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The map label for this gene is bioA [H]

Identifier: 86751444

GI number: 86751444

Start: 4926871

End: 4928130

Strand: Reverse

Name: bioA [H]

Synonym: RPB_4342

Alternate gene names: 86751444

Gene position: 4928130-4926871 (Counterclockwise)

Preceding gene: 86751445

Following gene: 86751443

Centisome position: 92.43

GC content: 66.9

Gene sequence:

>1260_bases
ATGACATCGACTTCGCCGGTCTGGCATCCCTTCACTCAGCACGCGGTGCAGCCCGAGGCGACGTTGATCGCCAAAGGCGA
GGGCGCCTGGCTCGAGACCGCCGACGGCCGCCGGATCTACGACGCGATCTCGTCCTGGTGGGTGGTGACCCACGGCCATC
GTCATCCGCGGATCGTTCAGGCGATCAAGGATCAGGCCGACCGTCTCGATCAGGTGATCTTCGCCGGCTTCACCCACGAG
CCGGCCGAGCAGCTCGCGCGGCGGCTGGTCGCGATCACGCCGCCCGGGCTCGACTACGTGTTCTTCTCCGACAGCGGCTC
GACCGCGGTCGAAGTCGGGTTGAAGATGGCGCTGGGCTTCTGGCGCAATCGCGGCGAGAGCCGCAGTCGCATCCTGGCGC
TGCAGGGCGCTTACCACGGCGACACCATCGGCGGCATGTCGGTCGGCGAACGCGGCGTCTTCAACGCGCCCTACGATCCG
CTGCTGTTCGAGGTCGACCGGCTGCCGTATCCGGCGGAAGGTCGCGCGCAGGCGACGCTCGATGCGCTGGAGAGGTCATG
CCGCGCCGGCGGCGTCGCAGCATTGATCGTCGAGCCGCTGGTGCTCGGCGCCGGCGGCATGCTGATCTATCCGCCTTCGG
TGCTGGCGGAGATGAAGCGGATCTGCGCCAGCCACGGCGTGCTGCTGATCGCCGACGAAGTGATGACCGGCTGGGGCCGC
ACCGGCACGCTGTTCGCCTGCGAACAAGCCGGCGTCGTACCGGACATCGCCTGCTACTCCAAGGGCCTCACCGGCGGCTC
GGTGCCGCTGGCGGTGACGCTGTGCAGCGCCGAGATTTTCGACGCGCACTACTCGACCGATCGGACCAAGACGTTCTTTC
ACTCCAGCTCGTACACCGCCAATCCGATCGCCTGCGCGGCGGCGGTGGCCAATCTAGAGATCTGGGACGAAGAGCCGGTG
CGCGAGCGCATCGCGCGACTGGGCGCATGGCACGCGACCAGGCTCGACCGCTTCCGCGACGATTCGCGGTTCGCCAATAT
CCGCCAGATCGGCACTATCGCGGCGCTCGATGTCGTCGCCGGCGACGCCGGCTACATGGCGAATATCGGCCCGTATCTGT
ACGAGAGTTTCCGCGCGCGTGGACTGCTGGTCCGACCGCTCGGCAACACGATCTATCTGATGCCGCCTTATTGCAGCACG
GAAGCCGATCTCGATCTGGTCTACGACGCGATCGGCGAAATCGTGGATGGGATCGGCTGA

Upstream 100 bases:

>100_bases
TGGGCCGCCTTCCGCGCCTGGTCGAGGTGACCGCCGATGCGTTGCGCGCCGCGTTCGCGCAGAACTTCAATACCGACGAC
TTCCTGAAAGACCCCGCTTC

Downstream 100 bases:

>100_bases
ACCTGCCGCGCCCCACGGGTGATGCGGGCGACGGGGAATGCGGGCGGAGCCGCGCCTCAGCCGAGTTCCTGGACGACATG
GTCGCAGTTGGAGCAGCGGA

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MTSTSPVWHPFTQHAVQPEATLIAKGEGAWLETADGRRIYDAISSWWVVTHGHRHPRIVQAIKDQADRLDQVIFAGFTHE
PAEQLARRLVAITPPGLDYVFFSDSGSTAVEVGLKMALGFWRNRGESRSRILALQGAYHGDTIGGMSVGERGVFNAPYDP
LLFEVDRLPYPAEGRAQATLDALERSCRAGGVAALIVEPLVLGAGGMLIYPPSVLAEMKRICASHGVLLIADEVMTGWGR
TGTLFACEQAGVVPDIACYSKGLTGGSVPLAVTLCSAEIFDAHYSTDRTKTFFHSSSYTANPIACAAAVANLEIWDEEPV
RERIARLGAWHATRLDRFRDDSRFANIRQIGTIAALDVVAGDAGYMANIGPYLYESFRARGLLVRPLGNTIYLMPPYCST
EADLDLVYDAIGEIVDGIG

Sequences:

>Translated_419_residues
MTSTSPVWHPFTQHAVQPEATLIAKGEGAWLETADGRRIYDAISSWWVVTHGHRHPRIVQAIKDQADRLDQVIFAGFTHE
PAEQLARRLVAITPPGLDYVFFSDSGSTAVEVGLKMALGFWRNRGESRSRILALQGAYHGDTIGGMSVGERGVFNAPYDP
LLFEVDRLPYPAEGRAQATLDALERSCRAGGVAALIVEPLVLGAGGMLIYPPSVLAEMKRICASHGVLLIADEVMTGWGR
TGTLFACEQAGVVPDIACYSKGLTGGSVPLAVTLCSAEIFDAHYSTDRTKTFFHSSSYTANPIACAAAVANLEIWDEEPV
RERIARLGAWHATRLDRFRDDSRFANIRQIGTIAALDVVAGDAGYMANIGPYLYESFRARGLLVRPLGNTIYLMPPYCST
EADLDLVYDAIGEIVDGIG
>Mature_418_residues
TSTSPVWHPFTQHAVQPEATLIAKGEGAWLETADGRRIYDAISSWWVVTHGHRHPRIVQAIKDQADRLDQVIFAGFTHEP
AEQLARRLVAITPPGLDYVFFSDSGSTAVEVGLKMALGFWRNRGESRSRILALQGAYHGDTIGGMSVGERGVFNAPYDPL
LFEVDRLPYPAEGRAQATLDALERSCRAGGVAALIVEPLVLGAGGMLIYPPSVLAEMKRICASHGVLLIADEVMTGWGRT
GTLFACEQAGVVPDIACYSKGLTGGSVPLAVTLCSAEIFDAHYSTDRTKTFFHSSSYTANPIACAAAVANLEIWDEEPVR
ERIARLGAWHATRLDRFRDDSRFANIRQIGTIAALDVVAGDAGYMANIGPYLYESFRARGLLVRPLGNTIYLMPPYCSTE
ADLDLVYDAIGEIVDGIG

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=414, Percent_Identity=28.2608695652174, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI13994255, Length=430, Percent_Identity=26.7441860465116, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI37574042, Length=416, Percent_Identity=26.9230769230769, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI284507298, Length=278, Percent_Identity=30.5755395683453, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=27.6485788113695, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI226442705, Length=416, Percent_Identity=26.4423076923077, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI24119277, Length=403, Percent_Identity=23.3250620347395, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786991, Length=418, Percent_Identity=38.5167464114833, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI145693181, Length=385, Percent_Identity=33.2467532467532, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1789759, Length=392, Percent_Identity=29.5918367346939, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1788044, Length=394, Percent_Identity=29.9492385786802, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1787560, Length=393, Percent_Identity=31.2977099236641, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789016, Length=397, Percent_Identity=28.9672544080605, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786349, Length=320, Percent_Identity=30.3125, Blast_Score=104, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=27.0207852193995, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25144271, Length=413, Percent_Identity=25.4237288135593, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=291, Percent_Identity=26.8041237113402, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71992977, Length=436, Percent_Identity=25.6880733944954, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17541228, Length=441, Percent_Identity=21.5419501133787, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324386, Length=454, Percent_Identity=29.5154185022026, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6323470, Length=421, Percent_Identity=28.2660332541568, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324432, Length=397, Percent_Identity=25.9445843828715, Blast_Score=116, Evalue=7e-27,
Organism=Drosophila melanogaster, GI21357415, Length=414, Percent_Identity=25.6038647342995, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=27.3781902552204, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI161085790, Length=433, Percent_Identity=26.3279445727483, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21356575, Length=411, Percent_Identity=27.7372262773723, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 45472; Mature: 45341

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTSPVWHPFTQHAVQPEATLIAKGEGAWLETADGRRIYDAISSWWVVTHGHRHPRIVQ
CCCCCCCCCCHHHHCCCCCEEEEECCCCCEEECCCCCHHHHHHHCCEEEECCCCCHHHHH
AIKDQADRLDQVIFAGFTHEPAEQLARRLVAITPPGLDYVFFSDSGSTAVEVGLKMALGF
HHHHHHHHHHHHHHCCCCCCHHHHHHHHEEEECCCCCEEEEEECCCCHHHHHHHHHHHHH
WRNRGESRSRILALQGAYHGDTIGGMSVGERGVFNAPYDPLLFEVDRLPYPAEGRAQATL
HHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCHHHHH
DALERSCRAGGVAALIVEPLVLGAGGMLIYPPSVLAEMKRICASHGVLLIADEVMTGWGR
HHHHHHHHCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCEEEEEHHHHHCCCC
TGTLFACEQAGVVPDIACYSKGLTGGSVPLAVTLCSAEIFDAHYSTDRTKTFFHSSSYTA
CCCEEEECCCCCCCCHHHHHCCCCCCCCCEEEEEEHHHHHHHHCCCCCCEEEEECCCCCC
NPIACAAAVANLEIWDEEPVRERIARLGAWHATRLDRFRDDSRFANIRQIGTIAALDVVA
CHHHHHHHHHCCEECCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
GDAGYMANIGPYLYESFRARGLLVRPLGNTIYLMPPYCSTEADLDLVYDAIGEIVDGIG
CCCCCHHHCCHHHHHHHHHCCEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSTSPVWHPFTQHAVQPEATLIAKGEGAWLETADGRRIYDAISSWWVVTHGHRHPRIVQ
CCCCCCCCCHHHHCCCCCEEEEECCCCCEEECCCCCHHHHHHHCCEEEECCCCCHHHHH
AIKDQADRLDQVIFAGFTHEPAEQLARRLVAITPPGLDYVFFSDSGSTAVEVGLKMALGF
HHHHHHHHHHHHHHCCCCCCHHHHHHHHEEEECCCCCEEEEEECCCCHHHHHHHHHHHHH
WRNRGESRSRILALQGAYHGDTIGGMSVGERGVFNAPYDPLLFEVDRLPYPAEGRAQATL
HHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCHHHHH
DALERSCRAGGVAALIVEPLVLGAGGMLIYPPSVLAEMKRICASHGVLLIADEVMTGWGR
HHHHHHHHCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCEEEEEHHHHHCCCC
TGTLFACEQAGVVPDIACYSKGLTGGSVPLAVTLCSAEIFDAHYSTDRTKTFFHSSSYTA
CCCEEEECCCCCCCCHHHHHCCCCCCCCCEEEEEEHHHHHHHHCCCCCCEEEEECCCCCC
NPIACAAAVANLEIWDEEPVRERIARLGAWHATRLDRFRDDSRFANIRQIGTIAALDVVA
CHHHHHHHHHCCEECCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
GDAGYMANIGPYLYESFRARGLLVRPLGNTIYLMPPYCSTEADLDLVYDAIGEIVDGIG
CCCCCHHHCCHHHHHHHHHCCEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]