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The map label for this gene is yciC [H]

Identifier: 86751175

GI number: 86751175

Start: 4640748

End: 4641959

Strand: Direct

Name: yciC [H]

Synonym: RPB_4067

Alternate gene names: 86751175

Gene position: 4640748-4641959 (Clockwise)

Preceding gene: 86751173

Following gene: 86751177

Centisome position: 87.04

GC content: 64.52

Gene sequence:

>1212_bases
ATGCTTGAATCCCGACTTCCGGTCACGGTGCTGTCCGGCTTTCTCGGCGCCGGAAAGACCACCTTGCTCAACCGCATGCT
GACCAATCGCGAGGGCCGGCGTATCGCGGTGATCGTCAATGACATGAGCGAGGTGAACATCGACGCCGAACTGGTGCGAC
AGGACGGCGGGCTGACGCGATCGGAAGAATCGCTGGTGGAAATGACCAATGGCTGCATCTGCTGCACGTTGCGCGAAGAT
CTCCTGATCGAGGTCCGCAAGCTCGCCGAAAGCGGCCGGTTCGACGCCCTGGTGATCGAATCGACGGGCATCGCCGAGCC
GCTGCCGATCGCCACCACCTTCGAGTTCCGTGACGAAGAAGGCGCCAGCCTGTCCGACATCGCCCGGCTCGACACCATGG
TGACCGTCGTTGACGCCGCGAGCCTGCTCTCCAACTATTCGAGCCAGGAGTTCCTGCGCGACCGTGGCGAGGTTGCCGGC
GAGCAGGACGATCGCACTTTGGTCGACCTGCTGGTCGAACAGATCGAGTTCGCCGACGTCATCGTGCTCAACAAGGTCTC
GGCCACCTCGCCGGCCCGACTCGAAGCGGCGCGGGCGATCGTCCGCTCGCTGAATTCGGACGCCCGGATCATCGAGACGG
ATTTCGGCGACGTTCCGCTGCAGTCGGTGCTGCACACCGGGCTGTTCGATTTCGAGCGGGCGCATCAGCACCCGCTGTGG
TTCAAAGAGTTGAACGGCTTCAAGGATCACGTACCCGAAACCGACGAATACGGCATCAGCTCGTTCGTGTATCGCGCCCG
GAGACCATTTCATCCGGCACGGTTTCAGGGGTTCTGCAACTGCAGCTGGCCGGGCGTGATCCGCGCCAAGGGGTTCTTCT
GGCTCGCAACCCGGCCGCATTACGTGGGCGAATTGGCCCAGGCCGGCGCCGTGGTGCGCACCTCGAAGCGTGGCCTGTGG
TGGTCGGCGGTGCCCAAGGCGCGATGGCCCGATCAGGAGTCCTGGCGCGAAGCGATGCAGCCCTATTTCGACCCGGTGTG
GGGCGACCGGCGCCAGGAAATCGTCTTCATCGGCACCGGCGAGATGGACGAGACCGCCTTGCGCCGGCAGCTCGACGCCT
GTCTGGTCGGCGACCCTGCACAGTTCACGCCGGACGCCTGGCGAGCACTGCCGGATCCGTTCCCGAATTGGGCTCCGGCC
GAGGTCTCATAG

Upstream 100 bases:

>100_bases
GTATTCGCCCCACCCTCTTCGCTCCGCTCGGGGTCACCTTGAATCCCTGTTTGTAATGTTATAACATTACAAACATGTCC
CCTTTCAGCGGATCCACGAC

Downstream 100 bases:

>100_bases
CGCACCGCCTATTCGTCGGATGCGACGAGGGAGGCCTTTCTGAGATGCAGATAGCTCGGGTCGAACTGGCCGATCTCGGC
CAAGCGCGACCAGTCCAGCA

Product: cobalamin synthesis protein, P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MLESRLPVTVLSGFLGAGKTTLLNRMLTNREGRRIAVIVNDMSEVNIDAELVRQDGGLTRSEESLVEMTNGCICCTLRED
LLIEVRKLAESGRFDALVIESTGIAEPLPIATTFEFRDEEGASLSDIARLDTMVTVVDAASLLSNYSSQEFLRDRGEVAG
EQDDRTLVDLLVEQIEFADVIVLNKVSATSPARLEAARAIVRSLNSDARIIETDFGDVPLQSVLHTGLFDFERAHQHPLW
FKELNGFKDHVPETDEYGISSFVYRARRPFHPARFQGFCNCSWPGVIRAKGFFWLATRPHYVGELAQAGAVVRTSKRGLW
WSAVPKARWPDQESWREAMQPYFDPVWGDRRQEIVFIGTGEMDETALRRQLDACLVGDPAQFTPDAWRALPDPFPNWAPA
EVS

Sequences:

>Translated_403_residues
MLESRLPVTVLSGFLGAGKTTLLNRMLTNREGRRIAVIVNDMSEVNIDAELVRQDGGLTRSEESLVEMTNGCICCTLRED
LLIEVRKLAESGRFDALVIESTGIAEPLPIATTFEFRDEEGASLSDIARLDTMVTVVDAASLLSNYSSQEFLRDRGEVAG
EQDDRTLVDLLVEQIEFADVIVLNKVSATSPARLEAARAIVRSLNSDARIIETDFGDVPLQSVLHTGLFDFERAHQHPLW
FKELNGFKDHVPETDEYGISSFVYRARRPFHPARFQGFCNCSWPGVIRAKGFFWLATRPHYVGELAQAGAVVRTSKRGLW
WSAVPKARWPDQESWREAMQPYFDPVWGDRRQEIVFIGTGEMDETALRRQLDACLVGDPAQFTPDAWRALPDPFPNWAPA
EVS
>Mature_403_residues
MLESRLPVTVLSGFLGAGKTTLLNRMLTNREGRRIAVIVNDMSEVNIDAELVRQDGGLTRSEESLVEMTNGCICCTLRED
LLIEVRKLAESGRFDALVIESTGIAEPLPIATTFEFRDEEGASLSDIARLDTMVTVVDAASLLSNYSSQEFLRDRGEVAG
EQDDRTLVDLLVEQIEFADVIVLNKVSATSPARLEAARAIVRSLNSDARIIETDFGDVPLQSVLHTGLFDFERAHQHPLW
FKELNGFKDHVPETDEYGISSFVYRARRPFHPARFQGFCNCSWPGVIRAKGFFWLATRPHYVGELAQAGAVVRTSKRGLW
WSAVPKARWPDQESWREAMQPYFDPVWGDRRQEIVFIGTGEMDETALRRQLDACLVGDPAQFTPDAWRALPDPFPNWAPA
EVS

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=231, Percent_Identity=33.7662337662338, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI148727351, Length=231, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI126722884, Length=231, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI146231952, Length=231, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI223941779, Length=214, Percent_Identity=33.1775700934579, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI223941776, Length=217, Percent_Identity=32.7188940092166, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI119120938, Length=151, Percent_Identity=36.4238410596026, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI87082430, Length=306, Percent_Identity=28.7581699346405, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788499, Length=213, Percent_Identity=28.169014084507, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324356, Length=237, Percent_Identity=28.6919831223629, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 45220; Mature: 45220

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLESRLPVTVLSGFLGAGKTTLLNRMLTNREGRRIAVIVNDMSEVNIDAELVRQDGGLTR
CCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCHHCCCCHHHHHCCCCCCC
SEESLVEMTNGCICCTLREDLLIEVRKLAESGRFDALVIESTGIAEPLPIATTFEFRDEE
CHHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCC
GASLSDIARLDTMVTVVDAASLLSNYSSQEFLRDRGEVAGEQDDRTLVDLLVEQIEFADV
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCE
IVLNKVSATSPARLEAARAIVRSLNSDARIIETDFGDVPLQSVLHTGLFDFERAHQHPLW
EEEECCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCH
FKELNGFKDHVPETDEYGISSFVYRARRPFHPARFQGFCNCSWPGVIRAKGFFWLATRPH
HHHHCCHHHCCCCCCCCCHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEECCEEEEECCCH
YVGELAQAGAVVRTSKRGLWWSAVPKARWPDQESWREAMQPYFDPVWGDRRQEIVFIGTG
HHHHHHHCCCEEEECCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECC
EMDETALRRQLDACLVGDPAQFTPDAWRALPDPFPNWAPAEVS
CCHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MLESRLPVTVLSGFLGAGKTTLLNRMLTNREGRRIAVIVNDMSEVNIDAELVRQDGGLTR
CCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCHHCCCCHHHHHCCCCCCC
SEESLVEMTNGCICCTLREDLLIEVRKLAESGRFDALVIESTGIAEPLPIATTFEFRDEE
CHHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCC
GASLSDIARLDTMVTVVDAASLLSNYSSQEFLRDRGEVAGEQDDRTLVDLLVEQIEFADV
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCE
IVLNKVSATSPARLEAARAIVRSLNSDARIIETDFGDVPLQSVLHTGLFDFERAHQHPLW
EEEECCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCH
FKELNGFKDHVPETDEYGISSFVYRARRPFHPARFQGFCNCSWPGVIRAKGFFWLATRPH
HHHHCCHHHCCCCCCCCCHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEECCEEEEECCCH
YVGELAQAGAVVRTSKRGLWWSAVPKARWPDQESWREAMQPYFDPVWGDRRQEIVFIGTG
HHHHHHHCCCEEEECCCCCEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECC
EMDETALRRQLDACLVGDPAQFTPDAWRALPDPFPNWAPAEVS
CCHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]