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The map label for this gene is serA [H]

Identifier: 86750734

GI number: 86750734

Start: 4159638

End: 4160552

Strand: Direct

Name: serA [H]

Synonym: RPB_3624

Alternate gene names: 86750734

Gene position: 4159638-4160552 (Clockwise)

Preceding gene: 86750733

Following gene: 86750735

Centisome position: 78.02

GC content: 67.43

Gene sequence:

>915_bases
ATGCACGCGGTGTTCGTCGACGCCAGCGAAACGCTGGCGATGATCATGGAAGCTCAGGCCCTGCCGGACGATCCGCCGAT
GGTGATCCATCGCGATCCCGACGTGACGCCGGAGGAGCTGCCCGGCGTACTCGCCGGCGCCGAGATCGCGATCATCGATC
ACACTTATCTGCCGACCGATATCGCACGGCAATGCGCCGGCCTGAAGCACGTGGTGTTTCTCGGCACCGGCGCGCGCAGC
TACATGAACATCGAGGAATTGGCCGAACTCGGCATCTCGGTGCATCTGATCCGCGGCTATGGCGATACGGCCGTTGCCGA
GGCGACCATCGCGCTGATGTGGGCGGCCGCGCGCAACCTCGCGCTGATGGACCGCGAGATGCGCGCCGGCCAATGGCTGC
GTGAGGACGGCATGCAACTCACCGGCAAGACCCTCGGCCTGATCGGATTCGGCGGCATCGGCGCCGAGGTCGCGCGGATC
GCGCATGGCTCCGGCATGAAGGTGATCGCCTGGAATCGCACGCCGAAGCCGACGCCCGGCGTGACGTTCGTCGACATCGA
CACGCTGCTGCGCGACAGCCACGTCGTCTCGTTACACCTGCTGCTCGACGACGAGACCCGCGGTTTCCTGTCGCGCGAAC
GCATCGCCGCGATGCGGCCCGGCGCGATCTTGGTCAACACCGCGCGCGCCGGCCTCACCGACGAGGCCGCGATGATCGAG
GCACTGCGATCCGGCCATCTGCGCCACGCCGCGCTCGACGTGTTCGAGATCGAACCGCTGCCGGCGGACCATCCGCTGAC
AACGCTGCCCAACGTCACGCTGTCGGCCCACTCGGCATTCCGCACGCCCGAGGCGAGTGACAACCTGATCGCCGCATCGC
TCGCGCATTGCCGGCGGATCGCGGCAGTGGAGTAG

Upstream 100 bases:

>100_bases
CGCAGACCGACTGCGCCTCCGGCGCCAATGTGCTGCTGCACACGGTGCTGTCGCTCGCGGGCGTCGCGAAGTAACAGTAA
AACAAAACCGGGGGACCAGG

Downstream 100 bases:

>100_bases
CTAACAAGCTCCGGCGACCCGGGGGCGGCAATTAGCTACCAGATTCGCGCGGCGCGCTGCTTACGGGCCGTGATCCGGAT
CAAGGCCGGATCGACCATCC

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MHAVFVDASETLAMIMEAQALPDDPPMVIHRDPDVTPEELPGVLAGAEIAIIDHTYLPTDIARQCAGLKHVVFLGTGARS
YMNIEELAELGISVHLIRGYGDTAVAEATIALMWAAARNLALMDREMRAGQWLREDGMQLTGKTLGLIGFGGIGAEVARI
AHGSGMKVIAWNRTPKPTPGVTFVDIDTLLRDSHVVSLHLLLDDETRGFLSRERIAAMRPGAILVNTARAGLTDEAAMIE
ALRSGHLRHAALDVFEIEPLPADHPLTTLPNVTLSAHSAFRTPEASDNLIAASLAHCRRIAAVE

Sequences:

>Translated_304_residues
MHAVFVDASETLAMIMEAQALPDDPPMVIHRDPDVTPEELPGVLAGAEIAIIDHTYLPTDIARQCAGLKHVVFLGTGARS
YMNIEELAELGISVHLIRGYGDTAVAEATIALMWAAARNLALMDREMRAGQWLREDGMQLTGKTLGLIGFGGIGAEVARI
AHGSGMKVIAWNRTPKPTPGVTFVDIDTLLRDSHVVSLHLLLDDETRGFLSRERIAAMRPGAILVNTARAGLTDEAAMIE
ALRSGHLRHAALDVFEIEPLPADHPLTTLPNVTLSAHSAFRTPEASDNLIAASLAHCRRIAAVE
>Mature_304_residues
MHAVFVDASETLAMIMEAQALPDDPPMVIHRDPDVTPEELPGVLAGAEIAIIDHTYLPTDIARQCAGLKHVVFLGTGARS
YMNIEELAELGISVHLIRGYGDTAVAEATIALMWAAARNLALMDREMRAGQWLREDGMQLTGKTLGLIGFGGIGAEVARI
AHGSGMKVIAWNRTPKPTPGVTFVDIDTLLRDSHVVSLHLLLDDETRGFLSRERIAAMRPGAILVNTARAGLTDEAAMIE
ALRSGHLRHAALDVFEIEPLPADHPLTTLPNVTLSAHSAFRTPEASDNLIAASLAHCRRIAAVE

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI145580578, Length=286, Percent_Identity=32.8671328671329, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4557499, Length=286, Percent_Identity=32.8671328671329, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI23308577, Length=274, Percent_Identity=31.3868613138686, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI145580575, Length=249, Percent_Identity=33.7349397590361, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI4557497, Length=273, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI61743967, Length=273, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI6912396, Length=222, Percent_Identity=28.3783783783784, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87082289, Length=206, Percent_Identity=35.9223300970874, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787645, Length=254, Percent_Identity=31.1023622047244, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789279, Length=249, Percent_Identity=30.5220883534137, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081824, Length=161, Percent_Identity=31.055900621118, Blast_Score=74, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=174, Percent_Identity=31.6091954022989, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI25147481, Length=239, Percent_Identity=28.4518828451883, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324055, Length=196, Percent_Identity=32.6530612244898, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=257, Percent_Identity=27.6264591439689, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322116, Length=224, Percent_Identity=29.0178571428571, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324964, Length=270, Percent_Identity=25.9259259259259, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24646446, Length=292, Percent_Identity=32.8767123287671, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646448, Length=292, Percent_Identity=32.8767123287671, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646452, Length=292, Percent_Identity=32.8767123287671, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646450, Length=292, Percent_Identity=32.8767123287671, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI62472511, Length=284, Percent_Identity=34.1549295774648, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI28571528, Length=220, Percent_Identity=33.6363636363636, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574286, Length=226, Percent_Identity=30.5309734513274, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585516, Length=211, Percent_Identity=31.2796208530806, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI19921140, Length=196, Percent_Identity=30.1020408163265, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45552429, Length=238, Percent_Identity=27.7310924369748, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24585514, Length=238, Percent_Identity=27.7310924369748, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28574282, Length=238, Percent_Identity=27.7310924369748, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28574284, Length=238, Percent_Identity=27.7310924369748, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45551003, Length=238, Percent_Identity=27.7310924369748, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 32700; Mature: 32700

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAVFVDASETLAMIMEAQALPDDPPMVIHRDPDVTPEELPGVLAGAEIAIIDHTYLPTD
CEEEEECCHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHCCCCCCCCEEEEEECCCCCHH
IARQCAGLKHVVFLGTGARSYMNIEELAELGISVHLIRGYGDTAVAEATIALMWAAARNL
HHHHHCCCEEEEEEECCCHHHCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCH
ALMDREMRAGQWLREDGMQLTGKTLGLIGFGGIGAEVARIAHGSGMKVIAWNRTPKPTPG
HHHHHHHHHHHHHHHCCCEECCCEEEEEEECCCHHHHHHHHCCCCCEEEEECCCCCCCCC
VTFVDIDTLLRDSHVVSLHLLLDDETRGFLSRERIAAMRPGAILVNTARAGLTDEAAMIE
EEEEEHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHH
ALRSGHLRHAALDVFEIEPLPADHPLTTLPNVTLSAHSAFRTPEASDNLIAASLAHCRRI
HHHCCCCHHHEEEEEEECCCCCCCCCCCCCCCEEECCHHCCCCCCCCCHHHHHHHHHHHH
AAVE
HCCC
>Mature Secondary Structure
MHAVFVDASETLAMIMEAQALPDDPPMVIHRDPDVTPEELPGVLAGAEIAIIDHTYLPTD
CEEEEECCHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHCCCCCCCCEEEEEECCCCCHH
IARQCAGLKHVVFLGTGARSYMNIEELAELGISVHLIRGYGDTAVAEATIALMWAAARNL
HHHHHCCCEEEEEEECCCHHHCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCH
ALMDREMRAGQWLREDGMQLTGKTLGLIGFGGIGAEVARIAHGSGMKVIAWNRTPKPTPG
HHHHHHHHHHHHHHHCCCEECCCEEEEEEECCCHHHHHHHHCCCCCEEEEECCCCCCCCC
VTFVDIDTLLRDSHVVSLHLLLDDETRGFLSRERIAAMRPGAILVNTARAGLTDEAAMIE
EEEEEHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHH
ALRSGHLRHAALDVFEIEPLPADHPLTTLPNVTLSAHSAFRTPEASDNLIAASLAHCRRI
HHHCCCCHHHEEEEEEECCCCCCCCCCCCCCCEEECCHHCCCCCCCCCHHHHHHHHHHHH
AAVE
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]