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The map label for this gene is hppA [H]

Identifier: 86749758

GI number: 86749758

Start: 3020836

End: 3022959

Strand: Direct

Name: hppA [H]

Synonym: RPB_2641

Alternate gene names: 86749758

Gene position: 3020836-3022959 (Clockwise)

Preceding gene: 86749757

Following gene: 86749759

Centisome position: 56.66

GC content: 66.15

Gene sequence:

>2124_bases
ATGACAGCTTTATGGGTGATCGTGCTCTGCGGAGCGCTTGCGATCGTATACGCCGTCTGGGCGACCTCGTCGGTGCTCGC
CGCCGATCAGGGCAACGCGCGGATGCAGGAAATCGCCGCCGCCGTGCGTGAAGGCGCGCAGGCCTATCTGAAGCGCCAGT
ATATGACCATCGCCATCGTCGGCGTGGTGATCTTCGCGCTGCTCGCTTACTTTCTCGGCGTCCTCGTCGCGATCGGCTTC
CTGATCGGCGCGGTGCTGTCGGGCGCGGCCGGCTTCATCGGCATGAACGTGTCGGTGCGTGCCAACGTCCGCACCGCGCA
GGCGGCGACCACCTCGCTCGCCGGCGGCCTCGAGCTCGCCTTCAAGGCTGGCGCCATCACCGGCCTTCTGGTCGCGGGTC
TCGCGCTGCTCGGCGTGACGCTGTATTTCATCTATCTGATCCACTACGCCAATCTGGCTCCGAACAGCCGCACCGTGGTC
GACGCGCTGGTCGCACTCGGCTTCGGCGCCTCGCTGATCTCGATCTTCGCTCGTCTCGGCGGCGGCATCTTCACCAAGGG
TGCGGACGTCGGCGGTGATCTCGTCGGCAAGGTCGAAGCCGGCATTCCGGAAGACGATCCGCGCAACCCGGCGACGATCG
CCGACAACGTCGGCGACAATGTCGGCGACTGCGCCGGCATGGCCGCCGATTTGTTCGAGACCTATGCGGTGACCGCGGTC
GCCACCATGGTGCTCGCCGCGATCTTCTTCGCCGCCACGCCTGACCTGTTGCTCAACATGATGACGCTGCCGCTCGCCAT
TGGCGGCATCTGCATCCTGACCTCGATCGCCGGCACCTTCTTCGTCAAGCTCGGCGCATCGCAGTCGATCATGGGGGCGC
TGTACAAGGGGCTGATCGCCACCGGCGTGCTGTCGCTGATCGGCGTCGGCGCCGTGATCCACCAGTTGATCGGCTTCGGT
CCGCTGGCCGGCGTCAGCTACACCGGCCTGGCGCTGTTCGAATGCGGTATCGTCGGTCTCGCCGTCACCGGCCTGATCAT
CTGGATCACCGAATACTACACCGGCACCGACTACCGGCCGGTGAAGTCGATCGCGCAATCGTCGGTCACCGGCCACGGCA
CCAACGTGATCCAGGGCCTCGCCATCTCGATGGAATCGACCGCGCTGCCCGCGATCGTGATCATCGCCGGCATCCTGGTC
ACCTACAGCCTCGCCGGCCTGTTCGGCATCGCGATCGCCACCACCACGATGCTGGCGCTGGCCGGCATGATCGTGGCGCT
CGACGCCTTCGGCCCGGTCACCGACAATGCCGGCGGCATCGCCGAAATGGCCGGCCTGCCGAAGGAAGTCCGCAAAGCCA
CCGACGCGCTCGACGCCGTCGGCAACACCACCAAGGCGGTGACCAAGGGCTACGCGATCGGCTCCGCCGGTCTCGGCGCG
CTGGTGCTGTTCGCGGCGTATAATGAAGATCTCAAATTCTTCATCGCCAACGCCGCGAAGTATCCGTACTTCGAGGGCGT
GCTGCCCGACTTCTCGCTGAACAACCCCTACGTCGTGGTCGGCCTGCTGTTCGGCGGCCTGCTGCCGTATCTGTTCGGCG
CGATGGGCATGACCGCGGTCGGCCGCGCCGCCGGCGCGATCGTCGAGGAAGTGCGTCGCCAGTTCCGCGAAAAGCCGGGC
ATCATGAAGGGCACCGACAAGCCGGATTACGGCAAGGCGGTCGACCTGCTGACCAAGGCGGCGATCAAGGAAATGATCAT
CCCGTCGCTGCTGCCGGTGCTGTCGCCGATCTTCGTCTACTTCGTGATCTACGCGATCGCGGGCGGCGGTCCGGCCGGCA
AGTCGGCGGCGTTCTCCGCGGTCGGCGCGATGCTGCTCGGCGTCATCGTCACCGGCCTCTTTGTGGCGATCTCGATGACT
TCGGGCGGCGGCGCCTGGGACAACGCCAAGAAGTACATCGAGGACGGCCACCACGGCGGCAAGGGCTCCGACGCCCACAA
GGCCGCGGTGACCGGCGACACCGTCGGCGACCCCTACAAGGACACGGCGGGCCCCGCCGTGAACCCGATGATCAAGATCA
CCAACATCGTGGCACTCTTGCTGCTGGCGATCCTGGCGCACTGA

Upstream 100 bases:

>100_bases
TTGAGACTGCCCCGGGAAGAGGGCACGTCGTCTTGTTGCGCGCCCGCGTCGCTCCCGCGTCGCAGGCACGGGGGTGAAAC
TCGGGACTGAGGCATCAGGA

Downstream 100 bases:

>100_bases
GGCTTCGGGCTTCTGACTGAGTAGAAACCCCGCGGTGTGAGCCGCGGGGTTTTTGTTTGGCGAGCGGCTTTTTCCCGCGA
TAGACTGACGCCATTGCCCG

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 707; Mature: 706

Protein sequence:

>707_residues
MTALWVIVLCGALAIVYAVWATSSVLAADQGNARMQEIAAAVREGAQAYLKRQYMTIAIVGVVIFALLAYFLGVLVAIGF
LIGAVLSGAAGFIGMNVSVRANVRTAQAATTSLAGGLELAFKAGAITGLLVAGLALLGVTLYFIYLIHYANLAPNSRTVV
DALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTAV
ATMVLAAIFFAATPDLLLNMMTLPLAIGGICILTSIAGTFFVKLGASQSIMGALYKGLIATGVLSLIGVGAVIHQLIGFG
PLAGVSYTGLALFECGIVGLAVTGLIIWITEYYTGTDYRPVKSIAQSSVTGHGTNVIQGLAISMESTALPAIVIIAGILV
TYSLAGLFGIAIATTTMLALAGMIVALDAFGPVTDNAGGIAEMAGLPKEVRKATDALDAVGNTTKAVTKGYAIGSAGLGA
LVLFAAYNEDLKFFIANAAKYPYFEGVLPDFSLNNPYVVVGLLFGGLLPYLFGAMGMTAVGRAAGAIVEEVRRQFREKPG
IMKGTDKPDYGKAVDLLTKAAIKEMIIPSLLPVLSPIFVYFVIYAIAGGGPAGKSAAFSAVGAMLLGVIVTGLFVAISMT
SGGGAWDNAKKYIEDGHHGGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAILAH

Sequences:

>Translated_707_residues
MTALWVIVLCGALAIVYAVWATSSVLAADQGNARMQEIAAAVREGAQAYLKRQYMTIAIVGVVIFALLAYFLGVLVAIGF
LIGAVLSGAAGFIGMNVSVRANVRTAQAATTSLAGGLELAFKAGAITGLLVAGLALLGVTLYFIYLIHYANLAPNSRTVV
DALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTAV
ATMVLAAIFFAATPDLLLNMMTLPLAIGGICILTSIAGTFFVKLGASQSIMGALYKGLIATGVLSLIGVGAVIHQLIGFG
PLAGVSYTGLALFECGIVGLAVTGLIIWITEYYTGTDYRPVKSIAQSSVTGHGTNVIQGLAISMESTALPAIVIIAGILV
TYSLAGLFGIAIATTTMLALAGMIVALDAFGPVTDNAGGIAEMAGLPKEVRKATDALDAVGNTTKAVTKGYAIGSAGLGA
LVLFAAYNEDLKFFIANAAKYPYFEGVLPDFSLNNPYVVVGLLFGGLLPYLFGAMGMTAVGRAAGAIVEEVRRQFREKPG
IMKGTDKPDYGKAVDLLTKAAIKEMIIPSLLPVLSPIFVYFVIYAIAGGGPAGKSAAFSAVGAMLLGVIVTGLFVAISMT
SGGGAWDNAKKYIEDGHHGGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAILAH
>Mature_706_residues
TALWVIVLCGALAIVYAVWATSSVLAADQGNARMQEIAAAVREGAQAYLKRQYMTIAIVGVVIFALLAYFLGVLVAIGFL
IGAVLSGAAGFIGMNVSVRANVRTAQAATTSLAGGLELAFKAGAITGLLVAGLALLGVTLYFIYLIHYANLAPNSRTVVD
ALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTAVA
TMVLAAIFFAATPDLLLNMMTLPLAIGGICILTSIAGTFFVKLGASQSIMGALYKGLIATGVLSLIGVGAVIHQLIGFGP
LAGVSYTGLALFECGIVGLAVTGLIIWITEYYTGTDYRPVKSIAQSSVTGHGTNVIQGLAISMESTALPAIVIIAGILVT
YSLAGLFGIAIATTTMLALAGMIVALDAFGPVTDNAGGIAEMAGLPKEVRKATDALDAVGNTTKAVTKGYAIGSAGLGAL
VLFAAYNEDLKFFIANAAKYPYFEGVLPDFSLNNPYVVVGLLFGGLLPYLFGAMGMTAVGRAAGAIVEEVRRQFREKPGI
MKGTDKPDYGKAVDLLTKAAIKEMIIPSLLPVLSPIFVYFVIYAIAGGGPAGKSAAFSAVGAMLLGVIVTGLFVAISMTS
GGGAWDNAKKYIEDGHHGGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAILAH

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 72242; Mature: 72111

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALWVIVLCGALAIVYAVWATSSVLAADQGNARMQEIAAAVREGAQAYLKRQYMTIAIV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVIFALLAYFLGVLVAIGFLIGAVLSGAAGFIGMNVSVRANVRTAQAATTSLAGGLELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCEEEEECCHHHHHHHHHHCCCHHHH
FKAGAITGLLVAGLALLGVTLYFIYLIHYANLAPNSRTVVDALVALGFGASLISIFARLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHC
GGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTAV
CCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLAAIFFAATPDLLLNMMTLPLAIGGICILTSIAGTFFVKLGASQSIMGALYKGLIA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TGVLSLIGVGAVIHQLIGFGPLAGVSYTGLALFECGIVGLAVTGLIIWITEYYTGTDYRP
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
VKSIAQSSVTGHGTNVIQGLAISMESTALPAIVIIAGILVTYSLAGLFGIAIATTTMLAL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGMIVALDAFGPVTDNAGGIAEMAGLPKEVRKATDALDAVGNTTKAVTKGYAIGSAGLGA
HHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHH
LVLFAAYNEDLKFFIANAAKYPYFEGVLPDFSLNNPYVVVGLLFGGLLPYLFGAMGMTAV
HHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
GRAAGAIVEEVRRQFREKPGIMKGTDKPDYGKAVDLLTKAAIKEMIIPSLLPVLSPIFVY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVIYAIAGGGPAGKSAAFSAVGAMLLGVIVTGLFVAISMTSGGGAWDNAKKYIEDGHHGG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCC
KGSDAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAILAH
CCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TALWVIVLCGALAIVYAVWATSSVLAADQGNARMQEIAAAVREGAQAYLKRQYMTIAIV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVIFALLAYFLGVLVAIGFLIGAVLSGAAGFIGMNVSVRANVRTAQAATTSLAGGLELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCEEEEECCHHHHHHHHHHCCCHHHH
FKAGAITGLLVAGLALLGVTLYFIYLIHYANLAPNSRTVVDALVALGFGASLISIFARLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHC
GGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTAV
CCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLAAIFFAATPDLLLNMMTLPLAIGGICILTSIAGTFFVKLGASQSIMGALYKGLIA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TGVLSLIGVGAVIHQLIGFGPLAGVSYTGLALFECGIVGLAVTGLIIWITEYYTGTDYRP
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
VKSIAQSSVTGHGTNVIQGLAISMESTALPAIVIIAGILVTYSLAGLFGIAIATTTMLAL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGMIVALDAFGPVTDNAGGIAEMAGLPKEVRKATDALDAVGNTTKAVTKGYAIGSAGLGA
HHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHH
LVLFAAYNEDLKFFIANAAKYPYFEGVLPDFSLNNPYVVVGLLFGGLLPYLFGAMGMTAV
HHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHH
GRAAGAIVEEVRRQFREKPGIMKGTDKPDYGKAVDLLTKAAIKEMIIPSLLPVLSPIFVY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVIYAIAGGGPAGKSAAFSAVGAMLLGVIVTGLFVAISMTSGGGAWDNAKKYIEDGHHGG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCC
KGSDAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAILAH
CCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]