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The map label for this gene is hom [H]

Identifier: 86750083

GI number: 86750083

Start: 3377296

End: 3378618

Strand: Reverse

Name: hom [H]

Synonym: RPB_2966

Alternate gene names: 86750083

Gene position: 3378618-3377296 (Counterclockwise)

Preceding gene: 86750084

Following gene: 86750082

Centisome position: 63.37

GC content: 68.93

Gene sequence:

>1323_bases
ATGGTCGCGCCACTCAGAGTGGGTATTGCGGGTCTCGGCACCGTCGGCGCCGAAGTGGTCCGCGTCATCGAACAGCAGCA
GCGCACGCTCGCGGCGCGCTGCGGCCGTCCCGTGCGTGTCGTCGCCGTCACCGCGCGGTCGAAGGCCAAGAAGCGCGGCG
TCGACCTCTCCGGCATTAGATGGGCCAAGAGCCCGCTGGCGATCGCCACCGATCCCGAAGTCGACTGCTTCGTCGAACTG
ATCGGCGGCGTCGACGAGCCGGCCGGGCCGGCGATCGAGGCGGCGCTCGCCGCCGGCAAATCGGTGGTCACCGCCAACAA
GGCGCTGATCGCCAAGCACGGCCTGAAACTCGCGGCGCTCGCCGAGAAGCACGGCGTCGCGCTGAACTACGAGGCCGCCG
TCGGCGCCGCTATTCCCGTCATCAAGACGCTGCGCGAGGGCCTCGCCGGCACCGACATTCATCGCATCTACGGCATCCTC
AACGGCACCTGCAACTACATCCTGACCCGGATGGAGCAGGAAGGGCTGTCGTTCGACGCGTGCCTGAAGGACGCGCAGCG
GCTCGGCTACGCCGAGGCCAATCCGGCGTTCGACATCGACGGCCACGACACCGCGCAGAAGCTGTCCATTCTCGCCAGTC
TGGCCTTCGGCACCAAGGTCGCGCAGAGCGCGGTCCATGTCGAAGGCATCACCTCGATTACGCCGGAGGATCTGCGCGCC
GCCGCCGATCTCGGCTACCGCGTCAAGCTGCTCGGCGTCGCGGTGCGCACGCCGCAGGGCATCGAGCAGCGCGTGCATCC
GACCATGGTGCCGAAGACCTCGTCGATCGCGCAAGTGATGGGCGTCACCAATGCGGTGACGATCGACGGCGACGGCATTC
CGCCGATCACGCTGGTCGGCGCCGGCGCCGGCGCGGCCGCGACGGCCTCGGCCGTGGTCGCCGATATCGCCGACGTCGCG
CGCGGCATTCGCGCCGAGCCGTTCGGCCGGCCGGTGGGCAAGCTCAAGGTGATCACCAAGGCGCCGATGCAGCGCCACGA
GGGCGGCTATTATCTGCGGCTGATGGCGCGCGACCACGCCGGCACCGCGGCGACGATCGCGACCCGTCTGGCCGAACAGG
AGATCTCGATCGAATCGATCGTGCAGCGCCAGCCCGAGCGGGCGATGGATGCCAACGGCAAGCCGTTGAAATCCGCGCCG
GTGCCGGTGATCCTGATCACTTATGCGACCAGCGAAGACGCGGTGCGCCGCGCGCTGCAGGCGGTGCAGCGCGACAAGGT
GATCAGCGGCCGGCCGCAGGTCATCCGGATCGAGAAGAACTAG

Upstream 100 bases:

>100_bases
CGCGGCCTTCGGCGCAGGTGCTTTGGTTTCTGGCCAGTCCGTTCGGGGCCGTCTCCGGTCCTTTCCGTCTCAACTCTTCC
GGCAGCAGGTTCAGCGCGTC

Downstream 100 bases:

>100_bases
AGCATGATCCCGAAAAGTGGATACCGGTTTTCGGATAAGATCATGCTCGAACAAGTAACCAGATCAGGATGACGGTTCGA
AGATAAGTCATCCTGCTTTG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MVAPLRVGIAGLGTVGAEVVRVIEQQQRTLAARCGRPVRVVAVTARSKAKKRGVDLSGIRWAKSPLAIATDPEVDCFVEL
IGGVDEPAGPAIEAALAAGKSVVTANKALIAKHGLKLAALAEKHGVALNYEAAVGAAIPVIKTLREGLAGTDIHRIYGIL
NGTCNYILTRMEQEGLSFDACLKDAQRLGYAEANPAFDIDGHDTAQKLSILASLAFGTKVAQSAVHVEGITSITPEDLRA
AADLGYRVKLLGVAVRTPQGIEQRVHPTMVPKTSSIAQVMGVTNAVTIDGDGIPPITLVGAGAGAAATASAVVADIADVA
RGIRAEPFGRPVGKLKVITKAPMQRHEGGYYLRLMARDHAGTAATIATRLAEQEISIESIVQRQPERAMDANGKPLKSAP
VPVILITYATSEDAVRRALQAVQRDKVISGRPQVIRIEKN

Sequences:

>Translated_440_residues
MVAPLRVGIAGLGTVGAEVVRVIEQQQRTLAARCGRPVRVVAVTARSKAKKRGVDLSGIRWAKSPLAIATDPEVDCFVEL
IGGVDEPAGPAIEAALAAGKSVVTANKALIAKHGLKLAALAEKHGVALNYEAAVGAAIPVIKTLREGLAGTDIHRIYGIL
NGTCNYILTRMEQEGLSFDACLKDAQRLGYAEANPAFDIDGHDTAQKLSILASLAFGTKVAQSAVHVEGITSITPEDLRA
AADLGYRVKLLGVAVRTPQGIEQRVHPTMVPKTSSIAQVMGVTNAVTIDGDGIPPITLVGAGAGAAATASAVVADIADVA
RGIRAEPFGRPVGKLKVITKAPMQRHEGGYYLRLMARDHAGTAATIATRLAEQEISIESIVQRQPERAMDANGKPLKSAP
VPVILITYATSEDAVRRALQAVQRDKVISGRPQVIRIEKN
>Mature_440_residues
MVAPLRVGIAGLGTVGAEVVRVIEQQQRTLAARCGRPVRVVAVTARSKAKKRGVDLSGIRWAKSPLAIATDPEVDCFVEL
IGGVDEPAGPAIEAALAAGKSVVTANKALIAKHGLKLAALAEKHGVALNYEAAVGAAIPVIKTLREGLAGTDIHRIYGIL
NGTCNYILTRMEQEGLSFDACLKDAQRLGYAEANPAFDIDGHDTAQKLSILASLAFGTKVAQSAVHVEGITSITPEDLRA
AADLGYRVKLLGVAVRTPQGIEQRVHPTMVPKTSSIAQVMGVTNAVTIDGDGIPPITLVGAGAGAAATASAVVADIADVA
RGIRAEPFGRPVGKLKVITKAPMQRHEGGYYLRLMARDHAGTAATIATRLAEQEISIESIVQRQPERAMDANGKPLKSAP
VPVILITYATSEDAVRRALQAVQRDKVISGRPQVIRIEKN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=250, Percent_Identity=30, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790376, Length=357, Percent_Identity=25.4901960784314, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=146, Percent_Identity=31.5068493150685, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46159; Mature: 46159

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAPLRVGIAGLGTVGAEVVRVIEQQQRTLAARCGRPVRVVAVTARSKAKKRGVDLSGIR
CCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHCCCCCCCCE
WAKSPLAIATDPEVDCFVELIGGVDEPAGPAIEAALAAGKSVVTANKALIAKHGLKLAAL
ECCCCEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHCCCEEEEE
AEKHGVALNYEAAVGAAIPVIKTLREGLAGTDIHRIYGILNGTCNYILTRMEQEGLSFDA
HHHCCEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHH
CLKDAQRLGYAEANPAFDIDGHDTAQKLSILASLAFGTKVAQSAVHVEGITSITPEDLRA
HHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHH
AADLGYRVKLLGVAVRTPQGIEQRVHPTMVPKTSSIAQVMGVTNAVTIDGDGIPPITLVG
HHCCCCEEEEEEEEECCCCCHHHCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCEEEEE
AGAGAAATASAVVADIADVARGIRAEPFGRPVGKLKVITKAPMQRHEGGYYLRLMARDHA
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHCCCCEEEEEEEECCC
GTAATIATRLAEQEISIESIVQRQPERAMDANGKPLKSAPVPVILITYATSEDAVRRALQ
CHHHHHHHHHHHHHCCHHHHHHCCCHHHHCCCCCCCCCCCCCEEEEEEECCHHHHHHHHH
AVQRDKVISGRPQVIRIEKN
HHHHCCCCCCCCCEEEEECC
>Mature Secondary Structure
MVAPLRVGIAGLGTVGAEVVRVIEQQQRTLAARCGRPVRVVAVTARSKAKKRGVDLSGIR
CCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHCCCCCCCCE
WAKSPLAIATDPEVDCFVELIGGVDEPAGPAIEAALAAGKSVVTANKALIAKHGLKLAAL
ECCCCEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHCCCEEEEE
AEKHGVALNYEAAVGAAIPVIKTLREGLAGTDIHRIYGILNGTCNYILTRMEQEGLSFDA
HHHCCEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHH
CLKDAQRLGYAEANPAFDIDGHDTAQKLSILASLAFGTKVAQSAVHVEGITSITPEDLRA
HHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHH
AADLGYRVKLLGVAVRTPQGIEQRVHPTMVPKTSSIAQVMGVTNAVTIDGDGIPPITLVG
HHCCCCEEEEEEEEECCCCCHHHCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCEEEEE
AGAGAAATASAVVADIADVARGIRAEPFGRPVGKLKVITKAPMQRHEGGYYLRLMARDHA
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHCCCCEEEEEEEECCC
GTAATIATRLAEQEISIESIVQRQPERAMDANGKPLKSAPVPVILITYATSEDAVRRALQ
CHHHHHHHHHHHHHCCHHHHHHCCCHHHHCCCCCCCCCCCCCEEEEEEECCHHHHHHHHH
AVQRDKVISGRPQVIRIEKN
HHHHCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]