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The map label for this gene is lig [H]

Identifier: 86751715

GI number: 86751715

Start: 5217870

End: 5219738

Strand: Direct

Name: lig [H]

Synonym: RPB_4617

Alternate gene names: 86751715

Gene position: 5217870-5219738 (Clockwise)

Preceding gene: 86751714

Following gene: 86751716

Centisome position: 97.87

GC content: 68.22

Gene sequence:

>1869_bases
ATGAACCGGTTCGCCGAATTGCTCGACCGCCTCGCCTATGAGCCCGGCCGCAACAACAAGCTGCGGCTGATCACCAATTA
CTTCCGCGCCACCGAAGACCCCGACCGCGGCTATGCGCTGGCCGCGCTGACCGGCGCATTGTCGTTTCGCCACGCCAAGC
CCGGCCTGATCCGGACTCTGATCGCCGAACGCACCGATCCGGTGCTGTTCGGCCTGTCCTACGACTATGTCGGCGACCTG
TCGGAGACGGTCGCGCTGATGTGGCCTGCGCCGCGAGGCCGAGCCTCCTCCCCTCCCCCTTGCGGGGAGGGAGCCTGCCC
CGGACTTGATCCGGGGTCGGGGGTGGGGGTCGACAACGGGAGCTTTTCCTCGGCGCACCCTCACCCCACCCCTCTCCCGC
AAGCGGGAGAGGGAGCGCGCAGTCCGTCGGGTGAACACACCTCTCCACTATCCGACGCAGCAACGAAAGCTGGCCACAAC
AACCCGCCGCCGCCGACGCTCACCGACATCGTCACCACGCTGCACAGCCTCGGCAAGGCCGAGCTGCCGGCGCAGCTTGC
GCGCTGGCTCGACGAACTCGACGAGACCGGACGCTGGGCGTTGTTGAAGCTCGTCACGGGCGGCCTGCGGATCGGCATCT
CGGCGCGCCTCGCAAAGACCGCTGCCGCAGCGCTCGGCGATAAGGATCCGCACGACGTCGAACTGGTCTGGCCCGGGCTC
GAGGCGCCCTATCTCGACTTGTTCGCCTGGCTCGACGGCCGCGGCCCGCAGCCGGTCAACCGCGATCCGGCGCCGTTCCG
CCCGGTGATGCTGGCGCATGCGGTCGAGGACGCCGACTTCGAGGCCATGACCCCGGCCGACTACATCGCCGAATGGAAAT
GGGACGGCATCCGCGTCCAGGCGGTGAGCGGCATCGGCGACGACGGCGAAACCGTGGTGCGGCTGTATTCGCGCAGCGGC
GAGGACATCACCATGAGCTTCCCGGACCTGTTGCCATCGCTGCGGCTGCCCGGCGCGATCGACGGCGAACTCCTGGTGCT
GCGCGAAGGCCGGGTGCAGTCGTTCAACGTGCTGCAGCAACGGCTCAACCGCAAATCGGTGACGCCGAAGCTGATCAAGG
AGTATCCGATTCATCTGCGCGCCTACGACCTGCTCGGCGACGGCGACGCGGATCTGCGGATACAGCCCTTCGTCGATCGA
CGTGCGCGGCTCGAGCGCTTCATCGCACGGCTCGACGACCCCAGAGTCGATCTTTCGCCGACGGTCGCGTTCGACGATTG
GGACGGCTTGCGGGCGGCGCGGCGCGATCCGGCCAGCGCCGGCGCCGGCCTCGACGCCGACGCGGTCGAGGGCGTGATGC
TGAAGCGGCGCGACGCGCTGTATCTGCCCGGCCGGCCGAAAGGCCAGTGGTGGAAGTGGAAGCACGACCCGCACATCATC
GACGCGGTGCTGATGTACGCCCAGCGTGGCCACGGCAAGCGCTCGTCTTATTACTCCGACTACACTTTCGGGGTCTGGAC
TGAAGGCGACGACGGCGACCAGCTCGTTCCGGTCGGCAAAGCCTATTTCGGCTTCACCGACGAGGAGCTGCTGCAGATCG
ACCGCTTCGTCCGCCGCAACACCACCGAGAAATTCGGCCCGGTCCGCCATGTCGTGCACGAGCCCGACCAGGGCCTGGTG
CTGGAAGTCGCGTTCGAGGGGCTGCAACGCTCGCCGCGGCACAAGTCCGGCGTGGCGATGCGGTTTCCGCGAATCAGCCG
GCTGCGCTGGGACAAGCCGCCGCGCGACGCCGACCGGCTGGCGACGCTGGAACGGATGCTGAAGGCCGACACCGCCGGCC
CCGAAAAAGCCGCCCCGAGCAGCCATTGA

Upstream 100 bases:

>100_bases
AGCGCAAGGGCCTCACCGCGCGCCCGCTCGATCTGGTCGGCTACGGTGACGAAGACGAAGACGTCGGCCTGGCGGCGGGC
GAGACCGAGGCCGCCGAGGC

Downstream 100 bases:

>100_bases
CGCCATCAGGCCGGTTCCCCATCTGCTCGACAGCGATTATCATGCGGCCGCACCGCACGAGGACCCAGTGATGCGCGACG
ACACCCGAAATATTCCGGCC

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MNRFAELLDRLAYEPGRNNKLRLITNYFRATEDPDRGYALAALTGALSFRHAKPGLIRTLIAERTDPVLFGLSYDYVGDL
SETVALMWPAPRGRASSPPPCGEGACPGLDPGSGVGVDNGSFSSAHPHPTPLPQAGEGARSPSGEHTSPLSDAATKAGHN
NPPPPTLTDIVTTLHSLGKAELPAQLARWLDELDETGRWALLKLVTGGLRIGISARLAKTAAAALGDKDPHDVELVWPGL
EAPYLDLFAWLDGRGPQPVNRDPAPFRPVMLAHAVEDADFEAMTPADYIAEWKWDGIRVQAVSGIGDDGETVVRLYSRSG
EDITMSFPDLLPSLRLPGAIDGELLVLREGRVQSFNVLQQRLNRKSVTPKLIKEYPIHLRAYDLLGDGDADLRIQPFVDR
RARLERFIARLDDPRVDLSPTVAFDDWDGLRAARRDPASAGAGLDADAVEGVMLKRRDALYLPGRPKGQWWKWKHDPHII
DAVLMYAQRGHGKRSSYYSDYTFGVWTEGDDGDQLVPVGKAYFGFTDEELLQIDRFVRRNTTEKFGPVRHVVHEPDQGLV
LEVAFEGLQRSPRHKSGVAMRFPRISRLRWDKPPRDADRLATLERMLKADTAGPEKAAPSSH

Sequences:

>Translated_622_residues
MNRFAELLDRLAYEPGRNNKLRLITNYFRATEDPDRGYALAALTGALSFRHAKPGLIRTLIAERTDPVLFGLSYDYVGDL
SETVALMWPAPRGRASSPPPCGEGACPGLDPGSGVGVDNGSFSSAHPHPTPLPQAGEGARSPSGEHTSPLSDAATKAGHN
NPPPPTLTDIVTTLHSLGKAELPAQLARWLDELDETGRWALLKLVTGGLRIGISARLAKTAAAALGDKDPHDVELVWPGL
EAPYLDLFAWLDGRGPQPVNRDPAPFRPVMLAHAVEDADFEAMTPADYIAEWKWDGIRVQAVSGIGDDGETVVRLYSRSG
EDITMSFPDLLPSLRLPGAIDGELLVLREGRVQSFNVLQQRLNRKSVTPKLIKEYPIHLRAYDLLGDGDADLRIQPFVDR
RARLERFIARLDDPRVDLSPTVAFDDWDGLRAARRDPASAGAGLDADAVEGVMLKRRDALYLPGRPKGQWWKWKHDPHII
DAVLMYAQRGHGKRSSYYSDYTFGVWTEGDDGDQLVPVGKAYFGFTDEELLQIDRFVRRNTTEKFGPVRHVVHEPDQGLV
LEVAFEGLQRSPRHKSGVAMRFPRISRLRWDKPPRDADRLATLERMLKADTAGPEKAAPSSH
>Mature_622_residues
MNRFAELLDRLAYEPGRNNKLRLITNYFRATEDPDRGYALAALTGALSFRHAKPGLIRTLIAERTDPVLFGLSYDYVGDL
SETVALMWPAPRGRASSPPPCGEGACPGLDPGSGVGVDNGSFSSAHPHPTPLPQAGEGARSPSGEHTSPLSDAATKAGHN
NPPPPTLTDIVTTLHSLGKAELPAQLARWLDELDETGRWALLKLVTGGLRIGISARLAKTAAAALGDKDPHDVELVWPGL
EAPYLDLFAWLDGRGPQPVNRDPAPFRPVMLAHAVEDADFEAMTPADYIAEWKWDGIRVQAVSGIGDDGETVVRLYSRSG
EDITMSFPDLLPSLRLPGAIDGELLVLREGRVQSFNVLQQRLNRKSVTPKLIKEYPIHLRAYDLLGDGDADLRIQPFVDR
RARLERFIARLDDPRVDLSPTVAFDDWDGLRAARRDPASAGAGLDADAVEGVMLKRRDALYLPGRPKGQWWKWKHDPHII
DAVLMYAQRGHGKRSSYYSDYTFGVWTEGDDGDQLVPVGKAYFGFTDEELLQIDRFVRRNTTEKFGPVRHVVHEPDQGLV
LEVAFEGLQRSPRHKSGVAMRFPRISRLRWDKPPRDADRLATLERMLKADTAGPEKAAPSSH

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=373, Percent_Identity=27.3458445040214, Blast_Score=88, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71985269, Length=383, Percent_Identity=27.154046997389, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 68646; Mature: 68646

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRFAELLDRLAYEPGRNNKLRLITNYFRATEDPDRGYALAALTGALSFRHAKPGLIRTL
CCHHHHHHHHHHCCCCCCCCEEEEEHHHHCCCCCCCCEEHHHHHHHHHHCCCCCHHHHHH
IAERTDPVLFGLSYDYVGDLSETVALMWPAPRGRASSPPPCGEGACPGLDPGSGVGVDNG
HHCCCCCEEEECCHHHHCCCHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SFSSAHPHPTPLPQAGEGARSPSGEHTSPLSDAATKAGHNNPPPPTLTDIVTTLHSLGKA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
ELPAQLARWLDELDETGRWALLKLVTGGLRIGISARLAKTAAAALGDKDPHDVELVWPGL
CHHHHHHHHHHHHHCCCCEEEEHHHHCCEEECHHHHHHHHHHHHHCCCCCCCEEEEECCC
EAPYLDLFAWLDGRGPQPVNRDPAPFRPVMLAHAVEDADFEAMTPADYIAEWKWDGIRVQ
CCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEEE
AVSGIGDDGETVVRLYSRSGEDITMSFPDLLPSLRLPGAIDGELLVLREGRVQSFNVLQQ
EECCCCCCHHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHH
RLNRKSVTPKLIKEYPIHLRAYDLLGDGDADLRIQPFVDRRARLERFIARLDDPRVDLSP
HHHHCCCCHHHHHHCCCEEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCC
TVAFDDWDGLRAARRDPASAGAGLDADAVEGVMLKRRDALYLPGRPKGQWWKWKHDPHII
EEEECCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHH
DAVLMYAQRGHGKRSSYYSDYTFGVWTEGDDGDQLVPVGKAYFGFTDEELLQIDRFVRRN
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEECCHHHCCCCHHHHHHHHHHHHHC
TTEKFGPVRHVVHEPDQGLVLEVAFEGLQRSPRHKSGVAMRFPRISRLRWDKPPRDADRL
CHHHHHHHHHHHCCCCCCEEEHEEHHHHHCCCCCCCCCEEECCCHHHCCCCCCCCHHHHH
ATLERMLKADTAGPEKAAPSSH
HHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNRFAELLDRLAYEPGRNNKLRLITNYFRATEDPDRGYALAALTGALSFRHAKPGLIRTL
CCHHHHHHHHHHCCCCCCCCEEEEEHHHHCCCCCCCCEEHHHHHHHHHHCCCCCHHHHHH
IAERTDPVLFGLSYDYVGDLSETVALMWPAPRGRASSPPPCGEGACPGLDPGSGVGVDNG
HHCCCCCEEEECCHHHHCCCHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SFSSAHPHPTPLPQAGEGARSPSGEHTSPLSDAATKAGHNNPPPPTLTDIVTTLHSLGKA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
ELPAQLARWLDELDETGRWALLKLVTGGLRIGISARLAKTAAAALGDKDPHDVELVWPGL
CHHHHHHHHHHHHHCCCCEEEEHHHHCCEEECHHHHHHHHHHHHHCCCCCCCEEEEECCC
EAPYLDLFAWLDGRGPQPVNRDPAPFRPVMLAHAVEDADFEAMTPADYIAEWKWDGIRVQ
CCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEEE
AVSGIGDDGETVVRLYSRSGEDITMSFPDLLPSLRLPGAIDGELLVLREGRVQSFNVLQQ
EECCCCCCHHHHHHHHHCCCCEEEEECHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHH
RLNRKSVTPKLIKEYPIHLRAYDLLGDGDADLRIQPFVDRRARLERFIARLDDPRVDLSP
HHHHCCCCHHHHHHCCCEEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCC
TVAFDDWDGLRAARRDPASAGAGLDADAVEGVMLKRRDALYLPGRPKGQWWKWKHDPHII
EEEECCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHH
DAVLMYAQRGHGKRSSYYSDYTFGVWTEGDDGDQLVPVGKAYFGFTDEELLQIDRFVRRN
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEECCHHHCCCCHHHHHHHHHHHHHC
TTEKFGPVRHVVHEPDQGLVLEVAFEGLQRSPRHKSGVAMRFPRISRLRWDKPPRDADRL
CHHHHHHHHHHHCCCCCCEEEHEEHHHHHCCCCCCCCCEEECCCHHHCCCCCCCCHHHHH
ATLERMLKADTAGPEKAAPSSH
HHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA