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The map label for this gene is glmS [H]

Identifier: 86749971

GI number: 86749971

Start: 3252407

End: 3254233

Strand: Reverse

Name: glmS [H]

Synonym: RPB_2854

Alternate gene names: 86749971

Gene position: 3254233-3252407 (Counterclockwise)

Preceding gene: 86749972

Following gene: 86749970

Centisome position: 61.04

GC content: 65.46

Gene sequence:

>1827_bases
ATGTGCGGCATCATCGGCATTCTGGGGCGCGGACCGGTTGCGGAGCAATTGGTCGATTCGCTGAAACGGCTCGAGTATCG
CGGCTATGATTCCGCCGGCGTCGCGACGCTGGAAGGAACCCGTCTCGATCGTCGGCGCGCCGAGGGCAAGCTGAGAAACC
TCGAAGCCTGCCTCAAGAAAGATCCCCTGAGCGGTCATTCCGGCATCGGCCATACCCGCTGGGCAACGCACGGCAAGCCG
ACCGTGGCGAACGCGCATCCGCATGTGGCCGACGGCGTCGCCGTGGTTCACAACGGCATCATCGAGAATTTTCGCGAGCT
GCGCACCGAGCTCGAAGCCGGTGGCGCCAAATTCACCAGCGAGACCGACACCGAGGTGGTCGCGCATCTGGTGAACAGCT
ACATGCGCAAAGGTGCGTCGCCGGTGGATGCGGTCAAGGCGGCGCTGCCGCGGCTGCGCGGCGCGTTCGCGCTGGCGTTC
CTGTTCGAGGGCCACGACGATCTGATGATCGGCGCGCGCAAGGGGTCGCCGCTGGCGATCGGCTACGGCGATGGCGAGAT
GTATCTCGGCTCGGATGCGATCGCGCTGGCGCCGCTCACCGACGACATCAGCTATCTCGACGACGACGACTGGGTGGTGT
TGACCCGGAAGGGCGCGGAAGTTCACGACGCCAAGGGCGACATCGTGCAGCGCGGCGTCATGAAGTCGGGCGCGTCGTCC
TTCGTCGTCGACAAGGCGAATTATCGCCATTTCATGGCCAAGGAAATCCACGAACAGCCGGAAGTCGTCGGCCATACGCT
GGCGCACTATCTCGACATGTCGACCGAGCGGGTGGCGCTGCCGACGCAGCTGCCGTTCGACTTCAAGGATATCCAGCGGA
TCTCGATCACCGCCTGCGGCACCGCGAACTACGCCGGCTACATCGGCAAGTACTGGTTCGAGCGGTTTGCCCGGCTGCCG
GTCGAGATCGATATCGCCTCGGAGTTCCGCTATCGCGAAGCGCCGCTGCGCAAGGGCGATCTGGCGATCTTCATTTCGCA
GTCGGGCGAGACGGCCGACACGCTGGCGGCGCTGCGCTACGCGAAAGAGCAGGGGTTGCACACGCTGTCGGTCGTCAACG
TGCCGACCTCGACCATCGCCCGCGACAGCGAGACGGTGATGCCGACGCTGGCCGGCCCCGAGATCGGCGTCGCCTCGACC
AAGGCCTTCACCTGCCAGCTAACGGTGCTTGCTGCGCTGGCCGTGGCGGCGGGCCGGGCCCGCGGCGAATTGTCCGAGCA
GGACGAAACGAAACTGGTCCACGGTCTGATCGAGTTGCCGCGGCTGATGGCGGCCGCACTCGCCACCGAGCATCAGGTCG
AGCGGCTGGCGCGCGACATCGCCAAGTCGCAGGACGTGCTCTATCTCGGTCGCGGCACCAGCTATCCGCTGGCGCTCGAA
GGCGCGCTGAAGCTCAAGGAAATCTCCTACATCCACGCCGAAGGCTACGCCGCCGGCGAACTCAAGCACGGCCCGATCGC
GCTGATCGACGAGAAGATGCCGGTGGTGGTGATTGCGCCCTATGATCGCGTGTTCGAAAAGACCGTGTCGAACATGCAGG
AGGTCGCGGCCCGCGGCGGCCGGATTATCCTGCTTACCGACGCCAAGGGGGCCGAGGAGGCGACGGTGGAGTCGCTGGTG
ACCATCGTGCTGCCGGACATGGCTGCGGCGTTCACGCCGTTGGTGTATGCGATCCCGGTGCAACTGCTCGCCTACCATAC
GGCCGTCGTGATGGGCACGGACGTCGACCAGCCGCGCAATCTGGCGAAGTCGGTGACCGTCGAATAG

Upstream 100 bases:

>100_bases
TCGCAATCCGCAATAATTATTGACTACCTCGGCTTCGGCGGAACTCGCTAGATGTCAAAGACGGCGGTTCGTTGTCGCCG
TTCGGGAGATATTCAACTGC

Downstream 100 bases:

>100_bases
GCGTAGGCGGCGGTTCTATCCACACCCGGCCTGTTGTTGAGGCGACACGAAACCCCTATATCGGGACCATCCGGCGCCGG
CGCTCGGCCCGGCCTGGGCA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MCGIIGILGRGPVAEQLVDSLKRLEYRGYDSAGVATLEGTRLDRRRAEGKLRNLEACLKKDPLSGHSGIGHTRWATHGKP
TVANAHPHVADGVAVVHNGIIENFRELRTELEAGGAKFTSETDTEVVAHLVNSYMRKGASPVDAVKAALPRLRGAFALAF
LFEGHDDLMIGARKGSPLAIGYGDGEMYLGSDAIALAPLTDDISYLDDDDWVVLTRKGAEVHDAKGDIVQRGVMKSGASS
FVVDKANYRHFMAKEIHEQPEVVGHTLAHYLDMSTERVALPTQLPFDFKDIQRISITACGTANYAGYIGKYWFERFARLP
VEIDIASEFRYREAPLRKGDLAIFISQSGETADTLAALRYAKEQGLHTLSVVNVPTSTIARDSETVMPTLAGPEIGVAST
KAFTCQLTVLAALAVAAGRARGELSEQDETKLVHGLIELPRLMAAALATEHQVERLARDIAKSQDVLYLGRGTSYPLALE
GALKLKEISYIHAEGYAAGELKHGPIALIDEKMPVVVIAPYDRVFEKTVSNMQEVAARGGRIILLTDAKGAEEATVESLV
TIVLPDMAAAFTPLVYAIPVQLLAYHTAVVMGTDVDQPRNLAKSVTVE

Sequences:

>Translated_608_residues
MCGIIGILGRGPVAEQLVDSLKRLEYRGYDSAGVATLEGTRLDRRRAEGKLRNLEACLKKDPLSGHSGIGHTRWATHGKP
TVANAHPHVADGVAVVHNGIIENFRELRTELEAGGAKFTSETDTEVVAHLVNSYMRKGASPVDAVKAALPRLRGAFALAF
LFEGHDDLMIGARKGSPLAIGYGDGEMYLGSDAIALAPLTDDISYLDDDDWVVLTRKGAEVHDAKGDIVQRGVMKSGASS
FVVDKANYRHFMAKEIHEQPEVVGHTLAHYLDMSTERVALPTQLPFDFKDIQRISITACGTANYAGYIGKYWFERFARLP
VEIDIASEFRYREAPLRKGDLAIFISQSGETADTLAALRYAKEQGLHTLSVVNVPTSTIARDSETVMPTLAGPEIGVAST
KAFTCQLTVLAALAVAAGRARGELSEQDETKLVHGLIELPRLMAAALATEHQVERLARDIAKSQDVLYLGRGTSYPLALE
GALKLKEISYIHAEGYAAGELKHGPIALIDEKMPVVVIAPYDRVFEKTVSNMQEVAARGGRIILLTDAKGAEEATVESLV
TIVLPDMAAAFTPLVYAIPVQLLAYHTAVVMGTDVDQPRNLAKSVTVE
>Mature_608_residues
MCGIIGILGRGPVAEQLVDSLKRLEYRGYDSAGVATLEGTRLDRRRAEGKLRNLEACLKKDPLSGHSGIGHTRWATHGKP
TVANAHPHVADGVAVVHNGIIENFRELRTELEAGGAKFTSETDTEVVAHLVNSYMRKGASPVDAVKAALPRLRGAFALAF
LFEGHDDLMIGARKGSPLAIGYGDGEMYLGSDAIALAPLTDDISYLDDDDWVVLTRKGAEVHDAKGDIVQRGVMKSGASS
FVVDKANYRHFMAKEIHEQPEVVGHTLAHYLDMSTERVALPTQLPFDFKDIQRISITACGTANYAGYIGKYWFERFARLP
VEIDIASEFRYREAPLRKGDLAIFISQSGETADTLAALRYAKEQGLHTLSVVNVPTSTIARDSETVMPTLAGPEIGVAST
KAFTCQLTVLAALAVAAGRARGELSEQDETKLVHGLIELPRLMAAALATEHQVERLARDIAKSQDVLYLGRGTSYPLALE
GALKLKEISYIHAEGYAAGELKHGPIALIDEKMPVVVIAPYDRVFEKTVSNMQEVAARGGRIILLTDAKGAEEATVESLV
TIVLPDMAAAFTPLVYAIPVQLLAYHTAVVMGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=685, Percent_Identity=37.6642335766423, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI4826742, Length=687, Percent_Identity=37.117903930131, Blast_Score=403, Evalue=1e-112,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=48.6133768352365, Blast_Score=569, Evalue=1e-163,
Organism=Escherichia coli, GI1788651, Length=223, Percent_Identity=31.390134529148, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI87082251, Length=315, Percent_Identity=21.9047619047619, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17532899, Length=429, Percent_Identity=37.2960372960373, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17532897, Length=429, Percent_Identity=37.2960372960373, Blast_Score=278, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI17539970, Length=429, Percent_Identity=37.7622377622378, Blast_Score=276, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6322745, Length=469, Percent_Identity=36.2473347547974, Blast_Score=276, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6323731, Length=429, Percent_Identity=30.0699300699301, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=36.0975609756098, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21357745, Length=686, Percent_Identity=36.8804664723032, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI28573187, Length=141, Percent_Identity=32.6241134751773, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65772; Mature: 65772

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGILGRGPVAEQLVDSLKRLEYRGYDSAGVATLEGTRLDRRRAEGKLRNLEACLKK
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHC
DPLSGHSGIGHTRWATHGKPTVANAHPHVADGVAVVHNGIIENFRELRTELEAGGAKFTS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ETDTEVVAHLVNSYMRKGASPVDAVKAALPRLRGAFALAFLFEGHDDLMIGARKGSPLAI
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEHEECCCCCEEEEECCCCEEEE
GYGDGEMYLGSDAIALAPLTDDISYLDDDDWVVLTRKGAEVHDAKGDIVQRGVMKSGASS
EECCCCEEECCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCC
FVVDKANYRHFMAKEIHEQPEVVGHTLAHYLDMSTERVALPTQLPFDFKDIQRISITACG
EEEECCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHCCEEEEEECC
TANYAGYIGKYWFERFARLPVEIDIASEFRYREAPLRKGDLAIFISQSGETADTLAALRY
CCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHH
AKEQGLHTLSVVNVPTSTIARDSETVMPTLAGPEIGVASTKAFTCQLTVLAALAVAAGRA
HHHCCCEEEEEEECCCHHHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCC
RGELSEQDETKLVHGLIELPRLMAAALATEHQVERLARDIAKSQDVLYLGRGTSYPLALE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEC
GALKLKEISYIHAEGYAAGELKHGPIALIDEKMPVVVIAPYDRVFEKTVSNMQEVAARGG
CCEEEEHEEEEEECCEECCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCC
RIILLTDAKGAEEATVESLVTIVLPDMAAAFTPLVYAIPVQLLAYHTAVVMGTDVDQPRN
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHH
LAKSVTVE
HHHHCCCC
>Mature Secondary Structure
MCGIIGILGRGPVAEQLVDSLKRLEYRGYDSAGVATLEGTRLDRRRAEGKLRNLEACLKK
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHC
DPLSGHSGIGHTRWATHGKPTVANAHPHVADGVAVVHNGIIENFRELRTELEAGGAKFTS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ETDTEVVAHLVNSYMRKGASPVDAVKAALPRLRGAFALAFLFEGHDDLMIGARKGSPLAI
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEHEECCCCCEEEEECCCCEEEE
GYGDGEMYLGSDAIALAPLTDDISYLDDDDWVVLTRKGAEVHDAKGDIVQRGVMKSGASS
EECCCCEEECCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCC
FVVDKANYRHFMAKEIHEQPEVVGHTLAHYLDMSTERVALPTQLPFDFKDIQRISITACG
EEEECCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHCCEEEEEECC
TANYAGYIGKYWFERFARLPVEIDIASEFRYREAPLRKGDLAIFISQSGETADTLAALRY
CCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHCCCCCCCCEEEEEECCCCHHHHHHHHHH
AKEQGLHTLSVVNVPTSTIARDSETVMPTLAGPEIGVASTKAFTCQLTVLAALAVAAGRA
HHHCCCEEEEEEECCCHHHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCC
RGELSEQDETKLVHGLIELPRLMAAALATEHQVERLARDIAKSQDVLYLGRGTSYPLALE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEC
GALKLKEISYIHAEGYAAGELKHGPIALIDEKMPVVVIAPYDRVFEKTVSNMQEVAARGG
CCEEEEHEEEEEECCEECCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCC
RIILLTDAKGAEEATVESLVTIVLPDMAAAFTPLVYAIPVQLLAYHTAVVMGTDVDQPRN
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHH
LAKSVTVE
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]