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The map label for this gene is lpxB

Identifier: 86749932

GI number: 86749932

Start: 3208353

End: 3209534

Strand: Reverse

Name: lpxB

Synonym: RPB_2815

Alternate gene names: 86749932

Gene position: 3209534-3208353 (Counterclockwise)

Preceding gene: 86749933

Following gene: 86749931

Centisome position: 60.2

GC content: 69.12

Gene sequence:

>1182_bases
GTGAGGGCTGCGAACGCCACAACGGGCGCGGTGCGCCGATTGTTTCTGATCGCCACGGAGGAATCCGGCGACAGGCTCGG
CGCGGCGCTGATGCAGGCGCTGAAAACGCGGCTCGGCGACGGCGTCGTGTTCGAAGGCGTCGGCGGGCGGGCGATGGCGG
AGCAGGGGCTGGTCTCGCTGTTTCCCATCGAGGAATTGTCGATCATGGGGATCTCCGCCGTGGTCCGGCGATTGCCCTCG
ATCCTGCGCCGGATCCGCAGCACGGCGGACGCGGTGCTCGGCGCCAAGCCCGACATGCTGATCATCATCGATAGCCCGGA
CTTCACGCACCGCGTCGCACGACGGGTCCGCGTGCGCGATCCGTCGATCGCGATCGTCAACTACGTGTCGCCGACGGTCT
GGGCGTGGCGGCCGGGCCGCGCTCGCGCGATGCGCCGCTATGTCGATCACGTGCTGGCGCTGCTGCCGTTCGAGCCGGAA
GAATATCGCAGGCTGCGCGGCCCCCCCTGCACCTATGTGGGCCATCCGCTGACCGAGCAGATCGCCCATCTGCGCCCGAG
TCCGGCCGAGCAGGCGCGGCGCGACGCCGAACCGCCCGTGCTGGTGGTGCTGCCGGGCAGCCGGCGCAGCGAGATCCATC
ATCTGATGGCGGTGTTCGGCGAAACGCTGGGGCGGCTGCAGGCCGAGCAGGGCGATCTCGAATTGATCCTGCCGACCGTT
CCGCATCTGCGCGACGCCGTCGAGGCGGGCGTGCGCGACTGGCCGGTGCAGCCGAGGATCGTGGTCGGCGACGCCGACAA
GAAGGCGGCGTTCCGGATCGCGCGTGCGGCGTTCGCCAAGTCCGGTACCGTGACGCTGGAACTGGCGCTGGCGCATGTGC
CGATGGTCGCGGTCTACAAGGCCGGCGCGATGGAGGCCTGGATCGGCAAGCGGGTGATCCGCTCGGCCTCGGTGATCCTC
GCCAATCTCGTGGTCGGCGAGAACGTCATCCCGGAATTCATCCAGGAGGATTGCGTCCCGGACAGACTGGTGCCGGCGCT
GCGCGAGGTGCTGGCCGACACGCCGATGCGGGCGCGCCAGCTCGAAGGCTTCGGGCGGATCGACGACATCATGTCGACCG
GCGCGCAGACGCCGAGCGGGCGTGCGGCCGATATTGTCCTGAACGTCCTTCGCAAACATTGA

Upstream 100 bases:

>100_bases
CGGGCGTCGCCGTGGCCGCCGGCAATACGCTGGTGGCCGAACCGCAGGCGATGATCGCGGCCGCCGACAAGGCGGGTCTG
TTCGTCACCGGTGTGCCGGC

Downstream 100 bases:

>100_bases
GACACGCGACCCGGTGCTGCGGGCGCGCTGTTGCAATCAATTCTCAATCAATGGGAACTAGCCTGCGGAAGCATTGAGCT
TCCGGCCGCGTGGATCGGAG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MRAANATTGAVRRLFLIATEESGDRLGAALMQALKTRLGDGVVFEGVGGRAMAEQGLVSLFPIEELSIMGISAVVRRLPS
ILRRIRSTADAVLGAKPDMLIIIDSPDFTHRVARRVRVRDPSIAIVNYVSPTVWAWRPGRARAMRRYVDHVLALLPFEPE
EYRRLRGPPCTYVGHPLTEQIAHLRPSPAEQARRDAEPPVLVVLPGSRRSEIHHLMAVFGETLGRLQAEQGDLELILPTV
PHLRDAVEAGVRDWPVQPRIVVGDADKKAAFRIARAAFAKSGTVTLELALAHVPMVAVYKAGAMEAWIGKRVIRSASVIL
ANLVVGENVIPEFIQEDCVPDRLVPALREVLADTPMRARQLEGFGRIDDIMSTGAQTPSGRAADIVLNVLRKH

Sequences:

>Translated_393_residues
MRAANATTGAVRRLFLIATEESGDRLGAALMQALKTRLGDGVVFEGVGGRAMAEQGLVSLFPIEELSIMGISAVVRRLPS
ILRRIRSTADAVLGAKPDMLIIIDSPDFTHRVARRVRVRDPSIAIVNYVSPTVWAWRPGRARAMRRYVDHVLALLPFEPE
EYRRLRGPPCTYVGHPLTEQIAHLRPSPAEQARRDAEPPVLVVLPGSRRSEIHHLMAVFGETLGRLQAEQGDLELILPTV
PHLRDAVEAGVRDWPVQPRIVVGDADKKAAFRIARAAFAKSGTVTLELALAHVPMVAVYKAGAMEAWIGKRVIRSASVIL
ANLVVGENVIPEFIQEDCVPDRLVPALREVLADTPMRARQLEGFGRIDDIMSTGAQTPSGRAADIVLNVLRKH
>Mature_393_residues
MRAANATTGAVRRLFLIATEESGDRLGAALMQALKTRLGDGVVFEGVGGRAMAEQGLVSLFPIEELSIMGISAVVRRLPS
ILRRIRSTADAVLGAKPDMLIIIDSPDFTHRVARRVRVRDPSIAIVNYVSPTVWAWRPGRARAMRRYVDHVLALLPFEPE
EYRRLRGPPCTYVGHPLTEQIAHLRPSPAEQARRDAEPPVLVVLPGSRRSEIHHLMAVFGETLGRLQAEQGDLELILPTV
PHLRDAVEAGVRDWPVQPRIVVGDADKKAAFRIARAAFAKSGTVTLELALAHVPMVAVYKAGAMEAWIGKRVIRSASVIL
ANLVVGENVIPEFIQEDCVPDRLVPALREVLADTPMRARQLEGFGRIDDIMSTGAQTPSGRAADIVLNVLRKH

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=335, Percent_Identity=35.2238805970149, Blast_Score=173, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_RHOP2 (Q2IW93)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_486428.1
- ProteinModelPortal:   Q2IW93
- STRING:   Q2IW93
- GeneID:   3910608
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_2815
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- ProtClustDB:   CLSK911278
- BioCyc:   RPAL316058:RPB_2815-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 43079; Mature: 43079

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAANATTGAVRRLFLIATEESGDRLGAALMQALKTRLGDGVVFEGVGGRAMAEQGLVSL
CCCCCCHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCCEEE
FPIEELSIMGISAVVRRLPSILRRIRSTADAVLGAKPDMLIIIDSPDFTHRVARRVRVRD
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCC
PSIAIVNYVSPTVWAWRPGRARAMRRYVDHVLALLPFEPEEYRRLRGPPCTYVGHPLTEQ
CCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCHHHH
IAHLRPSPAEQARRDAEPPVLVVLPGSRRSEIHHLMAVFGETLGRLQAEQGDLELILPTV
HHHCCCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
PHLRDAVEAGVRDWPVQPRIVVGDADKKAAFRIARAAFAKSGTVTLELALAHVPMVAVYK
HHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCHHHHHH
AGAMEAWIGKRVIRSASVILANLVVGENVIPEFIQEDCVPDRLVPALREVLADTPMRARQ
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHH
LEGFGRIDDIMSTGAQTPSGRAADIVLNVLRKH
HCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRAANATTGAVRRLFLIATEESGDRLGAALMQALKTRLGDGVVFEGVGGRAMAEQGLVSL
CCCCCCHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCCEEE
FPIEELSIMGISAVVRRLPSILRRIRSTADAVLGAKPDMLIIIDSPDFTHRVARRVRVRD
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCC
PSIAIVNYVSPTVWAWRPGRARAMRRYVDHVLALLPFEPEEYRRLRGPPCTYVGHPLTEQ
CCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCHHHH
IAHLRPSPAEQARRDAEPPVLVVLPGSRRSEIHHLMAVFGETLGRLQAEQGDLELILPTV
HHHCCCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
PHLRDAVEAGVRDWPVQPRIVVGDADKKAAFRIARAAFAKSGTVTLELALAHVPMVAVYK
HHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCHHHHHH
AGAMEAWIGKRVIRSASVILANLVVGENVIPEFIQEDCVPDRLVPALREVLADTPMRARQ
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHH
LEGFGRIDDIMSTGAQTPSGRAADIVLNVLRKH
HCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA