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The map label for this gene is dxr

Identifier: 86749939

GI number: 86749939

Start: 3216724

End: 3217947

Strand: Reverse

Name: dxr

Synonym: RPB_2822

Alternate gene names: 86749939

Gene position: 3217947-3216724 (Counterclockwise)

Preceding gene: 86749940

Following gene: 86749938

Centisome position: 60.36

GC content: 67.32

Gene sequence:

>1224_bases
ATGAGTGCAGTCCCTTTGAAAAATACCGACGCCGCCCATGATGGTGTGCGCAGCATCAGCGTCCTCGGCGCCACCGGGTC
GATCGGCGACAGCACGATGGACCTGCTGCGCGCGGCGCCGGAGAAGTACCGGGTCGAGGCGCTGACCGGCAACGCCAACG
TCGCGGGTCTCGCCAAGCTGGCGAAGGAGTTCAACGCAAGATTCGTCGCGGTGGCCGATCCGGCCCGGCTCGGCGAATTG
CGCGCCGCCCTCGCCGGAACCGACATTGCCTATGGGGCCGGCGAGAGCGCGGTGATCGAGGCCGCGGCGCGGCCGGCCGA
CTGGGTGATGGCGGCGATCTCTGGCGCAGCCGGGCTCAAGCCGGCGTTGGCCGCGGTCGATCGCGGCGCCACGGTGGCAC
TGGCCAACAAGGAGTGCCTGGTCTGCGCCGGGGACTTCTTCATGAGCCGGGCGGTCGCCGCGGGATCCTGCATCCTGCCG
GCCGATTCCGAACACAACGCGCTGTTCCAGGCGCTGGCCTCGGGCAACCGCCACGAACTGACCCGCGTCATCATCACCGC
CTCCGGTGGGCCGTTCCGGACCTGGTCCGCCGCCGATATCGAGCAGGCGACGCTGGCGCAGGCGCTGAAGCACCCGAACT
GGAGCATGGGCCAGAAGATCACCATCGACTCGGCCTCGATGATGAACAAGGGCCTCGAGGTGATCGAGGCCTCGTATTTG
TTCGCGCTGTCGCCGGACGAGATCGACGTGCTGGTGCATCCGCAGTCGATCGTTCACGGTATGGTCGAATTCGCCGATCA
TTCGGTGGTGGCGCAGCTCGGCGCCCCCGACATGCGGATCCCGATCGCGCACTGCCTGGGCTGGCCGGACCGGATCGTCG
GCCGCGCCGCCCGGCTGGATCTCGCCAAGATCGGCCAGTTGACCTTCGAGGCTCCGGATTTCGAACGATTTCCAGGCCTG
CGGCTGGCCTATGACGCGCTGCGCGCCGGCAATGGCGCCACGACCGTCTACAATGCGGCGAACGAGATCGCGGTCGCGGC
CTTCATCGCCCAGAAGATCAGGTTCGGGGCGATCGCCCGGCTGGTCGAGGATACGCTGAACGCGTGGATCCGGGCCGGCA
ATCTCGCGCCGCTCGGCAGCGCCGACGATGCCATCGCCGTTGACCATAACGCGCGAAAAATGGCTGCCACCCTATTGCCT
CAAATTGCCGCAAAGGCATCCTAG

Upstream 100 bases:

>100_bases
CTCGACGGATATGTCGCGGCCGTGGCGGTGGCCGTGCTGATCGGGCTGATGCGAGGATCGCCGGATGGTATTGGCCGCGG
TCTTATGGTGTGGTGATCCG

Downstream 100 bases:

>100_bases
AGCATTGGGGAACAGGGCCGTCGGTTCTGCTTGAGAGGAATGGGATGGCCGATCTTTTTATGAACGGGTTCAACACGTTG
AGCCACGGAATCGTGGGTTA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MSAVPLKNTDAAHDGVRSISVLGATGSIGDSTMDLLRAAPEKYRVEALTGNANVAGLAKLAKEFNARFVAVADPARLGEL
RAALAGTDIAYGAGESAVIEAAARPADWVMAAISGAAGLKPALAAVDRGATVALANKECLVCAGDFFMSRAVAAGSCILP
ADSEHNALFQALASGNRHELTRVIITASGGPFRTWSAADIEQATLAQALKHPNWSMGQKITIDSASMMNKGLEVIEASYL
FALSPDEIDVLVHPQSIVHGMVEFADHSVVAQLGAPDMRIPIAHCLGWPDRIVGRAARLDLAKIGQLTFEAPDFERFPGL
RLAYDALRAGNGATTVYNAANEIAVAAFIAQKIRFGAIARLVEDTLNAWIRAGNLAPLGSADDAIAVDHNARKMAATLLP
QIAAKAS

Sequences:

>Translated_407_residues
MSAVPLKNTDAAHDGVRSISVLGATGSIGDSTMDLLRAAPEKYRVEALTGNANVAGLAKLAKEFNARFVAVADPARLGEL
RAALAGTDIAYGAGESAVIEAAARPADWVMAAISGAAGLKPALAAVDRGATVALANKECLVCAGDFFMSRAVAAGSCILP
ADSEHNALFQALASGNRHELTRVIITASGGPFRTWSAADIEQATLAQALKHPNWSMGQKITIDSASMMNKGLEVIEASYL
FALSPDEIDVLVHPQSIVHGMVEFADHSVVAQLGAPDMRIPIAHCLGWPDRIVGRAARLDLAKIGQLTFEAPDFERFPGL
RLAYDALRAGNGATTVYNAANEIAVAAFIAQKIRFGAIARLVEDTLNAWIRAGNLAPLGSADDAIAVDHNARKMAATLLP
QIAAKAS
>Mature_406_residues
SAVPLKNTDAAHDGVRSISVLGATGSIGDSTMDLLRAAPEKYRVEALTGNANVAGLAKLAKEFNARFVAVADPARLGELR
AALAGTDIAYGAGESAVIEAAARPADWVMAAISGAAGLKPALAAVDRGATVALANKECLVCAGDFFMSRAVAAGSCILPA
DSEHNALFQALASGNRHELTRVIITASGGPFRTWSAADIEQATLAQALKHPNWSMGQKITIDSASMMNKGLEVIEASYLF
ALSPDEIDVLVHPQSIVHGMVEFADHSVVAQLGAPDMRIPIAHCLGWPDRIVGRAARLDLAKIGQLTFEAPDFERFPGLR
LAYDALRAGNGATTVYNAANEIAVAAFIAQKIRFGAIARLVEDTLNAWIRAGNLAPLGSADDAIAVDHNARKMAATLLPQ
IAAKAS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=393, Percent_Identity=45.8015267175573, Blast_Score=326, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_RHOP2 (Q2IW86)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_486435.1
- ProteinModelPortal:   Q2IW86
- SMR:   Q2IW86
- STRING:   Q2IW86
- GeneID:   3910615
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_2822
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   RPAL316058:RPB_2822-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42477; Mature: 42346

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: BINDING 137-137 BINDING 164-164 BINDING 188-188 BINDING 211-211 BINDING 233-233

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVPLKNTDAAHDGVRSISVLGATGSIGDSTMDLLRAAPEKYRVEALTGNANVAGLAKL
CCCCCCCCCCCHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHH
AKEFNARFVAVADPARLGELRAALAGTDIAYGAGESAVIEAAARPADWVMAAISGAAGLK
HHHHCCEEEEEECCHHHHHHHHHHHCCCEECCCCCHHHHHHHCCCHHHHHHHHHCCCCCC
PALAAVDRGATVALANKECLVCAGDFFMSRAVAAGSCILPADSEHNALFQALASGNRHEL
HHHHHHCCCCEEEEECCCEEEEECHHHHHHHHHCCCEECCCCCCHHHHHHHHHCCCCEEE
TRVIITASGGPFRTWSAADIEQATLAQALKHPNWSMGQKITIDSASMMNKGLEVIEASYL
EEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHCHHHHHHEEE
FALSPDEIDVLVHPQSIVHGMVEFADHSVVAQLGAPDMRIPIAHCLGWPDRIVGRAARLD
EEECCCCEEEEECCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHCC
LAKIGQLTFEAPDFERFPGLRLAYDALRAGNGATTVYNAANEIAVAAFIAQKIRFGAIAR
HHHHCCEEECCCCHHHCCCCHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
LVEDTLNAWIRAGNLAPLGSADDAIAVDHNARKMAATLLPQIAAKAS
HHHHHHHHHHCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAVPLKNTDAAHDGVRSISVLGATGSIGDSTMDLLRAAPEKYRVEALTGNANVAGLAKL
CCCCCCCCCCHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHH
AKEFNARFVAVADPARLGELRAALAGTDIAYGAGESAVIEAAARPADWVMAAISGAAGLK
HHHHCCEEEEEECCHHHHHHHHHHHCCCEECCCCCHHHHHHHCCCHHHHHHHHHCCCCCC
PALAAVDRGATVALANKECLVCAGDFFMSRAVAAGSCILPADSEHNALFQALASGNRHEL
HHHHHHCCCCEEEEECCCEEEEECHHHHHHHHHCCCEECCCCCCHHHHHHHHHCCCCEEE
TRVIITASGGPFRTWSAADIEQATLAQALKHPNWSMGQKITIDSASMMNKGLEVIEASYL
EEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHCHHHHHHEEE
FALSPDEIDVLVHPQSIVHGMVEFADHSVVAQLGAPDMRIPIAHCLGWPDRIVGRAARLD
EEECCCCEEEEECCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHCC
LAKIGQLTFEAPDFERFPGLRLAYDALRAGNGATTVYNAANEIAVAAFIAQKIRFGAIAR
HHHHCCEEECCCCHHHCCCCHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
LVEDTLNAWIRAGNLAPLGSADDAIAVDHNARKMAATLLPQIAAKAS
HHHHHHHHHHCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA