Click here to switch to the map view.

The map label for this gene is murB

Identifier: 86749121

GI number: 86749121

Start: 2269969

End: 2270898

Strand: Direct

Name: murB

Synonym: RPB_1998

Alternate gene names: 86749121

Gene position: 2269969-2270898 (Clockwise)

Preceding gene: 86749120

Following gene: 86749123

Centisome position: 42.58

GC content: 69.89

Gene sequence:

>930_bases
ATGTTTCCCGATCTCGCCGCCGACCTCAAAGCCGCGATGCCTGATTTGCGCGGCCGGCTGCTCGGCAACGAGCCGCTGGC
GCCGCTGACCTGGTTTCGTGTCGGCGGCCCGGCGCAGGTGCTGTTCACGCCGGCCGACGAGGATGATCTCGGTTACTTCC
TGTCGCTGCTGCCGGCGGAGGTGCCGGTGCTGTGCATCGGCGTCGGCTCCAATCTGATCGTGCGCGACGGCGGTTTGCCG
GGCGTGGTGATCAGGCTGGCGCCGCGCGGCTTCGGCGAAGCGCGCAGCGACGGCGAGACCGTCCATGCCGGTGCGGCCGC
GCTCGACAAGCGCGTCGCCGAGACCGCGGCGGCGGCGCAACTCGGCGGACTCGAGTTCTATTTCGGGATTCCCGGAACGA
TCGGCGGCGCGCTGCGGATGAACGCCGGCGCCAATGGCCGCGAGACCAGGGACGTGCTGATCGACGCCACCGCGGTCGAT
CGCGCCGGCCGCCGCCACGTCATCGATCTTGCGGGGATGCAGTTCAGCTATCGCAGCTCCGGCGCGGACCCGTCGCTGAT
CTTCACCTCGGCCCGGTTCCGCGGCACGCCGGCATCGCCGGACGCGATCCGCGCCAAGATGAACGAGGTGCAGGCGCACC
GTGAACTGGCGCAGCCGATCCGCGAGAAGACCGGCGGCTCGACGTTCAAGAATCCGCCGGGCCACAGCGCCTGGAAGCTG
ATCGACGCGGCGGGCTGCCGGGGGCTGCGGATCGGCGGCGCGCAGGTGTCGGAGATGCACTGCAACTTCCTGATCAACAT
CGGCGACGCCACCGCGGCCGACATCGAGACCCTCGGCGAAACCGTGCGCGAACGCGTCAAGGCGCAGTCCGGCATCGAGT
TGCAGTGGGAGATCAAGCGGATCGGCGTCACCGCCGGGATTGCCGGCTGA

Upstream 100 bases:

>100_bases
TGGTGGTGATGCTCGCGAAGACGTGGTTCGTCGATCGCATGGTGTGGCTGTTCGAGGACATGAAGGATCAACGGCCGGAG
TATCGCTCTTGGCTGTACTG

Downstream 100 bases:

>100_bases
GCTGTTACTTCGGCGCGGCGGACGGCGGAGCCGTCGCAGGCGCCGGGGCGGGCGCGACCGGCGGCGCCACCGTGTCGGAT
AGCGACAGCAGCCGCTCGAT

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MFPDLAADLKAAMPDLRGRLLGNEPLAPLTWFRVGGPAQVLFTPADEDDLGYFLSLLPAEVPVLCIGVGSNLIVRDGGLP
GVVIRLAPRGFGEARSDGETVHAGAAALDKRVAETAAAAQLGGLEFYFGIPGTIGGALRMNAGANGRETRDVLIDATAVD
RAGRRHVIDLAGMQFSYRSSGADPSLIFTSARFRGTPASPDAIRAKMNEVQAHRELAQPIREKTGGSTFKNPPGHSAWKL
IDAAGCRGLRIGGAQVSEMHCNFLINIGDATAADIETLGETVRERVKAQSGIELQWEIKRIGVTAGIAG

Sequences:

>Translated_309_residues
MFPDLAADLKAAMPDLRGRLLGNEPLAPLTWFRVGGPAQVLFTPADEDDLGYFLSLLPAEVPVLCIGVGSNLIVRDGGLP
GVVIRLAPRGFGEARSDGETVHAGAAALDKRVAETAAAAQLGGLEFYFGIPGTIGGALRMNAGANGRETRDVLIDATAVD
RAGRRHVIDLAGMQFSYRSSGADPSLIFTSARFRGTPASPDAIRAKMNEVQAHRELAQPIREKTGGSTFKNPPGHSAWKL
IDAAGCRGLRIGGAQVSEMHCNFLINIGDATAADIETLGETVRERVKAQSGIELQWEIKRIGVTAGIAG
>Mature_309_residues
MFPDLAADLKAAMPDLRGRLLGNEPLAPLTWFRVGGPAQVLFTPADEDDLGYFLSLLPAEVPVLCIGVGSNLIVRDGGLP
GVVIRLAPRGFGEARSDGETVHAGAAALDKRVAETAAAAQLGGLEFYFGIPGTIGGALRMNAGANGRETRDVLIDATAVD
RAGRRHVIDLAGMQFSYRSSGADPSLIFTSARFRGTPASPDAIRAKMNEVQAHRELAQPIREKTGGSTFKNPPGHSAWKL
IDAAGCRGLRIGGAQVSEMHCNFLINIGDATAADIETLGETVRERVKAQSGIELQWEIKRIGVTAGIAG

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_RHOP2 (Q2IYK4)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_485617.1
- ProteinModelPortal:   Q2IYK4
- SMR:   Q2IYK4
- STRING:   Q2IYK4
- GeneID:   3909504
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_1998
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- BioCyc:   RPAL316058:RPB_1998-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 32547; Mature: 32547

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 178-178 ACT_SITE 227-227 ACT_SITE 297-297

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPDLAADLKAAMPDLRGRLLGNEPLAPLTWFRVGGPAQVLFTPADEDDLGYFLSLLPAE
CCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHCC
VPVLCIGVGSNLIVRDGGLPGVVIRLAPRGFGEARSDGETVHAGAAALDKRVAETAAAAQ
CCEEEEECCCCEEEECCCCCEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
LGGLEFYFGIPGTIGGALRMNAGANGRETRDVLIDATAVDRAGRRHVIDLAGMQFSYRSS
HCCEEEEEECCCCCCCEEEECCCCCCCCCCEEEEEEHHHHCCCCCEEEEECCCEEEECCC
GADPSLIFTSARFRGTPASPDAIRAKMNEVQAHRELAQPIREKTGGSTFKNPPGHSAWKL
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
IDAAGCRGLRIGGAQVSEMHCNFLINIGDATAADIETLGETVRERVKAQSGIELQWEIKR
HHHCCCCEEEECCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
IGVTAGIAG
EEEEECCCC
>Mature Secondary Structure
MFPDLAADLKAAMPDLRGRLLGNEPLAPLTWFRVGGPAQVLFTPADEDDLGYFLSLLPAE
CCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHCC
VPVLCIGVGSNLIVRDGGLPGVVIRLAPRGFGEARSDGETVHAGAAALDKRVAETAAAAQ
CCEEEEECCCCEEEECCCCCEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
LGGLEFYFGIPGTIGGALRMNAGANGRETRDVLIDATAVDRAGRRHVIDLAGMQFSYRSS
HCCEEEEEECCCCCCCEEEECCCCCCCCCCEEEEEEHHHHCCCCCEEEEECCCEEEECCC
GADPSLIFTSARFRGTPASPDAIRAKMNEVQAHRELAQPIREKTGGSTFKNPPGHSAWKL
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
IDAAGCRGLRIGGAQVSEMHCNFLINIGDATAADIETLGETVRERVKAQSGIELQWEIKR
HHHCCCCEEEECCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
IGVTAGIAG
EEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA