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The map label for this gene is gltR [H]

Identifier: 86750732

GI number: 86750732

Start: 4157347

End: 4158297

Strand: Direct

Name: gltR [H]

Synonym: RPB_3622

Alternate gene names: 86750732

Gene position: 4157347-4158297 (Clockwise)

Preceding gene: 86750725

Following gene: 86750733

Centisome position: 77.97

GC content: 64.88

Gene sequence:

>951_bases
ATGGTGGACTTCAAGGCGCTCGAAACCTTCCTCTGGGTCGTCACGCTCGGCAGCTTTCGCGGCGCGGCGCAGAAACTCAA
CACCACCCAGCCGGCGATCTCGCAGCGCATCGCCCAACTCGAGCGCGAGCTCGGCGTGCGGCTGCTGCAGCGCGACCATC
GGATGGCGTCGCCGACGCCGAGCGGACGGCAACTGATGCTGTATGCGGAGAAGCTGATCGGGCTGCGTACCGAGATGCTG
GCCGCGATCGGCGATCAATCCAGCATGCGCGGCGTGTTGCGGCTCGGCGTCGCCGAAACCATCGTGCACACGTGGCTGCC
GCGACTGATCGAACGCGTGAACCGGCTCTATCCCAACCTGTCGCTGGAGATCGAGGTCGACATCACCCCGAATTTGCGTG
CGCGGCTGCTGGCGCAGGAGATCGAGTTGGCGTTCCTGCTGGGGCCGATGACGGCATCGACGGTGCGCAGCCGCGTGCTG
TGCGACTACGAGATCGGTTTCCTGGCGAGCCCATCACTCGGCCTCGGCACCGGACTGCTGAATGTGAACGATCTCGCCAG
GTTTCCGATCATCACCTTCCCGCGCAAGACCCAGCCCTACGAGATCGTGCGCTCGCTGTTCAACAAGCCGGAATTGCCGC
CGATCCGCCTGCACGCCTCAGCGTCGCTCGGCACCGTCATCCACATGGCGATCCAGGGTCTGGGCGTGGCCGTGATTCCG
ACCGCGATCGTCGAGGACGAACTCGCCGACCGCCGGCTCCAATTGCTGCAGACCGATCTGAAGATTTCGCCGTTGCGCTT
CTCTGCGAGTTGGCTCGCCTCGCCCGACACCATCGCGATCGAGCGCGTCGCCGAACTTGCGGCCGAGATCGCACACTCCG
GAGGCTTCATGCCGGAGACGTCTCATCTGGCACCAGACATTCTGCCCGCCGAAGAGCCAGTGGCAGGTTGA

Upstream 100 bases:

>100_bases
TCTCTCGACAGCAATGGAGCGCAAGCCTAATATAATGTCTAATCTTTGTTTCTGATCAGAAACGATAAATTGCCGTTATC
TCTTGAAGAGGAGTCGCCCC

Downstream 100 bases:

>100_bases
CGCGCGCCGCGCGGCGTTGAAATCTTCACCCTTCCTCGCGCCGTCGGCGCTTCGTCCGGAGATCGCATGACCAAGCCTGC
CTCGAACCTGCAGATCGATT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MVDFKALETFLWVVTLGSFRGAAQKLNTTQPAISQRIAQLERELGVRLLQRDHRMASPTPSGRQLMLYAEKLIGLRTEML
AAIGDQSSMRGVLRLGVAETIVHTWLPRLIERVNRLYPNLSLEIEVDITPNLRARLLAQEIELAFLLGPMTASTVRSRVL
CDYEIGFLASPSLGLGTGLLNVNDLARFPIITFPRKTQPYEIVRSLFNKPELPPIRLHASASLGTVIHMAIQGLGVAVIP
TAIVEDELADRRLQLLQTDLKISPLRFSASWLASPDTIAIERVAELAAEIAHSGGFMPETSHLAPDILPAEEPVAG

Sequences:

>Translated_316_residues
MVDFKALETFLWVVTLGSFRGAAQKLNTTQPAISQRIAQLERELGVRLLQRDHRMASPTPSGRQLMLYAEKLIGLRTEML
AAIGDQSSMRGVLRLGVAETIVHTWLPRLIERVNRLYPNLSLEIEVDITPNLRARLLAQEIELAFLLGPMTASTVRSRVL
CDYEIGFLASPSLGLGTGLLNVNDLARFPIITFPRKTQPYEIVRSLFNKPELPPIRLHASASLGTVIHMAIQGLGVAVIP
TAIVEDELADRRLQLLQTDLKISPLRFSASWLASPDTIAIERVAELAAEIAHSGGFMPETSHLAPDILPAEEPVAG
>Mature_316_residues
MVDFKALETFLWVVTLGSFRGAAQKLNTTQPAISQRIAQLERELGVRLLQRDHRMASPTPSGRQLMLYAEKLIGLRTEML
AAIGDQSSMRGVLRLGVAETIVHTWLPRLIERVNRLYPNLSLEIEVDITPNLRARLLAQEIELAFLLGPMTASTVRSRVL
CDYEIGFLASPSLGLGTGLLNVNDLARFPIITFPRKTQPYEIVRSLFNKPELPPIRLHASASLGTVIHMAIQGLGVAVIP
TAIVEDELADRRLQLLQTDLKISPLRFSASWLASPDTIAIERVAELAAEIAHSGGFMPETSHLAPDILPAEEPVAG

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693105, Length=154, Percent_Identity=31.8181818181818, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786401, Length=277, Percent_Identity=27.7978339350181, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788626, Length=248, Percent_Identity=27.4193548387097, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788481, Length=250, Percent_Identity=26.8, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787806, Length=245, Percent_Identity=24.0816326530612, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789204, Length=240, Percent_Identity=25.8333333333333, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788297, Length=242, Percent_Identity=25.2066115702479, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788706, Length=176, Percent_Identity=28.4090909090909, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI157672245, Length=147, Percent_Identity=29.9319727891156, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1789639, Length=267, Percent_Identity=26.2172284644195, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI87082132, Length=173, Percent_Identity=26.0115606936416, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34772; Mature: 34772

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDFKALETFLWVVTLGSFRGAAQKLNTTQPAISQRIAQLERELGVRLLQRDHRMASPTP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SGRQLMLYAEKLIGLRTEMLAAIGDQSSMRGVLRLGVAETIVHTWLPRLIERVNRLYPNL
CCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SLEIEVDITPNLRARLLAQEIELAFLLGPMTASTVRSRVLCDYEIGFLASPSLGLGTGLL
EEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEECCCEEECCCCCCCCCCC
NVNDLARFPIITFPRKTQPYEIVRSLFNKPELPPIRLHASASLGTVIHMAIQGLGVAVIP
CHHHHHHCCEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHCCHHHHH
TAIVEDELADRRLQLLQTDLKISPLRFSASWLASPDTIAIERVAELAAEIAHSGGFMPET
HHHHHHHHHHHHHHHHHHCCCCCCEEECHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
SHLAPDILPAEEPVAG
CCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVDFKALETFLWVVTLGSFRGAAQKLNTTQPAISQRIAQLERELGVRLLQRDHRMASPTP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SGRQLMLYAEKLIGLRTEMLAAIGDQSSMRGVLRLGVAETIVHTWLPRLIERVNRLYPNL
CCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SLEIEVDITPNLRARLLAQEIELAFLLGPMTASTVRSRVLCDYEIGFLASPSLGLGTGLL
EEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHEEEECCCEEECCCCCCCCCCC
NVNDLARFPIITFPRKTQPYEIVRSLFNKPELPPIRLHASASLGTVIHMAIQGLGVAVIP
CHHHHHHCCEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHCCHHHHH
TAIVEDELADRRLQLLQTDLKISPLRFSASWLASPDTIAIERVAELAAEIAHSGGFMPET
HHHHHHHHHHHHHHHHHHCCCCCCEEECHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
SHLAPDILPAEEPVAG
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]