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The map label for this gene is iscS [H]

Identifier: 86750112

GI number: 86750112

Start: 3408978

End: 3410144

Strand: Reverse

Name: iscS [H]

Synonym: RPB_2995

Alternate gene names: 86750112

Gene position: 3410144-3408978 (Counterclockwise)

Preceding gene: 86750114

Following gene: 86750111

Centisome position: 63.96

GC content: 67.01

Gene sequence:

>1167_bases
GTGACGGCCGACCGGGTGTATCTCGACTGGAATGCGACGACGCCGCTGCGGCCGCAGGCGCGGGCGGCGATGGCCGCGGC
GATGGAGCTGGCAGGCAACCCCTCCTCGATTCACGCCGAGGGCCGGGCTGCGCGTGGGCTGGTCGAGCAGGCGCGGGCGA
TGGTCGCGGCGGCGGTCGGGGCCGCGCCGCGCAATGTCGTGTTTACGTCAGGCGGCACCGAGGCCAACACGCTGGCGCTC
ACGCCCGGACTCGGGATCGGCTCCCAACGCATTGAGCAGCTTGTCGTTTCGGCGATCGAACATGCTTCGGTGCTGACCGG
CGGGCGGTTTCCGCACGGCAGCGTCGCGACCGTTCAAGTCTCACGTGAAGGCGTTGTCGATCTGGATCACCTGCGCGGGT
TGCTGGCCGGCGGGCACCCGGCGCTGGTGTCGGTGATGCTCGCCAACAACGAGACCGGCGCGCTGCAACCCCTTCCGGCG
ATTGCTGAAATCGTCCATGCCGCGGACGGCCTGCTGCATGTCGATGCGATTCAGGCGCTGGGGAAAATCCCGTTCACGGT
CAATGAATTGGGAGCCGACTTGGTGTCGCTGTCGGCACACAAGCTGGGCGGGCCGACCGGTGTCGGCGCTCTCGTGTTGA
CGGAGCGGCTGGCCGGTCTGGAGCCTCTGCTGCGGGGCGGCGGCCAGGAGCTGGGTCGGCGGGCCGGAACCGAGAATGTC
GCCGGGATCGCAGGCTTCGGCGCGGCGGTTGCGGCGGCGATGGCGGGGATGGAATCCGACATGGCGCGGATCGAAAACCT
GCGGAATCGGCTCGAGGCAAACCTGAGGCAAACCGAAGGCAGCGTCATCATCGCCGAATCCGTGCCGCGGCTGCCGAACA
CCACGCTGGTCGCGCTGCCCGGATTGCGCGCCGAGACCGCGGTGATCGGCTTCGACCTCGCCGGCGTCGCGGTGTCGTCC
GGCTCCGCGTGTTCGTCGGGCAAAGTTCGCGCGTCGCATGTGCTGGAGGCGATGGGGTTTGGTCCGGAACTTGCTCAGTC
GGCGATACGGCTCAGTCTCGGCTGGTCGAGTAGCGAATCCGACATTGATCGATGCTTGAAGGCTTGGCGAAAGCTTGCGG
GCAACCTAACTAAAAGGGATCATGAAACAGAGCTTGAACGGTTCTAA

Upstream 100 bases:

>100_bases
TGCAAGCATATTGAACAGGGCAGCGCGCCAGATCCGACCCCGGATCGCGGGTTCTAAAAAATGGAACCGGCTCAGGCTGT
TACAGAAGGACAGGAAATTC

Downstream 100 bases:

>100_bases
GAGGGTTTCATCCCGCGCCGGATCGTGTAAGCATGTTCCAGTAGATCCACCGCGGTCCTTGAAACCGCGAGCGGAGGTTT
AAATGGCTGCCGTCCAAGAG

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MTADRVYLDWNATTPLRPQARAAMAAAMELAGNPSSIHAEGRAARGLVEQARAMVAAAVGAAPRNVVFTSGGTEANTLAL
TPGLGIGSQRIEQLVVSAIEHASVLTGGRFPHGSVATVQVSREGVVDLDHLRGLLAGGHPALVSVMLANNETGALQPLPA
IAEIVHAADGLLHVDAIQALGKIPFTVNELGADLVSLSAHKLGGPTGVGALVLTERLAGLEPLLRGGGQELGRRAGTENV
AGIAGFGAAVAAAMAGMESDMARIENLRNRLEANLRQTEGSVIIAESVPRLPNTTLVALPGLRAETAVIGFDLAGVAVSS
GSACSSGKVRASHVLEAMGFGPELAQSAIRLSLGWSSSESDIDRCLKAWRKLAGNLTKRDHETELERF

Sequences:

>Translated_388_residues
MTADRVYLDWNATTPLRPQARAAMAAAMELAGNPSSIHAEGRAARGLVEQARAMVAAAVGAAPRNVVFTSGGTEANTLAL
TPGLGIGSQRIEQLVVSAIEHASVLTGGRFPHGSVATVQVSREGVVDLDHLRGLLAGGHPALVSVMLANNETGALQPLPA
IAEIVHAADGLLHVDAIQALGKIPFTVNELGADLVSLSAHKLGGPTGVGALVLTERLAGLEPLLRGGGQELGRRAGTENV
AGIAGFGAAVAAAMAGMESDMARIENLRNRLEANLRQTEGSVIIAESVPRLPNTTLVALPGLRAETAVIGFDLAGVAVSS
GSACSSGKVRASHVLEAMGFGPELAQSAIRLSLGWSSSESDIDRCLKAWRKLAGNLTKRDHETELERF
>Mature_387_residues
TADRVYLDWNATTPLRPQARAAMAAAMELAGNPSSIHAEGRAARGLVEQARAMVAAAVGAAPRNVVFTSGGTEANTLALT
PGLGIGSQRIEQLVVSAIEHASVLTGGRFPHGSVATVQVSREGVVDLDHLRGLLAGGHPALVSVMLANNETGALQPLPAI
AEIVHAADGLLHVDAIQALGKIPFTVNELGADLVSLSAHKLGGPTGVGALVLTERLAGLEPLLRGGGQELGRRAGTENVA
GIAGFGAAVAAAMAGMESDMARIENLRNRLEANLRQTEGSVIIAESVPRLPNTTLVALPGLRAETAVIGFDLAGVAVSSG
SACSSGKVRASHVLEAMGFGPELAQSAIRLSLGWSSSESDIDRCLKAWRKLAGNLTKRDHETELERF

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=378, Percent_Identity=36.2433862433862, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI156713448, Length=420, Percent_Identity=32.8571428571429, Blast_Score=189, Evalue=4e-48,
Organism=Escherichia coli, GI48994898, Length=379, Percent_Identity=36.9393139841689, Blast_Score=224, Evalue=5e-60,
Organism=Escherichia coli, GI1789175, Length=412, Percent_Identity=26.9417475728155, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787970, Length=371, Percent_Identity=24.2587601078167, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25143064, Length=382, Percent_Identity=35.0785340314136, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17533177, Length=310, Percent_Identity=32.258064516129, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6319831, Length=369, Percent_Identity=36.8563685636856, Blast_Score=217, Evalue=2e-57,
Organism=Drosophila melanogaster, GI20129463, Length=378, Percent_Identity=34.9206349206349, Blast_Score=200, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 39963; Mature: 39832

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADRVYLDWNATTPLRPQARAAMAAAMELAGNPSSIHAEGRAARGLVEQARAMVAAAVG
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
AAPRNVVFTSGGTEANTLALTPGLGIGSQRIEQLVVSAIEHASVLTGGRFPHGSVATVQV
CCCCCEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
SREGVVDLDHLRGLLAGGHPALVSVMLANNETGALQPLPAIAEIVHAADGLLHVDAIQAL
CCCCCCCHHHHHHHHCCCCHHHEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHH
GKIPFTVNELGADLVSLSAHKLGGPTGVGALVLTERLAGLEPLLRGGGQELGRRAGTENV
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHCCCHHHHHHCCCCCC
AGIAGFGAAVAAAMAGMESDMARIENLRNRLEANLRQTEGSVIIAESVPRLPNTTLVALP
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEC
GLRAETAVIGFDLAGVAVSSGSACSSGKVRASHVLEAMGFGPELAQSAIRLSLGWSSSES
CCCCCCEEEEEEHHHEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHEEEECCCCCHH
DIDRCLKAWRKLAGNLTKRDHETELERF
HHHHHHHHHHHHHCCCCCCCCHHHHHCC
>Mature Secondary Structure 
TADRVYLDWNATTPLRPQARAAMAAAMELAGNPSSIHAEGRAARGLVEQARAMVAAAVG
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
AAPRNVVFTSGGTEANTLALTPGLGIGSQRIEQLVVSAIEHASVLTGGRFPHGSVATVQV
CCCCCEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
SREGVVDLDHLRGLLAGGHPALVSVMLANNETGALQPLPAIAEIVHAADGLLHVDAIQAL
CCCCCCCHHHHHHHHCCCCHHHEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHH
GKIPFTVNELGADLVSLSAHKLGGPTGVGALVLTERLAGLEPLLRGGGQELGRRAGTENV
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHCCCHHHHHHCCCCCC
AGIAGFGAAVAAAMAGMESDMARIENLRNRLEANLRQTEGSVIIAESVPRLPNTTLVALP
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEC
GLRAETAVIGFDLAGVAVSSGSACSSGKVRASHVLEAMGFGPELAQSAIRLSLGWSSSES
CCCCCCEEEEEEHHHEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHEEEECCCCCHH
DIDRCLKAWRKLAGNLTKRDHETELERF
HHHHHHHHHHHHHCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA