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The map label for this gene is hsaA [H]

Identifier: 86751002

GI number: 86751002

Start: 4449703

End: 4450863

Strand: Direct

Name: hsaA [H]

Synonym: RPB_3894

Alternate gene names: 86751002

Gene position: 4449703-4450863 (Clockwise)

Preceding gene: 86750995

Following gene: 86751003

Centisome position: 83.46

GC content: 69.77

Gene sequence:

>1161_bases
ATGAACGACCTCGCCAGCGTGATTCACCTGAAGCCGGCCGCGCCGATCGAAGATTTCGATGCGCTGACCGCCGACATCCG
CGCCCGCCGGGGCGAGTTCACCGCACAGCAGCACGTGTCGCAGGACATCATCGCGCGGCTGCGCAAGGCCGGCATCTATC
GCGCCATGGTGGCGAAGATGTTCGGCGGCGACGAGAAGAGCCCGGCGGAATTCTGCCGGATGATCGAGCGGATCGCGCAG
GCCGACGGCTCGACCGGCTGGGTCGCGAGCTTCGGCGCGGCGGCGACCTATCTCGCCGCGCTGCCGGAGCCGACGCTGCG
CAAGCTCTACGCCAATGGCCCCGACGAGGTGTTCGCCGGCGGCCTGTTTCCGCTGCAACCGGCGAAGCGGACGCCGGAAG
GGTTTCTCGTCAACGGCACCTGGAAATTCGGCAGCGGCAGCATGGGCGCCTCGCTGATCGGCGTCGGCATCTCGGTCGAA
GGCGATGCGTCCGGCGGATTGCCGCGCGTCGCGGTGATGCCCGCCGAGCAGGTCGAGATCCGTCCGAACTGGGACGTGAT
CGGCTTGGAAGGCACCGGCAGCCACGACCTCGTCGTCAAGGACGTGATCGTGCCGGAGGAATGGACGCTGATCCGCGGCG
GCGCGGCTTCGGTCGACGCCGACATCTATCGCTATCCGTCGCTCGGCCTCGCCGCGCAGGTGCTCGCCGTGGTCGGGCTC
GGCGTCGCGCGCGGCGCGCTCGACGAGGTGATCGAGATGGCCGGCGGCCGGGTGTCGATCACCGGCGCGCCGAAGCTCGC
CGATCGTGGCTATGTGCAGGTCGCCATCGCCAAGGCCGAAGCCAATCTGCGCGCGGCCCGCGCCTTCTTCTACGACGCCA
CCGAAGAGACCTGGCGCATCGTCCGCGCCGGCGACAAGCCGTCGGTCGAAGCGACCACGGTGCTGCGGCTGGCGGCCAGC
CACGCCGCCAAGACCGGCGCCGACGTCACCCGGATGGCGACCGAACTCACCGGCACCACGTCGATCTACAACGGCCATCC
GCTGGCGCGAGCGCTGACCGACAGTTTCGTGGTCGCGCAGCACGCCTTCCTCAACGAGGGCACGATGCAGAGCGCCGGCC
GCGTGCTGCTCGGGCTGCCCTCGGTCCCCGGCTATCCATGA

Upstream 100 bases:

>100_bases
GTTCATGATTTCCTTTCGCATGTAGCGGCACGGATGCTCGCCGGCAACGGCCGAGACCGCAGCGCGGGACGACAGCAGCG
CCAACGCCAAAGAGGGCACC

Downstream 100 bases:

>100_bases
TGCCGCGCCCCTCTCCGACCATTTCCCAGCGACAAGGATCAGACACATGACCAGCCTGGCGGAGCTCTCCACCAATCCCG
ACGACCTGATCCGCAAGGAT

Product: Acyl-CoA dehydrogenase-like

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MNDLASVIHLKPAAPIEDFDALTADIRARRGEFTAQQHVSQDIIARLRKAGIYRAMVAKMFGGDEKSPAEFCRMIERIAQ
ADGSTGWVASFGAAATYLAALPEPTLRKLYANGPDEVFAGGLFPLQPAKRTPEGFLVNGTWKFGSGSMGASLIGVGISVE
GDASGGLPRVAVMPAEQVEIRPNWDVIGLEGTGSHDLVVKDVIVPEEWTLIRGGAASVDADIYRYPSLGLAAQVLAVVGL
GVARGALDEVIEMAGGRVSITGAPKLADRGYVQVAIAKAEANLRAARAFFYDATEETWRIVRAGDKPSVEATTVLRLAAS
HAAKTGADVTRMATELTGTTSIYNGHPLARALTDSFVVAQHAFLNEGTMQSAGRVLLGLPSVPGYP

Sequences:

>Translated_386_residues
MNDLASVIHLKPAAPIEDFDALTADIRARRGEFTAQQHVSQDIIARLRKAGIYRAMVAKMFGGDEKSPAEFCRMIERIAQ
ADGSTGWVASFGAAATYLAALPEPTLRKLYANGPDEVFAGGLFPLQPAKRTPEGFLVNGTWKFGSGSMGASLIGVGISVE
GDASGGLPRVAVMPAEQVEIRPNWDVIGLEGTGSHDLVVKDVIVPEEWTLIRGGAASVDADIYRYPSLGLAAQVLAVVGL
GVARGALDEVIEMAGGRVSITGAPKLADRGYVQVAIAKAEANLRAARAFFYDATEETWRIVRAGDKPSVEATTVLRLAAS
HAAKTGADVTRMATELTGTTSIYNGHPLARALTDSFVVAQHAFLNEGTMQSAGRVLLGLPSVPGYP
>Mature_386_residues
MNDLASVIHLKPAAPIEDFDALTADIRARRGEFTAQQHVSQDIIARLRKAGIYRAMVAKMFGGDEKSPAEFCRMIERIAQ
ADGSTGWVASFGAAATYLAALPEPTLRKLYANGPDEVFAGGLFPLQPAKRTPEGFLVNGTWKFGSGSMGASLIGVGISVE
GDASGGLPRVAVMPAEQVEIRPNWDVIGLEGTGSHDLVVKDVIVPEEWTLIRGGAASVDADIYRYPSLGLAAQVLAVVGL
GVARGALDEVIEMAGGRVSITGAPKLADRGYVQVAIAKAEANLRAARAFFYDATEETWRIVRAGDKPSVEATTVLRLAAS
HAAKTGADVTRMATELTGTTSIYNGHPLARALTDSFVVAQHAFLNEGTMQSAGRVLLGLPSVPGYP

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 40700; Mature: 40700

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLASVIHLKPAAPIEDFDALTADIRARRGEFTAQQHVSQDIIARLRKAGIYRAMVAKM
CCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGGDEKSPAEFCRMIERIAQADGSTGWVASFGAAATYLAALPEPTLRKLYANGPDEVFAG
HCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHCC
GLFPLQPAKRTPEGFLVNGTWKFGSGSMGASLIGVGISVEGDASGGLPRVAVMPAEQVEI
CCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCEEEECCCHHEEE
RPNWDVIGLEGTGSHDLVVKDVIVPEEWTLIRGGAASVDADIYRYPSLGLAAQVLAVVGL
CCCCCEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCHHEECCCCCHHHHHHHHHHH
GVARGALDEVIEMAGGRVSITGAPKLADRGYVQVAIAKAEANLRAARAFFYDATEETWRI
HHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEEEECCCHHHHHHHHEECCCHHHEEE
VRAGDKPSVEATTVLRLAASHAAKTGADVTRMATELTGTTSIYNGHPLARALTDSFVVAQ
EECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHH
HAFLNEGTMQSAGRVLLGLPSVPGYP
HHHHCCCCHHHCCCEEEECCCCCCCC
>Mature Secondary Structure
MNDLASVIHLKPAAPIEDFDALTADIRARRGEFTAQQHVSQDIIARLRKAGIYRAMVAKM
CCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGGDEKSPAEFCRMIERIAQADGSTGWVASFGAAATYLAALPEPTLRKLYANGPDEVFAG
HCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHCC
GLFPLQPAKRTPEGFLVNGTWKFGSGSMGASLIGVGISVEGDASGGLPRVAVMPAEQVEI
CCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCEEEECCCHHEEE
RPNWDVIGLEGTGSHDLVVKDVIVPEEWTLIRGGAASVDADIYRYPSLGLAAQVLAVVGL
CCCCCEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCHHEECCCCCHHHHHHHHHHH
GVARGALDEVIEMAGGRVSITGAPKLADRGYVQVAIAKAEANLRAARAFFYDATEETWRI
HHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEEEECCCHHHHHHHHEECCCHHHEEE
VRAGDKPSVEATTVLRLAASHAAKTGADVTRMATELTGTTSIYNGHPLARALTDSFVVAQ
EECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHH
HAFLNEGTMQSAGRVLLGLPSVPGYP
HHHHCCCCHHHCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA