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The map label for this gene is shc [H]

Identifier: 86748849

GI number: 86748849

Start: 1967570

End: 1969534

Strand: Direct

Name: shc [H]

Synonym: RPB_1726

Alternate gene names: 86748849

Gene position: 1967570-1969534 (Clockwise)

Preceding gene: 86748848

Following gene: 86748850

Centisome position: 36.9

GC content: 65.8

Gene sequence:

>1965_bases
ATGACTTCCGGTACGACCATTCTGGGCGCAGAGCGCGGCAGGACGCTCGACGCCTCGATCGATGCGGCGCGTGCCGCGCT
GCTCGGTTATCGCCGCGACGACGGCCATTGGGTGTTCGAGCTTGAGGCCGATTGTACCATTCCGGCCGAATACGTGCTGC
TGCGGCACTATCTCGGCGAGCCGGTCGATGCCGCGCTGGAGGCCAAGATCGCGGTCTACCTGCGCCGGACCCAGGGCGCG
CATGGCGGCTGGCCGCTGGTGCACGACGGCGAGTTCGATGTCAGCGCGACGGTAAAGGCCTACTTCGCCCTCAAGATGAT
CGGCGACAGCATCGACGCGCCGCATATGGCCAAGGCCCGCGAGGCGATCCTGGCGCGCGGCGGCGCGATCCACGTCAACG
TGTTCACCCGCTTCCTTCTGTCGATGTTCGGCATTCTGACCTGGCGCAGCGTGCCGGTGCTGCCGGTCGAGATCATGCTG
CTGCCGATGTGGGCGCCGTTCCACCTCAACAAGATCTCCTATTGGGCGCGCACCACGATCGTGCCGCTGATGGTGCTGGC
GGCGCTGAAGCCGCGCGCGGTCAACAAGCTCGACATCGGCCTCGATGAATTGTTCCTGCAGGACCCGCAATCGATCGGCA
TGCCGGCCAAGGCGCCGCATCAGAGCTGGGGCCTGTTCACGCTGTTCGGTTCGATCGACGCGGTGCTGCGGGTGATCGAG
CCGCTGATCCCGAAAAAGCTGCGCAGTTATGCGATCGGCCGCGCGGTCGCCTTCATCGAGGAGCGGCTGAACGGCGAGGA
CGGGCTCGGTGCGATCTATCCGCCGATGGCCAACACGGTGATGATGTACAAGGTGCTGGGCTATGGTGAGGACCATCCGC
CGCGCGCCATCACCCGACGCGGCATCGACCTGCTGCTGGTGGTCGGCGAGGAGGAGGCCTACTGCCAGCCCTGCGTCTCG
CCGATCTGGGACACCTCGCTGACCTGCCACGCGCTGCTGGAGGCGGGCGGCGCCGAGGCCGCGCTGCCGGTGCGCAAGGG
GCTGGACTGGCTGATTCCGAAGCAGGTGCTCGACCTCAAGGGCGACTGGGCGGTGAAGGCGCCCAACGTCCGCCCCGGGG
GCTGGGCGTTCCAGTACAACAATGCCCATTACCCCGATCTGGACGACACCGCCGTGGTGGTTATGGCGCTCGACCGCGCC
CGCCGCGATCAGCCGAGTGCGGCCTACGACAATGCGATCGCGCGCGGGCGCGAGTGGATCGAGGGGATGCAGAGCGACGA
TGGCGGCTGGGCTGCCTTCGACGTGAACAACACCGAGTATTATTTGAACAACATCCCGTTCTCGGATCACGGCGCGCTGC
TCGACCCGCCGACCGAGGACGTCACTGCGCGCTGCGTCTCGATGCTGGCGCAGCTCGGCGAGACCGCGGAGACCAGCTCG
GCGCTGGCCCGCGGCGTCGCCTATCTGCGCAAGACCCAACTCGCCGAAGGCTCGTGGTACGGCCGCTGGGGCCTGAATTA
CATCTACGGAACCTGGTCGGTGCTGTGCGCGCTGAATGCGGCCGGGGTCGCCCATCAGGATCCGGCGATGCGCAAGGCGG
TGGCCTGGCTGGCATCGATCCAGAATGCCGATGGCGGCTGGGGCGAGGATGCGGTCAGCTATCGCCTGGACTATCGGGGC
TACGAAAGTGCACCGTCCACGGCGTCCCAAACGGCATGGGCCTTGCTTGCCTTGATGGCTGCCGGGGAAGTCGATCATCC
GGCGGTGGCGCGCGGGGTTGAGTACCTAAAAGGCACACAGACCGAAAAAGGCGTGTGGGACGAGCAGCGCTACACCGCTA
CAGGCTTTCCGCGGGTGTTTTATCTGCGGTACCATGGCTATTCAAAGTTCTTTCCGCTCTGGGCGCTGGCGCGGTATCGA
AATTTGAGAGCCACGAACAGCAAGGTCGTAGGGGTCGGAATGTGA

Upstream 100 bases:

>100_bases
GGGTCGGTGCGGTCCGGGAACCGGGCCGCCGACCTGGTGCTGGCGCTGGGTCAGGCCTGAGCGCGAGCGCCGGCCGACAA
GCACGGAGACTAGCAATTCA

Downstream 100 bases:

>100_bases
TTCTGGGGGCTAGGGGCGACGCGGCCGCGGAGCGAGATCCGCGACCGGTTCTGATTGTAACGGGGCTGATCCAGGAAGCG
AAAATCGCCGAAGGGCCGGG

Product: squalene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 654; Mature: 653

Protein sequence:

>654_residues
MTSGTTILGAERGRTLDASIDAARAALLGYRRDDGHWVFELEADCTIPAEYVLLRHYLGEPVDAALEAKIAVYLRRTQGA
HGGWPLVHDGEFDVSATVKAYFALKMIGDSIDAPHMAKAREAILARGGAIHVNVFTRFLLSMFGILTWRSVPVLPVEIML
LPMWAPFHLNKISYWARTTIVPLMVLAALKPRAVNKLDIGLDELFLQDPQSIGMPAKAPHQSWGLFTLFGSIDAVLRVIE
PLIPKKLRSYAIGRAVAFIEERLNGEDGLGAIYPPMANTVMMYKVLGYGEDHPPRAITRRGIDLLLVVGEEEAYCQPCVS
PIWDTSLTCHALLEAGGAEAALPVRKGLDWLIPKQVLDLKGDWAVKAPNVRPGGWAFQYNNAHYPDLDDTAVVVMALDRA
RRDQPSAAYDNAIARGREWIEGMQSDDGGWAAFDVNNTEYYLNNIPFSDHGALLDPPTEDVTARCVSMLAQLGETAETSS
ALARGVAYLRKTQLAEGSWYGRWGLNYIYGTWSVLCALNAAGVAHQDPAMRKAVAWLASIQNADGGWGEDAVSYRLDYRG
YESAPSTASQTAWALLALMAAGEVDHPAVARGVEYLKGTQTEKGVWDEQRYTATGFPRVFYLRYHGYSKFFPLWALARYR
NLRATNSKVVGVGM

Sequences:

>Translated_654_residues
MTSGTTILGAERGRTLDASIDAARAALLGYRRDDGHWVFELEADCTIPAEYVLLRHYLGEPVDAALEAKIAVYLRRTQGA
HGGWPLVHDGEFDVSATVKAYFALKMIGDSIDAPHMAKAREAILARGGAIHVNVFTRFLLSMFGILTWRSVPVLPVEIML
LPMWAPFHLNKISYWARTTIVPLMVLAALKPRAVNKLDIGLDELFLQDPQSIGMPAKAPHQSWGLFTLFGSIDAVLRVIE
PLIPKKLRSYAIGRAVAFIEERLNGEDGLGAIYPPMANTVMMYKVLGYGEDHPPRAITRRGIDLLLVVGEEEAYCQPCVS
PIWDTSLTCHALLEAGGAEAALPVRKGLDWLIPKQVLDLKGDWAVKAPNVRPGGWAFQYNNAHYPDLDDTAVVVMALDRA
RRDQPSAAYDNAIARGREWIEGMQSDDGGWAAFDVNNTEYYLNNIPFSDHGALLDPPTEDVTARCVSMLAQLGETAETSS
ALARGVAYLRKTQLAEGSWYGRWGLNYIYGTWSVLCALNAAGVAHQDPAMRKAVAWLASIQNADGGWGEDAVSYRLDYRG
YESAPSTASQTAWALLALMAAGEVDHPAVARGVEYLKGTQTEKGVWDEQRYTATGFPRVFYLRYHGYSKFFPLWALARYR
NLRATNSKVVGVGM
>Mature_653_residues
TSGTTILGAERGRTLDASIDAARAALLGYRRDDGHWVFELEADCTIPAEYVLLRHYLGEPVDAALEAKIAVYLRRTQGAH
GGWPLVHDGEFDVSATVKAYFALKMIGDSIDAPHMAKAREAILARGGAIHVNVFTRFLLSMFGILTWRSVPVLPVEIMLL
PMWAPFHLNKISYWARTTIVPLMVLAALKPRAVNKLDIGLDELFLQDPQSIGMPAKAPHQSWGLFTLFGSIDAVLRVIEP
LIPKKLRSYAIGRAVAFIEERLNGEDGLGAIYPPMANTVMMYKVLGYGEDHPPRAITRRGIDLLLVVGEEEAYCQPCVSP
IWDTSLTCHALLEAGGAEAALPVRKGLDWLIPKQVLDLKGDWAVKAPNVRPGGWAFQYNNAHYPDLDDTAVVVMALDRAR
RDQPSAAYDNAIARGREWIEGMQSDDGGWAAFDVNNTEYYLNNIPFSDHGALLDPPTEDVTARCVSMLAQLGETAETSSA
LARGVAYLRKTQLAEGSWYGRWGLNYIYGTWSVLCALNAAGVAHQDPAMRKAVAWLASIQNADGGWGEDAVSYRLDYRGY
ESAPSTASQTAWALLALMAAGEVDHPAVARGVEYLKGTQTEKGVWDEQRYTATGFPRVFYLRYHGYSKFFPLWALARYRN
LRATNSKVVGVGM

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=657, Percent_Identity=27.0928462709285, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI47933397, Length=657, Percent_Identity=27.0928462709285, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI224177558, Length=657, Percent_Identity=27.0928462709285, Blast_Score=196, Evalue=8e-50,
Organism=Homo sapiens, GI224177556, Length=657, Percent_Identity=26.3318112633181, Blast_Score=181, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321863, Length=667, Percent_Identity=23.5382308845577, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 72064; Mature: 71933

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS01074 TERPENE_SYNTHASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSGTTILGAERGRTLDASIDAARAALLGYRRDDGHWVFELEADCTIPAEYVLLRHYLGE
CCCCCEEEECCCCCEECCHHHHHHHHHHCEEECCCCEEEEEECCCCCCHHHHHHHHHHCC
PVDAALEAKIAVYLRRTQGAHGGWPLVHDGEFDVSATVKAYFALKMIGDSIDAPHMAKAR
CHHHHHHHHEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
EAILARGGAIHVNVFTRFLLSMFGILTWRSVPVLPVEIMLLPMWAPFHLNKISYWARTTI
HHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHH
VPLMVLAALKPRAVNKLDIGLDELFLQDPQSIGMPAKAPHQSWGLFTLFGSIDAVLRVIE
HHHHHHHHCCCCCCCHHHCCHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
PLIPKKLRSYAIGRAVAFIEERLNGEDGLGAIYPPMANTVMMYKVLGYGEDHPPRAITRR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHCCCCCCCCHHHHHC
GIDLLLVVGEEEAYCQPCVSPIWDTSLTCHALLEAGGAEAALPVRKGLDWLIPKQVLDLK
CCEEEEEECCCHHHHHHHCCHHHCCCHHHHHHHHCCCCCCCCHHHHCCCHHCCHHHHCCC
GDWAVKAPNVRPGGWAFQYNNAHYPDLDDTAVVVMALDRARRDQPSAAYDNAIARGREWI
CCEEEECCCCCCCCEEEEECCCCCCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHH
EGMQSDDGGWAAFDVNNTEYYLNNIPFSDHGALLDPPTEDVTARCVSMLAQLGETAETSS
HCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHH
ALARGVAYLRKTQLAEGSWYGRWGLNYIYGTWSVLCALNAAGVAHQDPAMRKAVAWLASI
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
QNADGGWGEDAVSYRLDYRGYESAPSTASQTAWALLALMAAGEVDHPAVARGVEYLKGTQ
CCCCCCCCCCHHEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
TEKGVWDEQRYTATGFPRVFYLRYHGYSKFFPLWALARYRNLRATNSKVVGVGM
CCCCCCCCCCEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure 
TSGTTILGAERGRTLDASIDAARAALLGYRRDDGHWVFELEADCTIPAEYVLLRHYLGE
CCCCEEEECCCCCEECCHHHHHHHHHHCEEECCCCEEEEEECCCCCCHHHHHHHHHHCC
PVDAALEAKIAVYLRRTQGAHGGWPLVHDGEFDVSATVKAYFALKMIGDSIDAPHMAKAR
CHHHHHHHHEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHH
EAILARGGAIHVNVFTRFLLSMFGILTWRSVPVLPVEIMLLPMWAPFHLNKISYWARTTI
HHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHH
VPLMVLAALKPRAVNKLDIGLDELFLQDPQSIGMPAKAPHQSWGLFTLFGSIDAVLRVIE
HHHHHHHHCCCCCCCHHHCCHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
PLIPKKLRSYAIGRAVAFIEERLNGEDGLGAIYPPMANTVMMYKVLGYGEDHPPRAITRR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHCCCCCCCCHHHHHC
GIDLLLVVGEEEAYCQPCVSPIWDTSLTCHALLEAGGAEAALPVRKGLDWLIPKQVLDLK
CCEEEEEECCCHHHHHHHCCHHHCCCHHHHHHHHCCCCCCCCHHHHCCCHHCCHHHHCCC
GDWAVKAPNVRPGGWAFQYNNAHYPDLDDTAVVVMALDRARRDQPSAAYDNAIARGREWI
CCEEEECCCCCCCCEEEEECCCCCCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHH
EGMQSDDGGWAAFDVNNTEYYLNNIPFSDHGALLDPPTEDVTARCVSMLAQLGETAETSS
HCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHH
ALARGVAYLRKTQLAEGSWYGRWGLNYIYGTWSVLCALNAAGVAHQDPAMRKAVAWLASI
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
QNADGGWGEDAVSYRLDYRGYESAPSTASQTAWALLALMAAGEVDHPAVARGVEYLKGTQ
CCCCCCCCCCHHEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
TEKGVWDEQRYTATGFPRVFYLRYHGYSKFFPLWALARYRNLRATNSKVVGVGM
CCCCCCCCCCEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]