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The map label for this gene is hemN [H]

Identifier: 86750973

GI number: 86750973

Start: 4420208

End: 4421557

Strand: Direct

Name: hemN [H]

Synonym: RPB_3865

Alternate gene names: 86750973

Gene position: 4420208-4421557 (Clockwise)

Preceding gene: 86750972

Following gene: 86750974

Centisome position: 82.9

GC content: 66.59

Gene sequence:

>1350_bases
ATGTCGTCTGCCCTCGACAAATACGCCAAGAGCTCGGTGCCGCGCTACACCAGCTATCCGACGGCGCCGCATTTCGCCAA
GGATTTTCCGGAGGCCGTGTATCGTGGCTGGCTCGCCCAGCTCGACACCGACGAGCCGATCTCGCTTTATCTCCATGTGC
CGTTCTGCAAGCAGATGTGCTGGTACTGCGGCTGCAACATGAAGCTGGCGTCGAAATACGGGCCGGTCGCCGACTATGTC
GAGAGCCTGATCAACGAGATCGATCTGGTCGCCGATGCGATGCCCGGCACGATGCCGGTCCGCCATCTGCATTTCGGGGG
CGGCACGCCGACGGTGATCGAGCCCGAGGACCTCGGCGCGATCATGACGCTGCTGCGCGAGCGCTTCGAATTCGTGCCCG
ATGCGGAGCTCGCGATCGAGAGCGATCCGCGCACCCTGACCGACGAGATGGTCGCCAAGATCGGCGAACTCGGCTTCACC
CGCGCCAGCTTCGGCGTCCAGGAGTTCGACCCCAAGGTCCAGGCGGCGATCAACCGGATTCAGCCGCCGGAGATGGTCGC
GCACGCCATGAGCCGCTTCAAGGCGGCCGGCGTCGAGCGGATCAATTTCGACCTGATCTACGGCCTGCCCTATCAGACCG
CCGAAGATCTGCGTAGCACCGTCGAGCAGTGCGTCGAGATGAAGCCCGACCGCGTCGCGCTGTTCGGCTACGCCCATGTG
CCGTGGGTCGCCAAGAACCAGCGGATGATCCCGGACGATTCGCTGCCGCAGTCGGATCTGCGCGCCGAGCAGGCCGACGC
CGCCGCCGAGGCGCTGGTCAAGGGCGGCTATGTGCGGATCGGCATCGATCACTTCGCGCTGCCCAAGGATTCGCTGGCGA
TCGCCGCCGCGACCGGCGAACTGCACCGCAATTTTCAGGGCTACACCAGCGACGCGGCGCAGACCCTGATCGGGATCGGC
GCCACCTCGATCGGTCGGACCCCGAGCGGCTATCTGCAGAACATCAGCGAGACCGGCGCCTGGGCGCGCGCCGTCGCGGC
CGGCCAGTTGCCGGTGGCGCGCGGGCACGCCCTGACCCAGCAGGACAATCTGCGGGCGCATGTGATCGAACGGATCATGT
GCGACGGCAAGATCGACCTCGCCGCCGCCGGCCGCGCTTTCGGCTGCAGCGATGATTGGTATGCGCCCGAGCAGGATGCG
CTCGCCGAGCTGCAGCGCGACGGCGCCGTGATCTGCGACCAGGGCAAGCTGACGCTGACGCCGGACGGCGTCCGGCTGTC
ACGCGTGGTCGCCGCGGTGTTCGATACCTACCTGCGGAATTCGTCGGTGCGGCATTCCATCGCCGTCTGA

Upstream 100 bases:

>100_bases
CGCCGCCAACATCTACGCCGACCGACGATCTCAGCCGATCGCGGCAAACACTGAAACCCTTTCCGCGCGTTGATCCGCGG
ACGATGTGAGAGACAAACCG

Downstream 100 bases:

>100_bases
AGCTCCAACGCCGTCCACTTGCAACGCGCGCTTCGGCGCGCGTTTTGCGTTTTGATGCAGGTCAATCCGAACAGGTCGCA
TCAGGTGCATAAGTACCGCC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSSALDKYAKSSVPRYTSYPTAPHFAKDFPEAVYRGWLAQLDTDEPISLYLHVPFCKQMCWYCGCNMKLASKYGPVADYV
ESLINEIDLVADAMPGTMPVRHLHFGGGTPTVIEPEDLGAIMTLLRERFEFVPDAELAIESDPRTLTDEMVAKIGELGFT
RASFGVQEFDPKVQAAINRIQPPEMVAHAMSRFKAAGVERINFDLIYGLPYQTAEDLRSTVEQCVEMKPDRVALFGYAHV
PWVAKNQRMIPDDSLPQSDLRAEQADAAAEALVKGGYVRIGIDHFALPKDSLAIAAATGELHRNFQGYTSDAAQTLIGIG
ATSIGRTPSGYLQNISETGAWARAVAAGQLPVARGHALTQQDNLRAHVIERIMCDGKIDLAAAGRAFGCSDDWYAPEQDA
LAELQRDGAVICDQGKLTLTPDGVRLSRVVAAVFDTYLRNSSVRHSIAV

Sequences:

>Translated_449_residues
MSSALDKYAKSSVPRYTSYPTAPHFAKDFPEAVYRGWLAQLDTDEPISLYLHVPFCKQMCWYCGCNMKLASKYGPVADYV
ESLINEIDLVADAMPGTMPVRHLHFGGGTPTVIEPEDLGAIMTLLRERFEFVPDAELAIESDPRTLTDEMVAKIGELGFT
RASFGVQEFDPKVQAAINRIQPPEMVAHAMSRFKAAGVERINFDLIYGLPYQTAEDLRSTVEQCVEMKPDRVALFGYAHV
PWVAKNQRMIPDDSLPQSDLRAEQADAAAEALVKGGYVRIGIDHFALPKDSLAIAAATGELHRNFQGYTSDAAQTLIGIG
ATSIGRTPSGYLQNISETGAWARAVAAGQLPVARGHALTQQDNLRAHVIERIMCDGKIDLAAAGRAFGCSDDWYAPEQDA
LAELQRDGAVICDQGKLTLTPDGVRLSRVVAAVFDTYLRNSSVRHSIAV
>Mature_448_residues
SSALDKYAKSSVPRYTSYPTAPHFAKDFPEAVYRGWLAQLDTDEPISLYLHVPFCKQMCWYCGCNMKLASKYGPVADYVE
SLINEIDLVADAMPGTMPVRHLHFGGGTPTVIEPEDLGAIMTLLRERFEFVPDAELAIESDPRTLTDEMVAKIGELGFTR
ASFGVQEFDPKVQAAINRIQPPEMVAHAMSRFKAAGVERINFDLIYGLPYQTAEDLRSTVEQCVEMKPDRVALFGYAHVP
WVAKNQRMIPDDSLPQSDLRAEQADAAAEALVKGGYVRIGIDHFALPKDSLAIAAATGELHRNFQGYTSDAAQTLIGIGA
TSIGRTPSGYLQNISETGAWARAVAAGQLPVARGHALTQQDNLRAHVIERIMCDGKIDLAAAGRAFGCSDDWYAPEQDAL
AELQRDGAVICDQGKLTLTPDGVRLSRVVAAVFDTYLRNSSVRHSIAV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=245, Percent_Identity=22.8571428571429, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI87082341, Length=440, Percent_Identity=37.7272727272727, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI1789325, Length=210, Percent_Identity=29.5238095238095, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 49098; Mature: 48967

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSALDKYAKSSVPRYTSYPTAPHFAKDFPEAVYRGWLAQLDTDEPISLYLHVPFCKQMC
CCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHH
WYCGCNMKLASKYGPVADYVESLINEIDLVADAMPGTMPVRHLHFGGGTPTVIEPEDLGA
HHHCCCCEEHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECHHHHHH
IMTLLRERFEFVPDAELAIESDPRTLTDEMVAKIGELGFTRASFGVQEFDPKVQAAINRI
HHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHCCHHHCCHHHHHHHHHC
QPPEMVAHAMSRFKAAGVERINFDLIYGLPYQTAEDLRSTVEQCVEMKPDRVALFGYAHV
CCHHHHHHHHHHHHHCCCCEECEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEC
PWVAKNQRMIPDDSLPQSDLRAEQADAAAEALVKGGYVRIGIDHFALPKDSLAIAAATGE
CEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECHHHCCCCCCEEEEEEHHH
LHRNFQGYTSDAAQTLIGIGATSIGRTPSGYLQNISETGAWARAVAAGQLPVARGHALTQ
HHHCCCCCCHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
QDNLRAHVIERIMCDGKIDLAAAGRAFGCSDDWYAPEQDALAELQRDGAVICDQGKLTLT
CCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCEEEEC
PDGVRLSRVVAAVFDTYLRNSSVRHSIAV
CCCHHHHHHHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure 
SSALDKYAKSSVPRYTSYPTAPHFAKDFPEAVYRGWLAQLDTDEPISLYLHVPFCKQMC
CHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHH
WYCGCNMKLASKYGPVADYVESLINEIDLVADAMPGTMPVRHLHFGGGTPTVIEPEDLGA
HHHCCCCEEHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECHHHHHH
IMTLLRERFEFVPDAELAIESDPRTLTDEMVAKIGELGFTRASFGVQEFDPKVQAAINRI
HHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHCCHHHCCHHHHHHHHHC
QPPEMVAHAMSRFKAAGVERINFDLIYGLPYQTAEDLRSTVEQCVEMKPDRVALFGYAHV
CCHHHHHHHHHHHHHCCCCEECEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEC
PWVAKNQRMIPDDSLPQSDLRAEQADAAAEALVKGGYVRIGIDHFALPKDSLAIAAATGE
CEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECHHHCCCCCCEEEEEEHHH
LHRNFQGYTSDAAQTLIGIGATSIGRTPSGYLQNISETGAWARAVAAGQLPVARGHALTQ
HHHCCCCCCHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
QDNLRAHVIERIMCDGKIDLAAAGRAFGCSDDWYAPEQDALAELQRDGAVICDQGKLTLT
CCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCEEEEC
PDGVRLSRVVAAVFDTYLRNSSVRHSIAV
CCCHHHHHHHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]