| Definition | Novosphingobium aromaticivorans DSM 12444 chromosome, complete genome. |
|---|---|
| Accession | NC_007794 |
| Length | 3,561,584 |
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The map label for this gene is hom [H]
Identifier: 87198045
GI number: 87198045
Start: 14577
End: 15884
Strand: Direct
Name: hom [H]
Synonym: Saro_0019
Alternate gene names: 87198045
Gene position: 14577-15884 (Clockwise)
Preceding gene: 87198044
Following gene: 87198047
Centisome position: 0.41
GC content: 66.74
Gene sequence:
>1308_bases ATGAGCGAACCATTGCGCATCGCGCTGGCCGGACTTGGCACGGTAGGCGGCGGAGTGATCCGGCTGATCGAGGCGAACGC CGATCTGATCGCGCGCCGCGCGGGCCGGCCGATAGTCATTACCACCGTCAGCGCACGCAATCGCGACAAGGACCGCGGCT TCGACGTGTCGCGCTATGCCTGGGAAGACGACATGGTCATCCTCGGCGAGCGTCCTGACGTGGACGTCGTGGTCGAACTC GTCGGCGGCGCCGATGGCCCCGCCTTGGCGCTCGCCCGGACCACGTTCGAGGCCGGCAAGGCTCTTGTCACGGCCAACAA GGCAATGATCGCGCACCACGGCGTGGAACTTGCCACAAAGGCAGAAGCCGCCAAGGTGGCGCTGAAATTCGAGGCTGCGG TCGCTGGCGGCATCCCCGTTATCAAGGGACTCAAGGAAGGCGTCGCCGCCAACGAGATCGCACGGGTCTATGGCATTCTC AACGGCACCTGCAACTACATCCTCTCGACGATGGAAGACACCGGCCGCGATTTCGCCGACGTTCTCGCCGAGGCGCAGGC CAAGGGCTATGCCGAAGCCGACCCGACCTTCGACATCGACGGCATCGACGCCGCGCACAAGCTTTCGATCCTTTCGTCGA TCGCCTTCGGCACGGCGGTGGACTTCAAGCCCGTGGCCGCGACCGGCATCCGCCGCGTCCTTGCCGCCGACATCGCGCAG GCAGATGTGCTCGGCTACTATATCCGCCTGATCGGCATGGCCGAGACGGAAATGGACGCTGCGGGCAACCGCCGCCTGTT CCAGCGGGTCCACCCGCACCTCGTCCATCGCGACCATCCGCTCGCCCATGTCGACGGCGCGACCAATGCGGTCGTCGCCG AGGGCAATTTCGTGGGCAGGCTGCTGTTCCAGGGCGCGGGGGCCGGCGATGGTCCGACCGCCAGCGCCGTGGTCGCCGAT CTCATCGACATCGCGCGCGGCGACATCGGCGCGCCCTTCTCGATCCCGGTCGCGGAACTGGAAAGGGCAGCTCCGGCCGA AACCGGCCACCGCAGGGGCAAGGCCTATATCCGGTTCAACGTGGCCGATCGTCCGGGCGTGCTGGCCGAAATCACCGCCG CCATGCGCGACGCCGGGGTATCGATCGAGAGCTTCATCCAGAAGGGTGGGCAGGACGATGCACCGGTCATGGTGTCGATG GTCACGCACGAAGGCCCGGAAAGCGCCATCGCCGAAGCACTGCGCCTTCTCGATGGCTCGCCCGTCCTGGCCGAGCCGCC GCTGGTCATGCACATCCTCGGCGAATGA
Upstream 100 bases:
>100_bases CCGCTCGCGGCCTGCGATCTCCAACTGACGATTCCCGCTGTTGCCCCGCGCGGCCGCCTCCCCTAAGGCCCGCGCGGGAA TCCAGACAGACGGGAATGAC
Downstream 100 bases:
>100_bases GGCCGCAGAGCCCCCTGCTCAGGGGGCCGGGATCTCGCCCTTGGCGATGCGATCGGCGTCCGATCCGGGCGGCGGAGGCG GCAAGGCCTTGATATCGAAG
Product: homoserine dehydrogenase
Products: NA
Alternate protein names: HDH [H]
Number of amino acids: Translated: 435; Mature: 434
Protein sequence:
>435_residues MSEPLRIALAGLGTVGGGVIRLIEANADLIARRAGRPIVITTVSARNRDKDRGFDVSRYAWEDDMVILGERPDVDVVVEL VGGADGPALALARTTFEAGKALVTANKAMIAHHGVELATKAEAAKVALKFEAAVAGGIPVIKGLKEGVAANEIARVYGIL NGTCNYILSTMEDTGRDFADVLAEAQAKGYAEADPTFDIDGIDAAHKLSILSSIAFGTAVDFKPVAATGIRRVLAADIAQ ADVLGYYIRLIGMAETEMDAAGNRRLFQRVHPHLVHRDHPLAHVDGATNAVVAEGNFVGRLLFQGAGAGDGPTASAVVAD LIDIARGDIGAPFSIPVAELERAAPAETGHRRGKAYIRFNVADRPGVLAEITAAMRDAGVSIESFIQKGGQDDAPVMVSM VTHEGPESAIAEALRLLDGSPVLAEPPLVMHILGE
Sequences:
>Translated_435_residues MSEPLRIALAGLGTVGGGVIRLIEANADLIARRAGRPIVITTVSARNRDKDRGFDVSRYAWEDDMVILGERPDVDVVVEL VGGADGPALALARTTFEAGKALVTANKAMIAHHGVELATKAEAAKVALKFEAAVAGGIPVIKGLKEGVAANEIARVYGIL NGTCNYILSTMEDTGRDFADVLAEAQAKGYAEADPTFDIDGIDAAHKLSILSSIAFGTAVDFKPVAATGIRRVLAADIAQ ADVLGYYIRLIGMAETEMDAAGNRRLFQRVHPHLVHRDHPLAHVDGATNAVVAEGNFVGRLLFQGAGAGDGPTASAVVAD LIDIARGDIGAPFSIPVAELERAAPAETGHRRGKAYIRFNVADRPGVLAEITAAMRDAGVSIESFIQKGGQDDAPVMVSM VTHEGPESAIAEALRLLDGSPVLAEPPLVMHILGE >Mature_434_residues SEPLRIALAGLGTVGGGVIRLIEANADLIARRAGRPIVITTVSARNRDKDRGFDVSRYAWEDDMVILGERPDVDVVVELV GGADGPALALARTTFEAGKALVTANKAMIAHHGVELATKAEAAKVALKFEAAVAGGIPVIKGLKEGVAANEIARVYGILN GTCNYILSTMEDTGRDFADVLAEAQAKGYAEADPTFDIDGIDAAHKLSILSSIAFGTAVDFKPVAATGIRRVLAADIAQA DVLGYYIRLIGMAETEMDAAGNRRLFQRVHPHLVHRDHPLAHVDGATNAVVAEGNFVGRLLFQGAGAGDGPTASAVVADL IDIARGDIGAPFSIPVAELERAAPAETGHRRGKAYIRFNVADRPGVLAEITAAMRDAGVSIESFIQKGGQDDAPVMVSMV THEGPESAIAEALRLLDGSPVLAEPPLVMHILGE
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0460
COG function: function code E; Homoserine dehydrogenase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ACT domain [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=261, Percent_Identity=28.3524904214559, Blast_Score=71, Evalue=1e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR005106 - InterPro: IPR016204 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =1.1.1.3 [H]
Molecular weight: Translated: 45518; Mature: 45387
Theoretical pI: Translated: 5.00; Mature: 5.00
Prosite motif: PS01042 HOMOSER_DHGENASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSEPLRIALAGLGTVGGGVIRLIEANADLIARRAGRPIVITTVSARNRDKDRGFDVSRYA CCCCCEEEEECCCCCCCCEEEEEECCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHEE WEDDMVILGERPDVDVVVELVGGADGPALALARTTFEAGKALVTANKAMIAHHGVELATK CCCCEEEECCCCCHHHHHEECCCCCCCEEEHHHHHHHCCCEEEEECHHHHHHCCCHHHHH AEAAKVALKFEAAVAGGIPVIKGLKEGVAANEIARVYGILNGTCNYILSTMEDTGRDFAD HHHHHEEEEEEHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH VLAEAQAKGYAEADPTFDIDGIDAAHKLSILSSIAFGTAVDFKPVAATGIRRVLAADIAQ HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH ADVLGYYIRLIGMAETEMDAAGNRRLFQRVHPHLVHRDHPLAHVDGATNAVVAEGNFVGR HHHHHHHHHHHHCCHHHHCCCCCHHHHHHHCHHHHCCCCCCEEECCCCCEEEECCCCEEE LLFQGAGAGDGPTASAVVADLIDIARGDIGAPFSIPVAELERAAPAETGHRRGKAYIRFN HEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEE VADRPGVLAEITAAMRDAGVSIESFIQKGGQDDAPVMVSMVTHEGPESAIAEALRLLDGS ECCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCC PVLAEPPLVMHILGE CCCCCCCEEEEECCC >Mature Secondary Structure SEPLRIALAGLGTVGGGVIRLIEANADLIARRAGRPIVITTVSARNRDKDRGFDVSRYA CCCCEEEEECCCCCCCCEEEEEECCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHEE WEDDMVILGERPDVDVVVELVGGADGPALALARTTFEAGKALVTANKAMIAHHGVELATK CCCCEEEECCCCCHHHHHEECCCCCCCEEEHHHHHHHCCCEEEEECHHHHHHCCCHHHHH AEAAKVALKFEAAVAGGIPVIKGLKEGVAANEIARVYGILNGTCNYILSTMEDTGRDFAD HHHHHEEEEEEHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH VLAEAQAKGYAEADPTFDIDGIDAAHKLSILSSIAFGTAVDFKPVAATGIRRVLAADIAQ HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH ADVLGYYIRLIGMAETEMDAAGNRRLFQRVHPHLVHRDHPLAHVDGATNAVVAEGNFVGR HHHHHHHHHHHHCCHHHHCCCCCHHHHHHHCHHHHCCCCCCEEECCCCCEEEECCCCEEE LLFQGAGAGDGPTASAVVADLIDIARGDIGAPFSIPVAELERAAPAETGHRRGKAYIRFN HEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEE VADRPGVLAEITAAMRDAGVSIESFIQKGGQDDAPVMVSMVTHEGPESAIAEALRLLDGS ECCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCC PVLAEPPLVMHILGE CCCCCCCEEEEECCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 1333566; 10984043 [H]