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The map label for this gene is rkpK [H]

Identifier: 86748710

GI number: 86748710

Start: 1784879

End: 1786186

Strand: Reverse

Name: rkpK [H]

Synonym: RPB_1585

Alternate gene names: 86748710

Gene position: 1786186-1784879 (Counterclockwise)

Preceding gene: 86748717

Following gene: 86748703

Centisome position: 33.5

GC content: 67.66

Gene sequence:

>1308_bases
ATGCGAATAGCGATGATCGGAACCGGCTATGTGGGGCTGGTGTCGGGGGCCTGCTTTGCCGATTTCGGCCATGATGTGGT
GTGTGTCGACAAGGATGCCGGCAAGATCGCAGCGCTGCATCGCGGCGAGATTCCGATCTACGAGCCGGGACTCGACGAAC
TGGTGGCCGCGAACGTCAAGGCGGGCCGGCTGGGCTTCACCACCGATCTGACGGCGCCGGTGGGCGAGGCCGACGCGGTG
TTCATCGCGGTGGGCACGCCGTCGCGGCGCGGCGACGGCCATGCCGATCTCAGCTATGTCTATGCGGCGGCGCGCGAGAT
CGCCGCGGCGCTGAAGGGGTTCACCGTGGTGGTGACCAAGTCGACGGTCCCGGTCGGCACCGGCGACGAGGTCGAACGGC
TGATCCGCGAGACCAATCCGGACGCCGACGCCGCGGTCGCTTCCAATCCGGAATTCCTGCGCGAGGGCGCAGCGATCCGC
GACTTCAAGTTCCCGGACCGGATCGTGATCGGCACTTCCGACGAGCGCGCGCGGAAAGTGCTCGGCGAAATCTATCGGCC
GCTGTCGCTCAACCAGGGCCCGCTGATGTACACCGCGCGGCGCACCGCCGAACTGATCAAATACGCCGCCAACGCGTTCC
TGGCGACCAAGATCACCTTCATCAACGAGATGGCCGATCTCGCCGAAAAGGTCGGCGCCGACGTTCAGGACGTCGCTCGC
GGCATCGGCATGGACAACCGCATCGGCCCCAAATTCCTGCATGCCGGCCCGGGCTTCGGCGGCTCGTGCTTTCCCAAGGA
CACCCGCGCGCTGGTCAAGATCGGCGCCGACCACGAGGTGCCGCTGCGCATCGTCGAGGCGGTGCTGGCGGTCAACGACA
ACCGCAAGCGCGCGATGGCCCGCAAGGTCGCACACGCGCTCGGCGGCAGCCTGCGCGGCAAGACCGTCGCGGTGCTCGGC
CTCACCTTCAAGCCGGACACCGACGACATGCGCGAGGCGCCGTCGATCCCGCTGGTGACCGGGCTGATGGACATGGGCGC
CAAGGTCCGGGCGTTCGACCCGGTCGGCATGGCGCAGGCGAAGGCCGAGCTGCCGGATATCACCTATTGCGACGATGCTT
ATACGTGCGCCGCGGGCGCCGACGCGCTGGTGATCGTCACCGAATGGGTGCAGTTTCGTGCGCTCGACCTGCCGCGGCTG
AAGGCCGCGATGCAGCAGCCGGTGATCGTCGACCTGCGCAACGTCTACCGCGCCGACCAGATGGCCGAGCACGGCTTCGT
GTATCACAGCGTCGGGCGGCCGAGCTGA

Upstream 100 bases:

>100_bases
AACCCACTCATCTGGGCTCGTGTTATTTTTAAACCGGACTCGGTCTGCTAAGAGGCATCGACGCCGGCGTTCTGCCGGTT
TGCAGCCAAAAGAGCGTGAA

Downstream 100 bases:

>100_bases
ACGTCGGTCGGCTGAGCTGAACTGAGCGGCCAGTCGAGCGGAGCAATGGGGACCGCGCGATGCGCGGTCCTATCGTGCGC
CTGAGAGTCCGACCGACAAT

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MRIAMIGTGYVGLVSGACFADFGHDVVCVDKDAGKIAALHRGEIPIYEPGLDELVAANVKAGRLGFTTDLTAPVGEADAV
FIAVGTPSRRGDGHADLSYVYAAAREIAAALKGFTVVVTKSTVPVGTGDEVERLIRETNPDADAAVASNPEFLREGAAIR
DFKFPDRIVIGTSDERARKVLGEIYRPLSLNQGPLMYTARRTAELIKYAANAFLATKITFINEMADLAEKVGADVQDVAR
GIGMDNRIGPKFLHAGPGFGGSCFPKDTRALVKIGADHEVPLRIVEAVLAVNDNRKRAMARKVAHALGGSLRGKTVAVLG
LTFKPDTDDMREAPSIPLVTGLMDMGAKVRAFDPVGMAQAKAELPDITYCDDAYTCAAGADALVIVTEWVQFRALDLPRL
KAAMQQPVIVDLRNVYRADQMAEHGFVYHSVGRPS

Sequences:

>Translated_435_residues
MRIAMIGTGYVGLVSGACFADFGHDVVCVDKDAGKIAALHRGEIPIYEPGLDELVAANVKAGRLGFTTDLTAPVGEADAV
FIAVGTPSRRGDGHADLSYVYAAAREIAAALKGFTVVVTKSTVPVGTGDEVERLIRETNPDADAAVASNPEFLREGAAIR
DFKFPDRIVIGTSDERARKVLGEIYRPLSLNQGPLMYTARRTAELIKYAANAFLATKITFINEMADLAEKVGADVQDVAR
GIGMDNRIGPKFLHAGPGFGGSCFPKDTRALVKIGADHEVPLRIVEAVLAVNDNRKRAMARKVAHALGGSLRGKTVAVLG
LTFKPDTDDMREAPSIPLVTGLMDMGAKVRAFDPVGMAQAKAELPDITYCDDAYTCAAGADALVIVTEWVQFRALDLPRL
KAAMQQPVIVDLRNVYRADQMAEHGFVYHSVGRPS
>Mature_435_residues
MRIAMIGTGYVGLVSGACFADFGHDVVCVDKDAGKIAALHRGEIPIYEPGLDELVAANVKAGRLGFTTDLTAPVGEADAV
FIAVGTPSRRGDGHADLSYVYAAAREIAAALKGFTVVVTKSTVPVGTGDEVERLIRETNPDADAAVASNPEFLREGAAIR
DFKFPDRIVIGTSDERARKVLGEIYRPLSLNQGPLMYTARRTAELIKYAANAFLATKITFINEMADLAEKVGADVQDVAR
GIGMDNRIGPKFLHAGPGFGGSCFPKDTRALVKIGADHEVPLRIVEAVLAVNDNRKRAMARKVAHALGGSLRGKTVAVLG
LTFKPDTDDMREAPSIPLVTGLMDMGAKVRAFDPVGMAQAKAELPDITYCDDAYTCAAGADALVIVTEWVQFRALDLPRL
KAAMQQPVIVDLRNVYRADQMAEHGFVYHSVGRPS

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=461, Percent_Identity=38.177874186551, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI296040438, Length=362, Percent_Identity=38.6740331491713, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI296040443, Length=311, Percent_Identity=38.9067524115756, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI48994968, Length=432, Percent_Identity=29.6296296296296, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788340, Length=357, Percent_Identity=29.6918767507003, Blast_Score=152, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17560350, Length=461, Percent_Identity=36.2255965292842, Blast_Score=262, Evalue=3e-70,
Organism=Drosophila melanogaster, GI17136908, Length=461, Percent_Identity=37.0932754880694, Blast_Score=270, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 46524; Mature: 46524

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAMIGTGYVGLVSGACFADFGHDVVCVDKDAGKIAALHRGEIPIYEPGLDELVAANVK
CEEEEEECCHHHHHCCCHHHHCCCCEEEEECCCCCEEEEECCCCCCCCCCHHHHHHCCCC
AGRLGFTTDLTAPVGEADAVFIAVGTPSRRGDGHADLSYVYAAAREIAAALKGFTVVVTK
CCCCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEE
STVPVGTGDEVERLIRETNPDADAAVASNPEFLREGAAIRDFKFPDRIVIGTSDERARKV
CCCCCCCCHHHHHHHHHCCCCCCCEECCCHHHHHCCCCEECCCCCCEEEEECCHHHHHHH
LGEIYRPLSLNQGPLMYTARRTAELIKYAANAFLATKITFINEMADLAEKVGADVQDVAR
HHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GIGMDNRIGPKFLHAGPGFGGSCFPKDTRALVKIGADHEVPLRIVEAVLAVNDNRKRAMA
HCCCCCCCCCCCEECCCCCCCCCCCCCCHHHEEECCCCCCHHHHHHHHHHCCCCHHHHHH
RKVAHALGGSLRGKTVAVLGLTFKPDTDDMREAPSIPLVTGLMDMGAKVRAFDPVGMAQA
HHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHCCCCCHHHHHHHCCCEEEEECCCCHHHH
KAELPDITYCDDAYTCAAGADALVIVTEWVQFRALDLPRLKAAMQQPVIVDLRNVYRADQ
HHCCCCCEECCCCCCCCCCCCEEEEEEHHHHHHHCCCHHHHHHHCCCCEEEHHHHHHHHH
MAEHGFVYHSVGRPS
HHHCCCEEECCCCCC
>Mature Secondary Structure
MRIAMIGTGYVGLVSGACFADFGHDVVCVDKDAGKIAALHRGEIPIYEPGLDELVAANVK
CEEEEEECCHHHHHCCCHHHHCCCCEEEEECCCCCEEEEECCCCCCCCCCHHHHHHCCCC
AGRLGFTTDLTAPVGEADAVFIAVGTPSRRGDGHADLSYVYAAAREIAAALKGFTVVVTK
CCCCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEE
STVPVGTGDEVERLIRETNPDADAAVASNPEFLREGAAIRDFKFPDRIVIGTSDERARKV
CCCCCCCCHHHHHHHHHCCCCCCCEECCCHHHHHCCCCEECCCCCCEEEEECCHHHHHHH
LGEIYRPLSLNQGPLMYTARRTAELIKYAANAFLATKITFINEMADLAEKVGADVQDVAR
HHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GIGMDNRIGPKFLHAGPGFGGSCFPKDTRALVKIGADHEVPLRIVEAVLAVNDNRKRAMA
HCCCCCCCCCCCEECCCCCCCCCCCCCCHHHEEECCCCCCHHHHHHHHHHCCCCHHHHHH
RKVAHALGGSLRGKTVAVLGLTFKPDTDDMREAPSIPLVTGLMDMGAKVRAFDPVGMAQA
HHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHCCCCCHHHHHHHCCCEEEEECCCCHHHH
KAELPDITYCDDAYTCAAGADALVIVTEWVQFRALDLPRLKAAMQQPVIVDLRNVYRADQ
HHCCCCCEECCCCCCCCCCCCEEEEEEHHHHHHHCCCHHHHHHHCCCCEEEHHHHHHHHH
MAEHGFVYHSVGRPS
HHHCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]