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The map label for this gene is vdh [H]

Identifier: 86750741

GI number: 86750741

Start: 4167329

End: 4168528

Strand: Direct

Name: vdh [H]

Synonym: RPB_3631

Alternate gene names: 86750741

Gene position: 4167329-4168528 (Clockwise)

Preceding gene: 86750740

Following gene: 86750742

Centisome position: 78.16

GC content: 63.42

Gene sequence:

>1200_bases
ATGACCGAGCGAGCGCCTGTCACCGATTGGGCCAGCGACTTCGACCACACCGACCCGCGCTGGACCGAAAACCCCTATCC
GATCTGGGACGAACTGCGCGCGGCGAGCCCGGTCGTCCACACCGACCGCTTCCTGGGCGTCTATATGCCGACCACCTTCG
CGGCGGTGAAGGAGATTTCCTACGACACCGACCACTTCTCGTCGCGGCGCATCATCGTCCGCAACAGCCGGCCCGAGCCG
GTGCAATCGGCGCCGCCGATTACTTCAGATCCGCCGGAACACAAGCCGGCCAAGCGCCTGCTGCTGCCGCCGTTCACGCC
CGATGCGGTGGCCAAGCTCGAGCCGCGGGTTCGCTCGATCTGCAATGAACTGATCGACGATTTCATCGCGGATGGTCGCT
GCGACGCCGCGAAGGCCTACAGCAAGCACATTCCGGTCAAGACGATCTGCGCGATGCTCGGCATTCCAGAGACCGACAGC
GACCGGTTCATCCAGTGGATTCACGAAATCCTCGAACTCGGTATCCATGACGACGCGATGCTGATGAAGGCGATTCAGGA
AATGAGCGTGTACTTCGCCGGCCACATCGCGAAGCGCAAGCAGCATCCGACCGACGATCTGATCAGCACGCTGATGAACG
CGCGCGATGCCGACGGCCAGCCACTGTCCGATGTCCATGTGCTCGGCTCGTTGCGCCTGCTGCTGATCGCCGGCATCGAC
ACGACGTGGAGCGCGATCGGCGCGGCGTTGTGGCATCTGGCGACGCATCCGGAAGATCGCGTCCGGCTTGTCGCCGAGCC
GGACCTGATGTCGACGGCTATCGAAGAACTTCTCCGCGCCTATGCGCCGGTCACCATGGCCCGCGAGGTGATGAAGGAGA
CCACGATCGCCGGCTGCCCGGTGAAGCCCGGCAACATGGTGTTGCTGTCGTTCCCCGCCGCCAACCGCGATCCCGACGTC
TTCCCCGACGCCGATCGGGTCAAGATCGACCGCCAAGAAAATCCTCACGTCGCGTTCGGCCTCGGTATTCACCGCTGCGT
CGGGTCCAACTTGGCGCGAATGGAGATGACGGTTGCGATCGAGGAATGGCTGAAACGGATTCCGGAGTTTAGACTGGATT
CGTCACAAAATGTGCGCTGGTCGGAAGGTACGGTTCGTGGCCCGCGCCAACTGCCGCTGCTGCTCGGCCAGCCGAGCTGA

Upstream 100 bases:

>100_bases
CTGCCCGGAAAACGCGATCGACATCACAGAAGACTGATCTCGTTCATTCAAGTCGCGGCGCAGACCGTGACGCCAACGAT
AGCCGGAGGGAGAACGCGCA

Downstream 100 bases:

>100_bases
ACGAGGCCGAAAGAGACCCGATGTCCGACGATGCCGACCTTCCTCCCGACTCCAAGCTCACTCGGAGCAAGCAGCGTTGG
GCGGCCGAAGGCAAATTCAT

Product: cytochrome P450

Products: NA

Alternate protein names: Cytochrome P450 [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTERAPVTDWASDFDHTDPRWTENPYPIWDELRAASPVVHTDRFLGVYMPTTFAAVKEISYDTDHFSSRRIIVRNSRPEP
VQSAPPITSDPPEHKPAKRLLLPPFTPDAVAKLEPRVRSICNELIDDFIADGRCDAAKAYSKHIPVKTICAMLGIPETDS
DRFIQWIHEILELGIHDDAMLMKAIQEMSVYFAGHIAKRKQHPTDDLISTLMNARDADGQPLSDVHVLGSLRLLLIAGID
TTWSAIGAALWHLATHPEDRVRLVAEPDLMSTAIEELLRAYAPVTMAREVMKETTIAGCPVKPGNMVLLSFPAANRDPDV
FPDADRVKIDRQENPHVAFGLGIHRCVGSNLARMEMTVAIEEWLKRIPEFRLDSSQNVRWSEGTVRGPRQLPLLLGQPS

Sequences:

>Translated_399_residues
MTERAPVTDWASDFDHTDPRWTENPYPIWDELRAASPVVHTDRFLGVYMPTTFAAVKEISYDTDHFSSRRIIVRNSRPEP
VQSAPPITSDPPEHKPAKRLLLPPFTPDAVAKLEPRVRSICNELIDDFIADGRCDAAKAYSKHIPVKTICAMLGIPETDS
DRFIQWIHEILELGIHDDAMLMKAIQEMSVYFAGHIAKRKQHPTDDLISTLMNARDADGQPLSDVHVLGSLRLLLIAGID
TTWSAIGAALWHLATHPEDRVRLVAEPDLMSTAIEELLRAYAPVTMAREVMKETTIAGCPVKPGNMVLLSFPAANRDPDV
FPDADRVKIDRQENPHVAFGLGIHRCVGSNLARMEMTVAIEEWLKRIPEFRLDSSQNVRWSEGTVRGPRQLPLLLGQPS
>Mature_398_residues
TERAPVTDWASDFDHTDPRWTENPYPIWDELRAASPVVHTDRFLGVYMPTTFAAVKEISYDTDHFSSRRIIVRNSRPEPV
QSAPPITSDPPEHKPAKRLLLPPFTPDAVAKLEPRVRSICNELIDDFIADGRCDAAKAYSKHIPVKTICAMLGIPETDSD
RFIQWIHEILELGIHDDAMLMKAIQEMSVYFAGHIAKRKQHPTDDLISTLMNARDADGQPLSDVHVLGSLRLLLIAGIDT
TWSAIGAALWHLATHPEDRVRLVAEPDLMSTAIEELLRAYAPVTMAREVMKETTIAGCPVKPGNMVLLSFPAANRDPDVF
PDADRVKIDRQENPHVAFGLGIHRCVGSNLARMEMTVAIEEWLKRIPEFRLDSSQNVRWSEGTVRGPRQLPLLLGQPS

Specific function: Hydroxylates vitamin D(3) into 25-hydroxyvitamin D(3) and 1-alpha,25-dihydroxyvitamin D(3), its physiologically active forms. It first hydroxylates the C-25 position of vitamin D(3) to form 25-hydroxyvitamin D(3), then subsequently hydroxylates the C- 1-a

COG id: COG2124

COG function: function code Q; Cytochrome P450

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family [H]

Homologues:

Organism=Homo sapiens, GI158138530, Length=307, Percent_Identity=25.4071661237785, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001128
- InterPro:   IPR002397
- InterPro:   IPR017972 [H]

Pfam domain/function: PF00067 p450 [H]

EC number: =1.14.13.15 [H]

Molecular weight: Translated: 44731; Mature: 44599

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00086 CYTOCHROME_P450

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERAPVTDWASDFDHTDPRWTENPYPIWDELRAASPVVHTDRFLGVYMPTTFAAVKEIS
CCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHEEECHHHHHHHHHHC
YDTDHFSSRRIIVRNSRPEPVQSAPPITSDPPEHKPAKRLLLPPFTPDAVAKLEPRVRSI
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHCCHHHHHH
CNELIDDFIADGRCDAAKAYSKHIPVKTICAMLGIPETDSDRFIQWIHEILELGIHDDAM
HHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHH
LMKAIQEMSVYFAGHIAKRKQHPTDDLISTLMNARDADGQPLSDVHVLGSLRLLLIAGID
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHEECCC
TTWSAIGAALWHLATHPEDRVRLVAEPDLMSTAIEELLRAYAPVTMAREVMKETTIAGCP
HHHHHHHHHHHHHHCCCHHHEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
VKPGNMVLLSFPAANRDPDVFPDADRVKIDRQENPHVAFGLGIHRCVGSNLARMEMTVAI
CCCCCEEEEECCCCCCCCCCCCCCCCEEECCCCCCCEEECCHHHHHHCCCHHHHHHHHHH
EEWLKRIPEFRLDSSQNVRWSEGTVRGPRQLPLLLGQPS
HHHHHHCCHHCCCCCCCCEECCCCCCCCCCCCEEECCCC
>Mature Secondary Structure 
TERAPVTDWASDFDHTDPRWTENPYPIWDELRAASPVVHTDRFLGVYMPTTFAAVKEIS
CCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHEEECHHHHHHHHHHC
YDTDHFSSRRIIVRNSRPEPVQSAPPITSDPPEHKPAKRLLLPPFTPDAVAKLEPRVRSI
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHCCHHHHHH
CNELIDDFIADGRCDAAKAYSKHIPVKTICAMLGIPETDSDRFIQWIHEILELGIHDDAM
HHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHH
LMKAIQEMSVYFAGHIAKRKQHPTDDLISTLMNARDADGQPLSDVHVLGSLRLLLIAGID
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHEECCC
TTWSAIGAALWHLATHPEDRVRLVAEPDLMSTAIEELLRAYAPVTMAREVMKETTIAGCP
HHHHHHHHHHHHHHCCCHHHEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
VKPGNMVLLSFPAANRDPDVFPDADRVKIDRQENPHVAFGLGIHRCVGSNLARMEMTVAI
CCCCCEEEEECCCCCCCCCCCCCCCCEEECCCCCCCEEECCHHHHHHCCCHHHHHHHHHH
EEWLKRIPEFRLDSSQNVRWSEGTVRGPRQLPLLLGQPS
HHHHHHCCHHCCCCCCCCEECCCCCCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA