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The map label for this gene is lpxD

Identifier: 86749936

GI number: 86749936

Start: 3211715

End: 3212794

Strand: Reverse

Name: lpxD

Synonym: RPB_2819

Alternate gene names: 86749936

Gene position: 3212794-3211715 (Counterclockwise)

Preceding gene: 86749937

Following gene: 86749935

Centisome position: 60.26

GC content: 64.44

Gene sequence:

>1080_bases
ATGACCTCGACTTTGTTCTTCAAACCGCGTCCTTCGTCGACGTTGGCTGAAATCGCCGCGTTGACGAAGGCTGAGCTGGT
CGACCCGTCCCAGGGCGACCGCGTTATTTCCGGAATCGCCTCGCTCGACGAGGCGGGACCGATGCATCTCGGCTTCTTCG
AGAACATCAAATACGTCGCGGAACTGGAGCAGACCCACGCCGGGGCCTGCCTGGTGACGCAACGGTATGAGACCCGCGTG
CCGCCACATGTGGCCGTGCTGCGGGTGAAGAGCCCGGTTCAGGCGTTCGTGGCCTATGCGCGGCACATCCACGAAGATGC
GATGCGGCCGATGTCGGGCTTCGGAGGCACCGGCATTGCTCCCTCGGCGGTCATCCATCCCAGCGCCCGGCTCGAGGACG
GGGTGATTGTCGATCCACTGGCGGTGATCGGTCCTGATGTGGAGATCGGCGCAGGCAGCGTGATCGGGGCGGGTGCCGTG
ATCGCAAGCGGCGTCAAGATCGGTCGCGACTGCAATGTCGGCGCCAACACCACGATCCAGTTCTCGCTGATCGGCAACAA
CGTTCTGATTCACCCCGGCTGTCACATCGGGCAGGACGGCTTCCGCTTCATCTTCGCCCGGACCCATCAAAAGGTGCCGC
AGGTCGGGCGGGTGATCATCCAGAACGATGTCGAGATCGGCTCCGGTACCACCGTCGATCGGGGCGGCCTGCGCGATACG
GTGATCGGCGAGGGCACCAAGATCGACAATCAGGTGCAGGTCGGCCACAACGTAACAATTGGTCGACATTGTGTCATCGC
GGCGCAATGCGGCCTTGCCGGCAGCCTGACGCTGGGCGACAACGTCGCGCTGGGCGCCAAGGTCGGCATCAACAACCACG
TCATGATCGGCGACGGTGCGCAGATCACCGCGATGAGCGCGGTCAAGGACAGCGTCCCGGCCGGCGAGCGCTGGGGTGGC
TACTTCGCGAAGCCGACCAAGCAATGGTTCCGGGAAATCATCGCGGTCGAGCGGTTGATGCGGGGTGGTGCGGGCGCGGC
GCCGAAGGCCGACGACGGAAAAGACGAGGACCGGGGCTGA

Upstream 100 bases:

>100_bases
GCTGTCCCGATCACCAAGGGTAAGTACGACCGCGTCCAGGAATTCAAATTCGGCGGCGGGACTTCGTTCTAAGTCCCGCG
GTCCGGACTGCGACCGCAGG

Downstream 100 bases:

>100_bases
TGGAATCGCCGATACGTTTCGCGGATGTGGACATCAACACCATCCTCAAGACCCTCCCGCACCGTTTTCCGTTTCTGCTG
ATCGATCGCGTCAAGAACAT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MTSTLFFKPRPSSTLAEIAALTKAELVDPSQGDRVISGIASLDEAGPMHLGFFENIKYVAELEQTHAGACLVTQRYETRV
PPHVAVLRVKSPVQAFVAYARHIHEDAMRPMSGFGGTGIAPSAVIHPSARLEDGVIVDPLAVIGPDVEIGAGSVIGAGAV
IASGVKIGRDCNVGANTTIQFSLIGNNVLIHPGCHIGQDGFRFIFARTHQKVPQVGRVIIQNDVEIGSGTTVDRGGLRDT
VIGEGTKIDNQVQVGHNVTIGRHCVIAAQCGLAGSLTLGDNVALGAKVGINNHVMIGDGAQITAMSAVKDSVPAGERWGG
YFAKPTKQWFREIIAVERLMRGGAGAAPKADDGKDEDRG

Sequences:

>Translated_359_residues
MTSTLFFKPRPSSTLAEIAALTKAELVDPSQGDRVISGIASLDEAGPMHLGFFENIKYVAELEQTHAGACLVTQRYETRV
PPHVAVLRVKSPVQAFVAYARHIHEDAMRPMSGFGGTGIAPSAVIHPSARLEDGVIVDPLAVIGPDVEIGAGSVIGAGAV
IASGVKIGRDCNVGANTTIQFSLIGNNVLIHPGCHIGQDGFRFIFARTHQKVPQVGRVIIQNDVEIGSGTTVDRGGLRDT
VIGEGTKIDNQVQVGHNVTIGRHCVIAAQCGLAGSLTLGDNVALGAKVGINNHVMIGDGAQITAMSAVKDSVPAGERWGG
YFAKPTKQWFREIIAVERLMRGGAGAAPKADDGKDEDRG
>Mature_358_residues
TSTLFFKPRPSSTLAEIAALTKAELVDPSQGDRVISGIASLDEAGPMHLGFFENIKYVAELEQTHAGACLVTQRYETRVP
PHVAVLRVKSPVQAFVAYARHIHEDAMRPMSGFGGTGIAPSAVIHPSARLEDGVIVDPLAVIGPDVEIGAGSVIGAGAVI
ASGVKIGRDCNVGANTTIQFSLIGNNVLIHPGCHIGQDGFRFIFARTHQKVPQVGRVIIQNDVEIGSGTTVDRGGLRDTV
IGEGTKIDNQVQVGHNVTIGRHCVIAAQCGLAGSLTLGDNVALGAKVGINNHVMIGDGAQITAMSAVKDSVPAGERWGGY
FAKPTKQWFREIIAVERLMRGGAGAAPKADDGKDEDRG

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=327, Percent_Identity=39.1437308868502, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1786378, Length=201, Percent_Identity=29.8507462686567, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_RHOP2 (Q2IW89)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_486432.1
- ProteinModelPortal:   Q2IW89
- SMR:   Q2IW89
- STRING:   Q2IW89
- GeneID:   3910612
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_2819
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   WFREIIA
- ProtClustDB:   PRK00892
- BioCyc:   RPAL316058:RPB_2819-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 37658; Mature: 37527

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTLFFKPRPSSTLAEIAALTKAELVDPSQGDRVISGIASLDEAGPMHLGFFENIKYVA
CCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECHHHHHHHHH
ELEQTHAGACLVTQRYETRVPPHVAVLRVKSPVQAFVAYARHIHEDAMRPMSGFGGTGIA
HHHHHCCCEEEEEECHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCHHCCCCCCCCC
PSAVIHPSARLEDGVIVDPLAVIGPDVEIGAGSVIGAGAVIASGVKIGRDCNVGANTTIQ
CCEEECCCCCCCCCEEECCHHHHCCCCEECCCCEECCCHHHHCCCEECCCCCCCCCCEEE
FSLIGNNVLIHPGCHIGQDGFRFIFARTHQKVPQVGRVIIQNDVEIGSGTTVDRGGLRDT
EEEECCEEEECCCCCCCCCCCEEEEEHHHHHHHHHCEEEEECCCCCCCCCEECCCCCCCC
VIGEGTKIDNQVQVGHNVTIGRHCVIAAQCGLAGSLTLGDNVALGAKVGINNHVMIGDGA
CCCCCCCCCCEEECCCCEEECCEEEEEEECCCCEEEEECCCEEEEEEECCCCEEEECCCC
QITAMSAVKDSVPAGERWGGYFAKPTKQWFREIIAVERLMRGGAGAAPKADDGKDEDRG
CEEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSTLFFKPRPSSTLAEIAALTKAELVDPSQGDRVISGIASLDEAGPMHLGFFENIKYVA
CCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECHHHHHHHHH
ELEQTHAGACLVTQRYETRVPPHVAVLRVKSPVQAFVAYARHIHEDAMRPMSGFGGTGIA
HHHHHCCCEEEEEECHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCHHCCCCCCCCC
PSAVIHPSARLEDGVIVDPLAVIGPDVEIGAGSVIGAGAVIASGVKIGRDCNVGANTTIQ
CCEEECCCCCCCCCEEECCHHHHCCCCEECCCCEECCCHHHHCCCEECCCCCCCCCCEEE
FSLIGNNVLIHPGCHIGQDGFRFIFARTHQKVPQVGRVIIQNDVEIGSGTTVDRGGLRDT
EEEECCEEEECCCCCCCCCCCEEEEEHHHHHHHHHCEEEEECCCCCCCCCEECCCCCCCC
VIGEGTKIDNQVQVGHNVTIGRHCVIAAQCGLAGSLTLGDNVALGAKVGINNHVMIGDGA
CCCCCCCCCCEEECCCCEEECCEEEEEEECCCCEEEEECCCEEEEEEECCCCEEEECCCC
QITAMSAVKDSVPAGERWGGYFAKPTKQWFREIIAVERLMRGGAGAAPKADDGKDEDRG
CEEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA