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The map label for this gene is hemA [H]

Identifier: 86751661

GI number: 86751661

Start: 5158964

End: 5160193

Strand: Direct

Name: hemA [H]

Synonym: RPB_4563

Alternate gene names: 86751661

Gene position: 5158964-5160193 (Clockwise)

Preceding gene: 86751660

Following gene: 86751662

Centisome position: 96.76

GC content: 67.07

Gene sequence:

>1230_bases
ATGCAGTACAGCAAATTCTTCGAGGACGCTCTCACCCGCCTGCACGACGAGCGCCGCTATCGCGTCTTCGCCGATCTCGA
GCGCATCGCCGGCAGGTTTCCGCAGGCCGTGTGGCATTCGCCGACGGGTCCTCGCGATGTCGTGATCTGGTGCTCGAACG
ATTACCTCGGCATGGGTCAGCACCCGAAAGTGATTGGCGCGATGGTCGAGACCACGACCCGGATCGGCACCGGCGCCGGC
GGCACCCGCAACATCGCCGGCACGCACCATCCGCTGGTGCAGCTCGAGCGCGAAATCGCCGACCTGCACGGCAAGGAAGC
GGCCTTGCTGTTCACCTCGGGCTACGTGTCGAACCAGACCGGCCTGTCGACGCTCGGCAAGCTGATCCCGAACTGCCTGA
TCCTGTCGGACGCGCTGAACCACAATTCGATGATCGAAGGCATCCGTCAGTCGGGCTGCGAGCGCGTGGTCTGGCGCCAC
AACGACACCGCCCATCTCGAAGAGCTGCTGATCGCCGCCGGCCCCGACCGGCCGAAGCTGATCGCATTCGAGAGCCTGTA
TTCGATGGACGGCGACACCGCGCCGCTGGCGAAGATCTGCGATCTCGCCGAGAAGTACGACGCGATGACTTATTGCGACG
AAGTCCACGCCGTCGGCATGTACGGGCCGCGCGGCGCCGGCGTCGCCGAACGCGACGGCGTGATGGCCCGCATCGACATC
ATCGAAGCGACGCTGGCGAAGGCGTTCGGCTGCCTCGGCGGCTACATCGCCGGCAAGGCCGACGTGATCGACGCGGTGCG
CTCCTATGCGCCGGGCTTCATCTTCACCACCGCGCTGCCGCCGCCGATCTGCGCCGCCGCGACCGCCGCCATCCGCCACC
TCAAGGCGTCGACCTGGGAACGCGAGCGCCACCAGGACCGCGCCGCGCGGGTCAAGGCCGTGCTGAACAATGCCGGCATC
CCGGTGATGCCGACCGACACCCACATCGTGCCGGTGTTCGTCGGCGATGCCGAAAAATGCAAGATGGCGTCCGATCTGCT
GCTCGAGCAGCACGGTATCTACATCCAGCCGATCAACTACCCGACCGTCGCCCGCGGCCTCGAGCGGCTGCGGATCACGC
CGTCGCCGTATCACGACGACAAGCTGATCGACGCGCTGGCCGAGGCGCTGGTCCAGGTCTGGGGCCAGCTCGGCCTGCCG
CTCGGCGCCAAGGCGATCGCGGCCGAATAG

Upstream 100 bases:

>100_bases
TTGGACGAATTGCGCCTCGACATCCGAGCTGGAAGGGTTCTAATACCGAGGTCGCCCGTTGCGGCTCGTCGCTGTTTCCC
GTCCCTTCCAGGTCATTGCA

Downstream 100 bases:

>100_bases
CCCGCGCGCCACGGCCGGCAAACGATTTTCGGCGGAGACGCCGCGCGACGGGGCAAAATCCCTGTCGCGTGCGGCGTTCC
TACCCGCTAGAAATCCCGTC

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MQYSKFFEDALTRLHDERRYRVFADLERIAGRFPQAVWHSPTGPRDVVIWCSNDYLGMGQHPKVIGAMVETTTRIGTGAG
GTRNIAGTHHPLVQLEREIADLHGKEAALLFTSGYVSNQTGLSTLGKLIPNCLILSDALNHNSMIEGIRQSGCERVVWRH
NDTAHLEELLIAAGPDRPKLIAFESLYSMDGDTAPLAKICDLAEKYDAMTYCDEVHAVGMYGPRGAGVAERDGVMARIDI
IEATLAKAFGCLGGYIAGKADVIDAVRSYAPGFIFTTALPPPICAAATAAIRHLKASTWERERHQDRAARVKAVLNNAGI
PVMPTDTHIVPVFVGDAEKCKMASDLLLEQHGIYIQPINYPTVARGLERLRITPSPYHDDKLIDALAEALVQVWGQLGLP
LGAKAIAAE

Sequences:

>Translated_409_residues
MQYSKFFEDALTRLHDERRYRVFADLERIAGRFPQAVWHSPTGPRDVVIWCSNDYLGMGQHPKVIGAMVETTTRIGTGAG
GTRNIAGTHHPLVQLEREIADLHGKEAALLFTSGYVSNQTGLSTLGKLIPNCLILSDALNHNSMIEGIRQSGCERVVWRH
NDTAHLEELLIAAGPDRPKLIAFESLYSMDGDTAPLAKICDLAEKYDAMTYCDEVHAVGMYGPRGAGVAERDGVMARIDI
IEATLAKAFGCLGGYIAGKADVIDAVRSYAPGFIFTTALPPPICAAATAAIRHLKASTWERERHQDRAARVKAVLNNAGI
PVMPTDTHIVPVFVGDAEKCKMASDLLLEQHGIYIQPINYPTVARGLERLRITPSPYHDDKLIDALAEALVQVWGQLGLP
LGAKAIAAE
>Mature_409_residues
MQYSKFFEDALTRLHDERRYRVFADLERIAGRFPQAVWHSPTGPRDVVIWCSNDYLGMGQHPKVIGAMVETTTRIGTGAG
GTRNIAGTHHPLVQLEREIADLHGKEAALLFTSGYVSNQTGLSTLGKLIPNCLILSDALNHNSMIEGIRQSGCERVVWRH
NDTAHLEELLIAAGPDRPKLIAFESLYSMDGDTAPLAKICDLAEKYDAMTYCDEVHAVGMYGPRGAGVAERDGVMARIDI
IEATLAKAFGCLGGYIAGKADVIDAVRSYAPGFIFTTALPPPICAAATAAIRHLKASTWERERHQDRAARVKAVLNNAGI
PVMPTDTHIVPVFVGDAEKCKMASDLLLEQHGIYIQPINYPTVARGLERLRITPSPYHDDKLIDALAEALVQVWGQLGLP
LGAKAIAAE

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=412, Percent_Identity=49.2718446601942, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI83977440, Length=412, Percent_Identity=49.2718446601942, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI83977444, Length=412, Percent_Identity=49.2718446601942, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI4502025, Length=405, Percent_Identity=49.8765432098765, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI40316939, Length=405, Percent_Identity=49.8765432098765, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI7657118, Length=349, Percent_Identity=36.9627507163324, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI284448556, Length=349, Percent_Identity=36.9627507163324, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI119220554, Length=400, Percent_Identity=30, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI4758668, Length=396, Percent_Identity=28.030303030303, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI5454084, Length=248, Percent_Identity=27.0161290322581, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1790046, Length=399, Percent_Identity=34.8370927318296, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=29.5977011494253, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71994529, Length=375, Percent_Identity=35.2, Blast_Score=207, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI32566772, Length=386, Percent_Identity=30.0518134715026, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17560914, Length=372, Percent_Identity=29.0322580645161, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17560912, Length=372, Percent_Identity=28.7634408602151, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=251, Percent_Identity=27.8884462151394, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=251, Percent_Identity=27.8884462151394, Blast_Score=104, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6320438, Length=422, Percent_Identity=47.1563981042654, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6320267, Length=366, Percent_Identity=29.5081967213115, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=264, Percent_Identity=23.1060606060606, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17137420, Length=401, Percent_Identity=47.3815461346633, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24662918, Length=354, Percent_Identity=35.3107344632768, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI17136286, Length=372, Percent_Identity=29.0322580645161, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24653280, Length=284, Percent_Identity=27.4647887323944, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24653276, Length=284, Percent_Identity=27.4647887323944, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24653278, Length=284, Percent_Identity=27.4647887323944, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44568; Mature: 44568

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYSKFFEDALTRLHDERRYRVFADLERIAGRFPQAVWHSPTGPRDVVIWCSNDYLGMGQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEECCCCCCCCC
HPKVIGAMVETTTRIGTGAGGTRNIAGTHHPLVQLEREIADLHGKEAALLFTSGYVSNQT
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
GLSTLGKLIPNCLILSDALNHNSMIEGIRQSGCERVVWRHNDTAHLEELLIAAGPDRPKL
HHHHHHHHHHHHEEHHHHCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCCE
IAFESLYSMDGDTAPLAKICDLAEKYDAMTYCDEVHAVGMYGPRGAGVAERDGVMARIDI
EEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEHHH
IEATLAKAFGCLGGYIAGKADVIDAVRSYAPGFIFTTALPPPICAAATAAIRHLKASTWE
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
RERHQDRAARVKAVLNNAGIPVMPTDTHIVPVFVGDAEKCKMASDLLLEQHGIYIQPINY
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEEECCC
PTVARGLERLRITPSPYHDDKLIDALAEALVQVWGQLGLPLGAKAIAAE
HHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
>Mature Secondary Structure
MQYSKFFEDALTRLHDERRYRVFADLERIAGRFPQAVWHSPTGPRDVVIWCSNDYLGMGQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEECCCCCCCCC
HPKVIGAMVETTTRIGTGAGGTRNIAGTHHPLVQLEREIADLHGKEAALLFTSGYVSNQT
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
GLSTLGKLIPNCLILSDALNHNSMIEGIRQSGCERVVWRHNDTAHLEELLIAAGPDRPKL
HHHHHHHHHHHHEEHHHHCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCCE
IAFESLYSMDGDTAPLAKICDLAEKYDAMTYCDEVHAVGMYGPRGAGVAERDGVMARIDI
EEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEHHH
IEATLAKAFGCLGGYIAGKADVIDAVRSYAPGFIFTTALPPPICAAATAAIRHLKASTWE
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
RERHQDRAARVKAVLNNAGIPVMPTDTHIVPVFVGDAEKCKMASDLLLEQHGIYIQPINY
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEEECCC
PTVARGLERLRITPSPYHDDKLIDALAEALVQVWGQLGLPLGAKAIAAE
HHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]