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The map label for this gene is atpB

Identifier: 86751669

GI number: 86751669

Start: 5169539

End: 5170285

Strand: Direct

Name: atpB

Synonym: RPB_4571

Alternate gene names: 86751669

Gene position: 5169539-5170285 (Clockwise)

Preceding gene: 86751668

Following gene: 86751670

Centisome position: 96.96

GC content: 61.18

Gene sequence:

>747_bases
ATGGCCGCCGATCCAATTCATCAGTTCCAGATCACCAAGCTGTTTTCCCTTGGTCACATTGGCGGACAGGAAATCGCGTT
CACCAATTCGTCGGCCTACATGTTCGCCGCGGTGGCGATCATCGCGGTGATGATGCTGGCGCCGGGCCGCCAGCTGGTGC
CGGGCCGGTTCCAGTCGGTCGCCGAGCTGTCTTACGAATTCGTCGCCAACATGATCCGATCGACCGCCGGCAAGGAAGGC
CTGAAGTTCTTCCCGCTGGTGTTCTCGCTGTTCATGTTCATCGCGGTCTCAAATCTGGTCGGCATCATCCCCTACACCTT
CACGGTGTCGAGCCACCTGATCGTCACCGTGACGCTGGCGATGCTGGTGTTCGTCACCGTGCTGGTCTACGGCCTCGCCA
AGAACGGCCTGAAGTTCTTCAAGCTGTTCGTGCCGTCCGGCGTGCCGATCTACATCCTGCCGCTGGTGGTGTTCATCGAG
GTCATCTCGTTCTTCCTCAAGCCGGTGTCGCACTCCGTTCGTCTGTTCGCCAACATGCTGGCGGGCCACATCGCGCTGAA
AGTGTTCGCGAGCTTCATCGCCATGCTCGGCGCGCTCGGCGTCGTCGGCTGGGTCGGCGCGGTGCTGCCGCTCGGCCTGA
CCATCGCCTTGACCGCCCTCGAACTGCTGGTCGCGTTCCTGCAGGCCTACGTGTTCGCCATCCTGACTTGCATCTATCTC
AACGATGCGATTCACCCGGGCCACTGA

Upstream 100 bases:

>100_bases
GGTGTGATGGCGAAGCAGTCCGAGCGGCTCTGACGGGTTCCGAAGTGCAACCGACCATCGACACAAGCGCAAGTTCGCGA
AACCGGTAGACTGAGAAACA

Downstream 100 bases:

>100_bases
GGCCCGGTCTCCGACCTCTCGACAACCAAACCCCAACAGGAGTTCGTTACATGGATCCGATTGCCGCGAAGTACATTGGC
GCTGGTATTGCCTGCATTGG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MAADPIHQFQITKLFSLGHIGGQEIAFTNSSAYMFAAVAIIAVMMLAPGRQLVPGRFQSVAELSYEFVANMIRSTAGKEG
LKFFPLVFSLFMFIAVSNLVGIIPYTFTVSSHLIVTVTLAMLVFVTVLVYGLAKNGLKFFKLFVPSGVPIYILPLVVFIE
VISFFLKPVSHSVRLFANMLAGHIALKVFASFIAMLGALGVVGWVGAVLPLGLTIALTALELLVAFLQAYVFAILTCIYL
NDAIHPGH

Sequences:

>Translated_248_residues
MAADPIHQFQITKLFSLGHIGGQEIAFTNSSAYMFAAVAIIAVMMLAPGRQLVPGRFQSVAELSYEFVANMIRSTAGKEG
LKFFPLVFSLFMFIAVSNLVGIIPYTFTVSSHLIVTVTLAMLVFVTVLVYGLAKNGLKFFKLFVPSGVPIYILPLVVFIE
VISFFLKPVSHSVRLFANMLAGHIALKVFASFIAMLGALGVVGWVGAVLPLGLTIALTALELLVAFLQAYVFAILTCIYL
NDAIHPGH
>Mature_247_residues
AADPIHQFQITKLFSLGHIGGQEIAFTNSSAYMFAAVAIIAVMMLAPGRQLVPGRFQSVAELSYEFVANMIRSTAGKEGL
KFFPLVFSLFMFIAVSNLVGIIPYTFTVSSHLIVTVTLAMLVFVTVLVYGLAKNGLKFFKLFVPSGVPIYILPLVVFIEV
ISFFLKPVSHSVRLFANMLAGHIALKVFASFIAMLGALGVVGWVGAVLPLGLTIALTALELLVAFLQAYVFAILTCIYLN
DAIHPGH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=209, Percent_Identity=29.1866028708134, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1790176, Length=209, Percent_Identity=25.8373205741627, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6226527, Length=248, Percent_Identity=33.0645161290323, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_RHOP2 (Q2IRA6)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_488165.1
- ProteinModelPortal:   Q2IRA6
- STRING:   Q2IRA6
- GeneID:   3912388
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_4571
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   RFANTVE
- ProtClustDB:   PRK05815
- BioCyc:   RPAL316058:RPB_4571-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 26834; Mature: 26703

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1f2a60e4)-; HASH(0x21a17d40)-; HASH(0x19ab07a0)-; HASH(0x21d723b0)-; HASH(0x212dc38c)-; HASH(0x20de5fec)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAADPIHQFQITKLFSLGHIGGQEIAFTNSSAYMFAAVAIIAVMMLAPGRQLVPGRFQSV
CCCCCHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AELSYEFVANMIRSTAGKEGLKFFPLVFSLFMFIAVSNLVGIIPYTFTVSSHLIVTVTLA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVFVTVLVYGLAKNGLKFFKLFVPSGVPIYILPLVVFIEVISFFLKPVSHSVRLFANML
HHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGHIALKVFASFIAMLGALGVVGWVGAVLPLGLTIALTALELLVAFLQAYVFAILTCIYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NDAIHPGH
HCCCCCCH
>Mature Secondary Structure 
AADPIHQFQITKLFSLGHIGGQEIAFTNSSAYMFAAVAIIAVMMLAPGRQLVPGRFQSV
CCCCHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AELSYEFVANMIRSTAGKEGLKFFPLVFSLFMFIAVSNLVGIIPYTFTVSSHLIVTVTLA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVFVTVLVYGLAKNGLKFFKLFVPSGVPIYILPLVVFIEVISFFLKPVSHSVRLFANML
HHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGHIALKVFASFIAMLGALGVVGWVGAVLPLGLTIALTALELLVAFLQAYVFAILTCIYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NDAIHPGH
HCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA