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The map label for this gene is apt

Identifier: 87198699

GI number: 87198699

Start: 711968

End: 712504

Strand: Reverse

Name: apt

Synonym: Saro_0675

Alternate gene names: 87198699

Gene position: 712504-711968 (Counterclockwise)

Preceding gene: 87198700

Following gene: 87198694

Centisome position: 20.01

GC content: 65.74

Gene sequence:

>537_bases
ATGACCACCGACGATCTCAAGCGACTTGTCCGTACCGTCCCGGATTTCCCCTCCCCCGGAATCCTGTTCCGCGACATCAC
GACCCTGATCGCGCATGGCGAAGGTCTCTCGGCCTGCATCGACCACCTCGCCCACAAGGCACGCGCGGCCGGGGCACAGG
CCGTTGCGGGAATGGAGGCGCGCGGCTTCATCTTCGGCGCGGCGGTGGCTGCAAGGATGGGACTGGGCTTCATTCCGGTG
CGCAAGCCGGGCAAGCTTCCGGTCAAGACCATCGGCATCGACTATGCACTGGAATACGGGCGCGACCGGCTGGAGATCGA
TCCCACCGCCATTCGCGAAGGCCAGCGCGTTGTGATCGTCGACGACCTCATCGCGACCGGCGGCACTGCCCTGGCCGCGG
CCGAACTGCTCCGCATGGCGGGCGCACATGTCACGCACGCCCTCTTCGTGATCGACCTGCCCGAACTGCATGGCGCCGAA
CGACTTCGCGGTGCTGGTTTGACCGTCGAAGCGCTCATGGACTTTCCAGGGCACTGA

Upstream 100 bases:

>100_bases
ACGTCTGGGCCGACAAGCACTGAGTTCTACAGAAGCGAAACGAACAAAGGCCACCGGAAACGGTGGCCTTTTTCGTATCC
GGCGATAGCATCCGCGCACG

Downstream 100 bases:

>100_bases
AACGCGAAAGGGCGGCCCGATGGACCGCCCTTCCTGTCTTTAAACGTCGCAAGCCTCAATCCACGAGCATCAACGCGTCG
AGCGCAACCACGCCTTCGCC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MTTDDLKRLVRTVPDFPSPGILFRDITTLIAHGEGLSACIDHLAHKARAAGAQAVAGMEARGFIFGAAVAARMGLGFIPV
RKPGKLPVKTIGIDYALEYGRDRLEIDPTAIREGQRVVIVDDLIATGGTALAAAELLRMAGAHVTHALFVIDLPELHGAE
RLRGAGLTVEALMDFPGH

Sequences:

>Translated_178_residues
MTTDDLKRLVRTVPDFPSPGILFRDITTLIAHGEGLSACIDHLAHKARAAGAQAVAGMEARGFIFGAAVAARMGLGFIPV
RKPGKLPVKTIGIDYALEYGRDRLEIDPTAIREGQRVVIVDDLIATGGTALAAAELLRMAGAHVTHALFVIDLPELHGAE
RLRGAGLTVEALMDFPGH
>Mature_177_residues
TTDDLKRLVRTVPDFPSPGILFRDITTLIAHGEGLSACIDHLAHKARAAGAQAVAGMEARGFIFGAAVAARMGLGFIPVR
KPGKLPVKTIGIDYALEYGRDRLEIDPTAIREGQRVVIVDDLIATGGTALAAAELLRMAGAHVTHALFVIDLPELHGAER
LRGAGLTVEALMDFPGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=160, Percent_Identity=43.125, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=44, Blast_Score=111, Evalue=3e-25,
Organism=Escherichia coli, GI1786675, Length=173, Percent_Identity=49.7109826589595, Blast_Score=174, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17509087, Length=167, Percent_Identity=43.7125748502994, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=170, Percent_Identity=39.4117647058824, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320649, Length=169, Percent_Identity=35.5029585798817, Blast_Score=91, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17136334, Length=168, Percent_Identity=40.4761904761905, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_NOVAD (Q2GAK1)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_495956.1
- HSSP:   P07741
- ProteinModelPortal:   Q2GAK1
- SMR:   Q2GAK1
- STRING:   Q2GAK1
- GeneID:   3918100
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_0675
- NMPDR:   fig|48935.1.peg.1914
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q2GAK1
- ProtClustDB:   PRK02304
- BioCyc:   NARO279238:SARO_0675-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18865; Mature: 18734

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDDLKRLVRTVPDFPSPGILFRDITTLIAHGEGLSACIDHLAHKARAAGAQAVAGMEA
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHCCCC
RGFIFGAAVAARMGLGFIPVRKPGKLPVKTIGIDYALEYGRDRLEIDPTAIREGQRVVIV
CHHHHHHHHHHHHCCCCEECCCCCCCCEEEECHHHHHHCCCCCEEECHHHHHCCCEEEEE
DDLIATGGTALAAAELLRMAGAHVTHALFVIDLPELHGAERLRGAGLTVEALMDFPGH
ECHHHCCCHHHHHHHHHHHHCHHHHHEEEEEECCCCCCHHHHCCCCCCHHHHHCCCCC
>Mature Secondary Structure 
TTDDLKRLVRTVPDFPSPGILFRDITTLIAHGEGLSACIDHLAHKARAAGAQAVAGMEA
CHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHCCCC
RGFIFGAAVAARMGLGFIPVRKPGKLPVKTIGIDYALEYGRDRLEIDPTAIREGQRVVIV
CHHHHHHHHHHHHCCCCEECCCCCCCCEEEECHHHHHHCCCCCEEECHHHHHCCCEEEEE
DDLIATGGTALAAAELLRMAGAHVTHALFVIDLPELHGAERLRGAGLTVEALMDFPGH
ECHHHCCCHHHHHHHHHHHHCHHHHHEEEEEECCCCCCHHHHCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA