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The map label for this gene is ccmE

Identifier: 86750560

GI number: 86750560

Start: 3955410

End: 3955907

Strand: Reverse

Name: ccmE

Synonym: RPB_3449

Alternate gene names: 86750560

Gene position: 3955907-3955410 (Counterclockwise)

Preceding gene: 86750561

Following gene: 86750559

Centisome position: 74.2

GC content: 68.47

Gene sequence:

>498_bases
ATGACGCGTAAGCAGCGGCGGTTGATGATGATCGGTGGCGCCGGCGTGGTGCTCGTGGTCGCAGTGGGACTGGTGCTGAA
CGCGATGCGCGGCTCGATCGTGTTCTTCTCGACGCCGAAGATGGTGCACGAGCAGAACATCGAGGCCGGAAAGCGGTTCC
GGCTCGGCGGCGTGGTCGAGCCCGGCTCGCTCACGCGCGGCGATCAGCTCGCGGTGGCGTTCAAGGTTTCGGACGGCGAC
GCCACCGTGCCGGTGGCGTTCAAGGGCATTCTGCCGGACCTGTTCCGCGAGGGGCAGGGCGTGATCGCCGAGGGCGCGCT
CGACACCGCCGGCGTGTTCAAGGCCGACACCGTGCTCGCCAAGCACGACGAGACCTACATGCCCAAGGACGTGGCCGACG
CGCTGAAGAAGCAGGGCCACTGGAAGGACGATTACGAGAAGAAGCCGCCCGGGCCCGGTGCGGCGGCCTCCGCCGACGCC
ATGAGGCCGGCGCGATGA

Upstream 100 bases:

>100_bases
GAGCGCGTGCGGTTTTCCGACATAATGGTCCGGCAATTGTCGCGCACGAGCGAGACGCAACGATCTGGCGCCAATCAGGA
CGCCGGCACGAGGGTTGGCC

Downstream 100 bases:

>100_bases
TCGCCGAGGCCGGCCACTACGCGCTGGTGCTGGCGCTGGCGCTGGCGCTGATCCAGTCGACGGTGCCGATCCTCGGCGCG
CGGCTGGGCGACGGCGGGCT

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MTRKQRRLMMIGGAGVVLVVAVGLVLNAMRGSIVFFSTPKMVHEQNIEAGKRFRLGGVVEPGSLTRGDQLAVAFKVSDGD
ATVPVAFKGILPDLFREGQGVIAEGALDTAGVFKADTVLAKHDETYMPKDVADALKKQGHWKDDYEKKPPGPGAAASADA
MRPAR

Sequences:

>Translated_165_residues
MTRKQRRLMMIGGAGVVLVVAVGLVLNAMRGSIVFFSTPKMVHEQNIEAGKRFRLGGVVEPGSLTRGDQLAVAFKVSDGD
ATVPVAFKGILPDLFREGQGVIAEGALDTAGVFKADTVLAKHDETYMPKDVADALKKQGHWKDDYEKKPPGPGAAASADA
MRPAR
>Mature_164_residues
TRKQRRLMMIGGAGVVLVVAVGLVLNAMRGSIVFFSTPKMVHEQNIEAGKRFRLGGVVEPGSLTRGDQLAVAFKVSDGDA
TVPVAFKGILPDLFREGQGVIAEGALDTAGVFKADTVLAKHDETYMPKDVADALKKQGHWKDDYEKKPPGPGAAASADAM
RPAR

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=141, Percent_Identity=42.5531914893617, Blast_Score=111, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_RHOP2 (Q2IUG5)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_487056.1
- ProteinModelPortal:   Q2IUG5
- SMR:   Q2IUG5
- STRING:   Q2IUG5
- GeneID:   3911251
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_3449
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   ICFCSAC
- ProtClustDB:   PRK13254
- BioCyc:   RPAL316058:RPB_3449-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 17575; Mature: 17443

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: NA

Important sites: BINDING 122-122

Signals:

None

Transmembrane regions:

HASH(0x1edcc7fc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRKQRRLMMIGGAGVVLVVAVGLVLNAMRGSIVFFSTPKMVHEQNIEAGKRFRLGGVVE
CCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCCCEEECCCEEC
PGSLTRGDQLAVAFKVSDGDATVPVAFKGILPDLFREGQGVIAEGALDTAGVFKADTVLA
CCCCCCCCEEEEEEEECCCCCEEEEEHHHHHHHHHHCCCCEEECCCCCCCCCEECCEEEE
KHDETYMPKDVADALKKQGHWKDDYEKKPPGPGAAASADAMRPAR
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
TRKQRRLMMIGGAGVVLVVAVGLVLNAMRGSIVFFSTPKMVHEQNIEAGKRFRLGGVVE
CCCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCCCEEECCCEEC
PGSLTRGDQLAVAFKVSDGDATVPVAFKGILPDLFREGQGVIAEGALDTAGVFKADTVLA
CCCCCCCCEEEEEEEECCCCCEEEEEHHHHHHHHHHCCCCEEECCCCCCCCCEECCEEEE
KHDETYMPKDVADALKKQGHWKDDYEKKPPGPGAAASADAMRPAR
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA