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The map label for this gene is dut [H]

Identifier: 87198614

GI number: 87198614

Start: 635565

End: 636038

Strand: Reverse

Name: dut [H]

Synonym: Saro_0590

Alternate gene names: 87198614

Gene position: 636038-635565 (Counterclockwise)

Preceding gene: 87198615

Following gene: 87198608

Centisome position: 17.86

GC content: 68.78

Gene sequence:

>474_bases
TTGCCGATGTCCTCTCCTGAAATCCCCGTCCTCGTGAAGCGCCTGCCCCACGGGCAGGACCTTCCCCTTCCCGCCTACGC
CACCGAGGGCGCGGCGGGCATGGACGTGGTCTCGGCCGAGGACGTGGATCTTGCTCCCGGCGGGCGCCATGCCGTCGCCA
CCGGCCTTTCCGTCGCGATTCCGCATGGTTACGAGATCCAGGTGCGTCCCCGCTCGGGCCTCGCGCTCAAGCATGGGGTC
ACCGTACCCAACACGCCCGGCACCATCGACAGCGACTATCGCGGCGAACTCAAGGTCATCATGATCAACCTCGGGGCCGA
AACCTTCTCGATCCGCCGGGGGGACCGCGTGGCGCAGCTCGTCGTCGCACCTGTCACGCGAGGATCGTGGGTCGAGGTCG
ATGAGCTCGACGCCACCCAGCGGGGCGAGGGCGGCTTCGGATCGACCGGCGGCCTCGCGGCTCTCAAGGGCTGA

Upstream 100 bases:

>100_bases
GGCGGTGAAATCAACGGCTTGCACATCGTCAGCAGCAGCGGCGTCGAAAGCCTCCCGGAAATGCCCAAGGACGCGGCGGC
GGCCGCGCTCATCGAAAGAA

Downstream 100 bases:

>100_bases
AAAAAGGGGCCCCGCGTCGCCGCCGGGCCCCTTCGTGTATGTTCAGGTGCTTTCAGGTGCCGTTCGGGTCAATTGACCTT
CTTGACCGTCTTCTTCTCGG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MPMSSPEIPVLVKRLPHGQDLPLPAYATEGAAGMDVVSAEDVDLAPGGRHAVATGLSVAIPHGYEIQVRPRSGLALKHGV
TVPNTPGTIDSDYRGELKVIMINLGAETFSIRRGDRVAQLVVAPVTRGSWVEVDELDATQRGEGGFGSTGGLAALKG

Sequences:

>Translated_157_residues
MPMSSPEIPVLVKRLPHGQDLPLPAYATEGAAGMDVVSAEDVDLAPGGRHAVATGLSVAIPHGYEIQVRPRSGLALKHGV
TVPNTPGTIDSDYRGELKVIMINLGAETFSIRRGDRVAQLVVAPVTRGSWVEVDELDATQRGEGGFGSTGGLAALKG
>Mature_156_residues
PMSSPEIPVLVKRLPHGQDLPLPAYATEGAAGMDVVSAEDVDLAPGGRHAVATGLSVAIPHGYEIQVRPRSGLALKHGVT
VPNTPGTIDSDYRGELKVIMINLGAETFSIRRGDRVAQLVVAPVTRGSWVEVDELDATQRGEGGFGSTGGLAALKG

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI4503423, Length=127, Percent_Identity=44.0944881889764, Blast_Score=106, Evalue=9e-24,
Organism=Homo sapiens, GI70906444, Length=127, Percent_Identity=44.0944881889764, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI70906441, Length=127, Percent_Identity=44.0944881889764, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1790071, Length=151, Percent_Identity=41.7218543046358, Blast_Score=118, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71988561, Length=146, Percent_Identity=43.8356164383562, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319729, Length=129, Percent_Identity=39.5348837209302, Blast_Score=97, Evalue=9e-22,
Organism=Drosophila melanogaster, GI19921126, Length=127, Percent_Identity=42.5196850393701, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24583610, Length=127, Percent_Identity=42.5196850393701, Blast_Score=97, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 16331; Mature: 16200

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMSSPEIPVLVKRLPHGQDLPLPAYATEGAAGMDVVSAEDVDLAPGGRHAVATGLSVAI
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEEECCEEEEC
PHGYEIQVRPRSGLALKHGVTVPNTPGTIDSDYRGELKVIMINLGAETFSIRRGDRVAQL
CCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCEEEE
VVAPVTRGSWVEVDELDATQRGEGGFGSTGGLAALKG
EEEECCCCCEEEECCCCCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure 
PMSSPEIPVLVKRLPHGQDLPLPAYATEGAAGMDVVSAEDVDLAPGGRHAVATGLSVAI
CCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEEECCEEEEC
PHGYEIQVRPRSGLALKHGVTVPNTPGTIDSDYRGELKVIMINLGAETFSIRRGDRVAQL
CCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCEEEE
VVAPVTRGSWVEVDELDATQRGEGGFGSTGGLAALKG
EEEECCCCCEEEECCCCCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA