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The map label for this gene is ethA [H]

Identifier: 86751136

GI number: 86751136

Start: 4598208

End: 4599734

Strand: Reverse

Name: ethA [H]

Synonym: RPB_4028

Alternate gene names: 86751136

Gene position: 4599734-4598208 (Counterclockwise)

Preceding gene: 86751137

Following gene: 86751135

Centisome position: 86.27

GC content: 64.05

Gene sequence:

>1527_bases
ATGACCCAGCTTGCCGAAGCCGACGCGCCGCGCGTCGACCCCTCCGCCACGGCCCGATCCTGCCCCGACCATGTCGACGT
GCTGATCGTCGGCGCCGGAATTTCCGGAATCGGCGGCGCCTATCACCTGACGACGCAATGTCCCGGCACCAGTTTCGCGG
TGCTCGAGACGCAGGACAGCTTCGGCGGGACCTGGCTGACCCATCGCTATCCCGGCATCCGCTCCGACAGTGATCTCTAC
ACGTTCGGCTATCGCTTCAAGCCGTGGACCGGAAAGCCGATCGCGACCGCGGCCGAAATCCGCGACTATCTCGGCGAGGT
GATCGACGATAACGACCTCGACCGGCACATTCACTATCGCCACCGCATCGTGTCGGCGGACTGGTCGAGCGCGGACAAGC
GCTGGAGCATTCTGGCGGAGCGAACCGACACCGGCGAGGCGGTCCGCGTCACCGCGGATTTCCTCTGGATGTGCCAGGGC
TATTACCGCCACAGCGAAGGTTACACCCCCGAATGGGAGGGCATGGCGGCATTCAAGGGCCGCATCGTCCATCCGCAGAC
CTGGCCGGACGATCTCGATACGACCGGCAAGAAGGTCGTTGTCATCGGCTCCGGCGCGACCGCCGCGACGCTGGTGCCGG
CGATTGCGCCGAACTGCGAGCACGTCACCGTGCTGCAGCGCTCGCCGACCTATTTCATCCCCGGGCGCAACAAGATCGAG
ATCGCCGACACGTTGCGCGAGCTCGGCATCTCCGAGGACTGGATCCACGAGATCGTCCGGCGCAAGATCCTATTCGATCA
GGCCACCTTCACCCGCCGCTCGATGACCGAGCCGGAGGTGGTGAAGCAGGAACTGCTGGCCGGCGTTCGCGCCCACCTCG
GTCCGGACTACGATCTCGATCCGCATTTCATGCCGAGCTACCGGCCGTGGCGTCAGCGCATCGCCTTCGTGCCGGACGGC
GATCTGTTCAAAGGCATTGCGTCGGGCAAGGCGTCGGTGGTCACCGACGAGATCGTGCGATTCACCGAGACGGGGATCGC
GCTGAAGTCCGGCGAAACGGTCGCGGCCGACATCGTCGTCACCGCGACCGGCTTCAACCTCAATGTTCTCGGCGACATCG
CCTTCAGCATCGACGGCAGGCCGCTCGATTTCGCCGATACCGTGACCTATCGCGGTATGATGTTCACCGGTGTGCCGAAC
ATGGTTTGGGTATTCGGTTATTTCCGCGCGAGCTGGACGCTGCGCGCCGATCTGGTGGCGGATTTCGTCTGCCGTCTGCT
GCGTCATATGAAGCAGCACAATTGCCGCAGTGTCGTGCCGGCACTGCGCCCGGAAGACGCCGGGATGGAACTGCTGCCCT
GGATGGACCCGGAGAACTTCAACCCGGGTTACCTGATGCGCGGCATGAGCCTGCTGCCGAAACGTGGCGCCAAGCCGGAG
TGGCAGCACAGCCAGGACTATTGGACGGAGAAGGACGAGTTGCCGAAGATCGACCTCGATGATCCCGTTTTCGTCTATGG
CAGGTAG

Upstream 100 bases:

>100_bases
TCGTTCACAACCGCCGCTGCGGGCGGCCAAGAAAATGCTGGGCAAAACACCGCGCAGGCGTCAATCTGGTTTCCAACGAC
AGAAAAAAAGTCGAGGAAAC

Downstream 100 bases:

>100_bases
CGAGCGCAGCTGCCGCCGAACCGCCGCGCGATTCGGTTGCCCCTGTTAACTATATGTTAACGATCAGGAATAATGCGCCC
TGCCAGGGCGGTGCGAGACC

Product: flavin-containing monooxygenase FMO

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MTQLAEADAPRVDPSATARSCPDHVDVLIVGAGISGIGGAYHLTTQCPGTSFAVLETQDSFGGTWLTHRYPGIRSDSDLY
TFGYRFKPWTGKPIATAAEIRDYLGEVIDDNDLDRHIHYRHRIVSADWSSADKRWSILAERTDTGEAVRVTADFLWMCQG
YYRHSEGYTPEWEGMAAFKGRIVHPQTWPDDLDTTGKKVVVIGSGATAATLVPAIAPNCEHVTVLQRSPTYFIPGRNKIE
IADTLRELGISEDWIHEIVRRKILFDQATFTRRSMTEPEVVKQELLAGVRAHLGPDYDLDPHFMPSYRPWRQRIAFVPDG
DLFKGIASGKASVVTDEIVRFTETGIALKSGETVAADIVVTATGFNLNVLGDIAFSIDGRPLDFADTVTYRGMMFTGVPN
MVWVFGYFRASWTLRADLVADFVCRLLRHMKQHNCRSVVPALRPEDAGMELLPWMDPENFNPGYLMRGMSLLPKRGAKPE
WQHSQDYWTEKDELPKIDLDDPVFVYGR

Sequences:

>Translated_508_residues
MTQLAEADAPRVDPSATARSCPDHVDVLIVGAGISGIGGAYHLTTQCPGTSFAVLETQDSFGGTWLTHRYPGIRSDSDLY
TFGYRFKPWTGKPIATAAEIRDYLGEVIDDNDLDRHIHYRHRIVSADWSSADKRWSILAERTDTGEAVRVTADFLWMCQG
YYRHSEGYTPEWEGMAAFKGRIVHPQTWPDDLDTTGKKVVVIGSGATAATLVPAIAPNCEHVTVLQRSPTYFIPGRNKIE
IADTLRELGISEDWIHEIVRRKILFDQATFTRRSMTEPEVVKQELLAGVRAHLGPDYDLDPHFMPSYRPWRQRIAFVPDG
DLFKGIASGKASVVTDEIVRFTETGIALKSGETVAADIVVTATGFNLNVLGDIAFSIDGRPLDFADTVTYRGMMFTGVPN
MVWVFGYFRASWTLRADLVADFVCRLLRHMKQHNCRSVVPALRPEDAGMELLPWMDPENFNPGYLMRGMSLLPKRGAKPE
WQHSQDYWTEKDELPKIDLDDPVFVYGR
>Mature_507_residues
TQLAEADAPRVDPSATARSCPDHVDVLIVGAGISGIGGAYHLTTQCPGTSFAVLETQDSFGGTWLTHRYPGIRSDSDLYT
FGYRFKPWTGKPIATAAEIRDYLGEVIDDNDLDRHIHYRHRIVSADWSSADKRWSILAERTDTGEAVRVTADFLWMCQGY
YRHSEGYTPEWEGMAAFKGRIVHPQTWPDDLDTTGKKVVVIGSGATAATLVPAIAPNCEHVTVLQRSPTYFIPGRNKIEI
ADTLRELGISEDWIHEIVRRKILFDQATFTRRSMTEPEVVKQELLAGVRAHLGPDYDLDPHFMPSYRPWRQRIAFVPDGD
LFKGIASGKASVVTDEIVRFTETGIALKSGETVAADIVVTATGFNLNVLGDIAFSIDGRPLDFADTVTYRGMMFTGVPNM
VWVFGYFRASWTLRADLVADFVCRLLRHMKQHNCRSVVPALRPEDAGMELLPWMDPENFNPGYLMRGMSLLPKRGAKPEW
QHSQDYWTEKDELPKIDLDDPVFVYGR

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 57050; Mature: 56919

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLAEADAPRVDPSATARSCPDHVDVLIVGAGISGIGGAYHLTTQCPGTSFAVLETQDS
CCCCCCCCCCCCCCCCHHHCCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEEEECCC
FGGTWLTHRYPGIRSDSDLYTFGYRFKPWTGKPIATAAEIRDYLGEVIDDNDLDRHIHYR
CCCEEEEECCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHH
HRIVSADWSSADKRWSILAERTDTGEAVRVTADFLWMCQGYYRHSEGYTPEWEGMAAFKG
HEEEECCCCCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCHHHHCC
RIVHPQTWPDDLDTTGKKVVVIGSGATAATLVPAIAPNCEHVTVLQRSPTYFIPGRNKIE
EEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEEEECCCCEEECCCCEEE
IADTLRELGISEDWIHEIVRRKILFDQATFTRRSMTEPEVVKQELLAGVRAHLGPDYDLD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
PHFMPSYRPWRQRIAFVPDGDLFKGIASGKASVVTDEIVRFTETGIALKSGETVAADIVV
CCCCCCCCCHHHEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHCCEEEECCCEEEEEEEE
TATGFNLNVLGDIAFSIDGRPLDFADTVTYRGMMFTGVPNMVWVFGYFRASWTLRADLVA
EECCCCEEEEEEEEEEECCCCCCHHHHHEECCEEEECCCCHHHHHHHHHHCEEEHHHHHH
DFVCRLLRHMKQHNCRSVVPALRPEDAGMELLPWMDPENFNPGYLMRGMSLLPKRGAKPE
HHHHHHHHHHHHCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCHHHHCHHHHCCCCCCCC
WQHSQDYWTEKDELPKIDLDDPVFVYGR
CCCCCCCCCCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
TQLAEADAPRVDPSATARSCPDHVDVLIVGAGISGIGGAYHLTTQCPGTSFAVLETQDS
CCCCCCCCCCCCCCCHHHCCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEEEEECCC
FGGTWLTHRYPGIRSDSDLYTFGYRFKPWTGKPIATAAEIRDYLGEVIDDNDLDRHIHYR
CCCEEEEECCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHH
HRIVSADWSSADKRWSILAERTDTGEAVRVTADFLWMCQGYYRHSEGYTPEWEGMAAFKG
HEEEECCCCCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCCHHHHCC
RIVHPQTWPDDLDTTGKKVVVIGSGATAATLVPAIAPNCEHVTVLQRSPTYFIPGRNKIE
EEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEEEECCCCEEECCCCEEE
IADTLRELGISEDWIHEIVRRKILFDQATFTRRSMTEPEVVKQELLAGVRAHLGPDYDLD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
PHFMPSYRPWRQRIAFVPDGDLFKGIASGKASVVTDEIVRFTETGIALKSGETVAADIVV
CCCCCCCCCHHHEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHCCEEEECCCEEEEEEEE
TATGFNLNVLGDIAFSIDGRPLDFADTVTYRGMMFTGVPNMVWVFGYFRASWTLRADLVA
EECCCCEEEEEEEEEEECCCCCCHHHHHEECCEEEECCCCHHHHHHHHHHCEEEHHHHHH
DFVCRLLRHMKQHNCRSVVPALRPEDAGMELLPWMDPENFNPGYLMRGMSLLPKRGAKPE
HHHHHHHHHHHHCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCHHHHCHHHHCCCCCCCC
WQHSQDYWTEKDELPKIDLDDPVFVYGR
CCCCCCCCCCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA