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The map label for this gene is nat [H]

Identifier: 87198974

GI number: 87198974

Start: 998645

End: 999490

Strand: Reverse

Name: nat [H]

Synonym: Saro_0952

Alternate gene names: 87198974

Gene position: 999490-998645 (Counterclockwise)

Preceding gene: 87198975

Following gene: 229324846

Centisome position: 28.06

GC content: 66.31

Gene sequence:

>846_bases
ATGCTGCATGAAGCGTTGTCGGCCGAGGAACTTGCTGCCTACCTGCAACGGATCGGGTTCGACGACGAGCCTCGACGCGA
TCTCGCCACGCTTGACCGGATCGTGCAGGCTCATGTCAGGATGATCCCGTTCGAGAACCTCGACGCCCAGCTTGGCCGCC
CTCTCTCGACCGATCCGCGCGCGGCCTTTGCAAAGCTGGTGGAACGGCGGCGCGGCGGATGGTGCTATGAACACAACGGG
GTGCTGGCAGCGGCATTGAGGGCGATCGGTTTCGCGGTCACGCGGATGAGCGCGGGCGTGATGCGCGAGGTCAGGGGCGA
TGCGGCAATGGGTTCGCACTTGTGCCTGCTGGTAGAATGCGAGGGGCCGCGCCTCGTCGACGCCGGGTTCGGAAGCTGGA
TCGGGGCACCGCTTCCGCTGGAGACAGGGACCTGGGTCCACGATCCCCTTCCCGTCAGCCTCGGAACGCTGGAAGATGGA
ATGTGGCGGCTTTCCGCCACCATCGGCACGACGGCTATGTCCTACGATTTCCACGCCGCCCCGGCCGACGAAGATCTTCT
GTCACGGATGTGCCACTGGCAGGCCAATGACCCGGCATCGGTCTTCGTCCAGAACCTTACGGTGCAGCGACGCGACGCGG
GACAGTACCTGATGCTGCGCGGCAAGGTCCTGTCCGTGGTGACGGCCGGCGGAGAGGAACGGCGGGAGCTGGGCTCGGCC
GACGAACTGGCCGAGGCGTTGCGCGACCTGTTCCTGCTCGACGTGCCCGAGGCCGTCACGCTGTGGCCCGCGATAGAGGC
GCGCCACGAAGCGCTGTTCGGCGATCAGGCCGCACCCACGACATAG

Upstream 100 bases:

>100_bases
AAGCAGGCTGGGCTGGAGCCGTTCAACCACGCCGACTATGAGCCGGGCCGACGGTTCTACTTCTACGACTGGGACGGCAT
CGAGTTCGAGGTGGTCAGCT

Downstream 100 bases:

>100_bases
CAGGCCGCGGCCATCAGCAGACCGGCGAAGCGGTTTGAGCGGAACTTGGCCAGTGGGTCCGCCCCGTCTTCCTTCAGCGT
CAGCACCTGCCATGCCAGGT

Product: N-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MLHEALSAEELAAYLQRIGFDDEPRRDLATLDRIVQAHVRMIPFENLDAQLGRPLSTDPRAAFAKLVERRRGGWCYEHNG
VLAAALRAIGFAVTRMSAGVMREVRGDAAMGSHLCLLVECEGPRLVDAGFGSWIGAPLPLETGTWVHDPLPVSLGTLEDG
MWRLSATIGTTAMSYDFHAAPADEDLLSRMCHWQANDPASVFVQNLTVQRRDAGQYLMLRGKVLSVVTAGGEERRELGSA
DELAEALRDLFLLDVPEAVTLWPAIEARHEALFGDQAAPTT

Sequences:

>Translated_281_residues
MLHEALSAEELAAYLQRIGFDDEPRRDLATLDRIVQAHVRMIPFENLDAQLGRPLSTDPRAAFAKLVERRRGGWCYEHNG
VLAAALRAIGFAVTRMSAGVMREVRGDAAMGSHLCLLVECEGPRLVDAGFGSWIGAPLPLETGTWVHDPLPVSLGTLEDG
MWRLSATIGTTAMSYDFHAAPADEDLLSRMCHWQANDPASVFVQNLTVQRRDAGQYLMLRGKVLSVVTAGGEERRELGSA
DELAEALRDLFLLDVPEAVTLWPAIEARHEALFGDQAAPTT
>Mature_281_residues
MLHEALSAEELAAYLQRIGFDDEPRRDLATLDRIVQAHVRMIPFENLDAQLGRPLSTDPRAAFAKLVERRRGGWCYEHNG
VLAAALRAIGFAVTRMSAGVMREVRGDAAMGSHLCLLVECEGPRLVDAGFGSWIGAPLPLETGTWVHDPLPVSLGTLEDG
MWRLSATIGTTAMSYDFHAAPADEDLLSRMCHWQANDPASVFVQNLTVQRRDAGQYLMLRGKVLSVVTAGGEERRELGSA
DELAEALRDLFLLDVPEAVTLWPAIEARHEALFGDQAAPTT

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649128, Length=160, Percent_Identity=36.875, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI237649126, Length=160, Percent_Identity=36.875, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI237649124, Length=160, Percent_Identity=36.875, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI237649122, Length=160, Percent_Identity=36.875, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI237649119, Length=160, Percent_Identity=36.875, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI42741671, Length=160, Percent_Identity=36.875, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI237649009, Length=160, Percent_Identity=36.875, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI237649132, Length=160, Percent_Identity=36.875, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI237649130, Length=160, Percent_Identity=36.875, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI116295260, Length=160, Percent_Identity=35, Blast_Score=81, Evalue=9e-16,
Organism=Escherichia coli, GI1787736, Length=253, Percent_Identity=28.4584980237154, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 30770; Mature: 30770

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHEALSAEELAAYLQRIGFDDEPRRDLATLDRIVQAHVRMIPFENLDAQLGRPLSTDPR
CCCHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHH
AAFAKLVERRRGGWCYEHNGVLAAALRAIGFAVTRMSAGVMREVRGDAAMGSHLCLLVEC
HHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
EGPRLVDAGFGSWIGAPLPLETGTWVHDPLPVSLGTLEDGMWRLSATIGTTAMSYDFHAA
CCCEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEHHHCCCEEECCCCCC
PADEDLLSRMCHWQANDPASVFVQNLTVQRRDAGQYLMLRGKVLSVVTAGGEERRELGSA
CCCHHHHHHHHCCCCCCHHHHHHHHHHHEECCCCCEEEEECCEEEEEECCCHHHHHCCCH
DELAEALRDLFLLDVPEAVTLWPAIEARHEALFGDQAAPTT
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLHEALSAEELAAYLQRIGFDDEPRRDLATLDRIVQAHVRMIPFENLDAQLGRPLSTDPR
CCCHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHH
AAFAKLVERRRGGWCYEHNGVLAAALRAIGFAVTRMSAGVMREVRGDAAMGSHLCLLVEC
HHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
EGPRLVDAGFGSWIGAPLPLETGTWVHDPLPVSLGTLEDGMWRLSATIGTTAMSYDFHAA
CCCEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEHHHCCCEEECCCCCC
PADEDLLSRMCHWQANDPASVFVQNLTVQRRDAGQYLMLRGKVLSVVTAGGEERRELGSA
CCCHHHHHHHHCCCCCCHHHHHHHHHHHEECCCCCEEEEECCEEEEEECCCHHHHHCCCH
DELAEALRDLFLLDVPEAVTLWPAIEARHEALFGDQAAPTT
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]