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The map label for this gene is degP [H]

Identifier: 86749163

GI number: 86749163

Start: 2320339

End: 2321835

Strand: Direct

Name: degP [H]

Synonym: RPB_2041

Alternate gene names: 86749163

Gene position: 2320339-2321835 (Clockwise)

Preceding gene: 86749162

Following gene: 86749164

Centisome position: 43.52

GC content: 66.8

Gene sequence:

>1497_bases
ATGCCCGTTGCGATCACCGCCTTGAGCTTCCGGTTCAAGCCTCTGCTGACGGCTTTGTGCCTCGGCGCGGCTGCCGCCTT
GACCGCGGCGCCGGCGCAGGCCCGCGGCCCCGAGGGCATCGCGGACGTCGCCGAGAAGGTCATCGACGCCGTGGTCAACA
TCTCGACCAGCCAGACCGTCGAGGCCAAGAGTGCGCCCAGCGAGGGCAACAGCGCCAAGCCGAATCTGCCGCCGGGGTCG
CCCTTCGAGGAGTTTTTCGAGGACTTCTTCAAGAACCGCCGCGGCGAGAAGGGCGGTGGCGGCCCGCGCAAGACCAACTC
GCTCGGCTCGGGCTTCATCGTCGACACCGCCGGCATTGCCGTGACCAACAATCACGTCATCGCCGACGCCGACGAGATCA
ACCTGATCATGAACGACGGCACCAAAATCAAGGCGGAGCTGGTCGGCGTCGACAAGAAGACCGATCTGGCGGTGCTGAAG
TTCAAGCCGCCGGCGAACAAGCCGCTGGTGGCGGTGAAGTTCGGCGACAGTGACAAGCTGCGGCTCGGCGAATGGGTGGT
GGCGATCGGCAACCCGTTCTCGCTCGGCGGCACGGTCACCGCCGGCATCGTCTCGGCGCGCAACCGCGACATCAATTCGG
GGCCGTATGACAGCTACATCCAGACCGACGCCGCGATCAATCGCGGCAATTCCGGCGGCCCGCTGTTCAACCTCGACGGC
GAAGTCATCGGCGTCAACACGCTGATCATCTCGCCGTCCGGCGGCTCGATCGGCATCGGATTCGCGGTGCCTTCGAAGAC
CGTGGTCGGGGTGGTCGATCAGCTCCGCCAGTTCGGCGAGCTGCGCCGCGGCTGGCTCGGCGTGCGGATCCAGCAGGTCA
CCGACGAGATCGCCGAAAGCCTCAACATCAAGCCGGCGCGCGGCGCGCTGGTCGCCGGCATCGACGACAAGGGCCCGGCC
AAGCCCGCCGGCATCGAGCCCGGCGACGTCGTCGTCAAGTTCGACGGCAAGGACGTCAAGGAGCCGAAGGATCTGTCGCG
CGTGGTCGCCGACACGGCGGTCGGCAAGACCGTCGACGTGGTGATCATCCGCAAGGGCAAGGAAGAGACCAAGCAGGTCA
CGCTCGGCCGCCTCGACGACGGCGCCAAGCCGCAGCCGGCCTCCGCGAAGTCGCAGCCGGAGCCGGAAAAGCCGGTGACA
CAGAAGGCGCTCGGGCTCGACCTCGCCGCGCTGTCGAAGGACCTGCGCGGCAAGTACAAGATCAAGGACAGCGTCAAGGG
CGTCGTCGTGGTCGGCGTCGACACCGGCTCCGATGCCGCCGAGAAGCGGCTGTCGGCCGGCGACGTGATCGTCGAAGTGG
CGCAGGAAGCGGTCACCAGCGCCGCCGATATCAAGAAGCGGATCGATCAGGTCAAGAAGGACGGCAAGAAGTCGGTGCTG
CTGCTGGTTTCGAACGGAGCCGGCGAACTGCGCTTCGTGGCGCTCAGCCTGCAATAG

Upstream 100 bases:

>100_bases
CGATCGATTCCGATGCGTGCGCCGGTCCCCGGATCGGGCGCAGAGTTTTCAAGCGGCTGCGCCCAATTTGCCCGGCCTCG
ATGCAGGAGATGTTCCGATC

Downstream 100 bases:

>100_bases
ACGATGGCCGCGGCCGGCCGATCTGCGCTCGCCATCGACTTCGTCGGCGGCGCGGTCGGTTACAAATTGCGCTCCGGCGC
CGCCCGCAGCCACGCGCTGC

Product: peptidase S1C, Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MPVAITALSFRFKPLLTALCLGAAAALTAAPAQARGPEGIADVAEKVIDAVVNISTSQTVEAKSAPSEGNSAKPNLPPGS
PFEEFFEDFFKNRRGEKGGGGPRKTNSLGSGFIVDTAGIAVTNNHVIADADEINLIMNDGTKIKAELVGVDKKTDLAVLK
FKPPANKPLVAVKFGDSDKLRLGEWVVAIGNPFSLGGTVTAGIVSARNRDINSGPYDSYIQTDAAINRGNSGGPLFNLDG
EVIGVNTLIISPSGGSIGIGFAVPSKTVVGVVDQLRQFGELRRGWLGVRIQQVTDEIAESLNIKPARGALVAGIDDKGPA
KPAGIEPGDVVVKFDGKDVKEPKDLSRVVADTAVGKTVDVVIIRKGKEETKQVTLGRLDDGAKPQPASAKSQPEPEKPVT
QKALGLDLAALSKDLRGKYKIKDSVKGVVVVGVDTGSDAAEKRLSAGDVIVEVAQEAVTSAADIKKRIDQVKKDGKKSVL
LLVSNGAGELRFVALSLQ

Sequences:

>Translated_498_residues
MPVAITALSFRFKPLLTALCLGAAAALTAAPAQARGPEGIADVAEKVIDAVVNISTSQTVEAKSAPSEGNSAKPNLPPGS
PFEEFFEDFFKNRRGEKGGGGPRKTNSLGSGFIVDTAGIAVTNNHVIADADEINLIMNDGTKIKAELVGVDKKTDLAVLK
FKPPANKPLVAVKFGDSDKLRLGEWVVAIGNPFSLGGTVTAGIVSARNRDINSGPYDSYIQTDAAINRGNSGGPLFNLDG
EVIGVNTLIISPSGGSIGIGFAVPSKTVVGVVDQLRQFGELRRGWLGVRIQQVTDEIAESLNIKPARGALVAGIDDKGPA
KPAGIEPGDVVVKFDGKDVKEPKDLSRVVADTAVGKTVDVVIIRKGKEETKQVTLGRLDDGAKPQPASAKSQPEPEKPVT
QKALGLDLAALSKDLRGKYKIKDSVKGVVVVGVDTGSDAAEKRLSAGDVIVEVAQEAVTSAADIKKRIDQVKKDGKKSVL
LLVSNGAGELRFVALSLQ
>Mature_497_residues
PVAITALSFRFKPLLTALCLGAAAALTAAPAQARGPEGIADVAEKVIDAVVNISTSQTVEAKSAPSEGNSAKPNLPPGSP
FEEFFEDFFKNRRGEKGGGGPRKTNSLGSGFIVDTAGIAVTNNHVIADADEINLIMNDGTKIKAELVGVDKKTDLAVLKF
KPPANKPLVAVKFGDSDKLRLGEWVVAIGNPFSLGGTVTAGIVSARNRDINSGPYDSYIQTDAAINRGNSGGPLFNLDGE
VIGVNTLIISPSGGSIGIGFAVPSKTVVGVVDQLRQFGELRRGWLGVRIQQVTDEIAESLNIKPARGALVAGIDDKGPAK
PAGIEPGDVVVKFDGKDVKEPKDLSRVVADTAVGKTVDVVIIRKGKEETKQVTLGRLDDGAKPQPASAKSQPEPEKPVTQ
KALGLDLAALSKDLRGKYKIKDSVKGVVVVGVDTGSDAAEKRLSAGDVIVEVAQEAVTSAADIKKRIDQVKKDGKKSVLL
LVSNGAGELRFVALSLQ

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=261, Percent_Identity=37.1647509578544, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4506141, Length=282, Percent_Identity=35.8156028368794, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI24308541, Length=263, Percent_Identity=36.8821292775665, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI7019477, Length=285, Percent_Identity=36.8421052631579, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI1786356, Length=470, Percent_Identity=38.5106382978723, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1789629, Length=465, Percent_Identity=36.1290322580645, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1789630, Length=274, Percent_Identity=37.956204379562, Blast_Score=166, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24646839, Length=298, Percent_Identity=35.2348993288591, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 51928; Mature: 51797

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVAITALSFRFKPLLTALCLGAAAALTAAPAQARGPEGIADVAEKVIDAVVNISTSQTV
CCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEE
EAKSAPSEGNSAKPNLPPGSPFEEFFEDFFKNRRGEKGGGGPRKTNSLGSGFIVDTAGIA
ECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCEE
VTNNHVIADADEINLIMNDGTKIKAELVGVDKKTDLAVLKFKPPANKPLVAVKFGDSDKL
EECCEEEECCCCEEEEECCCCEEEEEEEECCCCCCEEEEEECCCCCCCEEEEEECCCCCE
RLGEWVVAIGNPFSLGGTVTAGIVSARNRDINSGPYDSYIQTDAAINRGNSGGPLFNLDG
EECEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHCCHHHHCCCCCCCCEEECCC
EVIGVNTLIISPSGGSIGIGFAVPSKTVVGVVDQLRQFGELRRGWLGVRIQQVTDEIAES
CEEEEEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LNIKPARGALVAGIDDKGPAKPAGIEPGDVVVKFDGKDVKEPKDLSRVVADTAVGKTVDV
CCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEE
VIIRKGKEETKQVTLGRLDDGAKPQPASAKSQPEPEKPVTQKALGLDLAALSKDLRGKYK
EEEECCCCHHHHEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCEE
IKDSVKGVVVVGVDTGSDAAEKRLSAGDVIVEVAQEAVTSAADIKKRIDQVKKDGKKSVL
ECCCCCEEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LLVSNGAGELRFVALSLQ
EEEECCCCCEEEEEEEEC
>Mature Secondary Structure 
PVAITALSFRFKPLLTALCLGAAAALTAAPAQARGPEGIADVAEKVIDAVVNISTSQTV
CEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEE
EAKSAPSEGNSAKPNLPPGSPFEEFFEDFFKNRRGEKGGGGPRKTNSLGSGFIVDTAGIA
ECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCEE
VTNNHVIADADEINLIMNDGTKIKAELVGVDKKTDLAVLKFKPPANKPLVAVKFGDSDKL
EECCEEEECCCCEEEEECCCCEEEEEEEECCCCCCEEEEEECCCCCCCEEEEEECCCCCE
RLGEWVVAIGNPFSLGGTVTAGIVSARNRDINSGPYDSYIQTDAAINRGNSGGPLFNLDG
EECEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHCCHHHHCCCCCCCCEEECCC
EVIGVNTLIISPSGGSIGIGFAVPSKTVVGVVDQLRQFGELRRGWLGVRIQQVTDEIAES
CEEEEEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LNIKPARGALVAGIDDKGPAKPAGIEPGDVVVKFDGKDVKEPKDLSRVVADTAVGKTVDV
CCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEE
VIIRKGKEETKQVTLGRLDDGAKPQPASAKSQPEPEKPVTQKALGLDLAALSKDLRGKYK
EEEECCCCHHHHEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCEE
IKDSVKGVVVVGVDTGSDAAEKRLSAGDVIVEVAQEAVTSAADIKKRIDQVKKDGKKSVL
ECCCCCEEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LLVSNGAGELRFVALSLQ
EEEECCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]