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The map label for this gene is fadH [H]

Identifier: 86750709

GI number: 86750709

Start: 4129228

End: 4130100

Strand: Direct

Name: fadH [H]

Synonym: RPB_3599

Alternate gene names: 86750709

Gene position: 4129228-4130100 (Clockwise)

Preceding gene: 86750706

Following gene: 86750710

Centisome position: 77.45

GC content: 65.75

Gene sequence:

>873_bases
ATGTTCTCCGATCAGCTTCTCGCAGGCCGTCGTATCCTCGTCACCGGTGGCGGCACCGGGCTCGGCAAATCGATGGCCGC
GCGCTTCCTGCAGCTCGGCGCCGAAGTCCATATCTGCGGCCGCCGCAAGGGCGTCTGCGACGAGACCGCGACCGAACTGA
TGGATCAGTACGGCGGCAAGGTGATGACCTACGGCGTCGACATCCGCGACTCGGCCGCGGTCGACCACATGGTCGAGACC
ATCTTCGCCGACGGCCCGCTCACCGATCTGATCAACAACGCCGCCGGAAATTTCATCTCGCGGACGGAAGAGCTGTCGCC
GCGCGGCTTTGACGCCGTCGCCAACATCGTGATGCACGGCACCTTCTACGTGACGCATGCGGTCGGCCGGCGCTGGATCG
CCGGCGGCCACCGCGGCAATGTGGTGTCGATCACCACCACCTGGGTCCGCAACGGCAGCCCCTATGTGGTGCCCTCGGCG
ATGAGCAAATCGGCGATCCACGCCATGACGATGTCGCTCGCCACCGAATGGGGCCGCTACGGCATCCGCCTCAACACCAT
TGCGCCCGGCGAAATTCCCACCGAAGGCATGAGCAAGCGGATCAAGCCCGGCGACGAGGCCGGCGCCCGCACCGTGAAGG
TGAATCCGATGGGCCGCGTCGGCACCATGGAGGAACTGCAGAACGTCGCGGTGTTCCTGATCTCCGGCGGCTGCGACTGG
ATCAACGGCGAAACCATCGCGATGGACGGCGCCCAGGGCCTGGCGATGGGCGGCAATTTCTATCAGCTGCGCGACTGGAG
CAACGCCGACTGGGACCAGGCCAAGGCCTCGATCAAGGCGCAGAACGAAAAAGACCGCGCACAGCGGGGGTGA

Upstream 100 bases:

>100_bases
GGATATGTTGTGATCTGTTCGCGGCGCTACAGAAAAGCGTTGTCGGAATTTAGTCAATCGCTTAATCAACAACGATCATC
CACTTTTCCGGGCACCTGAC

Downstream 100 bases:

>100_bases
TACGTTCACGGCCGTCATCCTGAGGTGCGCGCTCTTGCGCGCCTCGAAGGATGACAGCAGCGAGCGCCTGCGGCCCATCC
TTCGAGGCCGTCGCAGATGC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MFSDQLLAGRRILVTGGGTGLGKSMAARFLQLGAEVHICGRRKGVCDETATELMDQYGGKVMTYGVDIRDSAAVDHMVET
IFADGPLTDLINNAAGNFISRTEELSPRGFDAVANIVMHGTFYVTHAVGRRWIAGGHRGNVVSITTTWVRNGSPYVVPSA
MSKSAIHAMTMSLATEWGRYGIRLNTIAPGEIPTEGMSKRIKPGDEAGARTVKVNPMGRVGTMEELQNVAVFLISGGCDW
INGETIAMDGAQGLAMGGNFYQLRDWSNADWDQAKASIKAQNEKDRAQRG

Sequences:

>Translated_290_residues
MFSDQLLAGRRILVTGGGTGLGKSMAARFLQLGAEVHICGRRKGVCDETATELMDQYGGKVMTYGVDIRDSAAVDHMVET
IFADGPLTDLINNAAGNFISRTEELSPRGFDAVANIVMHGTFYVTHAVGRRWIAGGHRGNVVSITTTWVRNGSPYVVPSA
MSKSAIHAMTMSLATEWGRYGIRLNTIAPGEIPTEGMSKRIKPGDEAGARTVKVNPMGRVGTMEELQNVAVFLISGGCDW
INGETIAMDGAQGLAMGGNFYQLRDWSNADWDQAKASIKAQNEKDRAQRG
>Mature_290_residues
MFSDQLLAGRRILVTGGGTGLGKSMAARFLQLGAEVHICGRRKGVCDETATELMDQYGGKVMTYGVDIRDSAAVDHMVET
IFADGPLTDLINNAAGNFISRTEELSPRGFDAVANIVMHGTFYVTHAVGRRWIAGGHRGNVVSITTTWVRNGSPYVVPSA
MSKSAIHAMTMSLATEWGRYGIRLNTIAPGEIPTEGMSKRIKPGDEAGARTVKVNPMGRVGTMEELQNVAVFLISGGCDW
INGETIAMDGAQGLAMGGNFYQLRDWSNADWDQAKASIKAQNEKDRAQRG

Specific function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503301, Length=249, Percent_Identity=40.9638554216867, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI19923817, Length=269, Percent_Identity=31.9702602230483, Blast_Score=134, Evalue=7e-32,
Organism=Homo sapiens, GI10190704, Length=270, Percent_Identity=30.3703703703704, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=27.4900398406374, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI7705925, Length=251, Percent_Identity=26.2948207171315, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI59889578, Length=212, Percent_Identity=30.6603773584906, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=27.710843373494, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1789208, Length=249, Percent_Identity=29.3172690763052, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790717, Length=254, Percent_Identity=30.3149606299213, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=32.520325203252, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=25.7936507936508, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI87082160, Length=246, Percent_Identity=24.7967479674797, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=29.0697674418605, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787335, Length=246, Percent_Identity=26.4227642276423, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=24.3243243243243, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787820, Length=208, Percent_Identity=26.9230769230769, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=296, Percent_Identity=39.527027027027, Blast_Score=200, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17536651, Length=297, Percent_Identity=38.3838383838384, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17561272, Length=273, Percent_Identity=39.5604395604396, Blast_Score=192, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=26.1904761904762, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=278, Percent_Identity=25.5395683453237, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=278, Percent_Identity=26.978417266187, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562908, Length=284, Percent_Identity=27.4647887323944, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=284, Percent_Identity=25.7042253521127, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=25.2032520325203, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=276, Percent_Identity=27.536231884058, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=273, Percent_Identity=25.2747252747253, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=274, Percent_Identity=24.8175182481752, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=224, Percent_Identity=27.6785714285714, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=269, Percent_Identity=23.7918215613383, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=242, Percent_Identity=24.3801652892562, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=284, Percent_Identity=24.2957746478873, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=257, Percent_Identity=25.2918287937743, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=267, Percent_Identity=24.7191011235955, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=269, Percent_Identity=25.2788104089219, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=250, Percent_Identity=27.6, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=28.5140562248996, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357041, Length=246, Percent_Identity=27.2357723577236, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24643142, Length=251, Percent_Identity=27.8884462151394, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571526, Length=246, Percent_Identity=26.4227642276423, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=27.0161290322581, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=27.1317829457364, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24644339, Length=250, Percent_Identity=24.4, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 31230; Mature: 31230

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSDQLLAGRRILVTGGGTGLGKSMAARFLQLGAEVHICGRRKGVCDETATELMDQYGGK
CCCCCEECCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCE
VMTYGVDIRDSAAVDHMVETIFADGPLTDLINNAAGNFISRTEELSPRGFDAVANIVMHG
EEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHH
TFYVTHAVGRRWIAGGHRGNVVSITTTWVRNGSPYVVPSAMSKSAIHAMTMSLATEWGRY
HHEEEHHHCCCEECCCCCCCEEEEEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHC
GIRLNTIAPGEIPTEGMSKRIKPGDEAGARTVKVNPMGRVGTMEELQNVAVFLISGGCDW
CEEEEEECCCCCCCHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHCCEEEEEEECCCCE
INGETIAMDGAQGLAMGGNFYQLRDWSNADWDQAKASIKAQNEKDRAQRG
ECCCEEEECCCCCEEECCCEEEECCCCCCCHHHHHHHHHCCCCHHHHCCC
>Mature Secondary Structure
MFSDQLLAGRRILVTGGGTGLGKSMAARFLQLGAEVHICGRRKGVCDETATELMDQYGGK
CCCCCEECCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCE
VMTYGVDIRDSAAVDHMVETIFADGPLTDLINNAAGNFISRTEELSPRGFDAVANIVMHG
EEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHH
TFYVTHAVGRRWIAGGHRGNVVSITTTWVRNGSPYVVPSAMSKSAIHAMTMSLATEWGRY
HHEEEHHHCCCEECCCCCCCEEEEEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHC
GIRLNTIAPGEIPTEGMSKRIKPGDEAGARTVKVNPMGRVGTMEELQNVAVFLISGGCDW
CEEEEEECCCCCCCHHHHCCCCCCCCCCCEEEEECCCCCCCCHHHHCCEEEEEEECCCCE
INGETIAMDGAQGLAMGGNFYQLRDWSNADWDQAKASIKAQNEKDRAQRG
ECCCEEEECCCCCEEECCCEEEECCCCCCCHHHHHHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]