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The map label for this gene is xdhA [H]

Identifier: 86751517

GI number: 86751517

Start: 5001789

End: 5004056

Strand: Reverse

Name: xdhA [H]

Synonym: RPB_4416

Alternate gene names: 86751517

Gene position: 5004056-5001789 (Counterclockwise)

Preceding gene: 86751518

Following gene: 86751516

Centisome position: 93.86

GC content: 69.05

Gene sequence:

>2268_bases
ATGACCGCCGCGGCACGTCCCGATCGCGTTGACTTCCTCGACAAGGTGACCGGCCGCGCCGCGTTCATCTCCGATCTGGT
CGTGCCCGGCATGGCTCACGGCAAGGTGCTGCGCAGCACGATGCCGCACGCGCGGATCACCGGCATCGACATCGCCGCCG
CGCTTGCGATGCCGGGCGTGATCGGCATCGTCACGGGCGCCGATTTCGACGGCATCGACGCGATCTGGGGCGTGTCGCTG
AAGGACCGGCCGCTGATCGCGCTCGATCGCGTGCGCTATGTCGGCGAGCCGGTGGCGGTGGTGGTGGCCGAATCCGAGGC
CGCGGCCGAAGAGGCGCTCGATGCGGTGATGGTCGATTACGACCCGTTGCCTTACGTCACCGAGGCCGCCGATGCTTTGG
CGCCGGATGCGCCGCTGCTGCACGCCGCCGTCCAGCCGCTCAAGGACTTCTACTTCAAGGGCGAAGCCAAGCCGGTCGCC
GGCACCAACATCTTCCAGAGCTACGCTTACGAGACCGGCGACGTCGCGGCGGCATTCGCGTCGGCGGATCGCGTGTTCGA
AGACAGCTTCGACTTCCCGATGGTCTATCACTACGCGATGGAGCCGCATTGCGGCATCGCGTCGTTCGGCGACGACGGGC
TGACGGTGTGGAGCTGCGGCCAGGCGCCGACCGCGGTGCAGAAGGTGCTGTCGCGCATCTTCGATCTGCCGATCGCCAAG
GTGCGGATCATCACGCCGCTGATCGGCGGCGGCTTCGGCGGCAAGGCCTCGGTGAAGATCGATCCGCTGGTCGCGGCGGT
GGCGTGGAAGATCGGCCGCCCGGTGCGGATCTGCTTCTCCGCATCGGAATCGATGCTGACCGCGCGGCGGCTGAGCGCGA
CGATCAACCTGAAGACGGCGGTCAGCGCCGACGGCATGCTGCAGGCGAAATCCGTCGAGGTGCTGATGAACGGCGGCGCC
TATGCGGACACCGGGCCGGCCGTGGCGATCAAGGCGGCGATCCGCGCCATCGGCCCGTACAGGATTCCGAATCTGCGGCT
GCGGAGCACGGCGGTCTACACCAACACCGTGCCCGGCGCGGCGTTTCGCTCGATCGGCGGACCGCAGGGCGTATGGGCCA
CCGAATCCCAGATGGACATCATCGCCGACGCGCTCGGCATCGATCCGGTCGAGCTGCGCTACCGCAACATGCTGAAACGC
GGCGAGCATGTCCGCCCCGATCTGACGCCGATCGACGTCGATATGGCGGAAGCGATGGGGCTGGCGTCGCAGGCGATGAG
CCGGCTCGACGCGCAGGGGCCGCACGGCAGGATCGTCCACGGCACCGCGCTCGGCGTCGCCGATCCGGCGAACTCGCCGG
TCGCCGGCGTGCTGCTGCGGCTCAAGATCGACGGGTCGATCGCGGTGATCTCCTCCAGCATCGAGGTCGGGCAGGGCATT
CGCGAGGTGCTGTGCCGCGTTGCCGCCGAACAGCTCGGCCAGCCGGTGTCCGCGGTCAGCGCGCTGACGCCCGACACCGC
GATTGCGCCGTTCGACTGGGGCACCGGCGCCAGCCGCTCGTCGCTGATGATGGCGCTGGCGATCGAGGACGCCGCCGCCG
ACATCAAGGCGCAGATCGACGACATCGCCGCGTCGACGCTCGGGCTCGATCCCGCGAGCATCGCGCTGGTCTCGGGCGGC
TTCACGTCGGCAGGCCGGCGCTACAGCTTCGCCGATCTGCTGCATCCTTATTTCGGCATCGACAGCGGCGAACTGATCGG
CATCGGCCGGATCTCGCCGCGGTCACGCGGCGGCGCGCTGGCCAAGGCGCCGCTGTTCTGGGAAACGGCGGCCGGCCGCT
GCGGCATCACGCTCGACGAGGACACCGGCGAGATCGCAGTGAAGCGCTATGTCAGCGTCGCCGACATCGGCCGCGCCATC
AACCGCAGCGGCGCCGAAGGACAGGACGAGGGCGCGGCGATCATGGGGCTCGGCCACGCGCTGTTCGAGGAACTGATCTA
CGCCGACGGCCAGCCGGTCAACGGCACCATGATCGACTATCACGTCCCGACCATCGACGACGTGCCCGAGCAGTTTGAAA
CCGTGCTGATCGAAAACGGCGGCGGGCCGGGGCCGGGCGGCATGCGCGGCATGGGCGAGGGCGCGATCCTGCCGATCGCG
CCGGCGATCGCCAATGCGCTGGCGACCGGCTTCGGCATCCGCGTCAAACAGTTGCCGCTGACGCCGGAGCGCGTCTGGCG
TGCGCTGAAGGACAGGAAGGACCGCTGA

Upstream 100 bases:

>100_bases
TCGCTGACGATCCTGCTGGTCGCCGCGGTCATCCTGACGGCCCAGCTGTGGTCGCATTTCGGCCGCACGCGCCACCGCGC
CGTGCCGTCGGAGGGCTGAG

Downstream 100 bases:

>100_bases
GATGGAATTCCGGATGGAGGCCGATCTACCCTGCACGCCGGACCGGCTGTGGCCGATCATGCTCGACATCCGCGAGATGG
CCGGCTGTATTCCCGGCATC

Product: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 755; Mature: 754

Protein sequence:

>755_residues
MTAAARPDRVDFLDKVTGRAAFISDLVVPGMAHGKVLRSTMPHARITGIDIAAALAMPGVIGIVTGADFDGIDAIWGVSL
KDRPLIALDRVRYVGEPVAVVVAESEAAAEEALDAVMVDYDPLPYVTEAADALAPDAPLLHAAVQPLKDFYFKGEAKPVA
GTNIFQSYAYETGDVAAAFASADRVFEDSFDFPMVYHYAMEPHCGIASFGDDGLTVWSCGQAPTAVQKVLSRIFDLPIAK
VRIITPLIGGGFGGKASVKIDPLVAAVAWKIGRPVRICFSASESMLTARRLSATINLKTAVSADGMLQAKSVEVLMNGGA
YADTGPAVAIKAAIRAIGPYRIPNLRLRSTAVYTNTVPGAAFRSIGGPQGVWATESQMDIIADALGIDPVELRYRNMLKR
GEHVRPDLTPIDVDMAEAMGLASQAMSRLDAQGPHGRIVHGTALGVADPANSPVAGVLLRLKIDGSIAVISSSIEVGQGI
REVLCRVAAEQLGQPVSAVSALTPDTAIAPFDWGTGASRSSLMMALAIEDAAADIKAQIDDIAASTLGLDPASIALVSGG
FTSAGRRYSFADLLHPYFGIDSGELIGIGRISPRSRGGALAKAPLFWETAAGRCGITLDEDTGEIAVKRYVSVADIGRAI
NRSGAEGQDEGAAIMGLGHALFEELIYADGQPVNGTMIDYHVPTIDDVPEQFETVLIENGGGPGPGGMRGMGEGAILPIA
PAIANALATGFGIRVKQLPLTPERVWRALKDRKDR

Sequences:

>Translated_755_residues
MTAAARPDRVDFLDKVTGRAAFISDLVVPGMAHGKVLRSTMPHARITGIDIAAALAMPGVIGIVTGADFDGIDAIWGVSL
KDRPLIALDRVRYVGEPVAVVVAESEAAAEEALDAVMVDYDPLPYVTEAADALAPDAPLLHAAVQPLKDFYFKGEAKPVA
GTNIFQSYAYETGDVAAAFASADRVFEDSFDFPMVYHYAMEPHCGIASFGDDGLTVWSCGQAPTAVQKVLSRIFDLPIAK
VRIITPLIGGGFGGKASVKIDPLVAAVAWKIGRPVRICFSASESMLTARRLSATINLKTAVSADGMLQAKSVEVLMNGGA
YADTGPAVAIKAAIRAIGPYRIPNLRLRSTAVYTNTVPGAAFRSIGGPQGVWATESQMDIIADALGIDPVELRYRNMLKR
GEHVRPDLTPIDVDMAEAMGLASQAMSRLDAQGPHGRIVHGTALGVADPANSPVAGVLLRLKIDGSIAVISSSIEVGQGI
REVLCRVAAEQLGQPVSAVSALTPDTAIAPFDWGTGASRSSLMMALAIEDAAADIKAQIDDIAASTLGLDPASIALVSGG
FTSAGRRYSFADLLHPYFGIDSGELIGIGRISPRSRGGALAKAPLFWETAAGRCGITLDEDTGEIAVKRYVSVADIGRAI
NRSGAEGQDEGAAIMGLGHALFEELIYADGQPVNGTMIDYHVPTIDDVPEQFETVLIENGGGPGPGGMRGMGEGAILPIA
PAIANALATGFGIRVKQLPLTPERVWRALKDRKDR
>Mature_754_residues
TAAARPDRVDFLDKVTGRAAFISDLVVPGMAHGKVLRSTMPHARITGIDIAAALAMPGVIGIVTGADFDGIDAIWGVSLK
DRPLIALDRVRYVGEPVAVVVAESEAAAEEALDAVMVDYDPLPYVTEAADALAPDAPLLHAAVQPLKDFYFKGEAKPVAG
TNIFQSYAYETGDVAAAFASADRVFEDSFDFPMVYHYAMEPHCGIASFGDDGLTVWSCGQAPTAVQKVLSRIFDLPIAKV
RIITPLIGGGFGGKASVKIDPLVAAVAWKIGRPVRICFSASESMLTARRLSATINLKTAVSADGMLQAKSVEVLMNGGAY
ADTGPAVAIKAAIRAIGPYRIPNLRLRSTAVYTNTVPGAAFRSIGGPQGVWATESQMDIIADALGIDPVELRYRNMLKRG
EHVRPDLTPIDVDMAEAMGLASQAMSRLDAQGPHGRIVHGTALGVADPANSPVAGVLLRLKIDGSIAVISSSIEVGQGIR
EVLCRVAAEQLGQPVSAVSALTPDTAIAPFDWGTGASRSSLMMALAIEDAAADIKAQIDDIAASTLGLDPASIALVSGGF
TSAGRRYSFADLLHPYFGIDSGELIGIGRISPRSRGGALAKAPLFWETAAGRCGITLDEDTGEIAVKRYVSVADIGRAIN
RSGAEGQDEGAAIMGLGHALFEELIYADGQPVNGTMIDYHVPTIDDVPEQFETVLIENGGGPGPGGMRGMGEGAILPIAP
AIANALATGFGIRVKQLPLTPERVWRALKDRKDR

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=783, Percent_Identity=25.5427841634738, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI91823271, Length=781, Percent_Identity=25.6081946222791, Blast_Score=181, Evalue=3e-45,
Organism=Escherichia coli, GI1789230, Length=779, Percent_Identity=32.2207958921694, Blast_Score=329, Evalue=4e-91,
Organism=Escherichia coli, GI1789246, Length=791, Percent_Identity=27.5600505689001, Blast_Score=258, Evalue=1e-69,
Organism=Escherichia coli, GI1786478, Length=762, Percent_Identity=27.5590551181102, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17540638, Length=786, Percent_Identity=26.3358778625954, Blast_Score=186, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17539860, Length=741, Percent_Identity=22.8070175438596, Blast_Score=138, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32566215, Length=596, Percent_Identity=23.8255033557047, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17737937, Length=778, Percent_Identity=26.7352185089974, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24647199, Length=758, Percent_Identity=22.6912928759894, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24647193, Length=719, Percent_Identity=23.36578581363, Blast_Score=132, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24647195, Length=751, Percent_Identity=24.3675099866844, Blast_Score=128, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24647197, Length=751, Percent_Identity=24.5006657789614, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24647201, Length=735, Percent_Identity=22.5850340136054, Blast_Score=119, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 79136; Mature: 79005

