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The map label for this gene is crtE [H]

Identifier: 86751112

GI number: 86751112

Start: 4570898

End: 4571761

Strand: Reverse

Name: crtE [H]

Synonym: RPB_4004

Alternate gene names: 86751112

Gene position: 4571761-4570898 (Counterclockwise)

Preceding gene: 86751115

Following gene: 86751111

Centisome position: 85.75

GC content: 68.87

Gene sequence:

>864_bases
ATGGATGTCACCAATCGGATCGAGCGTGCCCTCACCGAGGCGCTCAGCCAGGCGGATCTGGCAGGATGCCCGCCCCGACT
GGCGGCGGCAATGCGAAGCGCGGTGTTCCCGCGCGGTGCCCGCGTTCGGCCCCGACTTTGTCACAGCGTTGCCGCAGCCT
GTGGCGATGACAATCCGGCCACCGAAGCCGCCGGCGCAGCCCTCGAATTGATGCATTGCGCCTCGCTGGTGCACGATGAT
CTGCCCTGTTTCGACGGCGCCGATATCCGCCGCGGCCGTCCCTCGGTGCACAAGGCGTTCGGCGAGCCGCTCGCGGTGCT
GACCGGCGACGCGCTGATCGTGCTGGCGTTCCAGACCATCGCCCGCGTCAATTGCGCGCCGGACCGCTTGCTGAAGCTCA
CCCAGGTCATCGGCAGCGCCGTCGGCGTGCCGCTCGGCATCGTCGCCGGGCAGGCGTGGGAATGCGAATCCGAAATCAAT
CTCGCCCATTATCACCGCTCCAAGACCGGTGCATTGTTCGTCGCCGCGACCGCGGCCGGGGCGGCCTCGGCCGGTGCCGA
TCCCGAGCCGTGGCGGATGGTCGGCGAGAAGATCGGCGAGGCCTATCAGGTCGCCGACGATCTGCGCGATGCCGCCGCCG
ATGAAGACGAGATCGGCAAGCCGGTCGGCCAGGACGTCGCCCATGATCGCCCGAGCGCGGTGCGCGAGATGGGCATCGAC
GGCGCGGTGTACCATCTGAAGTCGCTGGTGCGCGGCGCGGTCGAAGCGATGCCACCGTGCTCCAACGGCAACGAGCTGCG
CTCGCTGATCATGTCGGAAGCCACCCGGCTGGTGCCGGCGAAGCTCGCGCAATCCGCGGCGTAA

Upstream 100 bases:

>100_bases
AGTGTCATTGCGCCATGTCATTGACACGTGTCCATAATAATTTACAGTCGCGTATGACAAGTCAAATTGACACTTGCTGC
GCCTAGAGCGGGAGTCGGCC

Downstream 100 bases:

>100_bases
TGGCGTGATAAAGCCTTCCCCCGGCGTGGCCTCGGCGGCCGGCCGGTGGTAGCAGGAACGATGAACTCCTTGAGTCTGCG
TGACCGGCTGCTCGGCTGGC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: GGPP synthase; Farnesyltranstransferase [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MDVTNRIERALTEALSQADLAGCPPRLAAAMRSAVFPRGARVRPRLCHSVAAACGDDNPATEAAGAALELMHCASLVHDD
LPCFDGADIRRGRPSVHKAFGEPLAVLTGDALIVLAFQTIARVNCAPDRLLKLTQVIGSAVGVPLGIVAGQAWECESEIN
LAHYHRSKTGALFVAATAAGAASAGADPEPWRMVGEKIGEAYQVADDLRDAAADEDEIGKPVGQDVAHDRPSAVREMGID
GAVYHLKSLVRGAVEAMPPCSNGNELRSLIMSEATRLVPAKLAQSAA

Sequences:

>Translated_287_residues
MDVTNRIERALTEALSQADLAGCPPRLAAAMRSAVFPRGARVRPRLCHSVAAACGDDNPATEAAGAALELMHCASLVHDD
LPCFDGADIRRGRPSVHKAFGEPLAVLTGDALIVLAFQTIARVNCAPDRLLKLTQVIGSAVGVPLGIVAGQAWECESEIN
LAHYHRSKTGALFVAATAAGAASAGADPEPWRMVGEKIGEAYQVADDLRDAAADEDEIGKPVGQDVAHDRPSAVREMGID
GAVYHLKSLVRGAVEAMPPCSNGNELRSLIMSEATRLVPAKLAQSAA
>Mature_287_residues
MDVTNRIERALTEALSQADLAGCPPRLAAAMRSAVFPRGARVRPRLCHSVAAACGDDNPATEAAGAALELMHCASLVHDD
LPCFDGADIRRGRPSVHKAFGEPLAVLTGDALIVLAFQTIARVNCAPDRLLKLTQVIGSAVGVPLGIVAGQAWECESEIN
LAHYHRSKTGALFVAATAAGAASAGADPEPWRMVGEKIGEAYQVADDLRDAAADEDEIGKPVGQDVAHDRPSAVREMGID
GAVYHLKSLVRGAVEAMPPCSNGNELRSLIMSEATRLVPAKLAQSAA

Specific function: Supplies Octaprenyl Diphosphate, The Precursor For The Side Chain Of The Isoprenoid Quinones Ubiquinone And Menaquinone. [C]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=206, Percent_Identity=31.0679611650485, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1789578, Length=204, Percent_Identity=33.8235294117647, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786623, Length=241, Percent_Identity=33.6099585062241, Blast_Score=95, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17505681, Length=177, Percent_Identity=31.0734463276836, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24651612, Length=164, Percent_Identity=32.9268292682927, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.29 [H]

Molecular weight: Translated: 30010; Mature: 30010

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVTNRIERALTEALSQADLAGCPPRLAAAMRSAVFPRGARVRPRLCHSVAAACGDDNPA
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCH
TEAAGAALELMHCASLVHDDLPCFDGADIRRGRPSVHKAFGEPLAVLTGDALIVLAFQTI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHCCHHHHHHHHHH
ARVNCAPDRLLKLTQVIGSAVGVPLGIVAGQAWECESEINLAHYHRSKTGALFVAATAAG
HHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCC
AASAGADPEPWRMVGEKIGEAYQVADDLRDAAADEDEIGKPVGQDVAHDRPSAVREMGID
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHCCCHHHHHHHCCC
GAVYHLKSLVRGAVEAMPPCSNGNELRSLIMSEATRLVPAKLAQSAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDVTNRIERALTEALSQADLAGCPPRLAAAMRSAVFPRGARVRPRLCHSVAAACGDDNPA
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCH
TEAAGAALELMHCASLVHDDLPCFDGADIRRGRPSVHKAFGEPLAVLTGDALIVLAFQTI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHCCHHHHHHHHHH
ARVNCAPDRLLKLTQVIGSAVGVPLGIVAGQAWECESEINLAHYHRSKTGALFVAATAAG
HHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCC
AASAGADPEPWRMVGEKIGEAYQVADDLRDAAADEDEIGKPVGQDVAHDRPSAVREMGID
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHCCCHHHHHHHCCC
GAVYHLKSLVRGAVEAMPPCSNGNELRSLIMSEATRLVPAKLAQSAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721699; 10648776 [H]