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The map label for this gene is 86751556

Identifier: 86751556

GI number: 86751556

Start: 5047003

End: 5047932

Strand: Direct

Name: 86751556

Synonym: RPB_4458

Alternate gene names: NA

Gene position: 5047003-5047932 (Clockwise)

Preceding gene: 86751555

Following gene: 86751557

Centisome position: 94.66

GC content: 67.2

Gene sequence:

>930_bases
ATGACCACGCTCTTTCTGACCCATTCCGCGTGTCTCGAGCATCACACGCCGGAGGGCCATCCCGAACGCGCCGAGCGGCT
GATCGCCGTCAACGAGGCGCTGACCGCGGAGCGGTTTTCGATGCTGTCGCGCGGCGAGGCGCCGATCGGCTCGCTCGAGC
ACATCGCGCTGTGCCACACCGATCACCACATCGTCGAGATGCGCCACATGGCGCCCTCGACCGGCATCGTCTATGTCGAC
GGCGACACCTCGATGTCGCCGGGCACGTTCGAAGCCGCGTTGCGCGGCGTCGGCGGCGCGGTGTCGGCGGTCGACGCGGT
GATGAAGGGCTCGGCCGCCAACGCCTTCGTGGCGACGAGGCCGCCCGGTCACCACGCTGAAGTCACCAAGCCGATGGGCT
TCTGCTTCTTCGGCAACGCCGCGATCGCGGCGCGCTATGCGCAACGCAAATACGGCATCGAACGCGCCGCGGTGGTGGAT
TTCGACGTCCACCACGGCAACGGCACGCAGGACATCTTCTGGGGCGACCGCACCGTGATGTACTGTTCGACGCACCAGAT
GCCGCTGTTCCCCGGCACCGGCTCGGCCGGCGAGCGCGGAGAGCACGACAACATCGTCAACGCGCCGCTGGCCTCGGAAG
ACGGCGGCAAGGAGTTCCGTTTCGCGTTCGAGACCGTGATCCTGCCGCAGCTCACGCGGTTCGCGCCGGAACTGATCGTG
ATCTCCGCCGGCTTCGACGCGCACTACCGCGATCCGCTGGCCAGCCTCAATCTCAAGGCCGAAGACTTCACCTGGGTGAC
GCAGAAGCTGATGGAGGTCGCCGACAAGACCGCGGGCGGCCGCATTGTCTCGGTGCTCGAGGGCGGCTATGACTTGCAGG
GCCTGAGTGAATCGGTCGCCGCTCATGTCGGCGCGCTGATGGGCGCCTGA

Upstream 100 bases:

>100_bases
TCTAAGCCTTAAGCTGGCCTTTCGCGACACGCGACGGATAACTAGGTTGATCTGAAGTTATCGTCGTCACCACGCACCGG
ACGTTGCAGGCGCTCCCCGC

Downstream 100 bases:

>100_bases
CCGGCGCCTCCGCCTCGACGGCTCACAACAACAAGCCGCCGGCCGCGCCGCGGCGCATCCAGGAGCCGCCGATGGCCGAC
GCCGCCCCCGCCGATGTCAA

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTTLFLTHSACLEHHTPEGHPERAERLIAVNEALTAERFSMLSRGEAPIGSLEHIALCHTDHHIVEMRHMAPSTGIVYVD
GDTSMSPGTFEAALRGVGGAVSAVDAVMKGSAANAFVATRPPGHHAEVTKPMGFCFFGNAAIAARYAQRKYGIERAAVVD
FDVHHGNGTQDIFWGDRTVMYCSTHQMPLFPGTGSAGERGEHDNIVNAPLASEDGGKEFRFAFETVILPQLTRFAPELIV
ISAGFDAHYRDPLASLNLKAEDFTWVTQKLMEVADKTAGGRIVSVLEGGYDLQGLSESVAAHVGALMGA

Sequences:

>Translated_309_residues
MTTLFLTHSACLEHHTPEGHPERAERLIAVNEALTAERFSMLSRGEAPIGSLEHIALCHTDHHIVEMRHMAPSTGIVYVD
GDTSMSPGTFEAALRGVGGAVSAVDAVMKGSAANAFVATRPPGHHAEVTKPMGFCFFGNAAIAARYAQRKYGIERAAVVD
FDVHHGNGTQDIFWGDRTVMYCSTHQMPLFPGTGSAGERGEHDNIVNAPLASEDGGKEFRFAFETVILPQLTRFAPELIV
ISAGFDAHYRDPLASLNLKAEDFTWVTQKLMEVADKTAGGRIVSVLEGGYDLQGLSESVAAHVGALMGA
>Mature_308_residues
TTLFLTHSACLEHHTPEGHPERAERLIAVNEALTAERFSMLSRGEAPIGSLEHIALCHTDHHIVEMRHMAPSTGIVYVDG
DTSMSPGTFEAALRGVGGAVSAVDAVMKGSAANAFVATRPPGHHAEVTKPMGFCFFGNAAIAARYAQRKYGIERAAVVDF
DVHHGNGTQDIFWGDRTVMYCSTHQMPLFPGTGSAGERGEHDNIVNAPLASEDGGKEFRFAFETVILPQLTRFAPELIVI
SAGFDAHYRDPLASLNLKAEDFTWVTQKLMEVADKTAGGRIVSVLEGGYDLQGLSESVAAHVGALMGA

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI153085395, Length=247, Percent_Identity=40.8906882591093, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI17158039, Length=343, Percent_Identity=34.402332361516, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI30795204, Length=343, Percent_Identity=34.402332361516, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI30795202, Length=343, Percent_Identity=34.402332361516, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI20070354, Length=314, Percent_Identity=36.3057324840764, Blast_Score=158, Evalue=5e-39,
Organism=Homo sapiens, GI148539870, Length=350, Percent_Identity=34, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI62750349, Length=348, Percent_Identity=32.7586206896552, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI169234807, Length=350, Percent_Identity=34, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI62750347, Length=348, Percent_Identity=32.7586206896552, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI13128864, Length=317, Percent_Identity=34.384858044164, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI226529806, Length=314, Percent_Identity=33.1210191082803, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI8923769, Length=305, Percent_Identity=24.5901639344262, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI13128860, Length=261, Percent_Identity=24.5210727969349, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI262073088, Length=184, Percent_Identity=27.1739130434783, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI293336691, Length=261, Percent_Identity=24.5210727969349, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI13128862, Length=259, Percent_Identity=24.3243243243243, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI262073092, Length=216, Percent_Identity=26.3888888888889, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=309, Percent_Identity=35.2750809061489, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI193206283, Length=309, Percent_Identity=35.2750809061489, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17540332, Length=309, Percent_Identity=35.2750809061489, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI193209491, Length=314, Percent_Identity=35.3503184713376, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI25154020, Length=227, Percent_Identity=33.920704845815, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI25154022, Length=227, Percent_Identity=33.4801762114537, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17537347, Length=314, Percent_Identity=29.2993630573248, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17534739, Length=323, Percent_Identity=24.7678018575851, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17508561, Length=298, Percent_Identity=24.8322147651007, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17561978, Length=222, Percent_Identity=26.5765765765766, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324307, Length=244, Percent_Identity=34.8360655737705, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6325141, Length=319, Percent_Identity=29.4670846394984, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323999, Length=303, Percent_Identity=24.4224422442244, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321244, Length=168, Percent_Identity=29.1666666666667, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325325, Length=125, Percent_Identity=29.6, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24642142, Length=314, Percent_Identity=34.0764331210191, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24642144, Length=314, Percent_Identity=34.0764331210191, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI281360899, Length=314, Percent_Identity=34.0764331210191, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24642146, Length=314, Percent_Identity=34.0764331210191, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24641720, Length=347, Percent_Identity=34.0057636887608, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI281360801, Length=256, Percent_Identity=37.890625, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI281360799, Length=256, Percent_Identity=37.890625, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24657891, Length=268, Percent_Identity=25.3731343283582, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 33157; Mature: 33026

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLFLTHSACLEHHTPEGHPERAERLIAVNEALTAERFSMLSRGEAPIGSLEHIALCHT
CEEEEEEHHHHHHCCCCCCCHHHHHHEEHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
DHHIVEMRHMAPSTGIVYVDGDTSMSPGTFEAALRGVGGAVSAVDAVMKGSAANAFVATR
CCHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEC
PPGHHAEVTKPMGFCFFGNAAIAARYAQRKYGIERAAVVDFDVHHGNGTQDIFWGDRTVM
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCEEEECCCEEE
YCSTHQMPLFPGTGSAGERGEHDNIVNAPLASEDGGKEFRFAFETVILPQLTRFAPELIV
EEECCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
ISAGFDAHYRDPLASLNLKAEDFTWVTQKLMEVADKTAGGRIVSVLEGGYDLQGLSESVA
EECCCCCHHCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHH
AHVGALMGA
HHHHHHHCC
>Mature Secondary Structure 
TTLFLTHSACLEHHTPEGHPERAERLIAVNEALTAERFSMLSRGEAPIGSLEHIALCHT
EEEEEEHHHHHHCCCCCCCHHHHHHEEHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEC
DHHIVEMRHMAPSTGIVYVDGDTSMSPGTFEAALRGVGGAVSAVDAVMKGSAANAFVATR
CCHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEC
PPGHHAEVTKPMGFCFFGNAAIAARYAQRKYGIERAAVVDFDVHHGNGTQDIFWGDRTVM
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCEEEECCCEEE
YCSTHQMPLFPGTGSAGERGEHDNIVNAPLASEDGGKEFRFAFETVILPQLTRFAPELIV
EEECCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
ISAGFDAHYRDPLASLNLKAEDFTWVTQKLMEVADKTAGGRIVSVLEGGYDLQGLSESVA
EECCCCCHHCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHH
AHVGALMGA
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]