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAARPDRVDFLDKVTGRAAFISDLVVPGMAHGKVLRSTMPHARITGIDIAAALAMPGV
CCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHCCCCCEECCHHHHHHHHCCCE
IGIVTGADFDGIDAIWGVSLKDRPLIALDRVRYVGEPVAVVVAESEAAAEEALDAVMVDY
EEEEECCCCCCCHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHEEEECC
DPLPYVTEAADALAPDAPLLHAAVQPLKDFYFKGEAKPVAGTNIFQSYAYETGDVAAAFA
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHH
SADRVFEDSFDFPMVYHYAMEPHCGIASFGDDGLTVWSCGQAPTAVQKVLSRIFDLPIAK
HHHHHHHCCCCCCEEEEEECCCCCCEECCCCCCCEEEECCCCCHHHHHHHHHHHCCCHHH
VRIITPLIGGGFGGKASVKIDPLVAAVAWKIGRPVRICFSASESMLTARRLSATINLKTA
EEEEEHHHCCCCCCCEEEEECHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHEEEEEEEE
VSADGMLQAKSVEVLMNGGAYADTGPAVAIKAAIRAIGPYRIPNLRLRSTAVYTNTVPGA
ECCCCCEEECEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCH
AFRSIGGPQGVWATESQMDIIADALGIDPVELRYRNMLKRGEHVRPDLTPIDVDMAEAMG
HHHHCCCCCCCEECCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
LASQAMSRLDAQGPHGRIVHGTALGVADPANSPVAGVLLRLKIDGSIAVISSSIEVGQGI
HHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEEECCCEEEEECCHHHHHHH
REVLCRVAAEQLGQPVSAVSALTPDTAIAPFDWGTGASRSSLMMALAIEDAAADIKAQID
HHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCHHHEEEEEEECHHHHHHHHHHH
DIAASTLGLDPASIALVSGGFTSAGRRYSFADLLHPYFGIDSGELIGIGRISPRSRGGAL
HHHHHHCCCCCHHEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCE
AKAPLFWETAAGRCGITLDEDTGEIAVKRYVSVADIGRAINRSGAEGQDEGAAIMGLGHA
EECCEEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHH
LFEELIYADGQPVNGTMIDYHVPTIDDVPEQFETVLIENGGGPGPGGMRGMGEGAILPIA
HHHHHHHCCCCCCCCEEEEEECCCCCCCHHHEEEEEEECCCCCCCCCCCCCCCCCEEECH
PAIANALATGFGIRVKQLPLTPERVWRALKDRKDR
HHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
TAAARPDRVDFLDKVTGRAAFISDLVVPGMAHGKVLRSTMPHARITGIDIAAALAMPGV
CCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHCCCCCEECCHHHHHHHHCCCE
IGIVTGADFDGIDAIWGVSLKDRPLIALDRVRYVGEPVAVVVAESEAAAEEALDAVMVDY
EEEEECCCCCCCHHHCCCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHEEEECC
DPLPYVTEAADALAPDAPLLHAAVQPLKDFYFKGEAKPVAGTNIFQSYAYETGDVAAAFA
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHH
SADRVFEDSFDFPMVYHYAMEPHCGIASFGDDGLTVWSCGQAPTAVQKVLSRIFDLPIAK
HHHHHHHCCCCCCEEEEEECCCCCCEECCCCCCCEEEECCCCCHHHHHHHHHHHCCCHHH
VRIITPLIGGGFGGKASVKIDPLVAAVAWKIGRPVRICFSASESMLTARRLSATINLKTA
EEEEEHHHCCCCCCCEEEEECHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHEEEEEEEE
VSADGMLQAKSVEVLMNGGAYADTGPAVAIKAAIRAIGPYRIPNLRLRSTAVYTNTVPGA
ECCCCCEEECEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCH
AFRSIGGPQGVWATESQMDIIADALGIDPVELRYRNMLKRGEHVRPDLTPIDVDMAEAMG
HHHHCCCCCCCEECCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
LASQAMSRLDAQGPHGRIVHGTALGVADPANSPVAGVLLRLKIDGSIAVISSSIEVGQGI
HHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCEEEEEEEEECCCEEEEECCHHHHHHH
REVLCRVAAEQLGQPVSAVSALTPDTAIAPFDWGTGASRSSLMMALAIEDAAADIKAQID
HHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCHHHEEEEEEECHHHHHHHHHHH
DIAASTLGLDPASIALVSGGFTSAGRRYSFADLLHPYFGIDSGELIGIGRISPRSRGGAL
HHHHHHCCCCCHHEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCE
AKAPLFWETAAGRCGITLDEDTGEIAVKRYVSVADIGRAINRSGAEGQDEGAAIMGLGHA
EECCEEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHH
LFEELIYADGQPVNGTMIDYHVPTIDDVPEQFETVLIENGGGPGPGGMRGMGEGAILPIA
HHHHHHHCCCCCCCCEEEEEECCCCCCCHHHEEEEEEECCCCCCCCCCCCCCCCCEEECH
PAIANALATGFGIRVKQLPLTPERVWRALKDRKDR
HHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]