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The map label for this gene is rcsC [C]

Identifier: 86750625

GI number: 86750625

Start: 4022926

End: 4024809

Strand: Reverse

Name: rcsC [C]

Synonym: RPB_3515

Alternate gene names: 86750625

Gene position: 4024809-4022926 (Counterclockwise)

Preceding gene: 86750628

Following gene: 86750624

Centisome position: 75.49

GC content: 69.43

Gene sequence:

>1884_bases
TTGGGCGCCAACCAGAAACGGGGGCGCTACCTCCCGTCACGAGCGACAGCGAGCGCGGACAGCGTGGCACTATCCAGAAT
CATCGGCGAGAGACTCGACGCTTTGCTGCACCCGTCGGCGCGTTACGACGCGCTCGCGAGTGCGCGGCATCGCGCCTTCA
TCGCGCCGCGGCTGTTCGGCAGCCTCGCGGCGTTCGCCGCGTTTCCGATCTATCTGGCGATGCGCGGCGCGCCGACCGCG
CTCGAGGCGCTGGCGTTCGCCTGGCTGATCGCGCCGATCCTGCTGTCGTGGTTCCTGTCGCGCACCGGCCGCTACGAGAG
CGCGCATGTGCTGTCGTCGCTGTCGCTGACCGGCCTGATCCTGGTGATCGCGACGCTCACCGGCGGCATCACCTCCTTCG
CCGCGATCTGGCTGATCCTGGTGCCGCTCGAGGCCGCGTTGTCGGCGTCGCGCCGCGTCGTCGCTTTCGCCGCGATGCTG
GCGCTCGGCGCCGCCGCCGTGCTGATCGCGATCGGCCAGCTCGGCTGGCTGCCCGCGGCGCCCGCCGGCGACGTGTCGCA
CGGCGCGCTGATGGCGGTCAGCGTCGCATCGGCGACGCTGTACGCGGCCGGTCTCGCGTTCGGATCGGAATCGCTGACGC
GCACCAGCGACACGCTGCTCAGCGTCGAGGAAGAGCGCTACCGGCTGCTCGCCCGGCACATGAGCGACGTGATTTCGCGC
CACGGCCGCAACGGCGCGGTGCAGTTCATTTCGCCGGCGGTCGAAGCGCTGATCGGCGTGCCTGCGTCGGCTCTGTCCGG
GCACGGCCTGTTCGACCGCGTCCATGTCGCCGATCGCCCGGCCTATCTCAAGGCGCTGTCGGACGCCGGCCGCGGCGGCG
AAGCGCGCAGCGTCGAGTTCCGCGTCCGCCGCGAAGTCGCGCGCGACGATCGCGGCCGGCCGAGCGCGGCGGAATTCATC
TGGCTGGAGATGCGCTGCCGGCCGTTCGAAACCGGGGTCGTGAGCGCGGCGGGCGAGGCCGACGTGGTCGCGGTGATGCG
CGACGTCACCGACCGCAAGCAGCAGGAACAGGCGCTGGAGGAGGCGCGCGCCGAGGCCGGCCGCGCCGACGCCACCAAGA
GCCGCTTCCTCGCCACCATGAGCCACGAGCTGCGCACGCCGCTGAATGCGGTGATCGGCTTCTCCGACATGATCCTGCAC
GAGGACGAGCTGATGCTCGCGCCGGAGCGTCGCAAGGAATACGCGCAGTTGATCAATGATTCCGGCCAGCATCTGCTGTC
GGTGGTCAACGGCATCCTCGATATGTCGAAGATCGAGTCCGGCCATTTCGAGATCGCGCCGGAGCCGTTCGCGCCGCGGC
CGGCGCTGCTGAATTGCTGCAACCTGCTGGCGCTGAAAGCGCGCGAGAACGGCATCGACCTGGTGACGCGCGCGCCGGAA
AACCTGCCGGAGATCGTCGGCGATCCGCGCGCGTTCAAGCAGATCCTGCTCAATCTGGTGTCGAACGCGATCAAGTTCAC
CGAGCGCGGCGGCACCGTGTCGGTCGACGCGATGGTGGAAGGCGCGCGGCTGGTGCTGCGGGTCAGCGACACCGGCGTCG
GAATCGCGGCCGAGGATCTGAAGCGGATCGGCGATCCGTTCTTCCAGGCCGGCACCACCTATCAGCGCCGCCACGAAGGC
ACCGGCCTCGGCCTGTCGATCGTCAAGAGCCTCGTCGGAATGCACGGCGGCGACATCGAGGTGAAAAGCGAGGTTGATCG
GGGGACGACCGTCACGGTATCGCTGCCGCTGGCGCAGCCGGCGCTGACCAACGTCACGCCGCTCGCGCCGCCGCAACCGA
CAGAGCCGCAACGGCCGGACTATCAGGTGAAGAAGAGTGCGTAA

Upstream 100 bases:

>100_bases
TCACCATCCGTGCCGAATGCGGCGACGAACGCGGCGCAAATCCGGCGACGCCGCGCGCTGTTCGAACGCCTTAGCTTTCG
TTTAAGGTCGCTCTGACACG

Downstream 100 bases:

>100_bases
GACCCGGAAGGACGACGACGCGCCGCGGCGAGGCCGGGGCGCCGCTGCAGCGGCCGTCGCGGACAGCGACGAGCGGGGGC
TGGCGATGCGTCTGCTGACG

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MGANQKRGRYLPSRATASADSVALSRIIGERLDALLHPSARYDALASARHRAFIAPRLFGSLAAFAAFPIYLAMRGAPTA
LEALAFAWLIAPILLSWFLSRTGRYESAHVLSSLSLTGLILVIATLTGGITSFAAIWLILVPLEAALSASRRVVAFAAML
ALGAAAVLIAIGQLGWLPAAPAGDVSHGALMAVSVASATLYAAGLAFGSESLTRTSDTLLSVEEERYRLLARHMSDVISR
HGRNGAVQFISPAVEALIGVPASALSGHGLFDRVHVADRPAYLKALSDAGRGGEARSVEFRVRREVARDDRGRPSAAEFI
WLEMRCRPFETGVVSAAGEADVVAVMRDVTDRKQQEQALEEARAEAGRADATKSRFLATMSHELRTPLNAVIGFSDMILH
EDELMLAPERRKEYAQLINDSGQHLLSVVNGILDMSKIESGHFEIAPEPFAPRPALLNCCNLLALKARENGIDLVTRAPE
NLPEIVGDPRAFKQILLNLVSNAIKFTERGGTVSVDAMVEGARLVLRVSDTGVGIAAEDLKRIGDPFFQAGTTYQRRHEG
TGLGLSIVKSLVGMHGGDIEVKSEVDRGTTVTVSLPLAQPALTNVTPLAPPQPTEPQRPDYQVKKSA

Sequences:

>Translated_627_residues
MGANQKRGRYLPSRATASADSVALSRIIGERLDALLHPSARYDALASARHRAFIAPRLFGSLAAFAAFPIYLAMRGAPTA
LEALAFAWLIAPILLSWFLSRTGRYESAHVLSSLSLTGLILVIATLTGGITSFAAIWLILVPLEAALSASRRVVAFAAML
ALGAAAVLIAIGQLGWLPAAPAGDVSHGALMAVSVASATLYAAGLAFGSESLTRTSDTLLSVEEERYRLLARHMSDVISR
HGRNGAVQFISPAVEALIGVPASALSGHGLFDRVHVADRPAYLKALSDAGRGGEARSVEFRVRREVARDDRGRPSAAEFI
WLEMRCRPFETGVVSAAGEADVVAVMRDVTDRKQQEQALEEARAEAGRADATKSRFLATMSHELRTPLNAVIGFSDMILH
EDELMLAPERRKEYAQLINDSGQHLLSVVNGILDMSKIESGHFEIAPEPFAPRPALLNCCNLLALKARENGIDLVTRAPE
NLPEIVGDPRAFKQILLNLVSNAIKFTERGGTVSVDAMVEGARLVLRVSDTGVGIAAEDLKRIGDPFFQAGTTYQRRHEG
TGLGLSIVKSLVGMHGGDIEVKSEVDRGTTVTVSLPLAQPALTNVTPLAPPQPTEPQRPDYQVKKSA
>Mature_626_residues
GANQKRGRYLPSRATASADSVALSRIIGERLDALLHPSARYDALASARHRAFIAPRLFGSLAAFAAFPIYLAMRGAPTAL
EALAFAWLIAPILLSWFLSRTGRYESAHVLSSLSLTGLILVIATLTGGITSFAAIWLILVPLEAALSASRRVVAFAAMLA
LGAAAVLIAIGQLGWLPAAPAGDVSHGALMAVSVASATLYAAGLAFGSESLTRTSDTLLSVEEERYRLLARHMSDVISRH
GRNGAVQFISPAVEALIGVPASALSGHGLFDRVHVADRPAYLKALSDAGRGGEARSVEFRVRREVARDDRGRPSAAEFIW
LEMRCRPFETGVVSAAGEADVVAVMRDVTDRKQQEQALEEARAEAGRADATKSRFLATMSHELRTPLNAVIGFSDMILHE
DELMLAPERRKEYAQLINDSGQHLLSVVNGILDMSKIESGHFEIAPEPFAPRPALLNCCNLLALKARENGIDLVTRAPEN
LPEIVGDPRAFKQILLNLVSNAIKFTERGGTVSVDAMVEGARLVLRVSDTGVGIAAEDLKRIGDPFFQAGTTYQRRHEGT
GLGLSIVKSLVGMHGGDIEVKSEVDRGTTVTVSLPLAQPALTNVTPLAPPQPTEPQRPDYQVKKSA

Specific function: Member Of The Two-Component Regulatory System rcsC/rcsB Involved In The Regulation Of The Expression Of Genes Involved In Colanic Acid Capsule Synthesis. rcsC Probably Functions As A Membrane-Associated Protein Kinase That Phosphorylates rcsB In Response

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=262, Percent_Identity=41.9847328244275, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1789149, Length=244, Percent_Identity=40.1639344262295, Blast_Score=168, Evalue=1e-42,
Organism=Escherichia coli, GI87081816, Length=248, Percent_Identity=37.0967741935484, Blast_Score=146, Evalue=5e-36,
Organism=Escherichia coli, GI1788713, Length=286, Percent_Identity=33.5664335664336, Blast_Score=142, Evalue=8e-35,
Organism=Escherichia coli, GI48994928, Length=276, Percent_Identity=33.695652173913, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=34.6666666666667, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1786912, Length=242, Percent_Identity=31.8181818181818, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1786783, Length=233, Percent_Identity=29.1845493562232, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786600, Length=277, Percent_Identity=27.4368231046931, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1788549, Length=373, Percent_Identity=23.5924932975871, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=26.5217391304348, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=27.7777777777778, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788393, Length=222, Percent_Identity=26.5765765765766, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789808, Length=225, Percent_Identity=26.6666666666667, Blast_Score=63, Evalue=7e-11,
Organism=Escherichia coli, GI1790861, Length=254, Percent_Identity=23.2283464566929, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 67127; Mature: 66996

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGANQKRGRYLPSRATASADSVALSRIIGERLDALLHPSARYDALASARHRAFIAPRLFG
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SLAAFAAFPIYLAMRGAPTALEALAFAWLIAPILLSWFLSRTGRYESAHVLSSLSLTGLI
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LVIATLTGGITSFAAIWLILVPLEAALSASRRVVAFAAMLALGAAAVLIAIGQLGWLPAA
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PAGDVSHGALMAVSVASATLYAAGLAFGSESLTRTSDTLLSVEEERYRLLARHMSDVISR
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGRNGAVQFISPAVEALIGVPASALSGHGLFDRVHVADRPAYLKALSDAGRGGEARSVEF
CCCCCCHHHHHHHHHHHHCCCHHHHCCCCCHHEEECCCCHHHHHHHHHCCCCCCCCHHHH
RVRREVARDDRGRPSAAEFIWLEMRCRPFETGVVSAAGEADVVAVMRDVTDRKQQEQALE
HHHHHHHHCCCCCCCHHHEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EARAEAGRADATKSRFLATMSHELRTPLNAVIGFSDMILHEDELMLAPERRKEYAQLIND
HHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHCHHHHHEECCCCEECCHHHHHHHHHHCC
SGQHLLSVVNGILDMSKIESGHFEIAPEPFAPRPALLNCCNLLALKARENGIDLVTRAPE
CHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCC
NLPEIVGDPRAFKQILLNLVSNAIKFTERGGTVSVDAMVEGARLVLRVSDTGVGIAAEDL
CCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHEEECCCEEEEEEECCCCCEEHHHH
KRIGDPFFQAGTTYQRRHEGTGLGLSIVKSLVGMHGGDIEVKSEVDRGTTVTVSLPLAQP
HHHCCHHHHCCCCHHHHHCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECCCCC
ALTNVTPLAPPQPTEPQRPDYQVKKSA
CCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GANQKRGRYLPSRATASADSVALSRIIGERLDALLHPSARYDALASARHRAFIAPRLFG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
SLAAFAAFPIYLAMRGAPTALEALAFAWLIAPILLSWFLSRTGRYESAHVLSSLSLTGLI
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LVIATLTGGITSFAAIWLILVPLEAALSASRRVVAFAAMLALGAAAVLIAIGQLGWLPAA
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PAGDVSHGALMAVSVASATLYAAGLAFGSESLTRTSDTLLSVEEERYRLLARHMSDVISR
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGRNGAVQFISPAVEALIGVPASALSGHGLFDRVHVADRPAYLKALSDAGRGGEARSVEF
CCCCCCHHHHHHHHHHHHCCCHHHHCCCCCHHEEECCCCHHHHHHHHHCCCCCCCCHHHH
RVRREVARDDRGRPSAAEFIWLEMRCRPFETGVVSAAGEADVVAVMRDVTDRKQQEQALE
HHHHHHHHCCCCCCCHHHEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
EARAEAGRADATKSRFLATMSHELRTPLNAVIGFSDMILHEDELMLAPERRKEYAQLIND
HHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHCHHHHHEECCCCEECCHHHHHHHHHHCC
SGQHLLSVVNGILDMSKIESGHFEIAPEPFAPRPALLNCCNLLALKARENGIDLVTRAPE
CHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCC
NLPEIVGDPRAFKQILLNLVSNAIKFTERGGTVSVDAMVEGARLVLRVSDTGVGIAAEDL
CCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHEEECCCEEEEEEECCCCCEEHHHH
KRIGDPFFQAGTTYQRRHEGTGLGLSIVKSLVGMHGGDIEVKSEVDRGTTVTVSLPLAQP
HHHCCHHHHCCCCHHHHHCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEECCCCC
ALTNVTPLAPPQPTEPQRPDYQVKKSA
CCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 7756693 [H]