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The map label for this gene is bioA [H]

Identifier: 87199364

GI number: 87199364

Start: 1384468

End: 1385775

Strand: Direct

Name: bioA [H]

Synonym: Saro_1343

Alternate gene names: 87199364

Gene position: 1384468-1385775 (Clockwise)

Preceding gene: 87199363

Following gene: 87199365

Centisome position: 38.87

GC content: 66.28

Gene sequence:

>1308_bases
GTGGCACAGTGCGCGAGGGACAGGACGATGAGCGATCCGCAGTGGTATTCGACGGGGCGCGACCACGTCTGGCTTCCCTA
TACCCAGATGAAGACGGCACGCCCGCCGCTGCCGGTGGCTTCAGCCGAAGGGGTGAAGCTTCGCCTCGCGGACGGGCGCG
AACTGGTCGACGGCATTTCGAGCTGGTGGGCCACGGTTCACGGCTATCGTCACCCGCACATCGAGGAGGCGATCCGGCGC
CAGCTTGAAACCCTGCCGCACGTCATGCTGGGCGGGCTGGCGCACGAACAGGCCTATACCCTTGCGCGGCGGCTTGCAGG
AATGCTGCCGGGCGACCTCGATCATGTGTTCTTCAGCGATTCCGGGTCTGTCGCAGTCGAGGTTGCGATGAAGATGGCGG
CGCAGTTCTGGCTCAACCAAGGGCACCGGCGCGTGAAGTTCCTGTGCTTCCGTGGCGGTTACCATGGAGACACCTTTGCC
ACGATGAGCGTGTGCGACCCTGACGAGGGCATGCACAGCCTGTTCCGTGGTGCGCTGCTGGAACAGGTGGTGGTCGACCT
GCCAAGGGATGCGGAAGGCGAAGCGGCGCTTGGCGCCTTGATCGAGCAGCATCGCGGGGAACTCGCCGGGATCGTGGTCG
AGCCCTTGGTGCAGGGGGCAGGGGGGATGGTGTTCCATGACCCGTTTACGCTCCAGGCGCTGCGGCGGCTCGCGGATGAG
CATGAGCTTCTGCTGATCTTCGACGAGATCTTCGTCGGCCTTGGCAGGCTGGGCGATGCGATGTTCGCCTGTCAGATCGC
GGGCGTGCAGCCGGATATCGTGACATTGTCCAAGGCGCTGACCGGGGGCAACCTGCCGCTCGCCGCCACCATCGCCAGCG
GGCGCATCTACGACGCATTCCTCTCTGACGATCCGATGCATGCGCTGATGCACGGGCCGACCTACATGGGGAATGCGCTG
GGCTGCGCCGCGGCCAATGCCTCGCTCGACCTCTTCGAGAGCGAGCCCAGGCTGGAGCAGGCGCAGGCCATCGGACGCGG
GCTCGAGCAGGCGCTGGAGGTATTGCGCGGCCTGCCGGGCGTGCGCGACGTGCGCGTGCGCGGCGCCATCGGCGTGATCC
AGCTTGACCGAACCGCCCCCGCCGACCGCCTCTCCGCGGCCTGCATCGACCGCGGCGTGTGGCTGCGCCCGTTCCGCGAT
ATTCTCTACACTACGCCCCCGCTGGTGACGGGTGAGGAAGACCTTGCGAGGATCACCAGCGCAATGGTTGAAGCAGTCAC
CGAATGGAGCCGCGAAACCCACGTCTGA

Upstream 100 bases:

>100_bases
CACTACGCGGGCGGGCCGTGGACGCCGGCTGGTGGTTGGGCCTTTCGCGGGAAGGTTCGCGTGGGCTCTTGATTGCTGGA
GGCCATGCGGGCATCGGCGG

Downstream 100 bases:

>100_bases
CCGGCGCAAAACTTTACCGCGCCCCCCGCGAAAAAGGGTTGCCGAGCCTCCTAACCGTGGCTAAACGGCCCCCCTGCCCA
CAAGGCACGCCGCTTTAGCT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MAQCARDRTMSDPQWYSTGRDHVWLPYTQMKTARPPLPVASAEGVKLRLADGRELVDGISSWWATVHGYRHPHIEEAIRR
QLETLPHVMLGGLAHEQAYTLARRLAGMLPGDLDHVFFSDSGSVAVEVAMKMAAQFWLNQGHRRVKFLCFRGGYHGDTFA
TMSVCDPDEGMHSLFRGALLEQVVVDLPRDAEGEAALGALIEQHRGELAGIVVEPLVQGAGGMVFHDPFTLQALRRLADE
HELLLIFDEIFVGLGRLGDAMFACQIAGVQPDIVTLSKALTGGNLPLAATIASGRIYDAFLSDDPMHALMHGPTYMGNAL
GCAAANASLDLFESEPRLEQAQAIGRGLEQALEVLRGLPGVRDVRVRGAIGVIQLDRTAPADRLSAACIDRGVWLRPFRD
ILYTTPPLVTGEEDLARITSAMVEAVTEWSRETHV

Sequences:

>Translated_435_residues
MAQCARDRTMSDPQWYSTGRDHVWLPYTQMKTARPPLPVASAEGVKLRLADGRELVDGISSWWATVHGYRHPHIEEAIRR
QLETLPHVMLGGLAHEQAYTLARRLAGMLPGDLDHVFFSDSGSVAVEVAMKMAAQFWLNQGHRRVKFLCFRGGYHGDTFA
TMSVCDPDEGMHSLFRGALLEQVVVDLPRDAEGEAALGALIEQHRGELAGIVVEPLVQGAGGMVFHDPFTLQALRRLADE
HELLLIFDEIFVGLGRLGDAMFACQIAGVQPDIVTLSKALTGGNLPLAATIASGRIYDAFLSDDPMHALMHGPTYMGNAL
GCAAANASLDLFESEPRLEQAQAIGRGLEQALEVLRGLPGVRDVRVRGAIGVIQLDRTAPADRLSAACIDRGVWLRPFRD
ILYTTPPLVTGEEDLARITSAMVEAVTEWSRETHV
>Mature_434_residues
AQCARDRTMSDPQWYSTGRDHVWLPYTQMKTARPPLPVASAEGVKLRLADGRELVDGISSWWATVHGYRHPHIEEAIRRQ
LETLPHVMLGGLAHEQAYTLARRLAGMLPGDLDHVFFSDSGSVAVEVAMKMAAQFWLNQGHRRVKFLCFRGGYHGDTFAT
MSVCDPDEGMHSLFRGALLEQVVVDLPRDAEGEAALGALIEQHRGELAGIVVEPLVQGAGGMVFHDPFTLQALRRLADEH
ELLLIFDEIFVGLGRLGDAMFACQIAGVQPDIVTLSKALTGGNLPLAATIASGRIYDAFLSDDPMHALMHGPTYMGNALG
CAAANASLDLFESEPRLEQAQAIGRGLEQALEVLRGLPGVRDVRVRGAIGVIQLDRTAPADRLSAACIDRGVWLRPFRDI
LYTTPPLVTGEEDLARITSAMVEAVTEWSRETHV

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=400, Percent_Identity=31.5, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI37574042, Length=440, Percent_Identity=25.6818181818182, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI13994255, Length=358, Percent_Identity=27.9329608938547, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI284507298, Length=214, Percent_Identity=36.9158878504673, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI226442709, Length=398, Percent_Identity=26.6331658291457, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI226442705, Length=440, Percent_Identity=25.4545454545455, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1786991, Length=414, Percent_Identity=45.8937198067633, Blast_Score=354, Evalue=5e-99,
Organism=Escherichia coli, GI145693181, Length=337, Percent_Identity=32.3442136498516, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789016, Length=398, Percent_Identity=30.9045226130653, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1789759, Length=319, Percent_Identity=33.5423197492163, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1787560, Length=351, Percent_Identity=30.4843304843305, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1788044, Length=391, Percent_Identity=29.6675191815857, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786349, Length=388, Percent_Identity=28.3505154639175, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI25144271, Length=414, Percent_Identity=26.3285024154589, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI25144274, Length=230, Percent_Identity=30, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71992977, Length=442, Percent_Identity=26.2443438914027, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324386, Length=457, Percent_Identity=33.6980306345733, Blast_Score=274, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6323470, Length=397, Percent_Identity=28.9672544080605, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6324432, Length=356, Percent_Identity=28.0898876404494, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21357415, Length=397, Percent_Identity=29.2191435768262, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356575, Length=437, Percent_Identity=24.2562929061785, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47569; Mature: 47438

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQCARDRTMSDPQWYSTGRDHVWLPYTQMKTARPPLPVASAEGVKLRLADGRELVDGIS
CCCCCCCCCCCCCCHHCCCCCCEEECHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHH
SWWATVHGYRHPHIEEAIRRQLETLPHVMLGGLAHEQAYTLARRLAGMLPGDLDHVFFSD
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
SGSVAVEVAMKMAAQFWLNQGHRRVKFLCFRGGYHGDTFATMSVCDPDEGMHSLFRGALL
CCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHH
EQVVVDLPRDAEGEAALGALIEQHRGELAGIVVEPLVQGAGGMVFHDPFTLQALRRLADE
HHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCC
HELLLIFDEIFVGLGRLGDAMFACQIAGVQPDIVTLSKALTGGNLPLAATIASGRIYDAF
CCEEEEHHHHHHHHHHHCCHHHHEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCEEEHH
LSDDPMHALMHGPTYMGNALGCAAANASLDLFESEPRLEQAQAIGRGLEQALEVLRGLPG
CCCCCHHHHHCCCCHHCCCHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
VRDVRVRGAIGVIQLDRTAPADRLSAACIDRGVWLRPFRDILYTTPPLVTGEEDLARITS
CCEEEEECCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHH
AMVEAVTEWSRETHV
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
AQCARDRTMSDPQWYSTGRDHVWLPYTQMKTARPPLPVASAEGVKLRLADGRELVDGIS
CCCCCCCCCCCCCHHCCCCCCEEECHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHH
SWWATVHGYRHPHIEEAIRRQLETLPHVMLGGLAHEQAYTLARRLAGMLPGDLDHVFFSD
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
SGSVAVEVAMKMAAQFWLNQGHRRVKFLCFRGGYHGDTFATMSVCDPDEGMHSLFRGALL
CCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHH
EQVVVDLPRDAEGEAALGALIEQHRGELAGIVVEPLVQGAGGMVFHDPFTLQALRRLADE
HHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCC
HELLLIFDEIFVGLGRLGDAMFACQIAGVQPDIVTLSKALTGGNLPLAATIASGRIYDAF
CCEEEEHHHHHHHHHHHCCHHHHEEECCCCCHHHHHHHHHCCCCCCEEEEEECCCEEEHH
LSDDPMHALMHGPTYMGNALGCAAANASLDLFESEPRLEQAQAIGRGLEQALEVLRGLPG
CCCCCHHHHHCCCCHHCCCHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
VRDVRVRGAIGVIQLDRTAPADRLSAACIDRGVWLRPFRDILYTTPPLVTGEEDLARITS
CCEEEEECCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHH
AMVEAVTEWSRETHV
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8890743 [H]