffh [H]

Synonym: Saro_1404

Alternate gene names: 87199425

Gene position: 1447540-1449015 (Clockwise)

Preceding gene: 87199417

Following gene: 87199426

Centisome position: 40.64

GC content: 66.06

Gene sequence:

>1476_bases
GTGTTCGATAGTCTTTCAGACCGGCTTGGAGGCGTATTCGAGCGCCTGCGCGGCCGCGGCGCGCTGCGTGAGGAAGACGT
CCTTGCCGCCATGCGTGAAGTGCGCATCGCGCTGCTCGAGGCCGACGTTGCGCTTCCCGTTGTCCGCCGCTTCATCGACC
AGGTTTCCGAGCAGGCCGTCGGCCAGTCGGTCCTGAAGTCGGTTACGCCCGGCCAGCAGGTCGTCAAGATCGTGAACGAT
GCGCTGGTCGATATGCTCGGCGGCGGCACGGCCGAGCTTGACCTGAATGCCGCCCCGCCGGTCGTGATCATGATGGTCGG
CCTGCAGGGCTCGGGCAAGACCACCAGCACTGCCAAGATCGGCAAGCTGCTGAAGGAAAAGCAGGGCAAGAAGGTCCTGA
TGGCTTCGCTGGACGTCAACCGTCCGGCGGCGCAGGAACAGCTTGCGGTGCTGGGCGAGCAGGCGGGCGTGGCTACGCTG
CCTATCGTCGCCGGCCAGCAGCCGGTGGACATTGCCACCCGTGCCGTGAACGCGGCGAAGCTGCAGGCCGTGGACGTGCT
GCTGCTCGACACCGCGGGCCGTCTCCACGTCGATCAGGCGCTGATGGACGAGATGAAGGCGGTTGCCGCCGTCTCGGTTC
CCAGGGAAACGCTGCTCGTCGTCGACTCGCTGACCGGTCAGGATGCGGTCAACGTGGCGCAGTCGTTCTCGGGCGAGGTC
GACCTGACGGGTGTCGTGCTGACCCGCATGGACGGCGATGCGCGCGGCGGCGCGGCGCTGTCGATGCGCGCGGTTACCGG
CAAGCCGATCAAGTTCGCGGCGACCGGCGAAAAGCTCGACGCGATCGAGCCATTCCACCCGGAACGCGTTGCTGGCCGAA
TCCTTGGCATGGGCGATATCGTCTCCATCGTCGAGAAGGCGGCGGCGACGATCCAGGCGGAAGATGCCGAGCGTCTTGCC
CAGCGCATGTCGAAGGGGCAGTTCGACATGAACGACCTGCGCACCCAGTTGCGGCAGATGCAGAACATGGGCGGCCTCGG
TGCGCTGGCGGGCATGATGCCCGGCATGAAGAAGGCCAAGGCGGCGATGGCGCAGTCCGGCATGGACGACAAGGTCCTGC
TGCGCATGGACGCCATCATCGGCTCGATGACGCCCAAGGAGCGCGAGAAGCCCGAGCTGCTCAACGCCAAGCGCAAGATC
CGCGTGGCCAAGGGGTCCGGCACGCAGGTGCAGGACGTCAACAAGCTTCTGAAGATGCATCAGGAAATGGCCAAGGCCAT
GAAGCAGATCAAGAAGATGGGCGGCCTCAAGGGGCTGGGTGCGCTGTTCGGCAAGGGTGGTCTGGGTGCCGCCATGCCGG
GGCTCGACCAGCAGATGGGGCCGGGTGGTCTTGGCGGAATGGGCGGGGGCGGATTGCCCGGTCTTGGTTCGGGAGGACTT
CCCGGCAACCTTGGCGATCTCCTCAAGAAGCGCTGA

Upstream 100 bases:

>100_bases
TCAGGATGCCACACGCTGGTCGGCGAGGTTTCGCCCACCGGCGTTTTTCGCGTTACGCGAAAGTGGTTCCCGATCAAGGG
CATGATGATGGGAATTGGGC

Downstream 100 bases:

>100_bases
TTTTTCGAAGTTCAAAAGTTCAAACAGTTTGATTGAAAGGTAGTTCAAATGTCCGTTTCTATGCGTCTTTCGCGCGGTGG
TTCGAAGAAGCGCCCGTACT

Product: signal recognition particle subunit FFH/SRP54 (srp54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MFDSLSDRLGGVFERLRGRGALREEDVLAAMREVRIALLEADVALPVVRRFIDQVSEQAVGQSVLKSVTPGQQVVKIVND
ALVDMLGGGTAELDLNAAPPVVIMMVGLQGSGKTTSTAKIGKLLKEKQGKKVLMASLDVNRPAAQEQLAVLGEQAGVATL
PIVAGQQPVDIATRAVNAAKLQAVDVLLLDTAGRLHVDQALMDEMKAVAAVSVPRETLLVVDSLTGQDAVNVAQSFSGEV
DLTGVVLTRMDGDARGGAALSMRAVTGKPIKFAATGEKLDAIEPFHPERVAGRILGMGDIVSIVEKAAATIQAEDAERLA
QRMSKGQFDMNDLRTQLRQMQNMGGLGALAGMMPGMKKAKAAMAQSGMDDKVLLRMDAIIGSMTPKEREKPELLNAKRKI
RVAKGSGTQVQDVNKLLKMHQEMAKAMKQIKKMGGLKGLGALFGKGGLGAAMPGLDQQMGPGGLGGMGGGGLPGLGSGGL
PGNLGDLLKKR

Sequences:

>Translated_491_residues
MFDSLSDRLGGVFERLRGRGALREEDVLAAMREVRIALLEADVALPVVRRFIDQVSEQAVGQSVLKSVTPGQQVVKIVND
ALVDMLGGGTAELDLNAAPPVVIMMVGLQGSGKTTSTAKIGKLLKEKQGKKVLMASLDVNRPAAQEQLAVLGEQAGVATL
PIVAGQQPVDIATRAVNAAKLQAVDVLLLDTAGRLHVDQALMDEMKAVAAVSVPRETLLVVDSLTGQDAVNVAQSFSGEV
DLTGVVLTRMDGDARGGAALSMRAVTGKPIKFAATGEKLDAIEPFHPERVAGRILGMGDIVSIVEKAAATIQAEDAERLA
QRMSKGQFDMNDLRTQLRQMQNMGGLGALAGMMPGMKKAKAAMAQSGMDDKVLLRMDAIIGSMTPKEREKPELLNAKRKI
RVAKGSGTQVQDVNKLLKMHQEMAKAMKQIKKMGGLKGLGALFGKGGLGAAMPGLDQQMGPGGLGGMGGGGLPGLGSGGL
PGNLGDLLKKR
>Mature_491_residues
MFDSLSDRLGGVFERLRGRGALREEDVLAAMREVRIALLEADVALPVVRRFIDQVSEQAVGQSVLKSVTPGQQVVKIVND
ALVDMLGGGTAELDLNAAPPVVIMMVGLQGSGKTTSTAKIGKLLKEKQGKKVLMASLDVNRPAAQEQLAVLGEQAGVATL
PIVAGQQPVDIATRAVNAAKLQAVDVLLLDTAGRLHVDQALMDEMKAVAAVSVPRETLLVVDSLTGQDAVNVAQSFSGEV
DLTGVVLTRMDGDARGGAALSMRAVTGKPIKFAATGEKLDAIEPFHPERVAGRILGMGDIVSIVEKAAATIQAEDAERLA
QRMSKGQFDMNDLRTQLRQMQNMGGLGALAGMMPGMKKAKAAMAQSGMDDKVLLRMDAIIGSMTPKEREKPELLNAKRKI
RVAKGSGTQVQDVNKLLKMHQEMAKAMKQIKKMGGLKGLGALFGKGGLGAAMPGLDQQMGPGGLGGMGGGGLPGLGSGGL
PGNLGDLLKKR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=457, Percent_Identity=32.1663019693654, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI226371618, Length=379, Percent_Identity=33.509234828496, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI89061728, Length=159, Percent_Identity=35.8490566037736, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI23308697, Length=304, Percent_Identity=29.2763157894737, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI295424842, Length=304, Percent_Identity=29.2763157894737, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1788963, Length=426, Percent_Identity=57.2769953051643, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=34.2629482071713, Blast_Score=139, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=462, Percent_Identity=31.8181818181818, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI193206261, Length=304, Percent_Identity=29.2763157894737, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6325345, Length=451, Percent_Identity=31.9290465631929, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320498, Length=316, Percent_Identity=24.6835443037975, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17647949, Length=469, Percent_Identity=29.4243070362473, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24641198, Length=312, Percent_Identity=27.2435897435897, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 51353; Mature: 51353

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDSLSDRLGGVFERLRGRGALREEDVLAAMREVRIALLEADVALPVVRRFIDQVSEQAV
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQSVLKSVTPGQQVVKIVNDALVDMLGGGTAELDLNAAPPVVIMMVGLQGSGKTTSTAKI
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCCCCHHHHH
GKLLKEKQGKKVLMASLDVNRPAAQEQLAVLGEQAGVATLPIVAGQQPVDIATRAVNAAK
HHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEECEECCCCCHHHHHHHHHHHH
LQAVDVLLLDTAGRLHVDQALMDEMKAVAAVSVPRETLLVVDSLTGQDAVNVAQSFSGEV
HHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCCCHHHHHHHHCCCCC
DLTGVVLTRMDGDARGGAALSMRAVTGKPIKFAATGEKLDAIEPFHPERVAGRILGMGDI
EEEEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHCCHHHH
VSIVEKAAATIQAEDAERLAQRMSKGQFDMNDLRTQLRQMQNMGGLGALAGMMPGMKKAK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHH
AAMAQSGMDDKVLLRMDAIIGSMTPKEREKPELLNAKRKIRVAKGSGTQVQDVNKLLKMH
HHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCHHEEEEECCCCCHHHHHHHHHHHH
QEMAKAMKQIKKMGGLKGLGALFGKGGLGAAMPGLDQQMGPGGLGGMGGGGLPGLGSGGL
HHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGNLGDLLKKR
CCCHHHHHHCC
>Mature Secondary Structure
MFDSLSDRLGGVFERLRGRGALREEDVLAAMREVRIALLEADVALPVVRRFIDQVSEQAV
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQSVLKSVTPGQQVVKIVNDALVDMLGGGTAELDLNAAPPVVIMMVGLQGSGKTTSTAKI
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCCCCHHHHH
GKLLKEKQGKKVLMASLDVNRPAAQEQLAVLGEQAGVATLPIVAGQQPVDIATRAVNAAK
HHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEECEECCCCCHHHHHHHHHHHH
LQAVDVLLLDTAGRLHVDQALMDEMKAVAAVSVPRETLLVVDSLTGQDAVNVAQSFSGEV
HHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCCCHHHHHHHHCCCCC
DLTGVVLTRMDGDARGGAALSMRAVTGKPIKFAATGEKLDAIEPFHPERVAGRILGMGDI
EEEEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHCCHHHH
VSIVEKAAATIQAEDAERLAQRMSKGQFDMNDLRTQLRQMQNMGGLGALAGMMPGMKKAK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHH
AAMAQSGMDDKVLLRMDAIIGSMTPKEREKPELLNAKRKIRVAKGSGTQVQDVNKLLKMH
HHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCHHEEEEECCCCCHHHHHHHHHHHH
QEMAKAMKQIKKMGGLKGLGALFGKGGLGAAMPGLDQQMGPGGLGGMGGGGLPGLGSGGL
HHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGNLGDLLKKR
CCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]