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The map label for this gene is caiC [C]

Identifier: 86748685

GI number: 86748685

Start: 1758035

End: 1759966

Strand: Reverse

Name: caiC [C]

Synonym: RPB_1560

Alternate gene names: 86748685

Gene position: 1759966-1758035 (Counterclockwise)

Preceding gene: 86748686

Following gene: 86748683

Centisome position: 33.01

GC content: 65.89

Gene sequence:

>1932_bases
ATGATGGACTATGCCGGCCGCGTCGCGGCAGCCGATACGTTTCCGAAGCTGCTGCGGCTGAATGCGCGAGAGTTCGGCGA
ACAGATCGCCTTGCGCGAAAAATCGCTCGGACTGTGGCGTGTCTTCACCTGGGCCGACTACCAGAGCCGGGTGCACGATT
TCGCGCTCGGCATGATCGAGCTCGGGCTCGGTCGCGGCGACGTCATCGGCATCATCGGCGACAACCGGCCGGACTGGGTG
TCCGCCGAGATCGCCACGCACGCCATCGGCGCGATGAGCCTCGGGCTGTATCGCGACGTGCTCGACGAGGAAGCCGCCTA
TCTCCTGACCTATGGCGAGGCCAAGCTGGTTTTCGCCGAGGACGAGGAGCAGGTCGACAAGCTGCTGCTGCTCGCCGAGC
GGGTGCCGAACCTCAAGCACATCGTCTATTCGGATCCGCGCGGGATGCGCAAATACGACGACCCGCGGCTGCTGCCGGCC
GACACGCTGGCGGCGATGGGCCGCGCCCGCGCGGCGCGCGAGCCGGGGATCTACGATCGCCTGGTCGATGCGACGGGCGG
CGAGGACGTCGCGATCCTCTGCACCACTTCGGGCACCACCGCGCATCCCAAGCTGGCAATGCTGGCCGCGGGGCGCGTGC
TGAAACATTGCGCGACGTATCTCAGCTTCGACCCGAAGGGGCCGGACGACGAATACGTCTCGGTGCTGCCGCTGCCGTGG
ATCATGGAGCAGGTCTACGCGCTCGGCAAAGGGCTGTTGTGCCGGATGAAAGTCAATTTCGTCGAAGAACCCGACACCAT
GATGAACGACTTCCGCGAGATCGCGCCGACCTTCGTGCTGTTCGCGCCGCGCGTCTGGGAAGGCATCGCCGCGGATGTGC
GCGCGCGGGTGATGGACGCCTCGCCACTGAAACAGCGGCTGTACGAGACCGGCATGAAAGCGGGGCTCGCGGCGCTCGCC
GAGGGCAAGCATTCGGCCTTCGCCGACGCCGTGCTGTTCCGCGCGCTGCGCGACCGGCTCGGCTTCACGCGGCTGCGCTC
GGCGGCGACCGGCGGCGCGGCGCTCGGCCCGGATACTTTCAAGTTCTTCCGCGCGATGGGCGTGCCGCTGCGCACGCTGT
ACGGCCAGACCGAACTGCTCGGCGCCTACACGCTGCACAGAGCGGACGCGGTCGATCCCGACACCACCGGCGTGGCGATG
GGCGCCGAGATCGAGATCAAGGTCGAGAACCCCGATGTCCAGGGCATCGGCGAGATCGTGGTGCGCCACCCCAACATGTA
TCTCGGCTACTACAAGAACGAGGAAGCATCCAAAGCCGACATGCAGGACGGCTGGATGCAATCCGGCGACGCCGGCTATT
TCAACGCGGCCGGCCAGCTCGTGGTGATCGACCGCATCAAGGATCTCGCCGAGACCTCGCACGGCGAGAAATTCTCGCCG
CAATATATCGAGAACAAGCTGAAATTCTCGCCCTATGTGGCCGAAGCCGTGGTGCTCGGCGCCGGCCGCGACCGGCTCGC
GGCGATGATCTGCATCCGCTATTCGATCATCTCGAAATGGGCCGAGAAGAAGCGGATCGGCTTCACCACCTATTCGGACC
TCGCGTCGCGGCCCGAGGTCTACGAGATGCTGCGCAGCGAGGTCGAATCGGTCAATGCGACGCTGCCGCCGGCGCAGCGG
ATCGCCCGCTTCCTGCTGCTCTACAAGGAGCTCGACGCCGACGACGGCGAACTCACCCGCACCCGCAAGGTCCGCCGCTC
GGTGATCAATGAGAAATACGCCGACATCATCGACGGCATCTATGGCGGCCGGAGCGAGATCCCGGTCGACACCCAGATCC
AGTTTCAGGACGGTACCACCCAACGCATCCGAACGACGCTGAAGGTGGTCGACCTCGCCAGCGGCCACGCGCATGCGGAG
GCGGCGGAATGA

Upstream 100 bases:

>100_bases
CCGATCCGCACGTCAAGCGCGCTTATCTCGGCGAGGAGGACGAGGTGCTGGTCGATCCGGACGACATGCCCAGCCATCCG
AGCACTGCGGAGCATGTCGC

Downstream 100 bases:

>100_bases
GTTGTCGGCCTCGGAAAGATTGTCTGGCACGCCAGCTCGGCCGCGTTGAGACGCCCCCTCACCCGGATCACCGCTTCGCG
ATGATCCGACCTCTCCCCGC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 643; Mature: 643

Protein sequence:

>643_residues
MMDYAGRVAAADTFPKLLRLNAREFGEQIALREKSLGLWRVFTWADYQSRVHDFALGMIELGLGRGDVIGIIGDNRPDWV
SAEIATHAIGAMSLGLYRDVLDEEAAYLLTYGEAKLVFAEDEEQVDKLLLLAERVPNLKHIVYSDPRGMRKYDDPRLLPA
DTLAAMGRARAAREPGIYDRLVDATGGEDVAILCTTSGTTAHPKLAMLAAGRVLKHCATYLSFDPKGPDDEYVSVLPLPW
IMEQVYALGKGLLCRMKVNFVEEPDTMMNDFREIAPTFVLFAPRVWEGIAADVRARVMDASPLKQRLYETGMKAGLAALA
EGKHSAFADAVLFRALRDRLGFTRLRSAATGGAALGPDTFKFFRAMGVPLRTLYGQTELLGAYTLHRADAVDPDTTGVAM
GAEIEIKVENPDVQGIGEIVVRHPNMYLGYYKNEEASKADMQDGWMQSGDAGYFNAAGQLVVIDRIKDLAETSHGEKFSP
QYIENKLKFSPYVAEAVVLGAGRDRLAAMICIRYSIISKWAEKKRIGFTTYSDLASRPEVYEMLRSEVESVNATLPPAQR
IARFLLLYKELDADDGELTRTRKVRRSVINEKYADIIDGIYGGRSEIPVDTQIQFQDGTTQRIRTTLKVVDLASGHAHAE
AAE

Sequences:

>Translated_643_residues
MMDYAGRVAAADTFPKLLRLNAREFGEQIALREKSLGLWRVFTWADYQSRVHDFALGMIELGLGRGDVIGIIGDNRPDWV
SAEIATHAIGAMSLGLYRDVLDEEAAYLLTYGEAKLVFAEDEEQVDKLLLLAERVPNLKHIVYSDPRGMRKYDDPRLLPA
DTLAAMGRARAAREPGIYDRLVDATGGEDVAILCTTSGTTAHPKLAMLAAGRVLKHCATYLSFDPKGPDDEYVSVLPLPW
IMEQVYALGKGLLCRMKVNFVEEPDTMMNDFREIAPTFVLFAPRVWEGIAADVRARVMDASPLKQRLYETGMKAGLAALA
EGKHSAFADAVLFRALRDRLGFTRLRSAATGGAALGPDTFKFFRAMGVPLRTLYGQTELLGAYTLHRADAVDPDTTGVAM
GAEIEIKVENPDVQGIGEIVVRHPNMYLGYYKNEEASKADMQDGWMQSGDAGYFNAAGQLVVIDRIKDLAETSHGEKFSP
QYIENKLKFSPYVAEAVVLGAGRDRLAAMICIRYSIISKWAEKKRIGFTTYSDLASRPEVYEMLRSEVESVNATLPPAQR
IARFLLLYKELDADDGELTRTRKVRRSVINEKYADIIDGIYGGRSEIPVDTQIQFQDGTTQRIRTTLKVVDLASGHAHAE
AAE
>Mature_643_residues
MMDYAGRVAAADTFPKLLRLNAREFGEQIALREKSLGLWRVFTWADYQSRVHDFALGMIELGLGRGDVIGIIGDNRPDWV
SAEIATHAIGAMSLGLYRDVLDEEAAYLLTYGEAKLVFAEDEEQVDKLLLLAERVPNLKHIVYSDPRGMRKYDDPRLLPA
DTLAAMGRARAAREPGIYDRLVDATGGEDVAILCTTSGTTAHPKLAMLAAGRVLKHCATYLSFDPKGPDDEYVSVLPLPW
IMEQVYALGKGLLCRMKVNFVEEPDTMMNDFREIAPTFVLFAPRVWEGIAADVRARVMDASPLKQRLYETGMKAGLAALA
EGKHSAFADAVLFRALRDRLGFTRLRSAATGGAALGPDTFKFFRAMGVPLRTLYGQTELLGAYTLHRADAVDPDTTGVAM
GAEIEIKVENPDVQGIGEIVVRHPNMYLGYYKNEEASKADMQDGWMQSGDAGYFNAAGQLVVIDRIKDLAETSHGEKFSP
QYIENKLKFSPYVAEAVVLGAGRDRLAAMICIRYSIISKWAEKKRIGFTTYSDLASRPEVYEMLRSEVESVNATLPPAQR
IARFLLLYKELDADDGELTRTRKVRRSVINEKYADIIDGIYGGRSEIPVDTQIQFQDGTTQRIRTTLKVVDLASGHAHAE
AAE

Specific function: Could Catalyze The Transfer Of CoA To Crotonobetaine Or Carnitine. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI27477105, Length=618, Percent_Identity=25.4045307443366, Blast_Score=193, Evalue=5e-49,
Organism=Homo sapiens, GI83745141, Length=629, Percent_Identity=25.1192368839428, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI42794756, Length=563, Percent_Identity=25.3996447602131, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI42794760, Length=563, Percent_Identity=25.3996447602131, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI42794758, Length=563, Percent_Identity=25.3996447602131, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI40807491, Length=560, Percent_Identity=27.3214285714286, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI57165412, Length=596, Percent_Identity=25.6711409395973, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI4758332, Length=654, Percent_Identity=23.8532110091743, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI12669909, Length=654, Percent_Identity=23.8532110091743, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI57165410, Length=600, Percent_Identity=25.5, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI42794754, Length=602, Percent_Identity=24.5847176079734, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI42794752, Length=602, Percent_Identity=24.5847176079734, Blast_Score=143, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17541856, Length=586, Percent_Identity=26.7918088737201, Blast_Score=168, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17510401, Length=595, Percent_Identity=26.890756302521, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17556552, Length=604, Percent_Identity=23.5099337748344, Blast_Score=145, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI25147511, Length=597, Percent_Identity=24.9581239530988, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17553312, Length=606, Percent_Identity=24.4224422442244, Blast_Score=128, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI193204819, Length=616, Percent_Identity=23.7012987012987, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17564090, Length=620, Percent_Identity=23.3870967741935, Blast_Score=121, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI133901848, Length=214, Percent_Identity=28.9719626168224, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17559526, Length=473, Percent_Identity=24.1014799154334, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320852, Length=630, Percent_Identity=22.6984126984127, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324893, Length=606, Percent_Identity=22.1122112211221, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323903, Length=495, Percent_Identity=22.4242424242424, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322182, Length=589, Percent_Identity=20.7130730050934, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319699, Length=261, Percent_Identity=27.9693486590038, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921316, Length=667, Percent_Identity=25.6371814092954, Blast_Score=204, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17933690, Length=636, Percent_Identity=25, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI281366413, Length=590, Percent_Identity=25.9322033898305, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24666501, Length=589, Percent_Identity=25.9762308998302, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24666497, Length=589, Percent_Identity=25.9762308998302, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI62471681, Length=603, Percent_Identity=23.3830845771144, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI62471687, Length=603, Percent_Identity=23.3830845771144, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24586634, Length=603, Percent_Identity=23.3830845771144, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI22026970, Length=603, Percent_Identity=23.3830845771144, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI62471689, Length=603, Percent_Identity=23.3830845771144, Blast_Score=118, Evalue=2e-26,
Organism=Drosophila melanogaster, GI62471679, Length=603, Percent_Identity=23.3830845771144, Blast_Score=118, Evalue=2e-26,
Organism=Drosophila melanogaster, GI62471683, Length=603, Percent_Identity=23.3830845771144, Blast_Score=118, Evalue=2e-26,
Organism=Drosophila melanogaster, GI62471685, Length=603, Percent_Identity=23.3830845771144, Blast_Score=118, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24586636, Length=603, Percent_Identity=23.3830845771144, Blast_Score=118, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281365686, Length=139, Percent_Identity=34.5323741007194, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 71226; Mature: 71226

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDYAGRVAAADTFPKLLRLNAREFGEQIALREKSLGLWRVFTWADYQSRVHDFALGMIE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHH
LGLGRGDVIGIIGDNRPDWVSAEIATHAIGAMSLGLYRDVLDEEAAYLLTYGEAKLVFAE
HCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEEEC
DEEQVDKLLLLAERVPNLKHIVYSDPRGMRKYDDPRLLPADTLAAMGRARAAREPGIYDR
CHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHH
LVDATGGEDVAILCTTSGTTAHPKLAMLAAGRVLKHCATYLSFDPKGPDDEYVSVLPLPW
HHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECHHH
IMEQVYALGKGLLCRMKVNFVEEPDTMMNDFREIAPTFVLFAPRVWEGIAADVRARVMDA
HHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCHHEEECCHHHHHHHHHHHHHHCCC
SPLKQRLYETGMKAGLAALAEGKHSAFADAVLFRALRDRLGFTRLRSAATGGAALGPDTF
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
KFFRAMGVPLRTLYGQTELLGAYTLHRADAVDPDTTGVAMGAEIEIKVENPDVQGIGEIV
HHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEECCEEEEEECCCCCCCHHHHE
VRHPNMYLGYYKNEEASKADMQDGWMQSGDAGYFNAAGQLVVIDRIKDLAETSHGEKFSP
EECCCEEEEEECCCCCCCCHHHHCCCCCCCCCEECCCCCEEEHHHHHHHHHHCCCCCCCH
QYIENKLKFSPYVAEAVVLGAGRDRLAAMICIRYSIISKWAEKKRIGFTTYSDLASRPEV
HHHHHHHCCCHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHH
YEMLRSEVESVNATLPPAQRIARFLLLYKELDADDGELTRTRKVRRSVINEKYADIIDGI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YGGRSEIPVDTQIQFQDGTTQRIRTTLKVVDLASGHAHAEAAE
CCCCCCCCCCCEEEECCCCHHHHHHHHHHHEECCCCCCCCCCC
>Mature Secondary Structure
MMDYAGRVAAADTFPKLLRLNAREFGEQIALREKSLGLWRVFTWADYQSRVHDFALGMIE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHH
LGLGRGDVIGIIGDNRPDWVSAEIATHAIGAMSLGLYRDVLDEEAAYLLTYGEAKLVFAE
HCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEEEC
DEEQVDKLLLLAERVPNLKHIVYSDPRGMRKYDDPRLLPADTLAAMGRARAAREPGIYDR
CHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHH
LVDATGGEDVAILCTTSGTTAHPKLAMLAAGRVLKHCATYLSFDPKGPDDEYVSVLPLPW
HHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECHHH
IMEQVYALGKGLLCRMKVNFVEEPDTMMNDFREIAPTFVLFAPRVWEGIAADVRARVMDA
HHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCHHEEECCHHHHHHHHHHHHHHCCC
SPLKQRLYETGMKAGLAALAEGKHSAFADAVLFRALRDRLGFTRLRSAATGGAALGPDTF
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
KFFRAMGVPLRTLYGQTELLGAYTLHRADAVDPDTTGVAMGAEIEIKVENPDVQGIGEIV
HHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEECCEEEEEECCCCCCCHHHHE
VRHPNMYLGYYKNEEASKADMQDGWMQSGDAGYFNAAGQLVVIDRIKDLAETSHGEKFSP
EECCCEEEEEECCCCCCCCHHHHCCCCCCCCCEECCCCCEEEHHHHHHHHHHCCCCCCCH
QYIENKLKFSPYVAEAVVLGAGRDRLAAMICIRYSIISKWAEKKRIGFTTYSDLASRPEV
HHHHHHHCCCHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHH
YEMLRSEVESVNATLPPAQRIARFLLLYKELDADDGELTRTRKVRRSVINEKYADIIDGI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YGGRSEIPVDTQIQFQDGTTQRIRTTLKVVDLASGHAHAEAAE
CCCCCCCCCCCEEEECCCCHHHHHHHHHHHEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]