Click here to switch to the map view.

The map label for this gene is macA [H]

Identifier: 86750521

GI number: 86750521

Start: 3897362

End: 3898435

Strand: Reverse

Name: macA [H]

Synonym: RPB_3410

Alternate gene names: 86750521

Gene position: 3898435-3897362 (Counterclockwise)

Preceding gene: 86750522

Following gene: 86750520

Centisome position: 73.12

GC content: 66.01

Gene sequence:

>1074_bases
ATGACGGCGTCGCGGGTCACAGGGGTGATTGCAGCCTGCCTGCTCATCGCGGGCTGTCAGGAAAAAGCCAGCCAGCCGGA
ACCGATCCGGCCGGTGCTGTCGACCGTGGTCGCCCCGCTCGAAGCGACCAGCATCGGCGTCGTCGGCACGATCGAGGCGC
GGTTCAAGACCGACTACGGGTTTCGTGTCCTCGGCCGCATGATCGCGCGGCCCGTCAATATCGGTGACACCGTCGCGAAG
GGGCAGGCGCTCGCAGCGATCGATCCGTTGGCTGCCGAATTTTCCGTCAGGTCCGCTGTGGCGGATTTCGCCTCGGCTCA
GGCGCAACTGGTGAACGCCAGCAGCAACGTCAGCCGCCAGCGCACCTTGATCGAAACCGGTGCCATTACCAAAGCCACGC
TCGATTCGGCGGAGCAGGCCAATTCCGCCGCGCAGGCCGCGGTCGTCCGGGCCCAGTCGAGCCTGACCAAAGCGCGCGAG
CAATTGAGCTACACCAAGCTCGCCGCCGAATATGCCGGCGTCGTCACCGCGGTGAGCGTGCAGGTCGGCCAGATCGTCAG
TCCCGGCCAGACCGTGGTGACCGTCGCCCGACCGGATGTCCGCGAGGCGGTGATCGACGTCGCCGACGATCTCGCCGGCG
CCTTGAAGGTCGACATGCCGCTGAAGGTCGCGCTGCAGCTCGATCCGAAAATCCGGGTCGACGGAAAAGTGCGCGAGGTC
GCACCGCAAGCCGATCAGGTGACGCGCACCCGGCGGGTTCGGATCACGCTGGAGAATCCGCCGGAGACGTTCCGTCTCGG
CTCCACCATCACCACGCTGATCCCGGGCAAGCCGACGCGGGGATTTCGGCTGCCGGCCACGGCGATCCTGACCGAACGCG
GCCAGTCGAGCGTCTGGATGATCGATACGCAAGCCGGAACGGTGACCAAACGCAACGTGCAGATCGTCACCAACGACGAC
GGTTCGGTCGAGGTGGTCGAGGGAATTGCGGCGGGCGCACGTATCGTGACGGCGGGCGTGCATCATCTCGTGGAAGGCCA
GAAAATCCGCTTCGGAGAGGGTAGCTCGCTGTGA

Upstream 100 bases:

>100_bases
TCATCGTGGCCGACGGCCTGAAGGCCGGCGAGCGCGTCGTCGTCGACGGCGGCAAGATGCTCCGCCCCGCGGAGATCGTC
ACTTATGACGGGGAAAACGC

Downstream 100 bases:

>100_bases
AGTCTTTCAACCTTTCCGACTGGGCCCTGCAGCACCGCTCGCTGGTCTGGTACTTCATGATCGCGTTCATGGCCGCCGGG
CTGTTCTCCTATCTCGAGCT

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MTASRVTGVIAACLLIAGCQEKASQPEPIRPVLSTVVAPLEATSIGVVGTIEARFKTDYGFRVLGRMIARPVNIGDTVAK
GQALAAIDPLAAEFSVRSAVADFASAQAQLVNASSNVSRQRTLIETGAITKATLDSAEQANSAAQAAVVRAQSSLTKARE
QLSYTKLAAEYAGVVTAVSVQVGQIVSPGQTVVTVARPDVREAVIDVADDLAGALKVDMPLKVALQLDPKIRVDGKVREV
APQADQVTRTRRVRITLENPPETFRLGSTITTLIPGKPTRGFRLPATAILTERGQSSVWMIDTQAGTVTKRNVQIVTNDD
GSVEVVEGIAAGARIVTAGVHHLVEGQKIRFGEGSSL

Sequences:

>Translated_357_residues
MTASRVTGVIAACLLIAGCQEKASQPEPIRPVLSTVVAPLEATSIGVVGTIEARFKTDYGFRVLGRMIARPVNIGDTVAK
GQALAAIDPLAAEFSVRSAVADFASAQAQLVNASSNVSRQRTLIETGAITKATLDSAEQANSAAQAAVVRAQSSLTKARE
QLSYTKLAAEYAGVVTAVSVQVGQIVSPGQTVVTVARPDVREAVIDVADDLAGALKVDMPLKVALQLDPKIRVDGKVREV
APQADQVTRTRRVRITLENPPETFRLGSTITTLIPGKPTRGFRLPATAILTERGQSSVWMIDTQAGTVTKRNVQIVTNDD
GSVEVVEGIAAGARIVTAGVHHLVEGQKIRFGEGSSL
>Mature_356_residues
TASRVTGVIAACLLIAGCQEKASQPEPIRPVLSTVVAPLEATSIGVVGTIEARFKTDYGFRVLGRMIARPVNIGDTVAKG
QALAAIDPLAAEFSVRSAVADFASAQAQLVNASSNVSRQRTLIETGAITKATLDSAEQANSAAQAAVVRAQSSLTKAREQ
LSYTKLAAEYAGVVTAVSVQVGQIVSPGQTVVTVARPDVREAVIDVADDLAGALKVDMPLKVALQLDPKIRVDGKVREVA
PQADQVTRTRRVRITLENPPETFRLGSTITTLIPGKPTRGFRLPATAILTERGQSSVWMIDTQAGTVTKRNVQIVTNDDG
SVEVVEGIAAGARIVTAGVHHLVEGQKIRFGEGSSL

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=352, Percent_Identity=28.9772727272727, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082036, Length=324, Percent_Identity=26.2345679012346, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1789929, Length=305, Percent_Identity=24.9180327868852, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37491; Mature: 37360

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASRVTGVIAACLLIAGCQEKASQPEPIRPVLSTVVAPLEATSIGVVGTIEARFKTDYG
CCCHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCC
FRVLGRMIARPVNIGDTVAKGQALAAIDPLAAEFSVRSAVADFASAQAQLVNASSNVSRQ
HHHHHHHHHCCCCCCCHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHH
RTLIETGAITKATLDSAEQANSAAQAAVVRAQSSLTKAREQLSYTKLAAEYAGVVTAVSV
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
QVGQIVSPGQTVVTVARPDVREAVIDVADDLAGALKVDMPLKVALQLDPKIRVDGKVREV
EECCEECCCCEEEEEECCCHHHHHHHHHHHHHCCEEECCCEEEEEEECCCEEECCCHHHH
APQADQVTRTRRVRITLENPPETFRLGSTITTLIPGKPTRGFRLPATAILTERGQSSVWM
CCCHHHHCCEEEEEEEECCCCCCEECCCEEEEECCCCCCCCEECCHHHEECCCCCCCEEE
IDTQAGTVTKRNVQIVTNDDGSVEVVEGIAAGARIVTAGVHHLVEGQKIRFGEGSSL
EECCCCEEEECEEEEEECCCCCEEHHHHHHCCHHHHHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure 
TASRVTGVIAACLLIAGCQEKASQPEPIRPVLSTVVAPLEATSIGVVGTIEARFKTDYG
CCHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCC
FRVLGRMIARPVNIGDTVAKGQALAAIDPLAAEFSVRSAVADFASAQAQLVNASSNVSRQ
HHHHHHHHHCCCCCCCHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHEECCCCCCHHH
RTLIETGAITKATLDSAEQANSAAQAAVVRAQSSLTKAREQLSYTKLAAEYAGVVTAVSV
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
QVGQIVSPGQTVVTVARPDVREAVIDVADDLAGALKVDMPLKVALQLDPKIRVDGKVREV
EECCEECCCCEEEEEECCCHHHHHHHHHHHHHCCEEECCCEEEEEEECCCEEECCCHHHH
APQADQVTRTRRVRITLENPPETFRLGSTITTLIPGKPTRGFRLPATAILTERGQSSVWM
CCCHHHHCCEEEEEEEECCCCCCEECCCEEEEECCCCCCCCEECCHHHEECCCCCCCEEE
IDTQAGTVTKRNVQIVTNDDGSVEVVEGIAAGARIVTAGVHHLVEGQKIRFGEGSSL
EECCCCEEEECEEEEEECCCCCEEHHHHHHCCHHHHHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]