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The map label for this gene is ddc [H]

Identifier: 86751386

GI number: 86751386

Start: 4867549

End: 4869009

Strand: Direct

Name: ddc [H]

Synonym: RPB_4283

Alternate gene names: 86751386

Gene position: 4867549-4869009 (Clockwise)

Preceding gene: 86751385

Following gene: 86751387

Centisome position: 91.3

GC content: 70.84

Gene sequence:

>1461_bases
GTGAGTGAGACGGAGCGCGCCGGAGGGCATTCCGGCGCGCCGAGCCTCGATCCCGACGACTGGGAGAGCCTCCGCGCCGA
TGCGCACCGGATGCTCGACGACGTCATCGACTCCATCGCCGATGTGCGCGAGCGGCCGGTGTGGCAGCCGATCCCCGACG
ACGTGCGCGCGCGCTTCGGCGAGACGCTGCCGCGCGGGGAAACGCCGCTCGGCGAGGTGTATCAGGAGTTCTCGAACAGC
ATCGCGCCCTATGCGACCGGCAATGTGCATCCCGGCTTCATGGGCTGGGTGCATGGCGGCGGCACCGCCGTGGGCATGCT
CGCCGAGATGCTGGCCGCAGGACTGAACGCCAATTGCGGCGGCCGCGACCACATCGGCCTCGAGGTCGAGCGCCAGATCG
TACGCTGGGTGCGCGAATTGTTCGGCTTCCCGAAGACCGCGAGCGGGCTGTTCGTCACCGGCTCGTCGATGGCGAACTTC
ATGGCGCTGCTGGTGGCGCGGACCGCCGCGCTCGGGCCGCAGGTGCGCGAGGGCGGACTATCGGGTGAACCGCTCACCGC
CTACGCCTCGGCCGCGGCCCATGGCTGCGTGGTGCAGGCCGCCGATCTCGCCGGACTCGGTCGCGGCGCGGTGCGGCGGA
TCGCGTTCGACGCCGCGCATCGCATCGACATCGCCGCGCTGCGCCGGCGGATCGCCGAGGACCGCGCCGCCGGATTCAGG
CCGTTCCTGGTGACCGGCTCGGCCGGCACCGTCGACACCGGCGCGATCGACGATCTCGCCGCGCTGGCGCAGCTCTGCCG
CGACGAAGGGCTGTGGTTTCACGTCGACGGCGCCTATGGCGCGCTCGGGATGCTGTCGCCGCAGATCGCGCCGATGCTCG
CAGGCTTGAGCGAAGCGGATTCGGTCGCGCTCGACTTTCACAAATGGGGCCAGGTCAATTACGACGCCGGCTTCCTGATC
GTGCGCGACGGCGAGCAGCATCGCGCCACCTTCGCGGCGCCGGCCGCCTATCTACGCCGCGAGACCCGGGGGCTCGCCGC
CGGCTCGCCCTGGCCGTGCGACTACGGGCCGGACCTGTCGCGCGGCTTCCGCGCGCTGAAGACCTGGTTCACGCTGAAGA
CCTACGGCGCCGAGCGCCTCGGCGCGATGATCGCCCACACCTGCGCGGTGGCGCGGCATCTCGAAGCCCGGGTGCAGCGC
GAGCCGAAACTCGAACGACTGGCGCCGGTCGCCCTCAACATCGTCTGCTTCCGTCATCGAACGTCATCGGGCGATGCCGA
CGCGCTCAACGCCGAGATCGTCGCCGACCTGCACGAATCCGGGATCGCCGCGCCGTCTTCGACCACGATCGGCGGCCAGC
TCGCGATCCGCGCCGCGATCGTCAATCACCGGTCCACGTGCGCGGACGTCGACCGGATGGTCGATGCGGTGCTCACATTC
GGCGCGCAACGGCAGCGATAG

Upstream 100 bases:

>100_bases
CGGAGCTGTATCCCTACAAGCCGCCCCAGATGATCAAGATCTTCGACGCGTTCGCGGCGATGCTGGAGCGTCGCGTGACG
GCGCGTCGACAGAGCGTGGC

Downstream 100 bases:

>100_bases
GGCGTTTTCGAGCGATTGGATGCGGGCACGCCTGACGAGGACCCCATGTTTCAGGACGAGGACAAGGCCCGCGAAACCCT
TGAGGCAGTGCGATGACCCG

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSETERAGGHSGAPSLDPDDWESLRADAHRMLDDVIDSIADVRERPVWQPIPDDVRARFGETLPRGETPLGEVYQEFSNS
IAPYATGNVHPGFMGWVHGGGTAVGMLAEMLAAGLNANCGGRDHIGLEVERQIVRWVRELFGFPKTASGLFVTGSSMANF
MALLVARTAALGPQVREGGLSGEPLTAYASAAAHGCVVQAADLAGLGRGAVRRIAFDAAHRIDIAALRRRIAEDRAAGFR
PFLVTGSAGTVDTGAIDDLAALAQLCRDEGLWFHVDGAYGALGMLSPQIAPMLAGLSEADSVALDFHKWGQVNYDAGFLI
VRDGEQHRATFAAPAAYLRRETRGLAAGSPWPCDYGPDLSRGFRALKTWFTLKTYGAERLGAMIAHTCAVARHLEARVQR
EPKLERLAPVALNIVCFRHRTSSGDADALNAEIVADLHESGIAAPSSTTIGGQLAIRAAIVNHRSTCADVDRMVDAVLTF
GAQRQR

Sequences:

>Translated_486_residues
MSETERAGGHSGAPSLDPDDWESLRADAHRMLDDVIDSIADVRERPVWQPIPDDVRARFGETLPRGETPLGEVYQEFSNS
IAPYATGNVHPGFMGWVHGGGTAVGMLAEMLAAGLNANCGGRDHIGLEVERQIVRWVRELFGFPKTASGLFVTGSSMANF
MALLVARTAALGPQVREGGLSGEPLTAYASAAAHGCVVQAADLAGLGRGAVRRIAFDAAHRIDIAALRRRIAEDRAAGFR
PFLVTGSAGTVDTGAIDDLAALAQLCRDEGLWFHVDGAYGALGMLSPQIAPMLAGLSEADSVALDFHKWGQVNYDAGFLI
VRDGEQHRATFAAPAAYLRRETRGLAAGSPWPCDYGPDLSRGFRALKTWFTLKTYGAERLGAMIAHTCAVARHLEARVQR
EPKLERLAPVALNIVCFRHRTSSGDADALNAEIVADLHESGIAAPSSTTIGGQLAIRAAIVNHRSTCADVDRMVDAVLTF
GAQRQR
>Mature_485_residues
SETERAGGHSGAPSLDPDDWESLRADAHRMLDDVIDSIADVRERPVWQPIPDDVRARFGETLPRGETPLGEVYQEFSNSI
APYATGNVHPGFMGWVHGGGTAVGMLAEMLAAGLNANCGGRDHIGLEVERQIVRWVRELFGFPKTASGLFVTGSSMANFM
ALLVARTAALGPQVREGGLSGEPLTAYASAAAHGCVVQAADLAGLGRGAVRRIAFDAAHRIDIAALRRRIAEDRAAGFRP
FLVTGSAGTVDTGAIDDLAALAQLCRDEGLWFHVDGAYGALGMLSPQIAPMLAGLSEADSVALDFHKWGQVNYDAGFLIV
RDGEQHRATFAAPAAYLRRETRGLAAGSPWPCDYGPDLSRGFRALKTWFTLKTYGAERLGAMIAHTCAVARHLEARVQRE
PKLERLAPVALNIVCFRHRTSSGDADALNAEIVADLHESGIAAPSSTTIGGQLAIRAAIVNHRSTCADVDRMVDAVLTFG
AQRQR

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI92110055, Length=471, Percent_Identity=26.7515923566879, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4503281, Length=434, Percent_Identity=26.036866359447, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI132814448, Length=434, Percent_Identity=26.036866359447, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI197383062, Length=489, Percent_Identity=24.9488752556237, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI197276620, Length=449, Percent_Identity=25.3897550111359, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI4503875, Length=449, Percent_Identity=25.3897550111359, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI194294551, Length=492, Percent_Identity=25.8130081300813, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI58331246, Length=422, Percent_Identity=24.4075829383886, Blast_Score=110, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17534817, Length=473, Percent_Identity=26.6384778012685, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17534819, Length=473, Percent_Identity=26.6384778012685, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71981211, Length=528, Percent_Identity=22.9166666666667, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71981217, Length=537, Percent_Identity=22.5325884543762, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17555682, Length=485, Percent_Identity=24.7422680412371, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI133931025, Length=482, Percent_Identity=23.0290456431535, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71993062, Length=410, Percent_Identity=26.3414634146341, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17551992, Length=474, Percent_Identity=24.0506329113924, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71993058, Length=398, Percent_Identity=25.1256281407035, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24586044, Length=485, Percent_Identity=27.6288659793814, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI28573972, Length=472, Percent_Identity=28.3898305084746, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24652373, Length=471, Percent_Identity=28.6624203821656, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24585139, Length=425, Percent_Identity=27.0588235294118, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24585135, Length=471, Percent_Identity=26.3269639065817, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI221476190, Length=425, Percent_Identity=27.0588235294118, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24585143, Length=425, Percent_Identity=27.0588235294118, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17136190, Length=476, Percent_Identity=25, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI17136594, Length=335, Percent_Identity=27.4626865671642, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI21356415, Length=409, Percent_Identity=24.9388753056235, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24657193, Length=283, Percent_Identity=27.208480565371, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24657185, Length=283, Percent_Identity=27.208480565371, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24657188, Length=283, Percent_Identity=27.208480565371, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 51923; Mature: 51792

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETERAGGHSGAPSLDPDDWESLRADAHRMLDDVIDSIADVRERPVWQPIPDDVRARFG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHC
ETLPRGETPLGEVYQEFSNSIAPYATGNVHPGFMGWVHGGGTAVGMLAEMLAAGLNANCG
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCC
GRDHIGLEVERQIVRWVRELFGFPKTASGLFVTGSSMANFMALLVARTAALGPQVREGGL
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCHHHCCCC
SGEPLTAYASAAAHGCVVQAADLAGLGRGAVRRIAFDAAHRIDIAALRRRIAEDRAAGFR
CCCCHHHHHHHHHCCCEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PFLVTGSAGTVDTGAIDDLAALAQLCRDEGLWFHVDGAYGALGMLSPQIAPMLAGLSEAD
CEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHCCHHHHHHHHCCCCCC
SVALDFHKWGQVNYDAGFLIVRDGEQHRATFAAPAAYLRRETRGLAAGSPWPCDYGPDLS
CEEEEHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
RGFRALKTWFTLKTYGAERLGAMIAHTCAVARHLEARVQREPKLERLAPVALNIVCFRHR
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEEEEEC
TSSGDADALNAEIVADLHESGIAAPSSTTIGGQLAIRAAIVNHRSTCADVDRMVDAVLTF
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GAQRQR
CCCCCC
>Mature Secondary Structure 
SETERAGGHSGAPSLDPDDWESLRADAHRMLDDVIDSIADVRERPVWQPIPDDVRARFG
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHC
ETLPRGETPLGEVYQEFSNSIAPYATGNVHPGFMGWVHGGGTAVGMLAEMLAAGLNANCG
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCC
GRDHIGLEVERQIVRWVRELFGFPKTASGLFVTGSSMANFMALLVARTAALGPQVREGGL
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHCCCHHHCCCC
SGEPLTAYASAAAHGCVVQAADLAGLGRGAVRRIAFDAAHRIDIAALRRRIAEDRAAGFR
CCCCHHHHHHHHHCCCEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PFLVTGSAGTVDTGAIDDLAALAQLCRDEGLWFHVDGAYGALGMLSPQIAPMLAGLSEAD
CEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHHHCCHHHHHHHHCCCCCC
SVALDFHKWGQVNYDAGFLIVRDGEQHRATFAAPAAYLRRETRGLAAGSPWPCDYGPDLS
CEEEEHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
RGFRALKTWFTLKTYGAERLGAMIAHTCAVARHLEARVQREPKLERLAPVALNIVCFRHR
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHEEEEEEEC
TSSGDADALNAEIVADLHESGIAAPSSTTIGGQLAIRAAIVNHRSTCADVDRMVDAVLTF
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GAQRQR
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]