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The map label for this gene is hemC [H]

Identifier: 86751126

GI number: 86751126

Start: 4585683

End: 4586663

Strand: Reverse

Name: hemC [H]

Synonym: RPB_4018

Alternate gene names: 86751126

Gene position: 4586663-4585683 (Counterclockwise)

Preceding gene: 86751133

Following gene: 86751125

Centisome position: 86.03

GC content: 66.67

Gene sequence:

>981_bases
GTGAAAATTCCAGTCCGCATTGGGACGCGCAAGAGCGTGATGGCGCTTGCCCAGACCGAGGACATTGCCAACCAGTTGCG
CGCAGCCGCGAGCGAACTCGATCCCGAGATCGTCAGGTTCGAAACCGTCGGCGACAGCGACCAGGTCAGCAAGCTGTTGC
CGCACGGCGGCAAGGGCGGCGCTTTCGTCGCCGAGATCCGTGCCGCGATGCTGCGCGGCGAGCTGCATTGCGCGATGCAC
TCGCTGAAGGACATGCCCGCCAACGAGGAAACCCCCGGACTGATCGTCGCAGCCACGCTGGCGCGCGATCCGGCCAACGA
TTCGATGGTGTTGCGCAAGGGGCTGACGCTCGACGAACTGAAGGCGTCGCGCGGCAAGGGCTACACCATCGGCACCAATG
CGGTGCGGCGCGCGGCCTATGCCAAGCGGCTGTTCCCCGAAGTCGAGGTGATTCATTTCCGCGGCGCGGCAGACACCCGC
ATCCGCAAGCTCGACAATCGCGAGAAGCAGCGGATGCCCGACGGCGGCGAGGTCGGCCCGGCCGATGCGCTGATCATGGC
GCGCTCCGGGCTCGAGCGCGTCGGCTTCGTCGACCGCATCGTCCACGACTTCACGCCGCAGGAGATGTTGCCGGCCGCGG
GGCAGGGCATCGTCGCGGTCGAGTGCCCGGTTCACGAGTGGCAGACCCGCAAATATCTGGCGCTGATCGACGATCCCAAG
GCGCGGCTGTTCTGCGACGCCGAGCGCGAGGTGCTGTGGGTGCTGAACGGCCACTGCAATTCGCCGATGGCCGCCTATTC
CACCATCAACGGCTCGGAGATGACGCTGAGCGCCTCGGTGCTCGACGAGGCGGGCGGATTGTTCATCGAGGCGACGCGCA
CCGGTCCGGCCAATCGGCCCCGCGAACTCGGTCGTACGGTCGGTCTTGATCTGCTGGACAAGGGCGCCGCCGCGATCATC
GAAAAAACGCGGCCGGAGTGA

Upstream 100 bases:

>100_bases
CGAAAAATCCGGTGGTCATCTGTTTGCAATCTGGTTCGGACTGGTATGGTTCGACCGTCAGTCGCCGCGGGCCCTTCGCG
GTCGTCGAATGGAGCATGTG

Downstream 100 bases:

>100_bases
CTCATCCCATGGCGACCGTATTCCCGTTCTCAGCCATCGTCGGCCAGGAAGAGATGAAGCTCGCGCTGCTGATCGCGGCG
ATCGATCAGAAGGTCGGCGG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MKIPVRIGTRKSVMALAQTEDIANQLRAAASELDPEIVRFETVGDSDQVSKLLPHGGKGGAFVAEIRAAMLRGELHCAMH
SLKDMPANEETPGLIVAATLARDPANDSMVLRKGLTLDELKASRGKGYTIGTNAVRRAAYAKRLFPEVEVIHFRGAADTR
IRKLDNREKQRMPDGGEVGPADALIMARSGLERVGFVDRIVHDFTPQEMLPAAGQGIVAVECPVHEWQTRKYLALIDDPK
ARLFCDAEREVLWVLNGHCNSPMAAYSTINGSEMTLSASVLDEAGGLFIEATRTGPANRPRELGRTVGLDLLDKGAAAII
EKTRPE

Sequences:

>Translated_326_residues
MKIPVRIGTRKSVMALAQTEDIANQLRAAASELDPEIVRFETVGDSDQVSKLLPHGGKGGAFVAEIRAAMLRGELHCAMH
SLKDMPANEETPGLIVAATLARDPANDSMVLRKGLTLDELKASRGKGYTIGTNAVRRAAYAKRLFPEVEVIHFRGAADTR
IRKLDNREKQRMPDGGEVGPADALIMARSGLERVGFVDRIVHDFTPQEMLPAAGQGIVAVECPVHEWQTRKYLALIDDPK
ARLFCDAEREVLWVLNGHCNSPMAAYSTINGSEMTLSASVLDEAGGLFIEATRTGPANRPRELGRTVGLDLLDKGAAAII
EKTRPE
>Mature_326_residues
MKIPVRIGTRKSVMALAQTEDIANQLRAAASELDPEIVRFETVGDSDQVSKLLPHGGKGGAFVAEIRAAMLRGELHCAMH
SLKDMPANEETPGLIVAATLARDPANDSMVLRKGLTLDELKASRGKGYTIGTNAVRRAAYAKRLFPEVEVIHFRGAADTR
IRKLDNREKQRMPDGGEVGPADALIMARSGLERVGFVDRIVHDFTPQEMLPAAGQGIVAVECPVHEWQTRKYLALIDDPK
ARLFCDAEREVLWVLNGHCNSPMAAYSTINGSEMTLSASVLDEAGGLFIEATRTGPANRPRELGRTVGLDLLDKGAAAII
EKTRPE

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=316, Percent_Identity=30.379746835443, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI66933009, Length=316, Percent_Identity=30.379746835443, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI48994974, Length=316, Percent_Identity=32.9113924050633, Blast_Score=139, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6319996, Length=290, Percent_Identity=28.9655172413793, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20130425, Length=276, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35412; Mature: 35412

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIPVRIGTRKSVMALAQTEDIANQLRAAASELDPEIVRFETVGDSDQVSKLLPHGGKGG
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCCCC
AFVAEIRAAMLRGELHCAMHSLKDMPANEETPGLIVAATLARDPANDSMVLRKGLTLDEL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCCHHHH
KASRGKGYTIGTNAVRRAAYAKRLFPEVEVIHFRGAADTRIRKLDNREKQRMPDGGEVGP
HHCCCCCEEECHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCHHHHCCCCCCCCCC
ADALIMARSGLERVGFVDRIVHDFTPQEMLPAAGQGIVAVECPVHEWQTRKYLALIDDPK
HHHHHHHHHCHHHHHHHHHHHHCCCCHHHCCCCCCCEEEEECCCCCCCCCEEEEEEECCC
ARLFCDAEREVLWVLNGHCNSPMAAYSTINGSEMTLSASVLDEAGGLFIEATRTGPANRP
CEEEECCCCEEEEEEECCCCCCHHHHEECCCCCEEEEHHHHHCCCCEEEEEECCCCCCCH
RELGRTVGLDLLDKGAAAIIEKTRPE
HHHHHHHCHHHHHCCHHHHHHCCCCC
>Mature Secondary Structure
MKIPVRIGTRKSVMALAQTEDIANQLRAAASELDPEIVRFETVGDSDQVSKLLPHGGKGG
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCCCC
AFVAEIRAAMLRGELHCAMHSLKDMPANEETPGLIVAATLARDPANDSMVLRKGLTLDEL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCCHHHH
KASRGKGYTIGTNAVRRAAYAKRLFPEVEVIHFRGAADTRIRKLDNREKQRMPDGGEVGP
HHCCCCCEEECHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCHHHHCCCCCCCCCC
ADALIMARSGLERVGFVDRIVHDFTPQEMLPAAGQGIVAVECPVHEWQTRKYLALIDDPK
HHHHHHHHHCHHHHHHHHHHHHCCCCHHHCCCCCCCEEEEECCCCCCCCCEEEEEEECCC
ARLFCDAEREVLWVLNGHCNSPMAAYSTINGSEMTLSASVLDEAGGLFIEATRTGPANRP
CEEEECCCCEEEEEEECCCCCCHHHHEECCCCCEEEEHHHHHCCCCEEEEEECCCCCCCH
RELGRTVGLDLLDKGAAAIIEKTRPE
HHHHHHHCHHHHHCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA