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The map label for this gene is serS

Identifier: 86749859

GI number: 86749859

Start: 3125925

End: 3127355

Strand: Reverse

Name: serS

Synonym: RPB_2742

Alternate gene names: 86749859

Gene position: 3127355-3125925 (Counterclockwise)

Preceding gene: 86749860

Following gene: 86749858

Centisome position: 58.66

GC content: 64.29

Gene sequence:

>1431_bases
ATGCACGACATCAAAGCGATCCGCGACAATCCGCAGGCGTTCGACGCGGCGTTCACGCGGCGGGGGCTGGCGCCGATCGC
CGACAGCCTGATCAAGCTCGACGAGACCCGGCGCGCGGCGATCCTGGAGTCCGAGAAGGCGCAGGCGCGGCGCAATGCGG
CGTCGAAGGAGATCGGCGACGCCAAGAAGGCCAAGGACAATGCGCGGGCCGACGCGCTGATGGCCGAGGTCGCCGAGCTC
AAGACCACCATGCCGGCGCTCGAGGCCGCGGTGAAGGAGGCCGACGAGGCGCTGAAAAAGGCGCTGTCGGAAATCCCGAA
TCTGCCGCTCGACGAGGTGCCGGAAGGCGCCGACGAGCACGGCAATGTCGACCATCATCGCTTCGGCGCCAAGCGCGACT
ACGCGTTCACGCCCAAGGCTCACTACGATCTCGGCGAGGCGCTCGGGATGATGGACTTCGAAGCCGCCGCGAAGATCAGC
GGCGCGCGCTTTGTCGTGCTGAAGAAGGGCCTCGCCCGGCTCGAACGCGCGATCGGGCAGTTCTTCCTCGACGTGCATAC
TGGCGAGCATGGGTACACGGAAGTAAATCCTCCCCTGTTAGTGCGCGATGATGCAATGTTCGGGACGGCGCAGTTGCCGA
AATTCAGGGAAGACCAGTTCCAGACTGTTACAGAAGAGGTTCGCCGAAGAACGATAGTCGAGTTTGTTTCGTCGGCAATG
AAGCTCGGAGCATCGGCTACTGATGCTGGCGGTTCTGAGTTTGCTCGTCAGCTTGCTAACGAAGAGCTTGTGGATTTCAG
TTATGCCAAGATGCCCGAGCGTTTTTGGCTCATCCCCACCGCCGAAGTCTCGCTCACCAATCTCGTCCGCGAATCCATTC
TCGACGAGAAAGAGCTGCCGATGCGGCTGACGGCGCTGACGCCGTGTTTCCGCGCGGAGGCGGGGGCTGCGGGGCGGGAT
ACGCGCGGGATGATCCGGCAGCATCAGTTCACCAAGGTGGAGCTGGTGTCGATCACCACGCCGGAGCAGTCCAAGGACGA
GCACGAGCGGATGTTGAGCTGCGCCGAGGAAGTGCTGCGCCGGCTCGGGCTGCACTACCGCGTCATGACGCTGTGCACCG
GCGACATGGGGTTTGCGTCGCAGAAGACCTACGACATCGAAGTCTGGATGCCGGGGCAGGGCGAGGGCGGGGCTTACCGC
GAAATCTCGTCGTGCTCGGTGTGCGGCGACTTCCAGGCCCGCCGGATGGATGCGCGCTCGCGCGGCCCGGATGGCAAGCC
GCGCTTCGTCCACACGCTGAACGGCTCCGGCACCGCGGTCGGCCGCGCGTTGATCGCGGTGATCGAGAACTATCAGCAGG
AGGACGGCTCGATCGCCGTGCCCGACGCGCTGCAGCCCTATATGGGCGGGCTGAAAGTGATCGCGAAGTAA

Upstream 100 bases:

>100_bases
GATGACGACTCGGCGGATGCGGACGCGCATCAGCTTCCAAACCCGGCCCAATCGCGCTACTGCAGAGCCCTTCTTTGCGC
CGGTTTCCAGGACGAGACTC

Downstream 100 bases:

>100_bases
GCTGATGAATCTCCCCGTCATTGCGAGGAGCACCCGGATCGGCGCTCCGCGCCGTCCGAGCACAGGCTCCGCGACGAAGC
AATCCAGGGGCTCCGTACTC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MHDIKAIRDNPQAFDAAFTRRGLAPIADSLIKLDETRRAAILESEKAQARRNAASKEIGDAKKAKDNARADALMAEVAEL
KTTMPALEAAVKEADEALKKALSEIPNLPLDEVPEGADEHGNVDHHRFGAKRDYAFTPKAHYDLGEALGMMDFEAAAKIS
GARFVVLKKGLARLERAIGQFFLDVHTGEHGYTEVNPPLLVRDDAMFGTAQLPKFREDQFQTVTEEVRRRTIVEFVSSAM
KLGASATDAGGSEFARQLANEELVDFSYAKMPERFWLIPTAEVSLTNLVRESILDEKELPMRLTALTPCFRAEAGAAGRD
TRGMIRQHQFTKVELVSITTPEQSKDEHERMLSCAEEVLRRLGLHYRVMTLCTGDMGFASQKTYDIEVWMPGQGEGGAYR
EISSCSVCGDFQARRMDARSRGPDGKPRFVHTLNGSGTAVGRALIAVIENYQQEDGSIAVPDALQPYMGGLKVIAK

Sequences:

>Translated_476_residues
MHDIKAIRDNPQAFDAAFTRRGLAPIADSLIKLDETRRAAILESEKAQARRNAASKEIGDAKKAKDNARADALMAEVAEL
KTTMPALEAAVKEADEALKKALSEIPNLPLDEVPEGADEHGNVDHHRFGAKRDYAFTPKAHYDLGEALGMMDFEAAAKIS
GARFVVLKKGLARLERAIGQFFLDVHTGEHGYTEVNPPLLVRDDAMFGTAQLPKFREDQFQTVTEEVRRRTIVEFVSSAM
KLGASATDAGGSEFARQLANEELVDFSYAKMPERFWLIPTAEVSLTNLVRESILDEKELPMRLTALTPCFRAEAGAAGRD
TRGMIRQHQFTKVELVSITTPEQSKDEHERMLSCAEEVLRRLGLHYRVMTLCTGDMGFASQKTYDIEVWMPGQGEGGAYR
EISSCSVCGDFQARRMDARSRGPDGKPRFVHTLNGSGTAVGRALIAVIENYQQEDGSIAVPDALQPYMGGLKVIAK
>Mature_476_residues
MHDIKAIRDNPQAFDAAFTRRGLAPIADSLIKLDETRRAAILESEKAQARRNAASKEIGDAKKAKDNARADALMAEVAEL
KTTMPALEAAVKEADEALKKALSEIPNLPLDEVPEGADEHGNVDHHRFGAKRDYAFTPKAHYDLGEALGMMDFEAAAKIS
GARFVVLKKGLARLERAIGQFFLDVHTGEHGYTEVNPPLLVRDDAMFGTAQLPKFREDQFQTVTEEVRRRTIVEFVSSAM
KLGASATDAGGSEFARQLANEELVDFSYAKMPERFWLIPTAEVSLTNLVRESILDEKELPMRLTALTPCFRAEAGAAGRD
TRGMIRQHQFTKVELVSITTPEQSKDEHERMLSCAEEVLRRLGLHYRVMTLCTGDMGFASQKTYDIEVWMPGQGEGGAYR
EISSCSVCGDFQARRMDARSRGPDGKPRFVHTLNGSGTAVGRALIAVIENYQQEDGSIAVPDALQPYMGGLKVIAK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=473, Percent_Identity=30.8668076109937, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI8923421, Length=454, Percent_Identity=29.5154185022026, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI225579074, Length=450, Percent_Identity=28.6666666666667, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI1787120, Length=476, Percent_Identity=47.2689075630252, Blast_Score=401, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17539260, Length=493, Percent_Identity=31.4401622718053, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17542084, Length=187, Percent_Identity=34.2245989304813, Blast_Score=134, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321799, Length=479, Percent_Identity=29.0187891440501, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6320226, Length=464, Percent_Identity=27.3706896551724, Blast_Score=169, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24581334, Length=476, Percent_Identity=29.2016806722689, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI17737985, Length=414, Percent_Identity=30.6763285024155, Blast_Score=158, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_RHOP2 (Q2IWG6)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_486355.1
- ProteinModelPortal:   Q2IWG6
- SMR:   Q2IWG6
- STRING:   Q2IWG6
- GeneID:   3910535
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_2742
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- BioCyc:   RPAL316058:RPB_2742-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 52475; Mature: 52475

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 334-334 BINDING 436-436

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIKAIRDNPQAFDAAFTRRGLAPIADSLIKLDETRRAAILESEKAQARRNAASKEIGD
CCCCCHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AKKAKDNARADALMAEVAELKTTMPALEAAVKEADEALKKALSEIPNLPLDEVPEGADEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
GNVDHHRFGAKRDYAFTPKAHYDLGEALGMMDFEAAAKISGARFVVLKKGLARLERAIGQ
CCCCHHHCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHH
FFLDVHTGEHGYTEVNPPLLVRDDAMFGTAQLPKFREDQFQTVTEEVRRRTIVEFVSSAM
HHEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KLGASATDAGGSEFARQLANEELVDFSYAKMPERFWLIPTAEVSLTNLVRESILDEKELP
HCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCC
MRLTALTPCFRAEAGAAGRDTRGMIRQHQFTKVELVSITTPEQSKDEHERMLSCAEEVLR
EEHHHHCHHHHHCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHH
RLGLHYRVMTLCTGDMGFASQKTYDIEVWMPGQGEGGAYREISSCSVCGDFQARRMDARS
HHCCCEEEEEHEECCCCCCCCCEEEEEEEECCCCCCCCCHHHCCCCCCCCHHHHHHHHHC
RGPDGKPRFVHTLNGSGTAVGRALIAVIENYQQEDGSIAVPDALQPYMGGLKVIAK
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHCCHHHHCC
>Mature Secondary Structure
MHDIKAIRDNPQAFDAAFTRRGLAPIADSLIKLDETRRAAILESEKAQARRNAASKEIGD
CCCCCHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AKKAKDNARADALMAEVAELKTTMPALEAAVKEADEALKKALSEIPNLPLDEVPEGADEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCC
GNVDHHRFGAKRDYAFTPKAHYDLGEALGMMDFEAAAKISGARFVVLKKGLARLERAIGQ
CCCCHHHCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHHH
FFLDVHTGEHGYTEVNPPLLVRDDAMFGTAQLPKFREDQFQTVTEEVRRRTIVEFVSSAM
HHEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KLGASATDAGGSEFARQLANEELVDFSYAKMPERFWLIPTAEVSLTNLVRESILDEKELP
HCCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCC
MRLTALTPCFRAEAGAAGRDTRGMIRQHQFTKVELVSITTPEQSKDEHERMLSCAEEVLR
EEHHHHCHHHHHCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHH
RLGLHYRVMTLCTGDMGFASQKTYDIEVWMPGQGEGGAYREISSCSVCGDFQARRMDARS
HHCCCEEEEEHEECCCCCCCCCEEEEEEEECCCCCCCCCHHHCCCCCCCCHHHHHHHHHC
RGPDGKPRFVHTLNGSGTAVGRALIAVIENYQQEDGSIAVPDALQPYMGGLKVIAK
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA