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The map label for this gene is lvr [H]

Identifier: 86749774

GI number: 86749774

Start: 3038244

End: 3039212

Strand: Direct

Name: lvr [H]

Synonym: RPB_2657

Alternate gene names: 86749774

Gene position: 3038244-3039212 (Clockwise)

Preceding gene: 86749772

Following gene: 86749775

Centisome position: 56.98

GC content: 67.7

Gene sequence:

>969_bases
ATGAGGGATTTCGCCGGCAGGATTGCCGTGGTCACCGGCGGCGGCACCGGCATGGGCCGCGAACTCGCCCGCCAGCTCGC
CGCCGAAGGCTGCCACGTCGCGATCTGCGATGTCTCCGCCGAGGCGATGGCCGAGACCCGGCGGCTGTGCGAAGCGGACG
GGCTGCCGCAGGGGCTGCGGCTCACAACCCACATCGCCGACGTCTCGATCGAGACGCAGATGAACCGGTTTCGCGACGAG
GTCGCGGCGCAGCACCGGACCGATTGCATCCATCTGCTGTTCAACAATGCCGGGATCGGCGGCGGCGGCAGCATGATCAT
CAACAGCCGCGCGCAATGGGAACGCACCTTCGACATCTGCTGGGGCGGCGTGTATCTCGGCACCCGGATCTTCCTGCCGA
TGCTGATCGCCGCGGACGAGGGCCACATCGTCAACACGTCGAGCGTCAACGGCTTCTGGGCGTCGATCGGGCCGACCACG
CCGCACACCGCCTACAGCGCCGCGAAGTTTGCGGTGAAGGGCTTCTCGGAAGCGTTGATCGGCGATCTTCGGCTCAACGC
GCCGCATGTGAAATGTTCGGTGGTGATGCCGGGCCACATCGGCACCTCGATCGTCGCCAATTCGCGCAAGATCCAGAACA
ACGTCGCGGCCGACGAACTCTGCGCCGACGAGATCGCGGCGGTCCGTAAGCGGCTTGCCGCGGCCGGCATCGACGAGGCG
CAGATGTCCGACGACGCCATCCGGGCGATGGTGCAGGAGCGGGCACGCAGCTTCCTCGAGGAGGCGCCGACCAGTGCGGC
GGCGGCGGCGCGCATCATTCTCGACGGCGTGCGCGCGGAACGCTGGCGCATCCTAGTCGGCGACGATGCGCATCTGCTCG
ATCAACGCGTCCGCGCCATGCCGGAGCGCGCCTACGAGACCGACTTCTACCAGAGCTTCGCCGCCGAAGTCGGCTGGAAG
CTCGGCTGA

Upstream 100 bases:

>100_bases
GCGCGGCCGCGATGGACTCGGGCGCGCTGTGCCCTCTATGCTGGGGGGTGCAGCCGCGGCTCGAACCGCGGCGCGACGAC
ATCGGGGAGGACATGCGCCC

Downstream 100 bases:

>100_bases
GCGACGAACGCGACAACAACAAGATCGGGAGAGACGTCATGGACGCAGCGATTGCGCCGGAGACATTCGATTTCGCGGTC
ATGGTCGCCGACCTCAACGC

Product: Short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MRDFAGRIAVVTGGGTGMGRELARQLAAEGCHVAICDVSAEAMAETRRLCEADGLPQGLRLTTHIADVSIETQMNRFRDE
VAAQHRTDCIHLLFNNAGIGGGGSMIINSRAQWERTFDICWGGVYLGTRIFLPMLIAADEGHIVNTSSVNGFWASIGPTT
PHTAYSAAKFAVKGFSEALIGDLRLNAPHVKCSVVMPGHIGTSIVANSRKIQNNVAADELCADEIAAVRKRLAAAGIDEA
QMSDDAIRAMVQERARSFLEEAPTSAAAAARIILDGVRAERWRILVGDDAHLLDQRVRAMPERAYETDFYQSFAAEVGWK
LG

Sequences:

>Translated_322_residues
MRDFAGRIAVVTGGGTGMGRELARQLAAEGCHVAICDVSAEAMAETRRLCEADGLPQGLRLTTHIADVSIETQMNRFRDE
VAAQHRTDCIHLLFNNAGIGGGGSMIINSRAQWERTFDICWGGVYLGTRIFLPMLIAADEGHIVNTSSVNGFWASIGPTT
PHTAYSAAKFAVKGFSEALIGDLRLNAPHVKCSVVMPGHIGTSIVANSRKIQNNVAADELCADEIAAVRKRLAAAGIDEA
QMSDDAIRAMVQERARSFLEEAPTSAAAAARIILDGVRAERWRILVGDDAHLLDQRVRAMPERAYETDFYQSFAAEVGWK
LG
>Mature_322_residues
MRDFAGRIAVVTGGGTGMGRELARQLAAEGCHVAICDVSAEAMAETRRLCEADGLPQGLRLTTHIADVSIETQMNRFRDE
VAAQHRTDCIHLLFNNAGIGGGGSMIINSRAQWERTFDICWGGVYLGTRIFLPMLIAADEGHIVNTSSVNGFWASIGPTT
PHTAYSAAKFAVKGFSEALIGDLRLNAPHVKCSVVMPGHIGTSIVANSRKIQNNVAADELCADEIAAVRKRLAAAGIDEA
QMSDDAIRAMVQERARSFLEEAPTSAAAAARIILDGVRAERWRILVGDDAHLLDQRVRAMPERAYETDFYQSFAAEVGWK
LG

Specific function: Catalyzes the regio- and stereoselective reversible NAD- dependent reduction of (6R)-2,2,6-trimethyl-1,4-cyclohexanedione (levodione) to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI310128830, Length=207, Percent_Identity=30.4347826086957, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI310115468, Length=207, Percent_Identity=30.4347826086957, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI40807363, Length=204, Percent_Identity=29.9019607843137, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI109715829, Length=204, Percent_Identity=26.9607843137255, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI142976729, Length=208, Percent_Identity=27.4038461538462, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI31542939, Length=212, Percent_Identity=28.3018867924528, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI25282469, Length=234, Percent_Identity=25.2136752136752, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI15277342, Length=212, Percent_Identity=29.2452830188679, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI210032110, Length=207, Percent_Identity=25.1207729468599, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI66933014, Length=197, Percent_Identity=26.9035532994924, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI20149619, Length=205, Percent_Identity=25.8536585365854, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1786701, Length=205, Percent_Identity=31.7073170731707, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082100, Length=231, Percent_Identity=29.8701298701299, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082160, Length=224, Percent_Identity=25.8928571428571, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=203, Percent_Identity=27.0935960591133, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193203117, Length=200, Percent_Identity=27, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560332, Length=215, Percent_Identity=30.6976744186047, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=206, Percent_Identity=26.2135922330097, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=202, Percent_Identity=26.7326732673267, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=210, Percent_Identity=29.5238095238095, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=178, Percent_Identity=28.6516853932584, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=205, Percent_Identity=24.8780487804878, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=183, Percent_Identity=28.9617486338798, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24640492, Length=267, Percent_Identity=25.8426966292135, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355631, Length=185, Percent_Identity=28.6486486486486, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281364892, Length=183, Percent_Identity=31.6939890710383, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581726, Length=238, Percent_Identity=27.3109243697479, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI221510726, Length=239, Percent_Identity=30.9623430962343, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571526, Length=204, Percent_Identity=31.8627450980392, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644339, Length=202, Percent_Identity=27.7227722772277, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18859837, Length=197, Percent_Identity=28.4263959390863, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 34766; Mature: 34766

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDFAGRIAVVTGGGTGMGRELARQLAAEGCHVAICDVSAEAMAETRRLCEADGLPQGLR
CCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCE
LTTHIADVSIETQMNRFRDEVAAQHRTDCIHLLFNNAGIGGGGSMIINSRAQWERTFDIC
EEEEHHHEEHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCEEECCCHHHHHHHHHH
WGGVYLGTRIFLPMLIAADEGHIVNTSSVNGFWASIGPTTPHTAYSAAKFAVKGFSEALI
HHHHHHHHHHHHHHHEECCCCCEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
GDLRLNAPHVKCSVVMPGHIGTSIVANSRKIQNNVAADELCADEIAAVRKRLAAAGIDEA
HHHEECCCCEEEEEEECCCCCCHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHH
QMSDDAIRAMVQERARSFLEEAPTSAAAAARIILDGVRAERWRILVGDDAHLLDQRVRAM
HCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
PERAYETDFYQSFAAEVGWKLG
HHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRDFAGRIAVVTGGGTGMGRELARQLAAEGCHVAICDVSAEAMAETRRLCEADGLPQGLR
CCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCE
LTTHIADVSIETQMNRFRDEVAAQHRTDCIHLLFNNAGIGGGGSMIINSRAQWERTFDIC
EEEEHHHEEHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCEEECCCHHHHHHHHHH
WGGVYLGTRIFLPMLIAADEGHIVNTSSVNGFWASIGPTTPHTAYSAAKFAVKGFSEALI
HHHHHHHHHHHHHHHEECCCCCEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
GDLRLNAPHVKCSVVMPGHIGTSIVANSRKIQNNVAADELCADEIAAVRKRLAAAGIDEA
HHHEECCCCEEEEEEECCCCCCHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHH
QMSDDAIRAMVQERARSFLEEAPTSAAAAARIILDGVRAERWRILVGDDAHLLDQRVRAM
HCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
PERAYETDFYQSFAAEVGWKLG
HHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11388460; 10508066 [H]