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The map label for this gene is rnd [H]

Identifier: 87199358

GI number: 87199358

Start: 1377746

End: 1378963

Strand: Reverse

Name: rnd [H]

Synonym: Saro_1337

Alternate gene names: 87199358

Gene position: 1378963-1377746 (Counterclockwise)

Preceding gene: 87199366

Following gene: 87199357

Centisome position: 38.72

GC content: 63.88

Gene sequence:

>1218_bases
ATGAAGATACATCCCCTCATCACTACGACCGAAGCCCTCGCCGACCTTTGCGAGCGACTTGCGAAAGCCGATTTCGTCAC
CGTCGACACCGAATTCATGCGCGAGAACACCTATTGGCCGGAACTGTGCCTGGTGCAGATCGCGGACGACAAGGAAGCCG
CCGCGATCGATCCGCTGGCGCCGGGCCTCGACATGTCCCCCCTGCTCGACCTGCTGGTCGACAACGAGGACGTGCTCAAG
GTCTTCCACGCCGGGGGGCAGGACGTGGAGATAATCTACAACCTGACCGGCAAGACCCCGCACCCGATCTTCGACACGCA
GATCGCGATGATGGCGGTCAGCCAGTCCGAACAGATCGGCTATTCCAACCTAGTCGAGTCATGGCTCGGCCTGTCGATCG
ACAAGGGCGCCCGCTTCACCGACTGGTCGCGTCGCCCCCTGACCGAACGCCAGATCGAATACGCCATCGGCGACGTCACT
CACCTTTCGAAGATCTTCCCCAAGCTGCTCAAGCGCCTGATCAAGACAGGCCGCGGCGAATGGCTCGACATCGAGATGGA
AAAGCTGGCCGATCCGGAGAACTACCGGACCGACATGGACACCGTCTGGCAGAAGATCCGCGCCCCCAGCCGCAACCCCG
CCGTTCTCGGCCGGCTCAAGTCGCTCGCCGCCTGGCGCGAACGCGAGGCGATGGACAAGAACATTCCCAAGGGCCGCATC
ATGCGCGACGAGACGCTGGCCGACATCGCCAGCCATCCCCCGCGCGAACAGCATGACCTTGCAAAGGTGCGCGGCCTTTC
CGCTGGCTGGAAGGACAACGACATCGGCCGCCGCCTTATGCAGACGCTTGCCGATTCGAAGCCGCTGACCGACGCCGAAA
TGCCGCCCAAGGCTCCGCGCGGCGCCCCGCTCGGCAAGGAAGGCGCGCTGGTGGCCGACCTGCTGAAGCTGCTGCTCAAG
ATCCGCAGCCGCGAGATCGACATCGCCGCCCGCCTCCTCGCCCGCACCGACGACCTCGAACTGCTGGCCGCCGGACAACG
CAGGAACCTGCCGATCCTCGAAGGCTGGCGCTTCGAACAGTTTGGCCGCGACGCGCTAGAACTGGTCGAGGGCAAGCTCG
CCTTCGCGGTCGTGAACGGCAAGCTCAAGATGGCGCACATCGATGACATCGGCGGTTCGTCGGAAGAACCCGAAGTCGTC
GTCCACGTGGATGAATAA

Upstream 100 bases:

>100_bases
AGCCACGCCCCCGGCCAACCAAGGAGGGCGGGCAAGACGAAGCCCCCGGCAGGGAGCACCACCGGCCCGCTTTCACAGGC
GCGCCATACAGAAAAGCACG

Downstream 100 bases:

>100_bases
CCGCAAATGACAACCTACCTGCCCACGCTCAAGCAGTTGCAATACCTCGTGGCACTGCACGAGCATGGGCACTTCGGCCG
CGCCGCGGACGCCTGCTACG

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKIHPLITTTEALADLCERLAKADFVTVDTEFMRENTYWPELCLVQIADDKEAAAIDPLAPGLDMSPLLDLLVDNEDVLK
VFHAGGQDVEIIYNLTGKTPHPIFDTQIAMMAVSQSEQIGYSNLVESWLGLSIDKGARFTDWSRRPLTERQIEYAIGDVT
HLSKIFPKLLKRLIKTGRGEWLDIEMEKLADPENYRTDMDTVWQKIRAPSRNPAVLGRLKSLAAWREREAMDKNIPKGRI
MRDETLADIASHPPREQHDLAKVRGLSAGWKDNDIGRRLMQTLADSKPLTDAEMPPKAPRGAPLGKEGALVADLLKLLLK
IRSREIDIAARLLARTDDLELLAAGQRRNLPILEGWRFEQFGRDALELVEGKLAFAVVNGKLKMAHIDDIGGSSEEPEVV
VHVDE

Sequences:

>Translated_405_residues
MKIHPLITTTEALADLCERLAKADFVTVDTEFMRENTYWPELCLVQIADDKEAAAIDPLAPGLDMSPLLDLLVDNEDVLK
VFHAGGQDVEIIYNLTGKTPHPIFDTQIAMMAVSQSEQIGYSNLVESWLGLSIDKGARFTDWSRRPLTERQIEYAIGDVT
HLSKIFPKLLKRLIKTGRGEWLDIEMEKLADPENYRTDMDTVWQKIRAPSRNPAVLGRLKSLAAWREREAMDKNIPKGRI
MRDETLADIASHPPREQHDLAKVRGLSAGWKDNDIGRRLMQTLADSKPLTDAEMPPKAPRGAPLGKEGALVADLLKLLLK
IRSREIDIAARLLARTDDLELLAAGQRRNLPILEGWRFEQFGRDALELVEGKLAFAVVNGKLKMAHIDDIGGSSEEPEVV
VHVDE
>Mature_405_residues
MKIHPLITTTEALADLCERLAKADFVTVDTEFMRENTYWPELCLVQIADDKEAAAIDPLAPGLDMSPLLDLLVDNEDVLK
VFHAGGQDVEIIYNLTGKTPHPIFDTQIAMMAVSQSEQIGYSNLVESWLGLSIDKGARFTDWSRRPLTERQIEYAIGDVT
HLSKIFPKLLKRLIKTGRGEWLDIEMEKLADPENYRTDMDTVWQKIRAPSRNPAVLGRLKSLAAWREREAMDKNIPKGRI
MRDETLADIASHPPREQHDLAKVRGLSAGWKDNDIGRRLMQTLADSKPLTDAEMPPKAPRGAPLGKEGALVADLLKLLLK
IRSREIDIAARLLARTDDLELLAAGQRRNLPILEGWRFEQFGRDALELVEGKLAFAVVNGKLKMAHIDDIGGSSEEPEVV
VHVDE

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=261, Percent_Identity=25.2873563218391, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI50301240, Length=261, Percent_Identity=25.2873563218391, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788105, Length=373, Percent_Identity=32.7077747989276, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17531757, Length=208, Percent_Identity=26.9230769230769, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI161078302, Length=261, Percent_Identity=23.3716475095785, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 45415; Mature: 45415

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHPLITTTEALADLCERLAKADFVTVDTEFMRENTYWPELCLVQIADDKEAAAIDPLA
CCCCCCCCCHHHHHHHHHHHHHCCEEEECHHHHHCCCCCCCEEEEEECCCCCCCCCCCCC
PGLDMSPLLDLLVDNEDVLKVFHAGGQDVEIIYNLTGKTPHPIFDTQIAMMAVSQSEQIG
CCCCHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCC
YSNLVESWLGLSIDKGARFTDWSRRPLTERQIEYAIGDVTHLSKIFPKLLKRLIKTGRGE
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
WLDIEMEKLADPENYRTDMDTVWQKIRAPSRNPAVLGRLKSLAAWREREAMDKNIPKGRI
EEEEEHHHCCCCHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
MRDETLADIASHPPREQHDLAKVRGLSAGWKDNDIGRRLMQTLADSKPLTDAEMPPKAPR
CCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
GAPLGKEGALVADLLKLLLKIRSREIDIAARLLARTDDLELLAAGQRRNLPILEGWRFEQ
CCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHEECCCCCCCCCCCCCCHHH
FGRDALELVEGKLAFAVVNGKLKMAHIDDIGGSSEEPEVVVHVDE
HCHHHHHHHHCCEEEEEECCEEEEEEECCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MKIHPLITTTEALADLCERLAKADFVTVDTEFMRENTYWPELCLVQIADDKEAAAIDPLA
CCCCCCCCCHHHHHHHHHHHHHCCEEEECHHHHHCCCCCCCEEEEEECCCCCCCCCCCCC
PGLDMSPLLDLLVDNEDVLKVFHAGGQDVEIIYNLTGKTPHPIFDTQIAMMAVSQSEQIG
CCCCHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCC
YSNLVESWLGLSIDKGARFTDWSRRPLTERQIEYAIGDVTHLSKIFPKLLKRLIKTGRGE
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
WLDIEMEKLADPENYRTDMDTVWQKIRAPSRNPAVLGRLKSLAAWREREAMDKNIPKGRI
EEEEEHHHCCCCHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
MRDETLADIASHPPREQHDLAKVRGLSAGWKDNDIGRRLMQTLADSKPLTDAEMPPKAPR
CCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
GAPLGKEGALVADLLKLLLKIRSREIDIAARLLARTDDLELLAAGQRRNLPILEGWRFEQ
CCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHEECCCCCCCCCCCCCCHHH
FGRDALELVEGKLAFAVVNGKLKMAHIDDIGGSSEEPEVVVHVDE
HCHHHHHHHHCCEEEEEECCEEEEEEECCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]