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The map label for this gene is gppA [H]

Identifier: 86750308

GI number: 86750308

Start: 3655601

End: 3656677

Strand: Reverse

Name: gppA [H]

Synonym: RPB_3197

Alternate gene names: 86750308

Gene position: 3656677-3655601 (Counterclockwise)

Preceding gene: 86750310

Following gene: 86750307

Centisome position: 68.58

GC content: 70.29

Gene sequence:

>1077_bases
ATGGATGAGGAGACGCGGCTCCGCGACGGCCTGATGCCCGGCGGAGACACGCAGCATGAGCACGGGTGTGTTGCGAACGC
CGAGGAAGAGCATGGGTCGACGGCGCCGCATGGCGGCGTCTATGCCGCGCTCGACCTCGGCACCAATAATTGCCGGCTGC
TGATCGCGCGGCCGACCGGCGACGGCTTTCGCGTGGTCGATTCGTTTTCCCGGATCATCCGGCTCGGCGAGGGCGTCTCT
GCCACGGGGCGGATCAGCGATGCGGCGATCGCTCGGGCGATCTCCGCGCTGTCGATCTGCCGTGACAAGATCGATCAGCG
CAAGGCGAAGCGGCTGCGGCTGATCGCGACCGAGGCCTGCCGTGCCGCCGTCAATGCCGATGCGTTCTGTGACGCCGTCG
CACACGCCACCGGCATCCGTCTCGAAATCATCGATCGCGAGACCGAGGCGCGGCTGGCGGCGATCGGCTGTTCGCCGCTG
GTCGATACCGCCGGGCGCGGCGCGATCCTGTTCGATATCGGCGGCGGCTCCAGCGAATTGGTGCGGCTCGCGCGCGATCC
GGCGCGGCCGGACCTGCCGCCGCGGATCCGGGCCTGGATGTCGATTCCGCTCGGCGTGGTGACGCTGGCCGAGCAGTTCG
GCGGCAAGGTGGTGACCGCGGACAGCTATGCGGCGATGATCGCGGAGGTCGCCAGGCACGTCGCGCCGTTCGCGGCCGCG
CATGGCGGCGACCTCGGCGGCCTGCATCTGCTCGGCACCTCGGGCACGGTGACAACGCTCGCGGGGCTGTATCTCGACCT
GATCCGCTACGATCGCCGCCGCGTCGACGGCATCTGGATGAGCGACGCGGAACTGACCGCGACGATCGACCGGCTGCGCG
GCATGAGCTATCACGATCGCGCCCAGAACCATTGCATCGGCGCCGAGCGCGCCGACCTGGTGCTGGCCGGCTGCGCCATC
CTCGACGCGGTGCGTGCGGCGTTCCCGCTGCCGCGGCTGCGGGTCGCCGATCGCGGCCTGCGGGAGGGCATGCTGGTCGA
AATGATGCGCGAAGACGGCGTGCCGGGCGTGGCCTGA

Upstream 100 bases:

>100_bases
GCGGGCCGTGCGGGTGGCTTGCGCCGCGGCCGTGCGCTGCTAAACTTTCCGTGAATGTGAGCTCGACGTCGGCCGGACGG
CCACGAAAGACCGAATTGTG

Downstream 100 bases:

>100_bases
GGCGGTTCCGCGCTGGTTTTTCCGCGCTCATCTGCTAAGCAACGCGCCACCACCACCAATTTCAAGCAGGGTCATGGCCA
AAGACACCACCGGGCGGATG

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MDEETRLRDGLMPGGDTQHEHGCVANAEEEHGSTAPHGGVYAALDLGTNNCRLLIARPTGDGFRVVDSFSRIIRLGEGVS
ATGRISDAAIARAISALSICRDKIDQRKAKRLRLIATEACRAAVNADAFCDAVAHATGIRLEIIDRETEARLAAIGCSPL
VDTAGRGAILFDIGGGSSELVRLARDPARPDLPPRIRAWMSIPLGVVTLAEQFGGKVVTADSYAAMIAEVARHVAPFAAA
HGGDLGGLHLLGTSGTVTTLAGLYLDLIRYDRRRVDGIWMSDAELTATIDRLRGMSYHDRAQNHCIGAERADLVLAGCAI
LDAVRAAFPLPRLRVADRGLREGMLVEMMREDGVPGVA

Sequences:

>Translated_358_residues
MDEETRLRDGLMPGGDTQHEHGCVANAEEEHGSTAPHGGVYAALDLGTNNCRLLIARPTGDGFRVVDSFSRIIRLGEGVS
ATGRISDAAIARAISALSICRDKIDQRKAKRLRLIATEACRAAVNADAFCDAVAHATGIRLEIIDRETEARLAAIGCSPL
VDTAGRGAILFDIGGGSSELVRLARDPARPDLPPRIRAWMSIPLGVVTLAEQFGGKVVTADSYAAMIAEVARHVAPFAAA
HGGDLGGLHLLGTSGTVTTLAGLYLDLIRYDRRRVDGIWMSDAELTATIDRLRGMSYHDRAQNHCIGAERADLVLAGCAI
LDAVRAAFPLPRLRVADRGLREGMLVEMMREDGVPGVA
>Mature_358_residues
MDEETRLRDGLMPGGDTQHEHGCVANAEEEHGSTAPHGGVYAALDLGTNNCRLLIARPTGDGFRVVDSFSRIIRLGEGVS
ATGRISDAAIARAISALSICRDKIDQRKAKRLRLIATEACRAAVNADAFCDAVAHATGIRLEIIDRETEARLAAIGCSPL
VDTAGRGAILFDIGGGSSELVRLARDPARPDLPPRIRAWMSIPLGVVTLAEQFGGKVVTADSYAAMIAEVARHVAPFAAA
HGGDLGGLHLLGTSGTVTTLAGLYLDLIRYDRRRVDGIWMSDAELTATIDRLRGMSYHDRAQNHCIGAERADLVLAGCAI
LDAVRAAFPLPRLRVADRGLREGMLVEMMREDGVPGVA

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=318, Percent_Identity=25.1572327044025, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI48994966, Length=329, Percent_Identity=26.4437689969605, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 38101; Mature: 38101

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEETRLRDGLMPGGDTQHEHGCVANAEEEHGSTAPHGGVYAALDLGTNNCRLLIARPTG
CCCHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEEEEECCCCEEEEEECCCC
DGFRVVDSFSRIIRLGEGVSATGRISDAAIARAISALSICRDKIDQRKAKRLRLIATEAC
CCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAVNADAFCDAVAHATGIRLEIIDRETEARLAAIGCSPLVDTAGRGAILFDIGGGSSEL
HHHCCHHHHHHHHHHHCCCEEEEECCCHHHHEEEECCCHHHCCCCCCEEEEEECCCHHHH
VRLARDPARPDLPPRIRAWMSIPLGVVTLAEQFGGKVVTADSYAAMIAEVARHVAPFAAA
HHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHH
HGGDLGGLHLLGTSGTVTTLAGLYLDLIRYDRRRVDGIWMSDAELTATIDRLRGMSYHDR
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCHHHH
AQNHCIGAERADLVLAGCAILDAVRAAFPLPRLRVADRGLREGMLVEMMREDGVPGVA
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDEETRLRDGLMPGGDTQHEHGCVANAEEEHGSTAPHGGVYAALDLGTNNCRLLIARPTG
CCCHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEEEEECCCCEEEEEECCCC
DGFRVVDSFSRIIRLGEGVSATGRISDAAIARAISALSICRDKIDQRKAKRLRLIATEAC
CCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAVNADAFCDAVAHATGIRLEIIDRETEARLAAIGCSPLVDTAGRGAILFDIGGGSSEL
HHHCCHHHHHHHHHHHCCCEEEEECCCHHHHEEEECCCHHHCCCCCCEEEEEECCCHHHH
VRLARDPARPDLPPRIRAWMSIPLGVVTLAEQFGGKVVTADSYAAMIAEVARHVAPFAAA
HHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHH
HGGDLGGLHLLGTSGTVTTLAGLYLDLIRYDRRRVDGIWMSDAELTATIDRLRGMSYHDR
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCHHHH
AQNHCIGAERADLVLAGCAILDAVRAAFPLPRLRVADRGLREGMLVEMMREDGVPGVA
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA