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The map label for this gene is yusP [H]

Identifier: 86750606

GI number: 86750606

Start: 4000359

End: 4001954

Strand: Reverse

Name: yusP [H]

Synonym: RPB_3496

Alternate gene names: 86750606

Gene position: 4001954-4000359 (Counterclockwise)

Preceding gene: 86750608

Following gene: 86750605

Centisome position: 75.06

GC content: 69.36

Gene sequence:

>1596_bases
ATGAGCATGTCCGAACACCGACGCCGTGAGCCGTCCGGCAGGCAATTGTTGTCCGACGAAGCGGCGGCGGAACTGTCGCA
CATTCCCACCGAAGTGATCGATCTCGGCGACGCGCCGCCGCTGGCGCCGGCGAATACGCTGTCGCAGGGCGAAGTCCGCG
CCATCCTGATGAGTCTGCTGCTGGCGATGTTCCTCGCCGCGCTCGACCAGACCATCGTCGCCACCGCGCTGCCGACGATC
GGGCGGCAGTTCGGCGACGTCGAGAATCTGTCCTGGGTGATCACCGCTTATCTGTTGTCGTCGACCGCGGTGGCGCCGGT
GTTCGGCAGCCTCGCCGACATTTACGGCCGCCGCGCCACCATCATCGCGTCGATCAGCCTGTTCATCGCCGGTTCAGTGA
TGTGCGCGCTGGCGCCGAGCCTGCTGGTGCTGATTCTCGGTCGCGCGCTGCAGGGGCTGGGCGGCGGCGGCATCATGCCG
ATCGTGCAGACGGTGATCTCGGACGTGGTGACGCCGCGCGAGCGCGGCAAGTATCAGGCCTATTTCTCCGCCGTCTGGGT
CTCGGCCGGGATCGGCGGGCCGATCCTCGGCGGCGCCTTCGCCGAGCATCTGCACTGGTCGATGATCTTCTGGATCAATC
TGCCGCTGGCGATCGGCGCGCTGGCGTTGCTGCTGCCGAAGATGGCCAAGATTCCGACGTATCACCGCCGCCGCAAGGTC
GACTGGCTGGGCGGCGTGCTGCTGATGGCCTCGGCGATGGCGGTGATGCTGGCGCTGACCTGGGGCGGCACGCGGTTCTC
CTGGCTGTCGCCGACGATCCTGGCGCTGAGCGGCGGCGCAGTGCTGCTCGCGGTGTGCTTCGTCTGGCACGCGCTGCGGG
CGCCCGAGCCGTTCCTGCCGCTGCAATTGATGGGCGGCACGGTGGTGCCGTGGGCGATGGCGGCGGGCGGCTTCGCGATG
GGAGCGATGATCGGCCTGACGGTGCACATGCCGCTGTACTACGAGGCGGTGTATCACCTGACCGCGAGCCAGTCCGGCCT
GGCGCTGATCCCGATCGCCGCGGTGTCGGTGCTCGGCGCGGCGTTCACCGGCCGCGCTATGGTGAAGGTCGAGCGCTACA
AGCGGATCGCGATCCTCGGCACCGGCTTCTCGGCGCTGATGGCGGCGGCGATCGCGGTGACGACGCCGCTGCCGCTGTGG
CTGTTCCTGGCGCTGCTGTCGCTGTTCTCGATCGGGCTCGGCACGGTGTTCCCGGTCACCGTGGTGTCGATCCAGAACGC
GGTGGCGCGGCCGCAGATCGGCACCGCGACCGGGGCGATGAACTTCTTCCGCGCGCTGATGGCGTCGTTCACGGTGGCGG
CGTTCACCGCGGTGCTGCTGATCGCGTTCGGCGGCGAGATCCAGCTCGGCGGCGCCGAGCATCGCCACGCCATCGGCACG
GTCGCTGCCGCCGACATGGTGGCGGCGTTCCGCTGGGTGTTCGCCGCGGCCGCCGCGATGCTGGCCGCGTCGGCGATCTG
CGTGGCGATCATGGAAGAGCGCACGCTCGCCGGTCCGGAGCAGACTTCGCCGCCGCCGCTGGAGATGGCCGAGTAG

Upstream 100 bases:

>100_bases
ACCCATGCGCCGAAGCCGCTGTCTTGGGCGGATTTGATGCGCTATTGAACTTCAATAGCGAATTCCCCCCGATGCCAGCC
CGACGAGATTCCGCGACCGC

Downstream 100 bases:

>100_bases
GACGGCGCCTGGCCCGGCGCCTGCGCCGCGGACGTCCGATCGCGATCCATTTTACGGAATTTCGACACCTTCCCGCGGAA
ATTGACTAGTCTGCCGCAGA

Product: MFS transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MSMSEHRRREPSGRQLLSDEAAAELSHIPTEVIDLGDAPPLAPANTLSQGEVRAILMSLLLAMFLAALDQTIVATALPTI
GRQFGDVENLSWVITAYLLSSTAVAPVFGSLADIYGRRATIIASISLFIAGSVMCALAPSLLVLILGRALQGLGGGGIMP
IVQTVISDVVTPRERGKYQAYFSAVWVSAGIGGPILGGAFAEHLHWSMIFWINLPLAIGALALLLPKMAKIPTYHRRRKV
DWLGGVLLMASAMAVMLALTWGGTRFSWLSPTILALSGGAVLLAVCFVWHALRAPEPFLPLQLMGGTVVPWAMAAGGFAM
GAMIGLTVHMPLYYEAVYHLTASQSGLALIPIAAVSVLGAAFTGRAMVKVERYKRIAILGTGFSALMAAAIAVTTPLPLW
LFLALLSLFSIGLGTVFPVTVVSIQNAVARPQIGTATGAMNFFRALMASFTVAAFTAVLLIAFGGEIQLGGAEHRHAIGT
VAAADMVAAFRWVFAAAAAMLAASAICVAIMEERTLAGPEQTSPPPLEMAE

Sequences:

>Translated_531_residues
MSMSEHRRREPSGRQLLSDEAAAELSHIPTEVIDLGDAPPLAPANTLSQGEVRAILMSLLLAMFLAALDQTIVATALPTI
GRQFGDVENLSWVITAYLLSSTAVAPVFGSLADIYGRRATIIASISLFIAGSVMCALAPSLLVLILGRALQGLGGGGIMP
IVQTVISDVVTPRERGKYQAYFSAVWVSAGIGGPILGGAFAEHLHWSMIFWINLPLAIGALALLLPKMAKIPTYHRRRKV
DWLGGVLLMASAMAVMLALTWGGTRFSWLSPTILALSGGAVLLAVCFVWHALRAPEPFLPLQLMGGTVVPWAMAAGGFAM
GAMIGLTVHMPLYYEAVYHLTASQSGLALIPIAAVSVLGAAFTGRAMVKVERYKRIAILGTGFSALMAAAIAVTTPLPLW
LFLALLSLFSIGLGTVFPVTVVSIQNAVARPQIGTATGAMNFFRALMASFTVAAFTAVLLIAFGGEIQLGGAEHRHAIGT
VAAADMVAAFRWVFAAAAAMLAASAICVAIMEERTLAGPEQTSPPPLEMAE
>Mature_530_residues
SMSEHRRREPSGRQLLSDEAAAELSHIPTEVIDLGDAPPLAPANTLSQGEVRAILMSLLLAMFLAALDQTIVATALPTIG
RQFGDVENLSWVITAYLLSSTAVAPVFGSLADIYGRRATIIASISLFIAGSVMCALAPSLLVLILGRALQGLGGGGIMPI
VQTVISDVVTPRERGKYQAYFSAVWVSAGIGGPILGGAFAEHLHWSMIFWINLPLAIGALALLLPKMAKIPTYHRRRKVD
WLGGVLLMASAMAVMLALTWGGTRFSWLSPTILALSGGAVLLAVCFVWHALRAPEPFLPLQLMGGTVVPWAMAAGGFAMG
AMIGLTVHMPLYYEAVYHLTASQSGLALIPIAAVSVLGAAFTGRAMVKVERYKRIAILGTGFSALMAAAIAVTTPLPLWL
FLALLSLFSIGLGTVFPVTVVSIQNAVARPQIGTATGAMNFFRALMASFTVAAFTAVLLIAFGGEIQLGGAEHRHAIGTV
AAADMVAAFRWVFAAAAAMLAASAICVAIMEERTLAGPEQTSPPPLEMAE

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=336, Percent_Identity=28.5714285714286, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790195, Length=362, Percent_Identity=27.6243093922652, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1788392, Length=361, Percent_Identity=33.2409972299169, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788710, Length=412, Percent_Identity=28.6407766990291, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI87081983, Length=344, Percent_Identity=25, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790146, Length=153, Percent_Identity=28.7581699346405, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322958, Length=451, Percent_Identity=27.9379157427938, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323735, Length=434, Percent_Identity=26.2672811059908, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6325455, Length=260, Percent_Identity=32.6923076923077, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319770, Length=394, Percent_Identity=25.6345177664975, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6321663, Length=405, Percent_Identity=25.9259259259259, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324264, Length=236, Percent_Identity=27.9661016949153, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322071, Length=234, Percent_Identity=25.6410256410256, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322070, Length=224, Percent_Identity=25.4464285714286, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55769; Mature: 55638

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMSEHRRREPSGRQLLSDEAAAELSHIPTEVIDLGDAPPLAPANTLSQGEVRAILMSLL
CCCCHHHCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
LAMFLAALDQTIVATALPTIGRQFGDVENLSWVITAYLLSSTAVAPVFGSLADIYGRRAT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IIASISLFIAGSVMCALAPSLLVLILGRALQGLGGGGIMPIVQTVISDVVTPRERGKYQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHCCCHHH
YFSAVWVSAGIGGPILGGAFAEHLHWSMIFWINLPLAIGALALLLPKMAKIPTYHRRRKV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHCCCHHHHCCH
DWLGGVLLMASAMAVMLALTWGGTRFSWLSPTILALSGGAVLLAVCFVWHALRAPEPFLP
HHHHHHHHHHHHHHHHHHHHCCCCEEHHCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCCC
LQLMGGTVVPWAMAAGGFAMGAMIGLTVHMPLYYEAVYHLTASQSGLALIPIAAVSVLGA
HHHCCCCHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHH
AFTGRAMVKVERYKRIAILGTGFSALMAAAIAVTTPLPLWLFLALLSLFSIGLGTVFPVT
HHCCHHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHH
VVSIQNAVARPQIGTATGAMNFFRALMASFTVAAFTAVLLIAFGGEIQLGGAEHRHAIGT
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHH
VAAADMVAAFRWVFAAAAAMLAASAICVAIMEERTLAGPEQTSPPPLEMAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SMSEHRRREPSGRQLLSDEAAAELSHIPTEVIDLGDAPPLAPANTLSQGEVRAILMSLL
CCCHHHCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
LAMFLAALDQTIVATALPTIGRQFGDVENLSWVITAYLLSSTAVAPVFGSLADIYGRRAT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
IIASISLFIAGSVMCALAPSLLVLILGRALQGLGGGGIMPIVQTVISDVVTPRERGKYQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHCCCHHH
YFSAVWVSAGIGGPILGGAFAEHLHWSMIFWINLPLAIGALALLLPKMAKIPTYHRRRKV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHCCCHHHHCCH
DWLGGVLLMASAMAVMLALTWGGTRFSWLSPTILALSGGAVLLAVCFVWHALRAPEPFLP
HHHHHHHHHHHHHHHHHHHHCCCCEEHHCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCCC
LQLMGGTVVPWAMAAGGFAMGAMIGLTVHMPLYYEAVYHLTASQSGLALIPIAAVSVLGA
HHHCCCCHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHH
AFTGRAMVKVERYKRIAILGTGFSALMAAAIAVTTPLPLWLFLALLSLFSIGLGTVFPVT
HHCCHHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHH
VVSIQNAVARPQIGTATGAMNFFRALMASFTVAAFTAVLLIAFGGEIQLGGAEHRHAIGT
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHH
VAAADMVAAFRWVFAAAAAMLAASAICVAIMEERTLAGPEQTSPPPLEMAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]