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The map label for this gene is hisN [H]

Identifier: 86751615

GI number: 86751615

Start: 5104901

End: 5105683

Strand: Direct

Name: hisN [H]

Synonym: RPB_4517

Alternate gene names: 86751615

Gene position: 5104901-5105683 (Clockwise)

Preceding gene: 86751614

Following gene: 86751617

Centisome position: 95.75

GC content: 67.31

Gene sequence:

>783_bases
GTGACGGTCATCGATTTCGCCGCCTTTATCGGACGCCTCGCAACGTCGTCCGGCGACACCATCCTGCCGTTCTTTCGCAC
CTCGCTGACGATCGACAACAAGCAGCCGGGACGCGACTTCGATCCGGTGACCGAGGCCGACCGCGCCGGCGAGGCGGTGA
TGCGCCGGCTGATCAAGGCGAGCTTCCCGCAGCACGGCATCGTCGGCGAGGAATTCGGCAACGAGCGCGAGGACGCCGAT
TACGTCTGGGTGCTCGATCCGATCGACGGCACCAAATCCTTCATCGCCGGCTTTCCGGTGTGGGGCACGCTGATCGCGCT
GCTGCACAAGGGAACGCCGGTCTACGGCATGATGCATCAGCCCTTCATCGGCGAGCGCTTCACCGGGGACAATGGTTCGG
CATCGTACAAGGGCCCGTCCGGCGAGCGCCGCCTGACGGTGCGGCGCTGCGCGACGCTGAAGGACGCGACGCTGTTCACC
ACCTCGCCGCTGCTGATGAACGACACCGACCGCGCCACCTTCGAGCGGGTGCAGGCCGAGACCCGGCTGACCCGGTTCGG
CGGCGACTGCTATGCCTATTGCATGCTGGCGGCGGGCCAGCTCGATCTGGTGATCGAGACCGAACTGAAGCCCTACGACG
TCGCGGCGCTGATCCCGATCGTCACCGGCGCGGGCGGCGTCATCACCACCTGGGAAGGCCAGCCGGCGCAGAACGGCGGC
CGCATCGTCGCCGCCGGCGACAAGCGCGTCCACGAGGCCGCGATGAAGATCCTCAACGGCTGA

Upstream 100 bases:

>100_bases
GACCGCGGCTCAGCAGCCATAATAAGTGAGGCGGACGGGCGGGGTTTCAGGCAAGCCTAGGACCTCGTGCAGTGTAACCC
CAGACTGACAAGGAACGCCC

Downstream 100 bases:

>100_bases
GCACCGGCGGTCAGGGCGGCGCCGAGCGGCGCAGATGCGCGACCAGCTGCTGCGCCGGCCGTGGCAGCGCCTTCAGGCTG
CGGGCGCAGATCACCAGCTT

Product: histidinol-phosphate phosphatase, putative, inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTVIDFAAFIGRLATSSGDTILPFFRTSLTIDNKQPGRDFDPVTEADRAGEAVMRRLIKASFPQHGIVGEEFGNEREDAD
YVWVLDPIDGTKSFIAGFPVWGTLIALLHKGTPVYGMMHQPFIGERFTGDNGSASYKGPSGERRLTVRRCATLKDATLFT
TSPLLMNDTDRATFERVQAETRLTRFGGDCYAYCMLAAGQLDLVIETELKPYDVAALIPIVTGAGGVITTWEGQPAQNGG
RIVAAGDKRVHEAAMKILNG

Sequences:

>Translated_260_residues
MTVIDFAAFIGRLATSSGDTILPFFRTSLTIDNKQPGRDFDPVTEADRAGEAVMRRLIKASFPQHGIVGEEFGNEREDAD
YVWVLDPIDGTKSFIAGFPVWGTLIALLHKGTPVYGMMHQPFIGERFTGDNGSASYKGPSGERRLTVRRCATLKDATLFT
TSPLLMNDTDRATFERVQAETRLTRFGGDCYAYCMLAAGQLDLVIETELKPYDVAALIPIVTGAGGVITTWEGQPAQNGG
RIVAAGDKRVHEAAMKILNG
>Mature_259_residues
TVIDFAAFIGRLATSSGDTILPFFRTSLTIDNKQPGRDFDPVTEADRAGEAVMRRLIKASFPQHGIVGEEFGNEREDADY
VWVLDPIDGTKSFIAGFPVWGTLIALLHKGTPVYGMMHQPFIGERFTGDNGSASYKGPSGERRLTVRRCATLKDATLFTT
SPLLMNDTDRATFERVQAETRLTRFGGDCYAYCMLAAGQLDLVIETELKPYDVAALIPIVTGAGGVITTWEGQPAQNGGR
IVAAGDKRVHEAAMKILNG

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=260, Percent_Identity=23.8461538461538, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI221625487, Length=260, Percent_Identity=23.8461538461538, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI7657236, Length=260, Percent_Identity=25, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1788882, Length=250, Percent_Identity=30, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790659, Length=201, Percent_Identity=27.8606965174129, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320493, Length=213, Percent_Identity=25.3521126760563, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24664918, Length=238, Percent_Identity=26.4705882352941, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357957, Length=238, Percent_Identity=27.3109243697479, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24664922, Length=205, Percent_Identity=29.7560975609756, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357329, Length=201, Percent_Identity=28.8557213930348, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28296; Mature: 28164

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIDFAAFIGRLATSSGDTILPFFRTSLTIDNKQPGRDFDPVTEADRAGEAVMRRLIKA
CCCHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SFPQHGIVGEEFGNEREDADYVWVLDPIDGTKSFIAGFPVWGTLIALLHKGTPVYGMMHQ
CCCCCCCCCHHHCCCCCCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHCCCCEEEECCC
PFIGERFTGDNGSASYKGPSGERRLTVRRCATLKDATLFTTSPLLMNDTDRATFERVQAE
CCCCCEECCCCCCCCCCCCCCCCEEHHHHHCCCCCCEEEECCCEEECCCCHHHHHHHHHH
TRLTRFGGDCYAYCMLAAGQLDLVIETELKPYDVAALIPIVTGAGGVITTWEGQPAQNGG
HHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCCHHEEEHHHCCCCCEEEECCCCCCCCCC
RIVAAGDKRVHEAAMKILNG
EEEEECCHHHHHHHHHHHCC
>Mature Secondary Structure 
TVIDFAAFIGRLATSSGDTILPFFRTSLTIDNKQPGRDFDPVTEADRAGEAVMRRLIKA
CCHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SFPQHGIVGEEFGNEREDADYVWVLDPIDGTKSFIAGFPVWGTLIALLHKGTPVYGMMHQ
CCCCCCCCCHHHCCCCCCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHCCCCEEEECCC
PFIGERFTGDNGSASYKGPSGERRLTVRRCATLKDATLFTTSPLLMNDTDRATFERVQAE
CCCCCEECCCCCCCCCCCCCCCCEEHHHHHCCCCCCEEEECCCEEECCCCHHHHHHHHHH
TRLTRFGGDCYAYCMLAAGQLDLVIETELKPYDVAALIPIVTGAGGVITTWEGQPAQNGG
HHHHHCCCHHHHHHHHHCCCEEEEEECCCCCCCHHEEEHHHCCCCCEEEECCCCCCCCCC
RIVAAGDKRVHEAAMKILNG
EEEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]