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The map label for this gene is murC

Identifier: 86749119

GI number: 86749119

Start: 2268066

End: 2269472

Strand: Direct

Name: murC

Synonym: RPB_1996

Alternate gene names: 86749119

Gene position: 2268066-2269472 (Clockwise)

Preceding gene: 86749118

Following gene: 86749120

Centisome position: 42.54

GC content: 66.31

Gene sequence:

>1407_bases
ATGAGACTGCCGCGCGAGATCGGACCCATTCACTTCGTCGGGATCGGCGGCATCGGCATGAGCGGCATCGCCGAGGTGCT
GTGCAATCTCGGCTATACGGTGCAGGGCTCCGACGCGTCCGAGAGCGCCAACGTCAGTCGTTTGCGCGAAAAGGGCATCC
AGATCCACGTCGGCCACAAGGCCGACAACGTCGCCGGCGCCGACGTGCTGGTGGTGTCGACGGCGATCAAGCGCGACAAT
CCGGAACTCTTGGCGGCGCGGGCGCAACGCATTCCGGTGGTCCGCCGCGCCGAGATGCTGGCCGAACTGATGCGGCTGAA
GAGCTGCGTCGCAATCGCCGGCACCCATGGCAAGACCACGACGACCTCGATGGTCGCCGCCTTGCTCGACGCCGGCGATT
TCGATCCGACCGTGATCAATGGCGGCATCATCAACGCCTACGGCACCAATGCGCGGCTCGGCGCCGGCGACTGGATGGTG
GTCGAAGCCGACGAAAGCGACGGCACCTTCCTGAAGCTGCCGGCCGACGTCGCCATCGTCACCAATGTCGATCCCGAGCA
CCTCGATCACTTCAAGACTTTCGACGCCGTGCAGGACGCGTTCCGCAACTTCGTCGAGAACGTGCCGTTCTACGGCTTCG
CGGTGATGTGCATCGATCATCCGGTGGTGCAGGCGCTGGTCGGCAAGATCGAAGACCGCCGCATTATTACTTACGGCGAG
AACCCGCAGGCCGATGCGCGCCTGCTCGAGCTGAAGCCGTCCGGCAGCGGTTCGACCTTCAAGGTCGCGTTCCGCGACCG
CAAGGCCGGCACCGCGCACGAGATCGCCGAGCTGATGCTGCCGATGCCGGGCCGGCACAATGCGCTGAACGCAACGGCAG
CCATTGCGGTCGCGCATGAACTCGGCCTGTCCGACGACACCATCCGCAAGGCGCTGGCGGCATTCGGCGGCGTGCGGCGG
CGCTTCACCAAGACCGGCGACTGGAACGGCGTCACCATCATCGACGATTACGGCCATCATCCGGTCGAGATCGCCGCGGT
GCTGAAGGCGGCGCGGCAGTCGACCGACGGCCGGGTGATCGCCGTGGTGCAGCCGCATCGCTTCACCCGGCTGCAGTCGC
TGTTCGAGGAATTCTGCACCTGCTTCAACGACGCCGACAGCGTGATCGTCGCCGACGTCTATCCGGCCGGCGAGGCGCCG
ATCCAGGGGATCGATCGCGATCACTTCGTGCTCGGCCTGCGCGCCCACGGCCATCGCAACGTGATCCCGCTGCAGGATTC
CGCATCGCTGGCGGGAGTCGTCGCGGGCGTCGCCAAGAGCGGCGACTACGTCGTCTGCCTCGGCGCCGGCAACATCACCC
AATGGGCCTACGCACTGCCGGGCGAATTGAAGGCGCTGGGCGGCTGA

Upstream 100 bases:

>100_bases
TCAGGGTGCGACAGGCGGGGCATCCAAGGGGAGGCAGGCCGCCCGGGCCGCCTGCGCCGTTCTGCCGTCCGTTCCGGACG
ATGATTTCAAGGACCATGCC

Downstream 100 bases:

>100_bases
AGCGAGAGGAGGCGCCGATGGCTGTCCTGAGCGACGAGACCTGGAAGCGGCACGCCAATCCGTGGAGCGTGTGGACGCGC
TACGCGGCATTTCCGGTGCT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MRLPREIGPIHFVGIGGIGMSGIAEVLCNLGYTVQGSDASESANVSRLREKGIQIHVGHKADNVAGADVLVVSTAIKRDN
PELLAARAQRIPVVRRAEMLAELMRLKSCVAIAGTHGKTTTTSMVAALLDAGDFDPTVINGGIINAYGTNARLGAGDWMV
VEADESDGTFLKLPADVAIVTNVDPEHLDHFKTFDAVQDAFRNFVENVPFYGFAVMCIDHPVVQALVGKIEDRRIITYGE
NPQADARLLELKPSGSGSTFKVAFRDRKAGTAHEIAELMLPMPGRHNALNATAAIAVAHELGLSDDTIRKALAAFGGVRR
RFTKTGDWNGVTIIDDYGHHPVEIAAVLKAARQSTDGRVIAVVQPHRFTRLQSLFEEFCTCFNDADSVIVADVYPAGEAP
IQGIDRDHFVLGLRAHGHRNVIPLQDSASLAGVVAGVAKSGDYVVCLGAGNITQWAYALPGELKALGG

Sequences:

>Translated_468_residues
MRLPREIGPIHFVGIGGIGMSGIAEVLCNLGYTVQGSDASESANVSRLREKGIQIHVGHKADNVAGADVLVVSTAIKRDN
PELLAARAQRIPVVRRAEMLAELMRLKSCVAIAGTHGKTTTTSMVAALLDAGDFDPTVINGGIINAYGTNARLGAGDWMV
VEADESDGTFLKLPADVAIVTNVDPEHLDHFKTFDAVQDAFRNFVENVPFYGFAVMCIDHPVVQALVGKIEDRRIITYGE
NPQADARLLELKPSGSGSTFKVAFRDRKAGTAHEIAELMLPMPGRHNALNATAAIAVAHELGLSDDTIRKALAAFGGVRR
RFTKTGDWNGVTIIDDYGHHPVEIAAVLKAARQSTDGRVIAVVQPHRFTRLQSLFEEFCTCFNDADSVIVADVYPAGEAP
IQGIDRDHFVLGLRAHGHRNVIPLQDSASLAGVVAGVAKSGDYVVCLGAGNITQWAYALPGELKALGG
>Mature_468_residues
MRLPREIGPIHFVGIGGIGMSGIAEVLCNLGYTVQGSDASESANVSRLREKGIQIHVGHKADNVAGADVLVVSTAIKRDN
PELLAARAQRIPVVRRAEMLAELMRLKSCVAIAGTHGKTTTTSMVAALLDAGDFDPTVINGGIINAYGTNARLGAGDWMV
VEADESDGTFLKLPADVAIVTNVDPEHLDHFKTFDAVQDAFRNFVENVPFYGFAVMCIDHPVVQALVGKIEDRRIITYGE
NPQADARLLELKPSGSGSTFKVAFRDRKAGTAHEIAELMLPMPGRHNALNATAAIAVAHELGLSDDTIRKALAAFGGVRR
RFTKTGDWNGVTIIDDYGHHPVEIAAVLKAARQSTDGRVIAVVQPHRFTRLQSLFEEFCTCFNDADSVIVADVYPAGEAP
IQGIDRDHFVLGLRAHGHRNVIPLQDSASLAGVVAGVAKSGDYVVCLGAGNITQWAYALPGELKALGG

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=466, Percent_Identity=44.8497854077253, Blast_Score=335, Evalue=3e-93,
Organism=Escherichia coli, GI1790680, Length=459, Percent_Identity=29.6296296296296, Blast_Score=163, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_RHOP2 (Q2IYK6)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_485615.1
- ProteinModelPortal:   Q2IYK6
- SMR:   Q2IYK6
- STRING:   Q2IYK6
- GeneID:   3909502
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_1996
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   RPAL316058:RPB_1996-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49965; Mature: 49965

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLPREIGPIHFVGIGGIGMSGIAEVLCNLGYTVQGSDASESANVSRLREKGIQIHVGHK
CCCCCHHCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCEEEECCC
ADNVAGADVLVVSTAIKRDNPELLAARAQRIPVVRRAEMLAELMRLKSCVAIAGTHGKTT
CCCCCCCEEEEEEHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCCH
TTSMVAALLDAGDFDPTVINGGIINAYGTNARLGAGDWMVVEADESDGTFLKLPADVAIV
HHHHHHHHHHCCCCCCEEEECCEEEECCCCCEECCCCEEEEEECCCCCCEEEECCCEEEE
TNVDPEHLDHFKTFDAVQDAFRNFVENVPFYGFAVMCIDHPVVQALVGKIEDRRIITYGE
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCEEEEECC
NPQADARLLELKPSGSGSTFKVAFRDRKAGTAHEIAELMLPMPGRHNALNATAAIAVAHE
CCCCCCEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LGLSDDTIRKALAAFGGVRRRFTKTGDWNGVTIIDDYGHHPVEIAAVLKAARQSTDGRVI
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEE
AVVQPHRFTRLQSLFEEFCTCFNDADSVIVADVYPAGEAPIQGIDRDHFVLGLRAHGHRN
EEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCC
VIPLQDSASLAGVVAGVAKSGDYVVCLGAGNITQWAYALPGELKALGG
EEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHCCCC
>Mature Secondary Structure
MRLPREIGPIHFVGIGGIGMSGIAEVLCNLGYTVQGSDASESANVSRLREKGIQIHVGHK
CCCCCHHCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCEEEECCC
ADNVAGADVLVVSTAIKRDNPELLAARAQRIPVVRRAEMLAELMRLKSCVAIAGTHGKTT
CCCCCCCEEEEEEHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCCH
TTSMVAALLDAGDFDPTVINGGIINAYGTNARLGAGDWMVVEADESDGTFLKLPADVAIV
HHHHHHHHHHCCCCCCEEEECCEEEECCCCCEECCCCEEEEEECCCCCCEEEECCCEEEE
TNVDPEHLDHFKTFDAVQDAFRNFVENVPFYGFAVMCIDHPVVQALVGKIEDRRIITYGE
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCEEEEECC
NPQADARLLELKPSGSGSTFKVAFRDRKAGTAHEIAELMLPMPGRHNALNATAAIAVAHE
CCCCCCEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LGLSDDTIRKALAAFGGVRRRFTKTGDWNGVTIIDDYGHHPVEIAAVLKAARQSTDGRVI
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEE
AVVQPHRFTRLQSLFEEFCTCFNDADSVIVADVYPAGEAPIQGIDRDHFVLGLRAHGHRN
EEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCC
VIPLQDSASLAGVVAGVAKSGDYVVCLGAGNITQWAYALPGELKALGG
EEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA